Link to all Central Africa Publications in PubMed
2775998
ZVWK2Q45
2026
1
padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe
50
date
desc
year
257
https://www.iedea.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22TM3TEIY9%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222026-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZhang%2C%20Hongbin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZhu%2C%20Jiaqi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTymejczyk%2C%20Olga%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYotebieng%2C%20Marcel%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282026%29.%20HIV%20disease%20progression%20following%20WHO%20treat%20all%20guideline%20adoption%20among%20people%20enrolled%20in%20HIV%20care%20in%20Central%20Africa%3A%20A%20multistate%20analysis.%20%26lt%3Bi%26gt%3BAnnals%20of%20Epidemiology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B117%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20110063.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annepidem.2026.110063%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annepidem.2026.110063%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV%20disease%20progression%20following%20WHO%20treat%20all%20guideline%20adoption%20among%20people%20enrolled%20in%20HIV%20care%20in%20Central%20Africa%3A%20A%20multistate%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongbin%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiaqi%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Tymejczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22April%20D.%22%2C%22lastName%22%3A%22Kimmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donald%20R.%22%2C%22lastName%22%3A%22Hoover%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiuhu%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastase%22%2C%22lastName%22%3A%22Dzudie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20The%20World%20Health%20Organization%26%23039%3Bs%20Treat%20All%20guidelines%2C%20which%20eliminate%20eligibility%20thresholds%20for%20initiating%20antiretroviral%20therapy%20%28ART%29%20among%20people%20living%20with%20HIV%2C%20have%20been%20implemented%20by%20most%20countries.%20However%2C%20how%20Treat%20All%20relates%20to%20the%20clinical%20progression%20of%20HIV%20disease%20across%20stages%20remains%20less%20well%20characterized.%5CnMETHODS%3A%20We%20applied%20a%20target%20trial-inspired%20design%20to%20examine%20the%20association%20between%20Treat%20All%20policy%20implementation%20and%20HIV%20disease%20progression%20in%20the%20Central%20Africa%20region%20of%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29.%20The%20analysis%20included%20individuals%20enrolled%20in%20HIV%20care%20between%202013%20and%202019.%20Using%20continuous-time%20multistate%20models%2C%20we%20estimated%20transition-specific%20hazards%20across%20four%20WHO%20clinical%20stages%20%281%3A%20asymptomatic%3B%202%3A%20mild%3B%203%3A%20advanced%3B%204%3A%20severe%29%20and%20death.%20Disease%20progression%20was%20compared%20between%20individuals%20enrolling%20after%20%28n%5Cu202f%3D%5Cu202f4607%29%20versus%20before%20%28n%5Cu202f%3D%5Cu202f4439%29%20Treat%20All%20adoption%2C%20with%20hazard%20ratios%20%28HRs%29%20estimated%20with%20and%20without%20covariate%20adjustment.%5CnRESULTS%3A%20At%20enrollment%2C%20the%20distribution%20of%20WHO%20clinical%20stage%20in%20the%20Treat%20All%20cohort%20was%2063.4%25%20asymptomatic%2C%2017.7%25%20mild%2C%2015.6%25%20advanced%2C%20and%203.3%25%20severe%2C%20compared%20with%2059.1%25%2C%2018.3%25%2C%2019.0%25%2C%20and%203.6%25%2C%20respectively%2C%20in%20the%20pre-Treat%20All%20cohort.%20Treat%20All%20implementation%20was%20associated%20with%20lower%20hazards%20of%20disease%20progression%20for%20early-stage%20transitions.%20Specifically%2C%20reduced%20hazards%20were%20observed%20for%20transitions%20from%20stage%201%20to%20stage%202%20%28adjusted%20HR%20%5BaHR%5D%200.64%2C%2095%25%20CI%3A%200.44-0.94%29%20and%20from%20stage%201%20directly%20to%20death%20%28aHR%200.37%2C%2095%25%20CI%3A%200.17-0.81%29.%20Estimates%20for%20transitions%20originating%20from%20later%20disease%20stages%20were%20less%20precise%2C%20and%20no%20statistically%20significant%20differences%20were%20observed.%5CnCONCLUSIONS%3A%20Enrollment%20in%20HIV%20care%20following%20Treat%20All%20policy%20adoption%20was%20associated%20with%20reduced%20early-stage%20disease%20progression%20and%20mortality%2C%20suggesting%20more%20favorable%20disease-progression%20dynamics%20among%20individuals%20entering%20care%20in%20the%20Treat%20All%20era.%20These%20findings%20complement%20existing%20evidence%20on%20ART%20uptake%20and%20viral%20suppression%20and%20support%20the%20role%20of%20universal%20ART%20initiation%20in%20routine%20HIV%20care.%22%2C%22date%22%3A%222026-05%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.annepidem.2026.110063%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221873-2585%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-16T09%3A56%3A43Z%22%7D%7D%2C%7B%22key%22%3A%226YIIKAXE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222026-03-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRomo%2C%20Matthew%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCiaranello%2C%20Andrea%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOdhiambo%2C%20Francesca%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPujari%2C%20Sanjay%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282026%29.%20Lingering%20sex%20and%20age%20disparities%20in%20dolutegravir%20uptake%20among%20adults%20with%20HIV%3A%20a%20multicountry%20observational%20cohort%20study.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B11%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e020159.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2025-020159%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2025-020159%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lingering%20sex%20and%20age%20disparities%20in%20dolutegravir%20uptake%20among%20adults%20with%20HIV%3A%20a%20multicountry%20observational%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20L.%22%2C%22lastName%22%3A%22Romo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%20L.%22%2C%22lastName%22%3A%22Ciaranello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjay%22%2C%22lastName%22%3A%22Pujari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sasisopin%22%2C%22lastName%22%3A%22Kiertiburanakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambu%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winnie%22%2C%22lastName%22%3A%22Muyindike%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vohith%22%2C%22lastName%22%3A%22Khol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Man%20Po%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Since%20July%202019%2C%20the%20WHO%20has%20recommended%20dolutegravir%20%28DTG%29-based%20regimens%20as%20preferred%20first-line%20antiretroviral%20therapy%20%28ART%29%20for%20adults%20and%20adolescents%20living%20with%20HIV%20%28DTG-for-All%29%2C%20a%20reversal%20of%20a%202018%20safety%20alert%20on%20use%20of%20DTG-based%20regimens%20by%20women%20of%20reproductive%20age%20%28WRA%29.%20We%20examined%20sex%20and%20age%20disparities%20in%20DTG%20uptake%20before%20and%20after%20DTG-for-All%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS.%5CnMETHODS%3A%20We%20included%20patients%20%5Cu226516%20years%20on%20or%20initiating%20treatment%20between%20January%202017%20and%20July%202021%20in%2014%20low-%20and%20middle-income%20countries%20where%20initial%20guidelines%20on%20DTG-based%20regimens%20for%20first-line%20ART%20either%20restricted%20use%20by%20WRA%20or%20had%20no%20such%20restrictions.%20We%20estimated%20the%20cumulative%20incidence%20of%20DTG%20uptake%20%28CI-DTG%29%20by%20sex%20and%20age%20group%20%28aged%2016-49%20years%20vs%2050%2B%20years%29%2C%20stratified%20by%20patient%2C%20clinic%20and%20setting%20characteristics.%5CnRESULTS%3A%20Among%20177%5Cu2009706%20patients%20on%20ART%20during%20the%20study%20period%2C%2051%25%20were%20females%20aged%2016-49%20years%2C%20with%2025%25%20males%20aged%2016-49%20and%2013%25%20and%2011%25%2C%20respectively%2C%20females%20and%20males%20aged%2050%2B.%20At%20the%20time%20of%20DTG-for-All%2C%20overall%20CI-DTG%20was%2029.6%25%20%2895%25%20CI%2029.4%25%20to%2029.8%25%29%3B%20it%20was%20lower%20among%20females%20aged%2016-49%20%2816.2%25%3B%2095%25%5Cu2009CI%2016.0%25%20to%2016.5%25%29%20than%20males%20%2841.1%25%3B%2095%25%5Cu2009CI%2040.6%25%20to%2041.5%25%29%2C%20with%20no%20sex%20disparities%20among%20patients%20aged%2050%2B%20%28females%3A%2046.0%25%3B%20males%3A%2047.0%25%29.%20While%20DTG%20uptake%20subsequently%20increased%20among%20all%20groups%2C%20by%20July%202021%2C%20it%20remained%20substantially%20lower%20among%20females%2016-49%20%2866.4%25%3B%2095%25%5Cu2009CI%2066.1%25%20to%2066.7%25%29%2C%20compared%20with%20males%2016-49%20and%20older%20females%20and%20males%20%2875.8%25%20to%2077.5%25%29.%20Concentrated%20in%20countries%20where%20initial%20guidelines%20on%20DTG%20restricted%20use%20by%20WRA%2C%20disparities%20in%20DTG%20uptake%20persisted%20at%20all%20health%20system%20levels%20and%20in%20both%20low-income%20and%20lower-middle-income%20countries.%5CnCONCLUSIONS%3A%20While%20sex-age%20differentials%20in%20DTG%20uptake%20narrowed%20after%20WHO%26%23039%3Bs%20DTG-for-All%20recommendation%2C%20lingering%20disparities%20in%20uptake%20underscore%20the%20difficulty%20of%20policy%20de-implementation%20when%20new%20evidence%20emerges.%22%2C%22date%22%3A%222026-03-13%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2025-020159%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222059-7908%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22369YB7BV%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-16T09%3A55%3A25Z%22%7D%7D%2C%7B%22key%22%3A%224AWM86RP%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rosenberg%20et%20al.%22%2C%22parsedDate%22%3A%222026-02-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRosenberg%2C%20Nora%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYoung%2C%20Amber%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZou%2C%20Yating%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJustman%2C%20Jessica%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCharurat%2C%20Manhattan%20E.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282026%29.%20An%20HIV-1%20Risk%20Assessment%20Tool%20for%20Men%20Aged%2015-59%20years%20in%2013%20African%20Countries%3A%20A%20Pooled%20Analysis%20of%20Nationally%20Representative%20Surveys.%20%26lt%3Bi%26gt%3BJournal%20of%20Acquired%20Immune%20Deficiency%20Syndromes%20%281999%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B101%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20173%26%23x2013%3B182.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003773%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003773%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22An%20HIV-1%20Risk%20Assessment%20Tool%20for%20Men%20Aged%2015-59%20years%20in%2013%20African%20Countries%3A%20A%20Pooled%20Analysis%20of%20Nationally%20Representative%20Surveys%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nora%20E.%22%2C%22lastName%22%3A%22Rosenberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amber%20M.%22%2C%22lastName%22%3A%22Young%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yating%22%2C%22lastName%22%3A%22Zou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%22%2C%22lastName%22%3A%22Justman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manhattan%20E.%22%2C%22lastName%22%3A%22Charurat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sizulu%22%2C%22lastName%22%3A%22Moyo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khangelani%22%2C%22lastName%22%3A%22Zuma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda-Gail%22%2C%22lastName%22%3A%22Bekker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lynda%22%2C%22lastName%22%3A%22Stranix-Chibanda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sam%20J.%22%2C%22lastName%22%3A%22Phiri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%20A.%22%2C%22lastName%22%3A%22Sam-Agudu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20G.%22%2C%22lastName%22%3A%22Hudgens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20H.%22%2C%22lastName%22%3A%22Chi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bonnie%20E.%22%2C%22lastName%22%3A%22Shook-Sa%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Globally%2C%20approximately%20half%20of%20new%20HIV%20acquisitions%20occur%20among%20African%20adults.%20This%20analysis%20examines%20which%20cisgender%20men%20are%20at%20highest%20risk%20of%20acquiring%20HIV-1%20and%20in%20greatest%20need%20of%20HIV%20pre-exposure%20prophylaxis%20%28PrEP%29.%5CnSETTING%3A%20National%20population-based%20surveys%20from%20Eswatini%2C%20Ivory%20Coast%2C%20Kenya%2C%20Lesotho%2C%20Malawi%2C%20Namibia%2C%20Nigeria%2C%20Rwanda%2C%20South%20Africa%2C%20Tanzania%2C%20Uganda%2C%20Zambia%2C%20and%20Zimbabwe.%5CnMETHODS%3A%20The%2013%20surveys%20were%20pooled%20and%20sampling%20weights%20were%20applied%20to%20represent%20all%20susceptible%20men%20aged%2015-59%20years%20old.%20HIV-1%20incidence%20was%20calculated%20based%20on%20a%20recent%20HIV-1%20testing%20algorithm.%20A%20least%20absolute%20shrinkage%20and%20selection%20operator%20%28Lasso%29%20regression%20model%20was%20fit%20with%2028%20variables%20to%20predict%20recent%20HIV-1.%20Models%20were%20trained%20and%20internally%20cross-validated%20to%20estimate%20area%20under%20the%20receiver-operating%20characteristic%20curve%20%28AUC%29.%20Along%20the%20receiver-operating%20characteristic%20curve%2C%20at%20sensitivity%20levels%20from%2010%25%20to%2090%25%2C%20performance%20tradeoffs%20were%20evaluated.%5CnRESULTS%3A%20Of%20167%2C121%20participants%2C%20112%20had%20recent%20HIV-1%2C%20representing%20256%2C000%20new%20annual%20infections%20among%20122%20million%20men.%20Only%202%20variables%20were%20retained-reporting%20a%20male%20sexual%20partner%20and%20living%20in%20a%20subnational%20area%20where%20a%20high%20proportion%20of%20adults%20have%20detectable%20HIV-1%20viremia.%20Overall%20AUC%20was%200.80%20%2895%25%20Confidence%20Interval%3A%200.71%20to%200.89%29%3B%20cross-validated%20AUC%20was%200.76%20%2895%25%20CI%3A%200.64%20to%200.87%29.%20At%2010%25%20sensitivity%2C%2025%2C000%20cases%20could%20be%20averted%20if%20357%2C000%20men%20adhered%20to%20PrEP%20%28Number%20Needed%20to%20Treat%20%3D%2014%29.%20At%2090%25%20sensitivity%2C%20229%2C000%20cases%20could%20be%20averted%20if%2050%20million%20men%20adhered%20to%20PrEP%20%28Number%20Needed%20to%20Treat%5Cu00a0%3D%5Cu00a0219%29.%5CnCONCLUSIONS%3A%20This%20predictive%2C%20parsimonious%2C%20generalizable%20risk%20assessment%20tool%20could%20help%20policymakers%20weigh%20tradeoffs%20between%20PrEP%20reach%20and%20efficiency.%22%2C%22date%22%3A%222026-02-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003773%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221944-7884%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T11%3A26%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22Y4BDEQN6%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kimmel%20et%20al.%22%2C%22parsedDate%22%3A%222026-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKimmel%2C%20April%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPan%2C%20Zhongzhe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMurenzi%2C%20Gad%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BElul%2C%20Batya%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282026%29.%20Sustaining%20Rwanda%26%23x2019%3Bs%20HIV%20response%20after%20elimination%20of%20PEPFAR%20funding%3A%20a%20modelling%20analysis%20of%20HIV%20epidemic%20and%20care%20continuum%20outcomes.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B29%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e70078.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.70078%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.70078%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sustaining%20Rwanda%27s%20HIV%20response%20after%20elimination%20of%20PEPFAR%20funding%3A%20a%20modelling%20analysis%20of%20HIV%20epidemic%20and%20care%20continuum%20outcomes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22April%20D.%22%2C%22lastName%22%3A%22Kimmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhongzhe%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Batya%22%2C%22lastName%22%3A%22Elul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Muhoza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Central%20Africa%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28CA%5Cu2010IeDEA%29%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20HIV%20prevention%20and%20treatment%20supported%20by%20the%20United%20States%20President%26%23039%3Bs%20Emergency%20Plan%20for%20AIDS%20Relief%20%28PEPFAR%29%20have%20saved%20millions%20of%20lives.%20Rwanda%20is%20among%20the%20most%20successful%20countries%20worldwide%20in%20achieving%20global%20targets%20with%20PEPFAR%20support.%20Abrupt%20PEPFAR%20funding%20uncertainty%20raises%20concerns%20about%20continued%20HIV%20epidemic%20control.%20We%20projected%20the%20impact%20of%20the%20Government%20of%20Rwanda%26%23039%3Bs%20%28GoR%26%23039%3Bs%29%20capacity%20to%20offset%20PEPFAR%20funding%20elimination%20on%20adult%20HIV%20epidemic%20and%20care%20continuum%20outcomes%20over%2010%20years.%5CnMETHODS%3A%20Using%20an%20HIV%20policy%20model%20calibrated%20to%20Rwanda%2C%20we%20assessed%20capacity%20to%20sustain%20HIV%20services%20at%3A%2050%25%20%28with%20no%20capacity%20by%20GoR%20to%20cover%20the%20PEPFAR%20funding%20gap%29%2C%2075%25%2C%2090%25%20and%20100%25%20%28with%20full%20capacity%20by%20GoR%20to%20cover%20the%20gap%29.%20Scenarios%20involved%20reducing%20the%20number%20on%20antiretroviral%20therapy%20%28ART%29%2C%20immediately%20discontinuing%20ART%20and%20proportionally%20decreasing%20HIV%20diagnosis%2C%20ART%20initiation%2C%20and%20care%20re-engagement.%20We%20projected%20epidemic%20outcomes%20%28HIV%20prevalence%2C%20HIV%20incidence%2C%20number%20with%20HIV%2C%20new%20HIV%20infections%2C%20deaths%29%20and%20care%20continuum%20outcomes%20%28percentage%20diagnosed%2C%20percentage%20on%20ART%20among%20those%20diagnosed%2C%20percentage%20virally%20suppressed%20among%20those%20on%20ART%29.%20We%20calculated%20differences%20in%20projected%20outcomes%20for%20partial%20or%20no%20capacity%20versus%20full%20capacity.%20Secondary%20analyses%20assessed%20the%20timing%20of%20the%20GoR%26%23039%3Bs%20response.%5CnRESULTS%3A%20Compared%20to%20full%20capacity%20at%2010%20years%2C%20the%20model%20projected%20a%2013.9%25-38.7%25%20increase%20in%20HIV%20prevalence%20and%2069.0%25-246.7%25%20increase%20in%20HIV%20incidence%20across%20coverage%20capacity%20scenarios.%20This%20translated%20to%2029%2C000-64%2C000%20additional%20adults%20with%20HIV%20and%2020%2C000-92%2C000%20cumulative%20new%20adult%20HIV%20infections.%20Cumulative%20projected%20deaths%20increased%20by%2010%2C000-51%2C200.%20The%20model%20projected%20continual%20reductions%20in%20percentage%20diagnosed%20at%2010%20years%3B%20percentage%20virally%20suppressed%20among%20those%20on%20ART%20was%20similar%20across%20scenarios.%20Higher%2C%20and%20more%20delayed%2C%20coverage%20capacity%20had%20projected%20outcomes%20similar%20to%20lower%2C%20and%20less%20delayed%2C%20coverage%20capacity.%20Outcomes%20for%20gradual%20increases%20in%20coverage%20capacity%20were%20generally%20similar%20to%20or%20better%20than%20full%2C%20but%20delayed%2C%20coverage%20capacity.%5CnCONCLUSIONS%3A%20Even%20in%20countries%20like%20Rwanda%20that%20have%20achieved%20epidemic%20control%2C%20abrupt%20and%20persistent%20elimination%20of%20PEPFAR%20funding%20could%20drastically%20reverse%20critical%20gains.%20Evidence%20quantifying%20the%20consequences%20of%20different%20capacities%20to%20sustain%20HIV%20services%20underscores%20the%20high%20stakes%20of%20rapid%20and%20sufficient%20action.%22%2C%22date%22%3A%222026-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.70078%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-16T09%3A59%3A11Z%22%7D%7D%2C%7B%22key%22%3A%222G54YPCQ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222026-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDuda%2C%20Stephany%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoss%2C%20Jeremy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSemeere%2C%20Aggrey%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTiendrebeogo%2C%20Thierry%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282026%29.%20Impact%20of%20US%20government%20funding%20freezes%20on%20the%20HIV%20response%3A%20findings%20from%20a%20rapid%20survey%20in%2032%20countries.%20%26lt%3Bi%26gt%3BHealth%20Affairs%20Scholar%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20qxag020.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fhaschl%5C%2Fqxag020%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fhaschl%5C%2Fqxag020%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impact%20of%20US%20government%20funding%20freezes%20on%20the%20HIV%20response%3A%20findings%20from%20a%20rapid%20survey%20in%2032%20countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aggrey%20S.%22%2C%22lastName%22%3A%22Semeere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Tiendrebeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cleophas%22%2C%22lastName%22%3A%22Chimbetete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20After%20the%20freezing%20of%20US%20foreign%20assistance%20in%20January%202025%2C%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20conducted%20a%20rapid%20survey%20among%20clinics%20and%20programs%20actively%20participating%20in%20the%20research%20consortium%20to%20assess%20the%20status%20of%20HIV-related%20service%20delivery%20in%20mid-2025.%5CnMETHODS%3A%20In%20June-July%202025%2C%20an%20online%20survey%20was%20distributed%20to%20103%20IeDEA-participating%20clinics%5C%2Fprograms%20in%2041%20countries%20in%20sub-Saharan%20Africa%2C%20Latin%20America%20and%20the%20Caribbean%2C%20and%20Asia-Pacific.%20Survey%20domains%20included%20US%20funding-related%20disruptions%20in%20service%20delivery%2C%20medication%20availability%2C%20laboratory%20services%2C%20clinic%20operations%2C%20and%20attendant%20mitigation%20strategies.%20Responses%20were%20received%20from%2076%5C%2F103%20%2874%25%29%20clinics%5C%2Fprograms%20in%2032%5C%2F41%20%2878%25%29%20countries.%20Descriptive%20statistics%20were%20used%20to%20characterize%20disruptions%20in%20HIV-related%20care%20and%20mitigation%20measures.%5CnRESULTS%3A%20Almost%20half%20of%20responding%20sites%20reported%20disruptions%20in%20HIV-related%20services%20%2847%25%29%20since%20January%202025%2C%20along%20with%20disruptions%20in%20medication%20availability%20%2828%25%29%2C%20laboratory%20services%20%2834%25%29%2C%20and%20non-research%20clinic%20operations%20%2847%25%29.%20Among%20those%20reporting%20disruptions%20in%20HIV-related%20services%2C%20only%2014%25%20reported%20that%20all%20disruptions%20were%20fully%20resolved%20at%20the%20time%20of%20the%20survey.%5CnCONCLUSION%3A%20Given%20anticipated%20reductions%20in%20global%20HIV%20funding%2C%20government-%20and%20community-led%20monitoring%20of%20HIV%20prevention%20and%20treatment%20services%20and%20care%20outcomes%20are%20critical%20for%20informing%20national%20responses%20and%20averting%20reversal%20of%20progress%20in%20ending%20the%20epidemic.%22%2C%22date%22%3A%222026-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fhaschl%5C%2Fqxag020%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222976-5390%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22369YB7BV%22%2C%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-16T09%3A57%3A38Z%22%7D%7D%2C%7B%22key%22%3A%226EE452TQ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schmutz%20et%20al.%22%2C%22parsedDate%22%3A%222026-01-27%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchmutz%2C%20Remo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShearer%2C%20Kate%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGolub%2C%20Jonathan%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCortes%2C%20Claudia%20P.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282026%29.%20The%20implementation%20of%20tuberculosis%20preventive%20therapy%20in%20HIV%20care%20clinics%20in%20Africa%2C%20Asia%20and%20Latin%20America%3A%20a%20multiregional%20site%20survey.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B11%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20e018469.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-018469%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-018469%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20implementation%20of%20tuberculosis%20preventive%20therapy%20in%20HIV%20care%20clinics%20in%20Africa%2C%20Asia%20and%20Latin%20America%3A%20a%20multiregional%20site%20survey%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kate%22%2C%22lastName%22%3A%22Shearer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20E.%22%2C%22lastName%22%3A%22Golub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%20P.%22%2C%22lastName%22%3A%22Cortes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eug%5Cu00e8ne%22%2C%22lastName%22%3A%22Messou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Mbonze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Musaazi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anggraini%22%2C%22lastName%22%3A%22Alam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%22%2C%22lastName%22%3A%22Varela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Armel%22%2C%22lastName%22%3A%22Poda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Awachana%22%2C%22lastName%22%3A%22Jiamsakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Zannou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dickman%22%2C%22lastName%22%3A%22Gareta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Komena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winnie%22%2C%22lastName%22%3A%22Muyindike%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20Sarita%22%2C%22lastName%22%3A%22Shah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samyra%20R.%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20global%20consortium%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Towards%20the%20%26%23039%3BEnd%20TB%20Strategy%26%23039%3B%20targets%2C%20the%20WHO%20recommends%20the%20provision%20of%20tuberculosis%20%28TB%29%20preventive%20therapy%20%28TPT%29%20for%20high-risk%20groups%20including%20people%20living%20with%20HIV%20%28PLWH%29.%203%20years%20after%20the%20release%20of%20the%20updated%202020%20WHO%20guidelines%2C%20we%20investigated%20the%20implementation%20of%20TPT%20services%20at%20HIV%20clinics%20in%20low-income%20and%20middle-income%20countries%20%28LMICs%29%2C%20focusing%20on%20TB%20screening%2C%20populations%20eligible%20for%20TPT%20and%20available%20TPT%20regimens.%5CnMETHODS%3A%20In%202023%2C%20we%20surveyed%20HIV%20care%20clinics%20in%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20consortium%20in%20Africa%2C%20the%20Asia-Pacific%20and%20Latin%20America%20and%20the%20Caribbean.%20We%20used%20descriptive%20statistics%20to%20summarise%20TPT%20implementation%20according%20to%20WHO%20guidelines%20and%20multivariable%20logistic%20regression%20models%20to%20estimate%20associations%20with%20clinic%20characteristics.%5CnRESULTS%3A%20Of%20172%20HIV%20clinics%20included%2C%20142%20%2883%25%29%20were%20in%20Africa%2C%2022%20%2813%25%29%20in%20the%20Asia-Pacific%20and%208%20%285%25%29%20in%20Latin%20America%3B%20108%20%2863%25%29%20were%20located%20in%20urban%20areas.%20After%20ruling%20out%20active%20TB%2C%20TPT%20was%20reportedly%20offered%20to%20PLWH%20%28122%20clinics%2C%2071%25%29%2C%20household%20contacts%20of%20individuals%20with%20active%20TB%20%28120%20clinics%2C%2070%25%29%20and%20other%20high-risk%20populations.%20TPT%20for%20PLWH%20was%20more%20frequently%20available%20in%20clinics%20in%20lower-income%20and%20low-middle-income%20countries%2C%20in%20high%20TB%20burden%20countries%2C%20and%20in%20district%20hospitals%20compared%20with%20other%20facility%20types.%20Clinics%20reported%20use%20of%20isoniazid-based%20%28160%20clinics%2C%2093%25%29%20and%20shorter%20rifamycin-based%20%28129%20clinics%2C%2075%25%29%20TPT%20regimens.%20Reported%20barriers%20to%20TPT%20initiation%20included%20patient%20refusal%20at%2071%20%2841%25%29%20and%20drug%20shortages%20at%2067%20%2839%25%29%20clinics.%5CnCONCLUSIONS%3A%20TPT%20was%20available%20at%20most%20HIV%20care%20clinics%20in%20LMICs%20but%20further%20efforts%20are%20needed%20to%20reinforce%20WHO%20recommendations%20and%20ensure%20that%20TPT%20is%20consistently%20accessible%20to%20people%20at%20higher%20risk%20of%20developing%20active%20TB%2C%20especially%20PLWH.%22%2C%22date%22%3A%222026-01-27%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2024-018469%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222059-7908%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22369YB7BV%22%2C%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A21%3A03Z%22%7D%7D%5D%7D
Zhang, Hongbin; Zhu, Jiaqi; Brazier, Ellen; Tymejczyk, Olga; Yotebieng, Marcel et al. (2026). HIV disease progression following WHO treat all guideline adoption among people enrolled in HIV care in Central Africa: A multistate analysis.
Annals of Epidemiology,
117, S. 110063.
http://doi.org/10.1016/j.annepidem.2026.110063.
Brazier, Ellen; Romo, Matthew L.; Ciaranello, Andrea L.; Odhiambo, Francesca; Pujari, Sanjay et al. (2026). Lingering sex and age disparities in dolutegravir uptake among adults with HIV: a multicountry observational cohort study.
BMJ Global Health,
11 (3), S. e020159.
http://doi.org/10.1136/bmjgh-2025-020159.
Rosenberg, Nora E.; Young, Amber M.; Zou, Yating; Justman, Jessica; Charurat, Manhattan E. et al. (2026). An HIV-1 Risk Assessment Tool for Men Aged 15-59 years in 13 African Countries: A Pooled Analysis of Nationally Representative Surveys.
Journal of Acquired Immune Deficiency Syndromes (1999),
101 (2), S. 173–182.
http://doi.org/10.1097/QAI.0000000000003773.
Kimmel, April D.; Pan, Zhongzhe; Murenzi, Gad; Brazier, Ellen; Elul, Batya et al. (2026). Sustaining Rwanda’s HIV response after elimination of PEPFAR funding: a modelling analysis of HIV epidemic and care continuum outcomes.
Journal of the International AIDS Society,
29 (2), S. e70078.
http://doi.org/10.1002/jia2.70078.
Brazier, Ellen; Duda, Stephany N.; Ross, Jeremy; Semeere, Aggrey S.; Tiendrebeogo, Thierry et al. (2026). Impact of US government funding freezes on the HIV response: findings from a rapid survey in 32 countries.
Health Affairs Scholar,
4 (2), S. qxag020.
http://doi.org/10.1093/haschl/qxag020.
Schmutz, Remo; Banholzer, Nicolas; Shearer, Kate; Golub, Jonathan E.; Cortes, Claudia P. et al. (2026). The implementation of tuberculosis preventive therapy in HIV care clinics in Africa, Asia and Latin America: a multiregional site survey.
BMJ Global Health,
11 (1), S. e018469.
http://doi.org/10.1136/bmjgh-2024-018469.
2775998
ZVWK2Q45
2025
1
padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe
50
date
desc
year
257
https://www.iedea.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22BZPVK8PB%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Parcesepe%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-30%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BParcesepe%2C%20Angela%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFiliatreau%2C%20Lindsey%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEbasone%2C%20Peter%20Vanes%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDzudie%2C%20Anastase%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYotebieng%2C%20Marcel%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Gender%2C%20mental%20health%20symptoms%2C%20loss%20to%20clinic%2C%20and%20viral%20non-suppression%206%20months%20after%20HIV%20care%20initiation%20among%20a%20cohort%20of%20people%20with%20HIV%20in%20Cameroon.%20%26lt%3Bi%26gt%3BBMC%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B25%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%204374.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-025-24668-y%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-025-24668-y%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Gender%2C%20mental%20health%20symptoms%2C%20loss%20to%20clinic%2C%20and%20viral%20non-suppression%206%20months%20after%20HIV%20care%20initiation%20among%20a%20cohort%20of%20people%20with%20HIV%20in%20Cameroon%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lindsey%20M.%22%2C%22lastName%22%3A%22Filiatreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20Vanes%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastase%22%2C%22lastName%22%3A%22Dzudie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Pefura-Yone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annereke%22%2C%22lastName%22%3A%22Nyenti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20People%20with%20HIV%20%28PWH%29%20experience%20high%20levels%20of%20mental%20health%20or%20substance%20use%20disorders%20%28MSDs%29%20which%20may%20compromise%20HIV%20treatment%20outcomes.%20Differences%20in%20the%20relationship%20between%20MSDs%20and%20HIV%20treatment%20outcomes%20by%20gender%20remain%20understudied.%5CnMETHODS%3A%20We%20conducted%20interviews%20with%20426%20PWH%20aged%5Cu2009%5Cu2265%5Cu200921%20years%20initiating%20HIV%20care%20in%20Cameroon%20between%20June%202019%20and%20March%202020.%20Clinic%20data%20and%20laboratory%20results%20were%20used%20to%20ascertain%20loss%20to%20clinic%20and%20viral%20non-suppression%20six%20months%20after%20HIV%20care%20initiation.%20We%20used%20log%20binomial%20regression%20models%20to%20assess%20the%20relationship%20between%20symptoms%20of%20depression%20%28PHQ-9%20scores%5Cu2009%26gt%3B%5Cu20099%29%2C%20anxiety%20%28GAD-7%20scores%5Cu2009%26gt%3B%5Cu20099%29%2C%20post-traumatic%20stress%20disorder%20%28PTSD%3B%20PCL-5%20scores%5Cu2009%26gt%3B%5Cu200930%29%2C%20and%20harmful%20alcohol%20use%20%28AUDIT%20scores%5Cu2009%26gt%3B%5Cu200915%29%20at%20HIV%20care%20initiation%20and%206-month%20loss%20to%20clinic%20and%20viral%20non-suppression%20in%20the%20study%20population%20overall%2C%20and%20among%20men%20and%20women%2C%20separately.%5CnRESULTS%3A%20Nearly%2025%25%20of%20individuals%20%28N%5Cu2009%3D%5Cu2009100%29%20were%20lost%20to%20clinic%20at%206%20months.%20Among%20the%20326%20individuals%20retained%20in%20care%20at%20their%20original%20clinic%20at%206%20months%2C%20234%20had%20a%20measured%20viral%20load%2C%20of%20whom%2028%25%20were%20virally%20non-suppressed%20%28N%5Cu2009%3D%5Cu200965%29.%20Among%20men%2C%20the%20risk%20of%20disengagement%20was%20greater%20among%20those%20who%20reported%20PTSD%20symptoms%20at%20care%20initiation%20compared%20to%20those%20who%20did%20not.%20Viral%20non-suppression%20was%20significantly%20higher%20among%20those%20reporting%20symptoms%20of%20anxiety%20at%20care%20initiation%20in%20the%20population%20retained%20overall%20and%20among%20men.%5CnCONCLUSIONS%3A%20Men%20initiating%20HIV%20care%20with%20poor%20mental%20health%20may%20be%20particularly%20vulnerable%20to%20unstable%20care%20engagement%20and%20viral%20non-suppression.%20Interventions%20are%20needed%20for%20men%20specifically%20to%20foster%20improved%20mental%20health.%22%2C%22date%22%3A%222025-12-30%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12889-025-24668-y%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2458%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A10%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22TD6C852E%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pan%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPan%2C%20Zhongzhe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDuda%2C%20Stephany%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoss%2C%20Jeremy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTempleton%2C%20David%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Limited%20user%20fees%20for%20adult%20HIV%20diagnosis%20and%20routine%20laboratory%20monitoring%20in%20the%20global%20IeDEA%20consortium%3A%20analysis%20in%2042%20countries.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202025.12.05.25341715.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.64898%5C%2F2025.12.05.25341715%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.64898%5C%2F2025.12.05.25341715%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Limited%20user%20fees%20for%20adult%20HIV%20diagnosis%20and%20routine%20laboratory%20monitoring%20in%20the%20global%20IeDEA%20consortium%3A%20analysis%20in%2042%20countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhongzhe%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Templeton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjay%22%2C%22lastName%22%3A%22Pujari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauren%20C.%22%2C%22lastName%22%3A%22Zalla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%20M.%22%2C%22lastName%22%3A%22Galiwango%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Carriquiry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henri%22%2C%22lastName%22%3A%22Chenal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romanee%22%2C%22lastName%22%3A%22Chaiwarith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raynell%22%2C%22lastName%22%3A%22Lang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22Byakwaga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Cesar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%20O.%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%20Wagner%22%2C%22lastName%22%3A%22Cordoso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ephrem%22%2C%22lastName%22%3A%22Mensah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathleen%22%2C%22lastName%22%3A%22McGinnis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ethel%22%2C%22lastName%22%3A%22Rambiki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Armel%22%2C%22lastName%22%3A%22Poda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22April%20D.%22%2C%22lastName%22%3A%22Kimmel%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20While%20HIV%20services%20have%20scaled%20up%20dramatically%20under%20universal%20treatment%20recommendations%2C%20availability%20of%20routine%20laboratory%20services%20for%20HIV%20diagnosis%20and%20management%2C%20and%20the%20extent%20to%20which%20user%20fees%20are%20charged%20for%20these%20services%2C%20are%20not%20well%20documented.%20We%20described%20site-level%20availability%20and%20user%20fees%20for%20adult%20HIV%20laboratory%20testing%20among%20238%20sites%20in%2042%20countries%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20global%20consortium%2C%20and%20contextualized%20practices%20by%20site-%20and%20country-level%20characteristics%2C%20including%20country%20income%20level%20and%20receipt%20of%20Global%20Fund%20or%20PEPFAR%20support.%5CnMETHODS%3A%20Availability%20of%20HIV-related%20laboratory%20services%20and%20charging%20of%20user%20fees%2C%20were%20examined%20via%20an%20IeDEA%20site%20assessment%20survey%20conducted%20September%202020-March%202021%2C%20with%20responses%20reflecting%20practices%20in%202019.%20Laboratory%20services%20examined%20included%3A%20HIV-1%5C%2FHIV-2%20antigen%5C%2Fantibody%20immunoassay%20test%20%28HIV-1%5C%2F2%20Ag%5C%2FAb%29%2C%20HIV-1%20p24%20antigen%20test%20%28p24%29%2C%20supplemental%20HIV-1%5C%2FHIV-2%20antibody%20differentiation%20immunoassay%20%28HIV-1%5C%2F2%20Ab%20suppl%29%2C%20quantitative%20PCR%20for%20HIV%20viral%20load%20%28VL%29%2C%20HIV-1%20genotypic%20drug%20resistance%20testing%20%28genotyping%29%2C%20and%20CD4%20count%20testing%20%28CD4%29.%20Availability%20was%20defined%20as%20provided%20on-site%20in%20the%20HIV%20clinic%20or%20within%20the%20same%20health%20facility.%20User%20fees%20were%20fees%20other%20than%20insurance%20co-pays%20paid%20for%20a%20given%20test%2C%20conditional%20on%20their%20on-site%20availability.%20We%20reported%20frequencies%20and%20percentages%20of%20site-level%20availability%20and%20user%20fees%2C%20overall%20and%20by%20site-%20and%20country-level%20characteristics.%5CnRESULTS%3A%20Most%20sites%20%2888%25%29%20reported%20HIV-1%5C%2FHIV-2%20Ag%5C%2FAb%20availability%20on-site%2C%20while%20fewer%20than%20half%20of%20sites%20reported%20having%20p24%20and%20HIV-1%5C%2F2%20Ab%20suppl%20available.%20Approximately%20half%20of%20sites%20reported%20VL%20and%20CD4%20testing%20availability%2C%20while%20less%20than%20one-third%20of%20sites%20%2828%25%29%20reported%20genotyping%20availability.%20The%20percentage%20of%20sites%20reporting%20user%20fees%20ranged%20from%206.5%25%20%28HIV-1%5C%2F2%20Ag%5C%2FAb%29%20to%2010.5%25%20%28CD4%29.%20A%20higher%20percentage%20of%20sites%20reporting%20user%20fees%20were%20from%20upper-middle%20income%20countries%2C%20countries%20receiving%20any%20Global%20Fund%20or%20any%20PEPFAR%20country%20support%2C%20and%20the%20Asia-Pacific%20region.%5CnCONCLUSIONS%3A%20While%20most%20HIV%20care%20sites%20participating%20in%20IeDEA%20did%20not%20charge%20user%20fees%20for%20HIV-related%20laboratory%20tests%20in%202019%2C%20on-site%20availability%20of%20such%20tests%20was%20limited.%20Continued%20action%20to%20identify%20and%20address%20constraints%20in%20the%20routine%20provision%20of%20these%20laboratory%20services%20is%20critical%20for%20appropriate%20management%20of%20HIV.%22%2C%22date%22%3A%222025-12-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.64898%5C%2F2025.12.05.25341715%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-17T06%3A30%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22NCCI45EE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Curcio%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCurcio%2C%20Evan%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BXu%2C%20Kai%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSahakyan%2C%20Harutyun%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWolf%2C%20Yuri%20I.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKelvin%2C%20Elizabeth%20A.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Mosquito%20vector%20ecologies%20are%20destabilizing%20as%20a%20result%20of%20climate%20change.%20%26lt%3Bi%26gt%3BResearch%20Square%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20rs.3.rs-7776054.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21203%5C%2Frs.3.rs-7776054%5C%2Fv1%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21203%5C%2Frs.3.rs-7776054%5C%2Fv1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mosquito%20vector%20ecologies%20are%20destabilizing%20as%20a%20result%20of%20climate%20change%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evan%20J.%22%2C%22lastName%22%3A%22Curcio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kai%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harutyun%22%2C%22lastName%22%3A%22Sahakyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuri%20I.%22%2C%22lastName%22%3A%22Wolf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20A.%22%2C%22lastName%22%3A%22Kelvin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nash%20D.%22%2C%22lastName%22%3A%22Rochman%22%7D%5D%2C%22abstractNote%22%3A%22Mosquito-borne%20infectious%20disease%20is%20a%20major%20cause%20of%20mortality%20and%20a%20significant%20economic%20burden%20worldwide.%20Shifting%20regional%20and%20seasonal%20patterns%20make%20proactive%20intervention%20challenging.%20Here%20we%20introduce%20a%20machine%20learning%20approach%20trained%20on%20satellite%20and%20mosquito%20observational%20data%2C%20improving%20generalizability%20to%20sparse%20observations%20while%20retaining%20similar%20positive%20performance%20characteristics%20of%20models%20used%20in%20standard%20practice.%20We%20provide%20global%20estimates%20for%20Aedes%20habitability%20at%20high%20spatial%20resolution%20in%20five-year%20increments%20from%201970-2024.%20The%20vast%20majority%20of%20ecologies%20appear%20to%20be%20destabilizing.%20Overall%2C%20we%20demonstrate%20a%20decrease%20in%20risk%20near%20the%20equator%20and%20an%20increase%20in%20risk%20in%20historically%20temperate%20climates%20including%20the%20United%20States%2C%20the%20European%20Union%2C%20and%20China.%20Despite%20this%20decrease%20in%20risk%20relative%20to%20historical%20averages%2C%20regions%20near%20the%20equator%20remain%20among%20the%20highest%20risk%20worldwide.%20Together%2C%20these%20results%20reflect%20an%20overall%2C%20marked%20expanse%20of%20the%20regions%20of%20the%20globe%20that%20support%20Aedes%20mosquitos%20and%20we%20observe%20an%20ongoing%2C%20linear%20increase%20in%20the%20global%20population%20at%20risk%20of%20contracting%20mosquito-borne%20disease.%22%2C%22date%22%3A%222025-12-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.21203%5C%2Frs.3.rs-7776054%5C%2Fv1%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222693-5015%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A23%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22P7P7KZAU%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBerry%2C%20Amanda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKatz%2C%20Benjamin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLewis%2C%20Judith%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDuda%2C%20Stephany%20N.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20development%20of%20IeDEA%26%23x2019%3Bs%20Treat%20All%20Dashboard%20on%20HIV%20care%20outcomes%20at%20participating%20clinics%20in%20Sub-Saharan%20Africa.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202025.11.20.25340413.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.11.20.25340413%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.11.20.25340413%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20development%20of%20IeDEA%27s%20Treat%20All%20Dashboard%20on%20HIV%20care%20outcomes%20at%20participating%20clinics%20in%20Sub-Saharan%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%22%2C%22lastName%22%3A%22Berry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Katz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%20T.%22%2C%22lastName%22%3A%22Lewis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aggrey%22%2C%22lastName%22%3A%22Semeere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%20Oteko%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francois%22%2C%22lastName%22%3A%22Dabis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Muhoza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22Data%20dashboards%20are%20popular%20tools%20for%20communicating%20information%20and%20monitoring%20progress%20towards%20public%20health%20goals.%20To%20facilitate%20access%20to%20information%20on%20key%20metrics%20and%20emergent%20trends%20related%20to%20the%20roll-out%20of%20universal%20HIV%20treatment%20across%20diverse%20settings%2C%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20leveraged%20real-world%20service%20delivery%20data%20from%20clinics%20in%20sub-Saharan%20Africa%20to%20develop%201%29%20a%20publicly%20accessible%20interactive%20dashboard%20displaying%20regional%20and%20country-level%20metrics%20related%20to%20HIV%20care%20outcomes%20across%20IeDEA%20sites%20in%20sub-Saharan%20Africa%3B%20and%202%29%20a%20password-protected%20dashboard%20displaying%20similar%20metrics%20at%20the%20clinic%20level%20for%20staff%20at%20sites%20that%20contribute%20data%20to%20the%20IeDEA%20consortium.%20This%20paper%20describes%20the%20development%20of%20these%20dashboards%20and%20lessons%20learned.%22%2C%22date%22%3A%222025-11-20%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1101%5C%2F2025.11.20.25340413%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-17T06%3A30%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22CBKDISCQ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22He%20et%20al.%22%2C%22parsedDate%22%3A%222025-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHe%2C%20Jiawei%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrewer%2C%20Edmond%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNovotney%2C%20Amanda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCarter%2C%20Austin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPaul%2C%20Hilary%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20HIV-related%20mortality%20time%20trends%20among%20children%20and%20young%20adolescents%20on%20antiretroviral%20therapy%20by%20age%2C%20treatment%20duration%2C%20and%20region%3A%20a%20systematic%20review%20and%20meta-regression%20analysis.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20HIV%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%20%2811%29%2C%20S.%20e774%26%23x2013%3Be788.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2352-3018%2825%2900168-7%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2352-3018%2825%2900168-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV-related%20mortality%20time%20trends%20among%20children%20and%20young%20adolescents%20on%20antiretroviral%20therapy%20by%20age%2C%20treatment%20duration%2C%20and%20region%3A%20a%20systematic%20review%20and%20meta-regression%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiawei%22%2C%22lastName%22%3A%22He%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edmond%22%2C%22lastName%22%3A%22Brewer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%22%2C%22lastName%22%3A%22Novotney%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Austin%22%2C%22lastName%22%3A%22Carter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hilary%22%2C%22lastName%22%3A%22Paul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magdalene%20K.%22%2C%22lastName%22%3A%22Walters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kemal%22%2C%22lastName%22%3A%22Sherefa%20Oumer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joycelyn%22%2C%22lastName%22%3A%22Dame%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Desmonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azar%22%2C%22lastName%22%3A%22Kariminia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20F.%22%2C%22lastName%22%3A%22Rebeiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tavitiya%22%2C%22lastName%22%3A%22Sudjaritruk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constantin%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reed%20J.%20D.%22%2C%22lastName%22%3A%22Sorensen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20J.%20L.%22%2C%22lastName%22%3A%22Murray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%20I.%22%2C%22lastName%22%3A%22Hay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aleksandr%22%2C%22lastName%22%3A%22Aravkin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abraham%22%2C%22lastName%22%3A%22Flaxman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peng%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hmwe%20H.%22%2C%22lastName%22%3A%22Kyu%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Past%20cohort%20studies%20have%20examined%20mortality%20among%20children%20and%20young%20adolescents%20%28aged%200-14%20years%29%20who%20have%20received%20antiretroviral%20therapy%20%28ART%29%2C%20but%20no%20systematic%20reviews%20have%20been%20undertaken%20to%20synthesise%20these%20findings.%20Our%20study%20aims%20to%20provide%20the%20most%20comprehensive%20global%20estimates%20of%20paediatric%20mortality%20among%20children%20and%20adolescents%20receiving%20ART.%5CnMETHODS%3A%20For%20this%20systematic%20review%20and%20meta-regression%20analysis%2C%20we%20searched%20PubMed%20and%20Embase%20from%20Jan%201%2C%201990%20to%20July%2031%2C%202024%20for%20studies%20reporting%20mortality%20among%20children%20and%20young%20adolescents%20living%20with%20HIV%20who%20were%20on%20ART.%20We%20employed%20the%20meta-regression%20with%20Bayesian%20priors%2C%20regularisation%2C%20and%20trimming%20tool%2C%20developed%20for%20the%20Global%20Burden%20of%20Disease%20study%202019%2C%20for%20meta-regression%20analysis%20to%20estimate%20on-ART%20mortality%20by%20region%2C%20CD4%20cell%20count%20or%20percentage%2C%20age%2C%20sex%2C%20and%20treatment%20duration.%20We%20assessed%20the%20robustness%20of%20our%20results%20by%20doing%20a%20sensitivity%20analysis%2C%20restricting%20it%20to%20studies%20of%20good%20quality%20using%20the%20quality%20assessment%20tool%20adapted%20from%20the%20Newcastle-Ottawa%20Scale%20and%20the%20National%20Heart%2C%20Lung%2C%20and%20Blood%20Institute.%20This%20study%20has%20been%20registered%20with%20PROSPERO%20%28CRD42022382702%29.%5CnFINDINGS%3A%20Our%20literature%20search%20identified%207588%20records%2C%20of%20which%205853%20were%20determined%20relevant%20for%20title%20and%20abstract%20review.%20Following%20screening%2C%201068%20records%20were%20selected%20for%20full-text%20assessment.%20We%20included%2084%20studies%20in%20our%20systematic%20review%2C%20of%20which%2066%20were%20included%20in%20the%20meta-regression%20analysis.%20Our%20analysis%20indicated%20that%20HIV-related%20mortality%20for%20all%20children%20and%20young%20adolescents%20%28aged%200-14%20years%29%20decreased%20over%20time%2C%20between%202000%20and%202020%20globally%2C%20after%20adjusting%20for%20region%2C%20baseline%20CD4%20cell%20count%2C%20age%2C%20treatment%20duration%2C%20and%20sex.%20Additionally%2C%20HIV-related%20mortality%20decreased%20with%20increasing%20CD4%20cell%20count%20at%20ART%20initiation%20and%20longer%20treatment%20duration.%20There%20have%20been%20considerable%20geographical%20variations%20in%20the%20risk%20of%20mortality.%20Among%20the%20high-mortality%20group%20in%202020%20%28ART%20duration%20%26lt%3B6%20months%2C%20age%20%26lt%3B1%20year%2C%20male%2C%20and%20the%20lowest%20CD4%20cell%20counts%29%2C%20HIV-related%20mortality%20across%20regions%20ranged%20from%2011%5Cu00b77%20deaths%20%2895%25%20CI%208%5Cu00b73-15%5Cu00b74%29%20per%20100%20person-years%20in%20eastern%20Sub-Saharan%20Africa%20to%2072%5Cu00b70%20deaths%20%2847%5Cu00b71-98%5Cu00b71%29%20per%20100%20person-years%20in%20Asia-Pacific.%20Among%20the%20low-mortality%20group%20in%202020%20%28ART%20duration%20%5Cu22651%20year%2C%20age%205-9%20years%2C%20female%2C%20and%20the%20highest%20CD4%20cell%20counts%29%2C%20HIV-related%20mortality%20ranged%20from%200%5Cu00b709%20deaths%20%280%5Cu00b707-0%5Cu00b710%29%20per%20100%20person-years%20in%20eastern%20Sub-Saharan%20Africa%20to%200%5Cu00b720%20deaths%20%280%5Cu00b703-0%5Cu00b780%29%20per%20100%20person-years%20in%20Latin%20America%20and%20the%20Caribbean.%5CnINTERPRETATION%3A%20A%20comprehensive%20approach%20to%20paediatric%20HIV%20care%20is%20essential%20to%20improving%20outcomes%20for%20children%20and%20young%20adolescents%20living%20with%20HIV.%20Clinically%2C%20this%20approach%20includes%20strengthening%20the%20prevention%20of%20vertical%20transmission%2C%20ensuring%20early%20diagnosis%20in%20infants%2C%20and%20initiating%20treatment%20promptly-ideally%20at%20higher%20CD4%20cell%20counts.%20From%20a%20policy%20perspective%2C%20health%20systems%20need%20to%20address%20disparities%20in%20treatment%20access%20and%20outcomes%20across%20regions%2C%20age%20groups%2C%20and%20sex.%20Efforts%20should%20also%20prioritise%20minimising%20treatment%20dropout%20and%20expanding%20access%20to%20high-quality%20HIV%20services.%20These%20strategies%20could%20collectively%20support%20global%20goals%20to%20reduce%20the%20burden%20of%20paediatric%20HIV.%5CnFUNDING%3A%20The%20National%20Institute%20of%20Allergy%20and%20Infectious%20Diseases%20and%20the%20National%20Institutes%20of%20Health.%22%2C%22date%22%3A%222025-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2352-3018%2825%2900168-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222352-3018%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-17T06%3A30%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22QMCBXPUP%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mabou%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMabou%2C%20Gabriel%20Tchatchouang%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEbasone%2C%20Peter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDzudie%2C%20Anastase%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHoover%2C%20Donald%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Factors%20associated%20with%20HIV%20status%20non-disclosure%20among%20people%20entering%20care%20at%20IeDEA%20sites%20in%20Cameroon%3A%20a%20cross-sectional%20study.%20%26lt%3Bi%26gt%3BAIDS%20Research%20and%20Therapy%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B22%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20100.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12981-025-00765-1%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12981-025-00765-1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Factors%20associated%20with%20HIV%20status%20non-disclosure%20among%20people%20entering%20care%20at%20IeDEA%20sites%20in%20Cameroon%3A%20a%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%20Tchatchouang%22%2C%22lastName%22%3A%22Mabou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastase%22%2C%22lastName%22%3A%22Dzudie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donald%22%2C%22lastName%22%3A%22Hoover%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiuhu%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%22%2C%22lastName%22%3A%22Barthel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogers%22%2C%22lastName%22%3A%22Ajeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%20Nsame%22%2C%22lastName%22%3A%22Nforniwe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annereke%22%2C%22lastName%22%3A%22Nyenti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20Mendimi%22%2C%22lastName%22%3A%22Nkodo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adebola%22%2C%22lastName%22%3A%22Adedimeji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20While%20non-disclosure%20of%20HIV%20status%20may%20protect%20people%20living%20with%20HIV%20%28PLWH%29%20against%20stigma%2C%20discrimination%2C%20and%20violence%2C%20disclosure%20may%20facilitate%20access%20to%20social%20support%20and%20improve%20treatment%20adherence.%20This%20study%20examined%20factors%20associated%20with%20non-disclosure%20among%20recently-diagnosed%20PLWH%20at%20IeDEA%20study%20sites%20in%20Cameroon.%5CnMETHODS%3A%20We%20conducted%20a%20cross-sectional%20study%20of%20adults%5Cu2009%5Cu2265%5Cu200919%5Cu00a0years%20newly%20enrolling%20in%20HIV%20care%20at%20three%20Cameroon%20hospitals%20from%20January%202016%20to%20June%202023%20with%20recent%20%28%26lt%3B%5Cu20091%5Cu00a0year%29%20diagnoses%20and%20no%20evidence%20of%20prior%20HIV%20care.%20We%20used%20logistic%20regression%20to%20identify%20factors%20associated%20with%20non-disclosure%20of%20HIV%20status%20at%20the%20time%20of%20enrolment.%5CnRESULTS%3A%20Among%202880%20participants%2C%20the%20overall%20prevalence%20of%20HIV%20status%20non-disclosure%20at%20enrolment%20was%2034.4%25%2C%20ranging%20from%2048.0%25%20among%20those%20enrolling%20on%20the%20day%20of%20diagnosis%20to%2018.7%25%20among%20those%20enrolling%5Cu2009%26gt%3B%5Cu200930%5Cu00a0days%20after%20diagnosis.%20Men%20and%20single%20participants%20had%20higher%20odds%20of%20non-disclosure%20compared%20with%20women%20%28aOR%3A%201.68%3B%2095%25%20CI%201.38%2C%202.04%29%20and%20those%20who%20were%20married%5C%2Fliving%20with%20a%20partner%20%28aOR%3A%201.66%3B%2095%25%20CI%201.36%2C%202.02%29.%20Those%20with%20early-stage%20HIV%20disease%20%28WHO%20Stage%201%20or%202%20or%20CD4%5Cu2009%5Cu2265%5Cu2009200%20cells%5C%2Fmm3%29%20also%20had%20higher%20odds%20of%20non-disclosure%20%28aOR%3A%201.48%3B%2095%25%20CI%201.20%2C%201.83%29%20compared%20with%20participants%20with%20advanced-stage%20disease.%5CnCONCLUSION%3A%20Among%20those%20diagnosed%20with%20HIV%20within%201%5Cu00a0year%20prior%20to%20enrolment%2C%20men%2C%20single%5C%2Funmarried%20people%2C%20and%20those%20with%20early-stage%20HIV%20disease%20were%20less%20likely%20to%20disclose%20their%20status.%20Further%20research%20on%20barriers%20to%20status%20disclosure%20among%20these%20groups%20is%20needed%20to%20guide%20disclosure%20support%20and%20counselling%20interventions.%22%2C%22date%22%3A%222025-10-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12981-025-00765-1%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221742-6405%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A11%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22REQ75ZFT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vreeman%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVreeman%2C%20Rachel%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYiannoutsos%2C%20Constantin%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEdmonds%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLeroy%2C%20Val%26%23xE9%3Briane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFatti%2C%20Geoffrey%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Rates%20of%20adherence%2C%20adherence%20measurement%2C%20and%20support%20services%20for%20children%20and%20adolescents%20living%20with%20HIV%20followed%20in%20global%20sites%20of%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29.%20%26lt%3Bi%26gt%3BBMC%20Pediatrics%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B25%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20706.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12887-025-05939-4%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12887-025-05939-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rates%20of%20adherence%2C%20adherence%20measurement%2C%20and%20support%20services%20for%20children%20and%20adolescents%20living%20with%20HIV%20followed%20in%20global%20sites%20of%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%20C.%22%2C%22lastName%22%3A%22Vreeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constantin%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Edmonds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pope%22%2C%22lastName%22%3A%22Kosalaraksa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beverly%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winstone%22%2C%22lastName%22%3A%22Nyandiko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christelle%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Safari%22%2C%22lastName%22%3A%22Mbewe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%22%2C%22lastName%22%3A%22Mejia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20L.%22%2C%22lastName%22%3A%22Scanlon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxanne%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Supporting%20and%20improving%20antiretroviral%20therapy%20%28ART%29%20adherence%20and%20preventing%20the%20evolution%20of%20HIV%20drug%20resistance%20remain%20major%20challenges%20for%20children%20and%20adolescents%20living%20with%20HIV%20globally.%20In%20a%20large%20global%20HIV%20clinical%20data%20consortium%2C%20we%20sought%20to%20describe%20how%20global%20HIV%20care%20programs%20measure%20and%20support%20pediatric%20ART%20adherence%2C%20as%20well%20as%20patient-level%20measures%20of%20adherence.%5CnMETHODS%3A%20We%20prospectively%20collected%20site-level%20data%20between%20June%202014-March%202015%20using%20a%20site%20assessment%20survey%20and%20retrospectively%20examined%20patient-level%20data%20collected%20during%20routine%20clinical%20care%2C%20to%20provide%20a%20comprehensive%20assessment%20of%20pediatric%20ART%20adherence%20across%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20cohort%2C%20in%20six%20global%20regions.%20All%20regions%20capturing%20patient-level%20data%20on%20adherence%20by%20any%20measure%20for%20children%20living%20with%20HIV%20aged%20less%20than%2014%5Cu00a0years%20between%202000-2015%20were%20asked%20to%20contribute%20data.%20ART%20adherence%20was%20conceptualized%20as%20a%20binomial%20variable%20of%20%26quot%3Bgood%26quot%3B%20%28greater%20than%2090%25%29%20or%20%26quot%3Bpoor%26quot%3B%20%2890%25%20or%20less%29%20adherence%20per%20visit.%5CnRESULTS%3A%20Clinical%20staff%20from%20180%20pediatric%20sites%20in%2045%20countries%20completed%20the%20adherence%20survey.%20Clinician%20adherence%20assessment%20%28used%20at%2087%25%20of%20sites%29%20and%20pharmacy%20refills%20%2886%25%20of%20sites%29%20were%20the%20most%20common%20adherence%20measurement%20methods%20used%20globally.%20Counseling%20focused%20on%20adherence%20was%20the%20most%20commonly%20available%20support%20service%2C%20%2894%25%20of%20sites%29.%2028%2C664%20pediatric%20patients%20had%20at%20least%20one%20adherence%20measurement%2C%20to%20be%20included%20for%20adherence%20analyses.%20In%20East%20Africa%20and%20Southern%20Africa%2C%20higher%20baseline%20CD4%20counts%20were%20associated%20with%20a%20greater%20likelihood%20of%20viral%20suppression%3B%20however%2C%20in%20Central%20and%20South%20America%20and%20the%20Caribbean%20%28CCASAnet%29%20and%20Asia-Pacific%2C%20we%20did%20not%20find%20a%20consistent%20relationship%20between%20baseline%20CD4%20count%20and%20the%20likelihood%20of%20viral%20suppression.%20We%20found%20evidence%20that%20very%20young%20children%20%28%26lt%3B%5Cu20092%5Cu00a0years%20of%20age%29%2C%20older%20children%20%28%26gt%3B%5Cu200910%5Cu00a0years%20of%20age%29%2C%20and%20males%20were%20less%20likely%20to%20experience%20viral%20suppression%20in%20East%20Africa%20and%20Southern%20Africa.%5CnCONCLUSION%3A%20These%20findings%20indicate%20that%20the%20majority%20of%20global%20pediatric%20HIV%20care%20services%20routinely%20measure%20ART%20adherence%20for%20children%20living%20with%20HIV%3B%20however%2C%20few%20sites%20use%20objective%20or%20validated%20measures.%20Identifying%20subgroups%20of%20children%20and%20youth%20at%20highest%20risk%20for%20non-adherence%20allows%20care%20programs%20to%20target%20those%20most%20in%20need%20of%20adherence%20support%20or%20resistance%20monitoring.%22%2C%22date%22%3A%222025-10-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12887-025-05939-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2431%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T11%3A29%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22CUEBS2FF%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Corry%20et%20al.%22%2C%22parsedDate%22%3A%222025-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCorry%2C%20Jacqueline%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZotova%2C%20Natalia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTabala%2C%20Martine%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCotrone%2C%20Christina%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKasindi%2C%20Fid%26%23xE9%3Ble%20Lumande%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Dynamics%20of%20Cytokines%20and%20Chemokines%20During%20the%20Peripartum%20Period%20in%20People%20Living%20With%20Human%20Immunodeficiency%20Virus.%20%26lt%3Bi%26gt%3BAmerican%20Journal%20of%20Reproductive%20Immunology%20%28New%20York%2C%20N.Y.%3A%201989%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B94%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e70147.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Faji.70147%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Faji.70147%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Dynamics%20of%20Cytokines%20and%20Chemokines%20During%20the%20Peripartum%20Period%20in%20People%20Living%20With%20Human%20Immunodeficiency%20Virus%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Corry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Zotova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martine%22%2C%22lastName%22%3A%22Tabala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%20K.%22%2C%22lastName%22%3A%22Cotrone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fid%5Cu00e9le%20Lumande%22%2C%22lastName%22%3A%22Kasindi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bienvenu%20Lebwaze%22%2C%22lastName%22%3A%22Massamba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pelagie%22%2C%22lastName%22%3A%22Babakazo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Namal%20P.%20M.%22%2C%22lastName%22%3A%22Liyanage%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20T.%22%2C%22lastName%22%3A%22Funderburg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jesse%20J.%22%2C%22lastName%22%3A%22Kwiek%22%7D%5D%2C%22abstractNote%22%3A%22PROBLEM%3A%20Pregnancy%20requires%20a%20precisely%20regulated%20immune%20response%20to%20support%20fetal%20development%20and%20minimize%20complications.%20Human%20immunodeficiency%20virus%20%28HIV%29%20infection%20induces%20a%20chronic%20inflammatory%20state%20and%20is%20associated%20with%20adverse%20pregnancy%20outcomes.%20In%20this%20observational%20cohort%20of%20pregnant%20people%20living%20with%20HIV%20in%20the%20Democratic%20Republic%20of%20the%20Congo%20%28DRC%29%2C%20we%20sought%20to%20gain%20a%20deeper%20understanding%20of%20peripartum%20changes%20in%20cytokines%2C%20chemokines%20and%20soluble%20factors%20%28collectively%20termed%20immune%20factors%29.%5CnMETHOD%20OF%20STUDY%3A%20Pregnant%20individuals%20living%20with%20HIV%20were%20enrolled%20during%20their%20second%20or%20third%20trimester%20in%20Kinshasa%2C%20DRC%2C%20between%20October%202020%20and%20May%202021.%20Peripheral%20blood%20samples%20were%20collected%20at%3A%20enrollment%20%28second%20or%20third%20trimester%29%2C%201-3%20days%20postdelivery%20and%20postpartum.%20Concentrations%20of%2045%20immune%20factors%20were%20measured%20using%20LegendPlex%20and%20ELISAs.%5CnRESULTS%3A%20Most%20chemokines%20decreased%20significantly%20from%20enrollment%20to%20postdelivery%2C%20followed%20by%20a%20rebound%20in%20the%20postpartum%20period.%20Meanwhile%2C%20concentrations%20of%20myoglobin%2C%20serum%20amyloid%20A-1%20protein%20%28SAA%29%2C%20and%20interleukin%206%20%28IL-6%29%2C%20increased%20from%20enrollment%20to%20postdelivery%2C%20followed%20by%20a%20decrease%20postpartum.%20Finally%2C%20protein%20S100-A8%5C%2Fprotein%20S100-A9%20%28S100A8%5C%2FA9%29%20and%20insulin-like%20growth%20factor-binding%20protein%204%20%28IGFBP4%29%20consistently%20increased%20from%20enrollment%20through%20postpartum.%5CnCONCLUSIONS%3A%20The%20postdelivery%20decline%20in%20chemokines%20observed%20in%20this%20study%20has%20not%20previously%20been%20reported.%20This%20shift%20may%20result%20from%20two%20mechanisms%3A%20greater-than-expected%20placental%20chemokine%20production%20or%20the%20degradation%20of%20key%20signaling%20molecules%20during%20parturition%20and%20early%20uterine%20involution.%20Additionally%2C%20the%20rise%20in%20proinflammatory%20markers%20from%20enrollment%20to%20postdelivery%20suggests%20a%20persistent%20inflammatory%20state%2C%20either%20unaffected%20by%20fetal%20delivery%20or%20worsened%20by%20tissue%20damage%20in%20the%20gestational%20parent.%22%2C%22date%22%3A%222025-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Faji.70147%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221600-0897%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A17%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22CNX7AQL6%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Waal%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Waal%2C%20Rene%26%23xE9%3B%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWools-Kaloustian%2C%20Kara%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAlthoff%2C%20Keri%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJaquet%2C%20Antoine%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Global%20Trends%20in%20CD4%20Count%20Measurement%20and%20Distribution%20at%20First%20Antiretroviral%20Treatment%20Initiation.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B80%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%201332%26%23x2013%3B1336.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae548%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae548%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20Trends%20in%20CD4%20Count%20Measurement%20and%20Distribution%20at%20First%20Antiretroviral%20Treatment%20Initiation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rene%5Cu00e9%22%2C%22lastName%22%3A%22de%20Waal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nagalingeswaran%22%2C%22lastName%22%3A%22Kumarasamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodora%22%2C%22lastName%22%3A%22Savory%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22Byakwaga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%22%2C%22lastName%22%3A%22Justice%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%20K.%22%2C%22lastName%22%3A%22Ekouevi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Cesar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20K.%20U.%22%2C%22lastName%22%3A%22Pasayan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agness%22%2C%22lastName%22%3A%22Thawani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pelagie%22%2C%22lastName%22%3A%22Babakazo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maile%22%2C%22lastName%22%3A%22Karris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%22%2C%22lastName%22%3A%22Messou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%20P.%22%2C%22lastName%22%3A%22Cortes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%20Yong%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noela%20C.%22%2C%22lastName%22%3A%22Owarwo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annabelle%22%2C%22lastName%22%3A%22Niyongabo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%20C.%22%2C%22lastName%22%3A%22Marconi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%20L.%22%2C%22lastName%22%3A%22Castilho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathy%22%2C%22lastName%22%3A%22Petoumenos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20While%20people%20with%20human%20immunodeficiency%20virus%20%28PWH%29%20start%20antiretroviral%20treatment%20%28ART%29%20regardless%20of%20CD4%20count%2C%20CD4%20measurement%20remains%20crucial%20for%20detecting%20advanced%20human%20immunodeficiency%20virus%20%28HIV%29%20disease%20and%20evaluating%20ART%20programs.%20We%20explored%20CD4%20measurement%20%28proportion%20of%20PWH%20with%20a%20CD4%20result%20available%29%20and%20prevalence%20of%20CD4%20%26lt%3B200%20cells%5C%2F%5Cu00b5L%20%28hereafter%20%26quot%3BCD4%20%26lt%3B200%26quot%3B%29%20at%20ART%20initiation%20within%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20global%20collaboration.%5CnMETHODS%3A%20We%20included%20PWH%20at%20participating%20ART%20programs%20who%20first%20initiated%20ART%20at%20age%2015-80%20years%20during%202005-2019.%20We%20described%20proportions%20of%20PWH%20with%20a%20CD4%20result%20%28measured%20within%206%20months%20before%20to%202%20weeks%20after%20ART%20initiation%29%20and%2C%20among%20those%20with%20a%20CD4%20result%2C%20with%20CD4%20%26lt%3B200%2C%20by%20year%20of%20ART%20initiation%20and%20region.%5CnRESULTS%3A%20We%20included%201%20355%20104%20PWH%20from%2042%20countries%20in%207%20regions%3B%2063%25%20were%20female.%20The%20median%20%28interquartile%20range%29%20age%20at%20ART%20initiation%20was%2037%20%283144%29%20years%20in%20males%20and%2032%20%2826-39%29%20years%20in%20females.%20CD4%20measurement%20initially%20increased%2C%20or%20remained%20stable%20over%20time%20until%20around%202013%2C%20but%20then%20declined%20to%20low%20levels%20in%20some%20regions%20%28Southern%20Africa%2C%20except%20South%20Africa%3A%20from%2054%25%20to%2013%25%3B%20East%20Africa%3A%2085%25%20to%2031%25%3B%20Central%20Africa%3A%2072%25%20to%2020%25%3B%20West%20Africa%3A%2091%25%20to%2053%25%3B%20and%20Latin%20America%3A%2087%25%20to%2056%25%29.%20Prevalence%20of%20CD4%20%26lt%3B200%20declined%20over%20time%20in%20all%20regions%2C%20but%20plateaued%20after%202015%20at%20%5Cu226530%25.%5CnCONCLUSIONS%3A%20CD4%20measurement%20has%20declined%20sharply%20in%20recent%20years%2C%20especially%20in%20sub-Saharan%20Africa.%20Among%20those%20with%20a%20CD4%20measurement%2C%20the%20prevalence%20of%20CD4%20%26lt%3B200%20remains%20concerningly%20high.%20Scaling%20up%20CD4%20testing%20and%20securing%20adequate%20funding%20are%20urgent%20priorities.%22%2C%22date%22%3A%222025-07-18%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciae548%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221537-6591%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A34%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22LEWGPKLC%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zotova%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZotova%2C%20Natalia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShongo%2C%20Alisho%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLelo%2C%20Patricia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMbonze%2C%20Nana%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKaba%2C%20Didine%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Attrition%20from%20Care%20and%20Barriers%20to%20PrEP%20Use%20Among%20Key%20Populations%20in%20Kinshasa%2C%20DRC%3A%20A%20Multiple%20Methods%20Study.%20%26lt%3Bi%26gt%3BAIDS%20and%20Behavior%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-025-04809-5%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-025-04809-5%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Attrition%20from%20Care%20and%20Barriers%20to%20PrEP%20Use%20Among%20Key%20Populations%20in%20Kinshasa%2C%20DRC%3A%20A%20Multiple%20Methods%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Zotova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alisho%22%2C%22lastName%22%3A%22Shongo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Mbonze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didine%22%2C%22lastName%22%3A%22Kaba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Ntangu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiuhu%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adebola%22%2C%22lastName%22%3A%22Adedimeji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viraj%22%2C%22lastName%22%3A%22Patel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ross%22%7D%5D%2C%22abstractNote%22%3A%22Female%20sex%20workers%20%28FSW%29%20and%20gay%20and%20other%20men%20who%20have%20sex%20with%20men%20%28MSM%29%20are%20disproportionately%20affected%20by%20HIV.%20Oral%20pre-exposure%20prophylaxis%20%28PrEP%29%20is%20increasingly%20available%20in%20African%20countries%2C%20including%20the%20Democratic%20Republic%20of%20Congo%20%28DRC%29%2C%20but%20data%20on%20factors%20influencing%20PrEP%20use%20remain%20limited.%20This%20multiple%20methods%20study%20examined%20PrEP%20attrition%20patterns%20and%20barriers%20to%20engagement%20among%20FSW%20and%20MSM%20in%20Kinshasa%2C%20DRC%2C%20using%20programmatic%20data%20from%20five%20sites%2C%20clinical%20records%2C%20and%20qualitative%20interviews.%20Logistic%20regression%20identified%20factors%20associated%20with%20attrition%3B%20qualitative%20data%20were%20thematically%20analyzed.%20Among%208%2C822%20FSW%20and%20MSM%20eligible%20for%20PrEP%20in%202019-2021%2C%20only%2024%25%20%28n%5Cu2009%3D%5Cu20092%2C070%29%20initiated%20it.%20Of%20809%20FSW%20initiators%2C%2033%25%20%28n%5Cu2009%3D%5Cu2009268%29%20were%20lost%20to%20follow-up%20by%201%20month%20and%2078%25%20%28n%5Cu2009%3D%5Cu2009421%29%20by%203%20months.%20Among%201%2C261%20MSM%2C%2026%25%20%28n%5Cu2009%3D%5Cu2009332%29%20and%2087%25%20%28n%5Cu2009%3D%5Cu2009808%29%20were%20lost%20by%201%20and%203%20months%2C%20respectively.%20For%20FSW%2C%20prior%20PrEP%20use%20and%20recent%20STIs%20were%20associated%20with%20higher%20attrition%20at%201%20month.%20Older%20age%2C%20more%20sexual%20partners%2C%20income%20beyond%20sex%20work%2C%20and%20no%20prior%20PrEP%20use%20were%20linked%20to%20lower%20attrition%20at%203%20months.%20Among%20MSM%2C%20no%20prior%20PrEP%20use%20predicted%20higher%20attrition%20at%201%20month%20but%20lower%20attrition%20at%203%20months.%20Qualitative%20findings%20identified%20stigma%2C%20side%20effects%2C%20dislike%20of%20daily%20dosing%2C%20and%20limited%20services%20for%20key%20populations%20at%20risk%20of%20HIV%20as%20major%20barriers.%20Findings%20underscore%20the%20need%20for%20improved%20PrEP%20messaging%2C%20including%20information%20on%20side%20effects%20decreasing%20over%20time.%20Raising%20awareness%20among%20key%20and%20general%20populations%20may%20reduce%20stigma%20and%20improve%20PrEP%20engagement.%22%2C%22date%22%3A%222025-07-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10461-025-04809-5%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221573-3254%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T11%3A27%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22C2TMM3CP%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fern%5Cu00e1ndez%20Villalobos%20et%20al.%22%2C%22parsedDate%22%3A%222025-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFern%26%23xE1%3Bndez%20Villalobos%2C%20Nathalie%20Ver%26%23xF3%3Bnica%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHelfenstein%2C%20Fabrice%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKhol%2C%20Vohith%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTwizere%2C%20Christella%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSecco%2C%20Mayara%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Scale%20of%20differentiated%20service%20delivery%20implementation%20in%20HIV%20care%20facilities%20in%20low-%20and%20middle-income%20countries%3A%20a%20global%20facility%20survey.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%20Suppl%203%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20e26477.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26477%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26477%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Scale%20of%20differentiated%20service%20delivery%20implementation%20in%20HIV%20care%20facilities%20in%20low-%20and%20middle-income%20countries%3A%20a%20global%20facility%20survey%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20Ver%5Cu00f3nica%22%2C%22lastName%22%3A%22Fern%5Cu00e1ndez%20Villalobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Helfenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vohith%22%2C%22lastName%22%3A%22Khol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mayara%22%2C%22lastName%22%3A%22Secco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Castelnuovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Tiendredbeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20William%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Siew%20Moy%22%2C%22lastName%22%3A%22Fong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanink%22%2C%22lastName%22%3A%22Caro-Vega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%20Elias%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovinio%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Djimon%20Marcel%22%2C%22lastName%22%3A%22Zannou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathy%22%2C%22lastName%22%3A%22Petoumenos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambou%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%20Bolton%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ounoo%20Elom%22%2C%22lastName%22%3A%22Takassi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sasisopin%22%2C%22lastName%22%3A%22Kiertiburanakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogers%20Ajeh%22%2C%22lastName%22%3A%22Awoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shamim%20M.%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Malateste%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Zaniewski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20In%202016%2C%20the%20World%20Health%20Organization%20recommended%20differentiated%20service%20delivery%20%28DSD%29%20as%20a%20client-centred%20approach%20to%20simplify%20HIV%20care%20in%20frequency%20and%20intensity%2C%20thus%20reducing%20the%20clinic%20visit%20burden%20on%20individuals%20and%20HIV%20programmes.%20We%20describe%20the%20scale%20of%20DSD%20implementation%20among%20HIV%20facilities%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29%20in%20Latin%20America%2C%20Africa%20and%20the%20Asia-Pacific%20before%20the%20COVID-19%20pandemic.%5CnMETHODS%3A%20We%20analysed%20facility-level%20survey%20data%20from%20HIV%20care%20facilities%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20consortium%20in%202019.%20We%20used%20descriptive%20statistics%20to%20summarise%20the%20availability%20of%20DSD%2C%20multi-month%20dispensing%20%28MMD%29%20and%20DSD%20for%20HIV%20treatment%20models.%20We%20explored%20factors%20associated%20with%20DSD%20implementation%20using%20multivariable%20models.%5CnRESULTS%3A%20We%20included%20175%20facilities%20in%20the%20Asia-Pacific%20%28n%20%3D%2030%29%2C%20Latin%20America%20%28n%20%3D%208%29%2C%20Central%20Africa%20%28n%20%3D%2021%29%2C%20East%20Africa%20%28n%20%3D%2074%29%2C%20Southern%20Africa%20%28n%20%3D%2028%29%20and%20West%20Africa%20%28n%20%3D%2014%29.%20Overall%2C%20133%20facilities%20%2876%25%29%20reported%20implementing%20DSD.%20Of%20these%2C%2091%25%20offered%20DSD%20for%20HIV%20treatment%2C%2061%25%20for%20HIV%20testing%20and%2059%25%20for%20antiretroviral%20therapy%20%28ART%29%20initiation.%20The%20most%20common%20duration%20of%20ART%20refills%20for%20clinically%20stable%20clients%20was%203MMD%2C%20%2870%25%29%2C%20followed%20by%20monthly%20%2814%25%29%20and%206MMD%20%2810%25%29.%20Facility-based%20individual%20models%20were%20the%20most%20frequently%20available%20DSD%20for%20the%20HIV%20treatment%20model%20%2882%25%29%2C%20followed%20by%20client-managed%20group%20models%20%2860%25%29.%20Out-of-facility%20individual%20models%20were%20available%20at%2048%25%20of%20facilities.%20Facility-based%20individual%20models%20were%20particularly%20common%20among%20facilities%20in%20East%20%2892%25%29%20and%20Southern%20Africa%20%2896%25%29.%20Facilities%20in%20medium%20and%20high%20HIV%20prevalence%20countries%2C%20and%20those%20with%203MMD%2C%20were%20more%20likely%20to%20implement%20DSD.%5CnCONCLUSIONS%3A%20In%202019%2C%20DSD%20was%20available%20in%20most%20HIV%20care%20facilities%20globally%20but%20was%20not%20evenly%20implemented%20across%20regions%20and%20HIV%20services.%20Most%20offered%20facility-based%20DSD%20for%20HIV%20treatment%20models%20and%203MMD%20for%20clinically%20stable%20clients.%20Efforts%20to%20expand%20DSD%20for%20HIV%20testing%20and%20ART%20initiation%20and%20to%20offer%20longer%20MMD%20can%20improve%20long-term%20retention%20in%20care%20of%20people%20living%20with%20HIV%20in%20LMICs%2C%20while%20further%20alleviating%20the%20operational%20burden%20on%20healthcare%20services.%20These%20findings%20from%20the%20pre-COVID-19%20era%20underline%20the%20need%20for%20strengthening%20DSD%20in%20HIV%20care%2C%20which%20remains%20at%20the%20centre%20of%20current%20efforts%20towards%20client-centred%20care.%22%2C%22date%22%3A%222025-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26477%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A16%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22FLITJWZJ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Laycock%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLaycock%2C%20Katherine%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-G%26%23xFC%3Bnter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLelo%2C%20Patricia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJantarabenjakul%2C%20Watsamon%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYonaba%2C%20Caroline%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Tuberculosis%20Diagnosis%2C%20Treatment%2C%20and%20Prevention%20Services%20for%20Children%20Living%20with%20HIV%20in%20Low-%20and%20Middle-Income%20Countries%3A%20A%20Multiregional%20Site%20Survey.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20Pediatric%20Infectious%20Diseases%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B14%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20piaf050.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjpids%5C%2Fpiaf050%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjpids%5C%2Fpiaf050%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Tuberculosis%20Diagnosis%2C%20Treatment%2C%20and%20Prevention%20Services%20for%20Children%20Living%20with%20HIV%20in%20Low-%20and%20Middle-Income%20Countries%3A%20A%20Multiregional%20Site%20Survey%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katherine%22%2C%22lastName%22%3A%22Laycock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Watsamon%22%2C%22lastName%22%3A%22Jantarabenjakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Yonaba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Menser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ethel%22%2C%22lastName%22%3A%22Rambiki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%5Cu00e9lagie%22%2C%22lastName%22%3A%22Babakazo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Van%20Lam%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelson%22%2C%22lastName%22%3A%22Kalema%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dinh%20Qui%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joycelyn%22%2C%22lastName%22%3A%22Dame%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%20Tulio%22%2C%22lastName%22%3A%22Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aggrey%22%2C%22lastName%22%3A%22Semeere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azar%22%2C%22lastName%22%3A%22Kariminia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22Byakwaga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Marcy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Tuberculosis%20%28TB%29%20remains%20a%20leading%20cause%20of%20morbidity%20and%20mortality%20for%20children%20living%20with%20HIV%20%28CLHIV%29%2C%20with%20gaps%20in%20TB%20screening%2C%20diagnostics%2C%20management%2C%20and%20TB%20preventive%20therapy%20%28TPT%29.%20We%20investigated%20reported%20practices%20in%20these%20domains%20at%20sites%20caring%20for%20CLHIV%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29%20within%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%5CnMETHODS%3A%20We%20implemented%20a%20site%20survey%20from%20September%202020%20to%20February%202021%2C%20querying%20pre-pandemic%20practices.%20This%20analysis%20included%20sites%20in%20LMICs%20providing%20care%20for%20CLHIV%20that%20diagnosed%20TB%20in%202019.%20We%20analyzed%20responses%20using%20descriptive%20statistics%20and%20assessed%20regional%20differences%20using%20Fisher%26%23039%3Bs%20exact%20or%20chi-square%20tests.%5CnRESULTS%3A%20Of%20238%20IeDEA%20sites%2C%20227%20%2895%25%29%20responded%20and%20135%20met%20the%20inclusion%20criteria.%20Most%20%2890%25%29%20reported%20screening%20for%20TB%20at%20HIV%20care%20enrollment.%20Access%20to%20diagnostics%20varied%20significantly%20by%20region%2C%20including%20nucleic%20acid%20amplification%20testing%20%28NAAT%2C%20range%2067-100%25%29%2C%20mycobacterial%20culture%20%28range%2043%25-83%25%29%2C%20and%20drug%20susceptibility%20testing%20%28range%2030%25-82%25%29%20%28P%5Cu2005%26lt%3B%5Cu2005.001%29.%20On-site%20TB%20treatment%20was%20high%20%2890%25%29.%20Reported%20stock-outs%20occurred%20for%20isoniazid%20%2823%5C%2F116%2C%2020%25%29%20and%20other%20TB%20medications%20%2811%5C%2F114%2C%209.6%25%2C%20range%200%25-33%25%2C%20P%5Cu2005%3D%5Cu2005.008%29.%20TPT%20provision%20ranged%2050%25-100%25%20%28P%5Cu2005%26lt%3B%5Cu2005.001%29.%20Six%20months%20of%20isoniazid%20was%20the%20most%20common%20TPT%20regimen%20for%20children%20%2888%25%29.%20Shorter%20TPT%20regimens%20were%20uncommon%20%280.9%25-2.8%25%29%2C%20as%20were%20regimens%20for%20multidrug-resistant%20TB%20exposure%20%284.6%25%29.%5CnCONCLUSIONS%3A%20Overall%20reported%20availability%20of%20NAAT%20and%20integrated%20TB%5C%2FHIV%20treatment%20for%20CLHIV%20cared%20for%20at%20these%20IeDEA%20sites%20in%20LMICs%20is%20encouraging%20but%20varies%20by%20context.%20Heterogeneous%20implementation%20gaps%20remain-particularly%20for%20drug%20susceptibility%20testing%2C%20TPT%20delivery%2C%20and%20TPT%20regimens-which%20may%20impede%20TB%20prevention%2C%20management%2C%20and%20successful%20outcomes%20for%20CLHIV%2C%20warranting%20continued%20close%20attention%20over%20time%20and%20as%20global%20TB%20care%20guidelines%20and%20services%20evolve.%22%2C%22date%22%3A%222025-06-16%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fjpids%5C%2Fpiaf050%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222048-7207%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22F2Y6PLUL%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-04-16T10%3A16%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22QV9TTYFH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-23%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRomo%2C%20Matthew%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCiaranello%2C%20Andrea%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOdhiambo%2C%20Francesca%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPujari%2C%20Sanjay%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Lingering%20sex%20and%20age%20disparities%20in%20dolutegravir%20uptake%20among%20adults%20with%20HIV%3A%20A%20multi-country%20observational%20cohort%20study.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202025.05.23.25325682.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.05.23.25325682%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.05.23.25325682%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lingering%20sex%20and%20age%20disparities%20in%20dolutegravir%20uptake%20among%20adults%20with%20HIV%3A%20A%20multi-country%20observational%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20L.%22%2C%22lastName%22%3A%22Romo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Ciaranello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjay%22%2C%22lastName%22%3A%22Pujari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sasisopin%22%2C%22lastName%22%3A%22Kiertiburanakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambou%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winnie%20R.%22%2C%22lastName%22%3A%22Muyindike%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vohith%22%2C%22lastName%22%3A%22Khol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Man%20Po%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Since%20July%202019%2C%20the%20World%20Health%20Organization%20%28WHO%29%20has%20recommended%20dolutegravir%20%28DTG%29-based%20regimens%20as%20preferred%20first-line%20antiretroviral%20therapy%20%28ART%29%20for%20adults%20and%20adolescents%20living%20with%20HIV%20%28DTG-for-All%29%2C%20a%20reversal%20of%20a%202018%20safety%20alert%20on%20use%20of%20DTG-based%20regimens%20by%20women%20of%20reproductive%20age%20%28WRA%29.%20We%20examined%20sex%20and%20age%20disparities%20in%20DTG%20uptake%20before%20and%20after%20DTG-for-All%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29.%5CnMETHODS%3A%20We%20included%20patients%20%5Cu226516%20years%20on%20or%20initiating%20treatment%20between%20January%202017%20and%20July%202021%20in%2014%20low-%20and%20middle-income%20countries%20where%20initial%20guidelines%20on%20DTG-based%20regimens%20for%20first-line%20ART%20either%20restricted%20use%20by%20WRA%20or%20had%20no%20such%20restrictions.%20We%20estimated%20the%20cumulative%20incidence%20of%20DTG%20uptake%20%28CI-DTG%29%20by%20sex%20and%20age%20group%20%28aged%2016-49%20years%20vs.%2050%2B%20years%29%2C%20stratified%20by%20patient%2C%20clinic%20and%20setting%20characteristics.%5CnRESULTS%3A%20Among%20177%2C706%20patients%20on%20ART%20during%20the%20study%20period%2C%2051%25%20were%20females%20aged%2016-49%20years%2C%20with%2025%25%20males%20aged%2016-49%2C%20and%2013%25%20and%2011%25%2C%20respectively%2C%20females%20and%20males%20aged%2050%2B.%20At%20the%20time%20of%20DTG-for-All%2C%20overall%20CI-DTG%20was%2029.6%25%20%2895%25CI%3A%2029.4%2C%2029.8%29%3B%20it%20was%20lower%20among%20females%20aged%2016-49%20%2816.2%25%3B%2095%25CI%3A%2016.0-16.5%29%20than%20males%20%2841.1%25%3B%2095%25CI%3A%2040.6%2C%2041.5%29%2C%20with%20no%20sex%20disparities%20among%20patients%20aged%2050%2B%20%28females%3A%2046.0%25%3B%20males%3A%2047.0%25%29.%20While%20DTG%20uptake%20subsequently%20increased%20among%20all%20groups%2C%20by%20July%202021%2C%20it%20remained%20substantially%20lower%20among%20females%2016-49%20%2866.4%25%3B%2095%25CI%3A%2066.1%2C%2066.7%29%2C%20compared%20with%20males%2016-49%20and%20older%20females%20and%20males%20%2875.8%25%20to%2077.5%25%29.%20Concentrated%20in%20countries%20where%20initial%20guidelines%20on%20DTG%20restricted%20use%20by%20WRA%2C%20disparities%20in%20DTG%20uptake%20persisted%20at%20all%20health%20system%20levels%20and%20in%20both%20low-income%20and%20lower-middle%20income%20countries.%5CnCONCLUSIONS%3A%20While%20sex-age%20differentials%20in%20DTG%20uptake%20narrowed%20after%20WHO%26%23039%3Bs%20DTG-for-All%20recommendation%2C%20lingering%20disparities%20uptake%20underscore%20the%20challenges%20of%20policy%20de-implementation%20when%20new%20evidence%20emerges.%22%2C%22date%22%3A%222025-05-23%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1101%5C%2F2025.05.23.25325682%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A18%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22Z3DRFMDQ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kimmel%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKimmel%2C%20April%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPan%2C%20Zhongzhe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMurenzi%2C%20Gad%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BElul%2C%20Batya%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Sustaining%20Rwanda%26%23x2019%3Bs%20HIV%20response%20after%20elimination%20of%20PEPFAR%20funding%3A%20a%20modeling%20analysis.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202025.04.25.25326450.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.04.25.25326450%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.04.25.25326450%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sustaining%20Rwanda%27s%20HIV%20response%20after%20elimination%20of%20PEPFAR%20funding%3A%20a%20modeling%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22April%20D.%22%2C%22lastName%22%3A%22Kimmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhongzhe%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Batya%22%2C%22lastName%22%3A%22Elul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Muhoza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20HIV%20prevention%20and%20treatment%20supported%20by%20the%20United%20States%20President%26%23039%3Bs%20Emergency%20Plan%20for%20AIDS%20Relief%20%28PEPFAR%29%20have%20saved%20millions%20of%20lives.%20Rwanda%20is%20among%20the%20most%20successful%20countries%20around%20the%20world%20in%20achieving%20global%20targets%20with%20PEPFAR%20support.%20However%2C%20abrupt%20funding%20uncertainty%20around%20PEPFAR%20raises%20concerns%20about%20continued%20HIV%20epidemic%20control.%20We%20projected%20the%20impact%20of%20the%20Government%20of%20Rwanda%26%23039%3Bs%20%28GoR%26%23039%3Bs%29%20capacity%20to%20offset%20the%20elimination%20of%20PEPFAR%20funding%20on%20adult%20HIV%20epidemic%20and%20care%20continuum%20outcomes%20over%2010%20years.%5CnMETHODS%3A%20Using%20an%20HIV%20policy%20model%20calibrated%20to%20Rwanda%2C%20we%20assessed%3A%20capacity%20to%20sustain%20HIV%20services%20at%2050%25%20%28with%20no%20capacity%20by%20GoR%20to%20cover%20the%20PEPFAR%20funding%20gap%29%2C%2075%25%2C%2090%25%2C%20and%20100%25%20%28with%20full%20capacity%20by%20GoR%20to%20cover%20the%20PEPFAR%20funding%20gap%29.%20Scenarios%20were%20operationalized%20by%20reducing%20the%20number%20on%20antiretroviral%20therapy%20%28ART%29%2C%20with%20immediate%20ART%20discontinuation%20and%20proportional%20decreases%20in%20HIV%20diagnosis%2C%20ART%20initiation%2C%20and%20care%20re-engagement.%20We%20projected%20HIV%20epidemic%20outcomes%20%28HIV%20prevalence%2C%20HIV%20incidence%2C%20number%20with%20HIV%2C%20new%20HIV%20infections%2C%20deaths%29%20and%20care%20continuum%20outcomes%20%28percent%20diagnosed%2C%20percent%20on%20ART%20among%20those%20diagnosed%2C%20percent%20virally%20suppressed%20among%20those%20on%20ART%29.%20We%20calculated%20differences%20in%20projected%20outcomes%20for%20partial%20or%20no%20capacity%20versus%20full%20capacity.%20Secondary%20analyses%20assessed%20delayed%20coverage%20capacity%20by%201%20and%203%20years.%5CnRESULTS%3A%20Compared%20to%20full%20capacity%20at%2010%20years%2C%20the%20model%20projected%20a%2013.9%25-38.7%25%20increase%20in%20HIV%20prevalence%20and%2069.0%25-246.7%25%20increase%20in%20HIV%20incidence%20across%20coverage%20capacity%20scenarios.%20This%20translated%20to%2029%2C000-64%2C000%20additional%20adults%20with%20HIV%20and%2020%2C000-92%2C000%20cumulative%20new%20adult%20HIV%20infections.%20Cumulative%20projected%20deaths%20increased%20by%2010%2C000-51%2C200.%20The%20model%20projected%20continual%20reductions%20in%20percent%20diagnosed%20at%2010%20years%3B%20percent%20virally%20suppressed%20among%20those%20on%20ART%20was%20similar%20across%20scenarios.%20Higher%2C%20and%20more%20delayed%2C%20coverage%20capacity%20had%20projected%20outcomes%20similar%20to%20lower%2C%20and%20less%20delayed%2C%20coverage%20capacity.%5CnCONCLUSIONS%3A%20Even%20in%20countries%20like%20Rwanda%20that%20have%20achieved%20epidemic%20control%2C%20abrupt%20and%20persistent%20elimination%20of%20PEPFAR%20funding%20could%20drastically%20reverse%20critical%20gains.%20Evidence%20quantifying%20the%20consequences%20of%20different%20capacities%20to%20sustain%20HIV%20services%20underscores%20the%20high%20stakes%20of%20rapid%20and%20sufficient%20action.%22%2C%22date%22%3A%222025-04-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1101%5C%2F2025.04.25.25326450%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A12%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22BS29FRDB%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20Gabriela%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMalateste%2C%20Karen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBolton%20Moore%2C%20Carolyn%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSipambo%2C%20Nosisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMokone%2C%20Limpho%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Global%20Trends%20in%20CD4%20Measurement%20and%20Immunosuppression%20at%20ART%20Initiation%20Among%20Children%20With%20HIV.%20%26lt%3Bi%26gt%3BThe%20Pediatric%20Infectious%20Disease%20Journal%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004819%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004819%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20Trends%20in%20CD4%20Measurement%20and%20Immunosuppression%20at%20ART%20Initiation%20Among%20Children%20With%20HIV%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Malateste%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%20Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nosisa%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Limpho%22%2C%22lastName%22%3A%22Mokone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denna%22%2C%22lastName%22%3A%22Michael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Desmonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dewi%22%2C%22lastName%22%3A%22Kumara%20Wati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Revathy%22%2C%22lastName%22%3A%22Nallusamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aarti%22%2C%22lastName%22%3A%22Kinikar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Du%20Tuan%22%2C%22lastName%22%3A%22Quy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20Vanes%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nel%20Jason%22%2C%22lastName%22%3A%22Haw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20collaboration%22%7D%5D%2C%22abstractNote%22%3A%22Eligibility%20for%20antiretroviral%20therapy%20is%20no%20longer%20based%20on%20immune%20criteria.%20In%20a%20global%20cohort%20of%2097%2C453%20children%2C%20between%202005%20and%202021%2C%20we%20observed%20large%20declines%20in%20CD4%20measurement%2C%20from%2051%25%20to%2012%25%20among%20%26lt%3B5%20seconds%2C%20and%20from%2074%25%20to%2020%25%20among%20those%205-14%20years%20of%20age.%20Lack%20of%20CD4%20testing%20may%20negatively%20affect%20clinical%20care%20and%20surveillance%20of%20severe%20immune%20suppression.%22%2C%22date%22%3A%222025-04-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FINF.0000000000004819%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221532-0987%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A09%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22CGJDXP9C%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Embleton%20et%20al.%22%2C%22parsedDate%22%3A%222025-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEmbleton%2C%20Lonnie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSudjaritruk%2C%20Tavitiya%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMachado%2C%20Daisy%20Maria%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChihota%2C%20Belinda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusabyimana%2C%20Fran%26%23xE7%3Boise%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Characterizing%20adolescent%20and%20youth-friendly%20HIV%20services%3A%20a%20cross-sectional%20assessment%20across%2016%20global%20sites.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e26437.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26437%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26437%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Characterizing%20adolescent%20and%20youth-friendly%20HIV%20services%3A%20a%20cross-sectional%20assessment%20across%2016%20global%20sites%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lonnie%22%2C%22lastName%22%3A%22Embleton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tavitiya%22%2C%22lastName%22%3A%22Sudjaritruk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Musabyimana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Jesson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%22%2C%22lastName%22%3A%22Apondi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thanyawee%22%2C%22lastName%22%3A%22Puthanakit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%20Tulio%22%2C%22lastName%22%3A%22Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%20Ellen%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zachary%22%2C%22lastName%22%3A%22Kwena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Perreras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Batya%22%2C%22lastName%22%3A%22Elul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxanne%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Vreeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Adolescent%20and%20youth-friendly%20health%20services%20%28AYFHS%29%20have%20been%20promoted%20as%20a%20best%20practice%20for%20adolescents%20and%20young%20people%20living%20with%20HIV%20%28AYLH%29.%20However%2C%20thorough%20descriptions%20of%20AYFHS%20for%20AYLH%20remain%20scarce.%20We%20sought%20to%20characterize%20adolescent-friendly%20HIV%20services%20in%20a%20global%20paediatric%20research%20consortium.%5CnMETHODS%3A%20Cross-sectional%20data%20were%20collected%20from%2016%20global%20sites%20in%20the%20Adolescent%20and%20Young%20Adult%20Network%20of%20IeDEA%20%28AYANI%29%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20consortium%20between%20August%202020%20and%20October%202022%20using%20a%20standardized%20site%20assessment%20tool%20that%20collected%20data%20on%20clinic%2C%20patient%20and%20provider%20characteristics%2C%20differentiated%20care%2C%20and%20transition%20to%20adult%20services%20processes.%20Descriptive%20analyses%20characterized%20the%20health%20services%20available%20across%20the%20participating%20sites%2C%20using%20frequencies%20and%20proportions%20for%20categorical%20variables%20and%20medians%20and%20interquartile%20range%20for%20continuous%20variables.%20Data%20were%20analysed%20using%20RStudio.%5CnRESULTS%3A%20Overall%2C%2013%20of%2016%20sites%20%2881%25%29%20reported%20having%20dedicated%20adolescent%20services%2C%20which%20most%20often%20consisted%20of%20dedicated%20clinic%20days%20%2862%25%2C%20n%20%3D%208%5C%2F13%29%2C%20primarily%20offered%20on%20weekdays.%20Across%20all%20sites%2C%20nurses%20and%20counsellors%20delivered%20services%20to%20adolescents.%20Over%20half%20of%20all%20clinics%20%2869%25%2C%20n%20%3D%2011%5C%2F16%29%20reported%20offering%20health%20education%20to%20adolescents%20to%20facilitate%20adolescent%20health%20literacy.%20Peer%20educators%20and%20navigators%20were%20involved%20in%20delivering%20services%20at%2062%25%20of%20sites%2C%20primarily%20in%20those%20with%20dedicated%20adolescent%20services%20%2869%25%2C%20n%20%3D%209%5C%2F13%29.%20There%20was%20limited%20integration%20of%20sexual%20and%20reproductive%20health%20services%20into%20HIV%20clinics%20for%20adolescents.%20With%2063%25%20of%20clinics%20conducting%20pregnancy%20screening%2C%2050%25%20providing%20family%20planning%20methods%20and%2038%25%20providing%20cervical%20cancer%20screening.%20Under%20half%20of%20all%20HIV%20clinics%20screened%20for%20physical%20abuse%20or%20violence%20%2844%25%2C%20n%20%3D%207%5C%2F16%29%20and%20sexual%20abuse%20or%20rape%20%2838%25%2C%20n%20%3D%206%5C%2F16%29.%20A%20low%20proportion%20of%20clinics%20screened%20for%20risk%20factors%20related%20to%20young%20key%20populations%2C%20including%20drug%20use%20%2856%25%2C%20n%20%3D%209%5C%2F16%29%2C%20homelessness%20%2838%25%2C%20n%20%3D%206%5C%2F16%29%20young%20men%20having%20sex%20with%20men%20%2831%25%2C%20n%20%3D%205%5C%2F16%29%20and%20transactional%20sex%20%2831%25%2C%20n%20%3D%205%5C%2F16%29.%20Mental%20health%20screening%20for%20concerns%20was%20variable.%5CnCONCLUSIONS%3A%20Findings%20suggest%20gaps%20in%20AYFHS%20for%20AYLH%20across%20the%20HIV%20clinics%20included%20in%20this%20analysis.%20There%20is%20a%20vital%20need%20to%20design%20health%20services%20for%20AYLH%20that%20are%20accessible%2C%20equitable%2C%20and%20effective%20and%20meet%20the%20global%20standards%20for%20delivering%20high-quality%20healthcare%20to%20adolescents.%22%2C%22date%22%3A%222025-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26437%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A16%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22JVIGBFUD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ballif%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBallif%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPerrig%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAvihingsanon%2C%20Anchalee%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNsonde%2C%20Dominique%20Mahambu%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20long-term%20impact%20of%20the%20COVID-19%20pandemic%20on%20tuberculosis%20care%20and%20infection%20control%20measures%20in%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20low-%20and%20middle-income%20countries%3A%20a%20multiregional%20site%20survey%20in%20Asia%20and%20Africa.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e017828.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017828%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017828%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20long-term%20impact%20of%20the%20COVID-19%20pandemic%20on%20tuberculosis%20care%20and%20infection%20control%20measures%20in%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20low-%20and%20middle-income%20countries%3A%20a%20multiregional%20site%20survey%20in%20Asia%20and%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Perrig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anchalee%22%2C%22lastName%22%3A%22Avihingsanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambu%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Obatsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Komena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haruka%22%2C%22lastName%22%3A%22Uemura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Otaalo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrice%22%2C%22lastName%22%3A%22Gou%5Cu00e9ss%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nagalingeswaran%22%2C%22lastName%22%3A%22Kumarasamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denna%22%2C%22lastName%22%3A%22Michael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Ramd%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%20Ketut%20Agus%22%2C%22lastName%22%3A%22Somia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Global%20IeDEA%20consortium%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20COVID-19%20pandemic%20challenged%20healthcare%20systems%2C%20particularly%20in%20settings%20with%20high%20infectious%20disease%20burden.%20We%20examined%20the%20postpandemic%20long-term%20impacts%20of%20COVID-19%20on%20tuberculosis%20%28TB%29%20services%20at%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20lower-income%20countries.%5CnMETHODS%3A%20Using%20standardised%20online%20questionnaires%2C%20we%20conducted%20a%20cross-sectional%20site%20survey%20among%20ART%20clinics%20providing%20TB%20services%20in%20Africa%20and%20Asia%20from%20July%20to%20September%202023%20%28site-level%20information%20and%20number%20of%20TB%20diagnoses%20and%20tests%29.%5CnRESULTS%3A%20Of%2045%20participating%20ART%20clinics%2C%2032%20%2871%25%29%20were%20in%20Africa%20and%2013%20%2829%25%29%20in%20Asia.%20During%20the%20COVID-19%20pandemic%20%282020-2022%29%2C%2043%20%2896%25%29%20clinics%20reported%20implementing%20social%20distancing%20or%20separation%20measures%2C%2039%20%2887%25%29%20personal%20protections%20for%20staff%20members%20and%2032%20%2871%25%29%20protections%20for%20patients.%20Infection%20control%20measures%20were%20in%20place%20in%2045%25%20of%20the%20clinics%20before%20the%20pandemic%20%28until%202019%29%2C%2023%25%20introduced%20measures%20during%20the%20pandemic%20and%2015%25%20maintained%20them%20after%20the%20pandemic%20%28after%202022%29.%20Service%20provision%20was%20affected%20during%20the%20pandemic%20in%2033%20%2873%25%29%20clinics%2C%20including%20TB%20services%20in%2022%20%2849%25%29%20clinics.%20TB%20service%20restrictions%20were%20addressed%20by%20introducing%20changes%20in%20directly%20observed%20therapy%20provision%20in%208%20%2818%25%29%20clinics%2C%20multimonth%20TB%20drug%20dispensing%20in%2023%20%2851%25%29%2C%20telehealth%20services%20in%2025%20%2856%25%29%20and%20differentiated%20service%20delivery%20in%2019%20%2842%25%29.%20These%20changes%20were%20sustained%20after%20the%20pandemic%20at%204%20%289%25%29%2C%2011%20%2824%25%29%2C%2017%20%2838%25%29%20and%2012%20%2827%25%29%20clinics%2C%20respectively.%20Compared%20with%202018-2019%2C%20the%20number%20of%20TB%20diagnoses%20decreased%20sharply%20in%202020-2021%20and%20improved%20after%20the%20pandemic.%5CnCONCLUSIONS%3A%20COVID-19%20affected%20TB%20care%20services%20in%20ART%20clinics%20in%20Africa%20and%20Asia.%20This%20was%20paralleled%20by%20a%20reduction%20in%20TB%20diagnoses%2C%20which%20partly%20resumed%20after%20the%20pandemic.%20Infection%20control%20measures%20and%20alternative%20modes%20of%20service%20delivery%20were%20adopted%20during%20the%20pandemic%20and%20only%20partially%20maintained.%20Efforts%20should%20be%20made%20to%20sustain%20the%20lessons%20learnt%20during%20the%20COVID-19%20pandemic%2C%20particularly%20approaches%20that%20reduce%20the%20risk%20of%20transmission%20of%20infectious%20diseases%2C%20including%20TB%2C%20in%20ART%20clinics.%22%2C%22date%22%3A%222025-03-24%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2024-017828%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222059-7908%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A19%3A33Z%22%7D%7D%2C%7B%22key%22%3A%223235IX24%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bernard%20et%20al.%22%2C%22parsedDate%22%3A%222025-02-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBernard%2C%20Charlotte%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFont%2C%20H%26%23xE9%3Bl%26%23xE8%3Bne%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZotova%2C%20Natalia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWools-Kaloustian%2C%20Kara%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGoodrich%2C%20Suzanne%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Accuracy%20of%20Alternative%20PHQ-9%20Scoring%20Algorithms%20to%20Screen%20for%20Depression%20in%20People%20Living%20With%20HIV%20in%20Sub-Saharan%20Africa.%20%26lt%3Bi%26gt%3BJournal%20of%20Acquired%20Immune%20Deficiency%20Syndromes%20%281999%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B98%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20143%26%23x2013%3B149.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003551%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003551%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Accuracy%20of%20Alternative%20PHQ-9%20Scoring%20Algorithms%20to%20Screen%20for%20Depression%20in%20People%20Living%20With%20HIV%20in%20Sub-Saharan%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Font%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Zotova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%22%2C%22lastName%22%3A%22Goodrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%20Kamaru%22%2C%22lastName%22%3A%22Kwobah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajeh%20Rogers%22%2C%22lastName%22%3A%22Awoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%20Calvin%22%2C%22lastName%22%3A%22Nko%27o%20Mbongo%27o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambu%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Gandou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judica%5Cu00ebl%20Malick%22%2C%22lastName%22%3A%22Tine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ibrahima%22%2C%22lastName%22%3A%22Ndiaye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Dabis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moussa%22%2C%22lastName%22%3A%22Seydi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22de%20Rekeneire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Cohort%20Collaboration%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Screening%20for%20depression%20remains%20a%20priority%20for%20people%20living%20with%20HIV%20%28PLWH%29%20accessing%20care.%20The%209-item%20Patient%20Health%20Questionnaire%20%28PHQ-9%29%20is%20a%20widely%20used%20depression%20screening%20tool%2C%20but%20has%20limited%20accuracy%20when%20applied%20across%20various%20cultural%20contexts.%20We%20aimed%20to%20evaluate%20the%20performance%20of%20alternative%20PHQ-9%20scoring%20algorithms%20in%20sub-Saharan%20African%20PLWH.%5CnSETTING%3A%20Five%20HIV%20programs%20in%20Cameroon%2C%20C%5Cu00f4te%20d%26%23039%3BIvoire%2C%20Kenya%2C%20Senegal%2C%20and%20the%20Republic%20of%20Congo.%5CnMETHODS%3A%20Adult%20PLWH%20were%20screened%20for%20depression%20during%20the%202018-2022%20period.%20Diagnosis%20confirmation%20was%20done%20by%20psychiatrist%20blinded%20clinical%20evaluation%20%28gold%20standard%29.%20Diagnostic%20performances%2C%20including%20sensitivity%20and%20area%20under%20the%20curve%20%28AUC%29%20of%20the%20traditional%20PHQ-9%20scoring%20%28positive%20screening%20-%20score%20%5Cu2265%2010%29%2C%20were%20compared%20to%20alternative%20scoring%20algorithms%20including%20%281%29%20the%20presence%20of%20%5Cu22651%20mood%20symptom%20%28PHQ-9%20items%201%20and%202%29%20combined%20with%20%5Cu22652%20other%20symptoms%20listed%20in%20the%20PHQ-9%2C%20and%20%282%29%20a%20simplified%20recoding%20of%20each%204-response%20item%20into%202%20categories%20%28absence%5C%2Fpresence%29.%5CnRESULTS%3A%20A%20total%20of%20735%20participants%20were%20included%20%5B54%25%20women%2C%20median%20age%2042%20years%20%28interquartile%20range%2034-50%29%5D.%20Depression%20was%20diagnosed%20by%20a%20psychiatrist%20in%2095%20%2813%25%29%20participants.%20Alternative%20scoring%20sensitivities%20%280.59-0.74%29%20were%20higher%20than%20that%20of%20the%20traditional%20score%26%23039%3Bs%20%280.39%29.%20Compared%20to%20traditional%20scoring%2C%20AUC%20was%20significantly%20higher%20for%20PHQ-9%20alternative%20scoring.%20Across%20settings%2C%20alternative%20scoring%20algorithms%20increased%20sensitivity%20and%20reduced%20variability.%5CnCONCLUSIONS%3A%20As%20a%20primary%20screening%20test%2C%20new%20scoring%20algorithms%20seemed%20to%20improve%20the%20PHQ-9%20sensitivity%20in%20identifying%20depression%20and%20reducing%20heterogeneity%20across%20settings.%20This%20alternative%20might%20be%20considered%20to%20identify%20PLWH%20in%20need%20of%20referral%20for%20further%20diagnostic%20evaluations.%22%2C%22date%22%3A%222025-02-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003551%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221944-7884%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A18%3A47Z%22%7D%7D%2C%7B%22key%22%3A%224H6RFYTE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ford%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A7%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFord%2C%20Nathan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20Reshma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStelzle%2C%20Dominik%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJarvis%2C%20Joseph%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSued%2C%20Omar%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Global%20prevalence%20of%20advanced%20HIV%20disease%20in%20healthcare%20settings%3A%20a%20rapid%20review.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e26415.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26415%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26415%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20prevalence%20of%20advanced%20HIV%20disease%20in%20healthcare%20settings%3A%20a%20rapid%20review.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Stelzle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20N.%22%2C%22lastName%22%3A%22Jarvis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Omar%22%2C%22lastName%22%3A%22Sued%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georges%22%2C%22lastName%22%3A%22Perrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meg%22%2C%22lastName%22%3A%22Doherty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajay%22%2C%22lastName%22%3A%22Rangaraj%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Recent%20studies%20have%20indicated%20a%20high%20enduring%20burden%20of%20advanced%20HIV%20disease%2C%20but%20estimates%20across%20regions%20and%20settings%20are%20lacking.%20The%20aim%20of%20this%20study%20was%20to%20estimate%20the%20prevalence%20of%20advanced%20HIV%20disease%20since%202015%20among%20those%20people%20with%20CD4%20measured%20in%20healthcare%20settings%2C%20disaggregated%20by%20age%20group%2C%20level%20of%20healthcare%20and%20region.%20METHODS%3A%20We%20searched%20MedLine%20via%20Pubmed%20and%20Hinari%20for%20studies%20that%20reported%20the%20proportion%20of%20individuals%20with%20advanced%20HIV%20disease%20%28defined%20as%20CD4%20cell%20count%20%26lt%3B200%20cells%5C%2Fmm%283%29%29%20in%20healthcare%20settings%20since%202015%3B%20this%20search%20was%20complemented%20by%20conference%20abstracts%20and%20data%20from%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20Consortium%20%28IeDEA%29.%20We%20estimated%20pooled%20prevalence%20of%20advanced%20HIV%20disease%20using%20random-%20effects%20models%20and%20performed%20subgroup%20and%20sensitivity%20analyses%20to%20explore%20heterogeneity.%20RESULTS%3A%20We%20obtained%20data%20from%20117%20cohorts%2C%20representing%201%2C814%2C362%20individuals%20from%2052%20countries%20across%20all%20six%20World%20Health%20Organization%20regions.%20The%20majority%20of%20studies%20%28n%20%3D%2083%29%20were%20conducted%20among%20adults%20and%20recorded%20CD4%20cell%20count%20among%20treatment%20naive%20individuals%20at%20antiretroviral%20therapy%20start%20%28n%20%3D%2086%29.%20Studies%20included%20data%20reported%20up%20to%202023.%20The%20proportion%20of%20individuals%20with%20advanced%20HIV%20disease%20was%20higher%20in%20inpatient%20settings%20%2844.3%25%2C%2095%25%20CI%2039.1-49.6%25%29%20compared%20to%20outpatient%20settings%20%2833.5%25%2C%2095%25%20CI%2031.5-35.4%25%29.%20Prevalence%20was%20similar%20across%20age%20groups%2C%20time%20since%20HIV%20diagnosis%20and%20treatment%20status%2C%20and%20highest%20in%20West%20and%20Central%20Africa%2C%20South-East%20Asia%20and%20the%20Eastern%20Mediterranean%20region.%20DISCUSSION%3A%20This%20review%20finds%20that%20at%20least%20a%20third%20of%20people%20presenting%20to%20healthcare%20settings%20have%20advanced%20HIV%20disease%2C%20with%20no%20evidence%20that%20this%20has%20changed%20in%20recent%20years.%20Screening%20for%20advanced%20HIV%20remains%20important%20to%20be%20able%20to%20direct%20appropriate%20preventive%2C%20diagnostic%20and%20therapeutic%20interventions%20to%20prevent%20progression%20to%20severe%20illness%20and%20death.%20CONCLUSIONS%3A%20This%20review%20summarizes%20recent%20evidence%20of%20the%20continued%20high%20proportion%20of%20individuals%20who%20%28re%29present%20to%20care%20with%20advanced%20HIV%20disease.%20These%20findings%20underscore%20the%20urgent%20need%20to%20reinforce%20programme%20capacity%20to%20diagnose%2C%20prevent%20and%20treat%20advanced%20HIV%20disease%20as%20an%20essential%20pillar%20of%20the%20global%20AIDS%20response.%22%2C%22date%22%3A%222025%20Feb%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26415%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A16%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22QLUE586N%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zumla%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZumla%2C%20Alimuddin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRosenthal%2C%20Philip%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSam-Agudu%2C%20Nada%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOgoina%2C%20Dimie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMbala-Kingebeni%2C%20Placide%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%202024%20Public%20Health%20Emergency%20of%20International%20Concern%3A%20A%20Global%20Failure%20to%20Control%20Mpox.%20%26lt%3Bi%26gt%3BThe%20American%20Journal%20of%20Tropical%20Medicine%20and%20Hygiene%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B112%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%2017%26%23x2013%3B20.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4269%5C%2Fajtmh.24-0606%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4269%5C%2Fajtmh.24-0606%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%202024%20Public%20Health%20Emergency%20of%20International%20Concern%3A%20A%20Global%20Failure%20to%20Control%20Mpox%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alimuddin%22%2C%22lastName%22%3A%22Zumla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20J.%22%2C%22lastName%22%3A%22Rosenthal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nada%20A.%22%2C%22lastName%22%3A%22Sam-Agudu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimie%22%2C%22lastName%22%3A%22Ogoina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Placide%22%2C%22lastName%22%3A%22Mbala-Kingebeni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francine%22%2C%22lastName%22%3A%22Ntoumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Nakoun%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Njouom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicaise%22%2C%22lastName%22%3A%22Ndembi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edward%20J.%22%2C%22lastName%22%3A%22Mills%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Jacques%22%2C%22lastName%22%3A%22Muyembe-Tamfum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20B.%22%2C%22lastName%22%3A%22Nachega%22%7D%5D%2C%22abstractNote%22%3A%22On%20August%2014%2C%202024%2C%20following%20a%20regional%20declaration%20by%20the%20Africa%20Centres%20for%20Disease%20Control%20and%20Prevention%2C%20the%20World%20Health%20Organization%20declared%20mpox%20a%20Public%20Health%20Emergency%20of%20International%20Concern%2C%20marking%20the%20second%20such%20declaration%20in%20two%20years.%20A%20series%20of%20outbreaks%20involving%20the%20more%20virulent%20clade%20I%20virus%20%28compared%20to%20clade%20II%2C%20which%20caused%20a%20global%20outbreak%20in%202022%29%2C%20has%20now%20spread%20in%2013%20African%20countries%2C%20exposing%20the%20inadequacies%20of%20the%20public%20health%20infrastructure%20in%20these%20settings.%20There%20was%20significant%20investment%20during%20the%202022%20global%20outbreak%2C%20but%20these%20efforts%20failed%20to%20address%20vaccine%20access%20and%20treatment%20in%20the%20Global%20South.%20Regulatory%20delays%2C%20unequal%20access%20to%20vaccines%2C%20and%20a%20lack%20of%20compassionate%20use%20treatments%20for%20severe%20cases%20have%20resulted%20in%20preventable%20cases%20and%20deaths%2C%20especially%20among%20vulnerable%20populations%20such%20as%20pregnant%20women%2C%20children%2C%20and%20the%20immunocompromised.%20The%20current%20outbreak%20also%20underscores%20critical%20knowledge%20gaps%20in%20our%20understanding%20of%20mpox%2C%20including%20its%20transmission%2C%20pathogenesis%2C%20and%20viral%20evolution.%20We%20join%20intensified%20calls%20for%20global%20solidarity%20and%20action%20to%20control%20mpox%2C%20emphasizing%20immediate%20containment%20measures%20and%20long-term%20local%20and%20international%20investment%20in%20African%20public%20health%20systems%2C%20to%20prevent%20future%20epidemics.%22%2C%22date%22%3A%222025-01-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.4269%5C%2Fajtmh.24-0606%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221476-1645%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T11%3A27%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22PP74SNPV%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kuniholm%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKuniholm%2C%20Mark%20H.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMurenzi%2C%20Gad%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShumbusho%2C%20Fabienne%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPlaisy%2C%20Marie%20K.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Association%20of%20cardiovascular%20disease%20risk%20with%20liver%20steatosis%20and%20fibrosis%20in%20people%20with%20HIV%20in%20low-%20and%20middle-income%20countries.%20%26lt%3Bi%26gt%3BAIDS%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B39%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%2011%26%23x2013%3B21.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004012%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004012%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20cardiovascular%20disease%20risk%20with%20liver%20steatosis%20and%20fibrosis%20in%20people%20with%20HIV%20in%20low-%20and%20middle-income%20countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20H.%22%2C%22lastName%22%3A%22Kuniholm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabienne%22%2C%22lastName%22%3A%22Shumbusho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20K.%22%2C%22lastName%22%3A%22Plaisy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ephrem%22%2C%22lastName%22%3A%22Mensah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlotta%22%2C%22lastName%22%3A%22Riebensahm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%20V.%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niharika%22%2C%22lastName%22%3A%22Samala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aggrey%20S.%22%2C%22lastName%22%3A%22Semeere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thida%22%2C%22lastName%22%3A%22Chanyachukul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rohidas%22%2C%22lastName%22%3A%22Borse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dung%20T.%20H.%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Perazzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alvaro%22%2C%22lastName%22%3A%22Lopez-Iniguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%20L.%22%2C%22lastName%22%3A%22Castilho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20The%20aim%20of%20this%20study%20was%20to%20understand%20the%20relationship%20between%20cardiovascular%20disease%20%28CVD%29%20risk%20and%20liver%20steatosis%20and%20fibrosis%20among%20people%20with%20HIV%20%28PLWH%29%20at%20least%2040%5Cu200ayears%20of%20age%20on%20antiretroviral%20therapy%20%28ART%29%20in%20low%20and%20middle-income%20countries%20%28LMIC%29.%5CnDESIGN%3A%20We%20used%20cross-sectional%20behavioral%20and%20clinical%20data%20collected%20during%20study%20enrollment%20visits%20in%202020-2022%20for%20the%20Sentinel%20Research%20Network%20of%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28SRN%20of%20IeDEA%29.%5CnMETHODS%3A%20Ten-year%20CVD%20risk%20was%20calculated%20using%202019%20WHO%20nonlaboratory%20and%20laboratory%20models.%20Transient%20elastography%20was%20used%20to%20assess%20liver%20disease.%20Presence%20of%20steatosis%20and%20significant%20fibrosis%20were%20defined%20by%20controlled%20attenuation%20parameter%20%28CAP%29%20at%20least%20248%5Cu200adB%5C%2Fm%20and%20liver%20stiffness%20measurement%20%28LSM%29%20at%20least%207.1%5Cu200akPa%2C%20respectively.%20Participants%20with%20viral%20hepatitis%2C%20hazardous%20alcohol%20consumption%2C%20and%20unsuppressed%20HIV%20viral%20load%20were%20excluded%20from%20the%20analysis.%20Logistic%20regression%20was%20used%20to%20estimate%20odds%20ratios%2C%20adjusting%20for%20study%20site%2C%20CD4%20%2B%20%5Cu200aT%20cell%20count%2C%20stavudine%20and%20didanosine%20exposure%2C%20and%20in%20models%20stratified%20by%20sex%20and%20geographic%20region.%5CnRESULTS%3A%20There%20were%201750%20participants%20from%20nine%20LMIC.%20Median%20CVD%20risk%20was%203%25%20for%20both%20nonlaboratory%20and%20laboratory-based%20models.%20Adjusted%20odds%20ratios%20%28ORs%29%20for%20steatosis%20and%20significant%20fibrosis%20associated%20with%20laboratory%20CVD%20risk%20%28%5Cu226510%20vs.%20%26lt%3B5%25%29%20were%20OR%5Cu200a%3D%5Cu200a1.83%20%5B95%25%20confidence%20interval%20%2895%25%20CI%29%5Cu200a%3D%5Cu200a1.21-2.76%3B%20P%20%5Cu200a%3D%5Cu200a0.004%5D%20and%20OR%5Cu200a%3D%5Cu200a1.62%20%2895%25%20CI%5Cu200a%3D%5Cu200a0.85-3.07%3B%20P%20%5Cu200a%3D%5Cu200a0.14%29%2C%20respectively.%20Associations%20of%20CVD%20risk%20with%20steatosis%20were%20stronger%20in%20men%20and%20among%20participants%20at%20study%20sites%20outside%20Africa.%5CnCONCLUSION%3A%20Higher%20CVD%20risk%20was%20associated%20with%20steatosis%20but%20not%20with%20significant%20fibrosis%20in%20PWH%20in%20our%20LMIC%20cohort.%22%2C%22date%22%3A%222025-01-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000004012%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221473-5571%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%223FNU2D64%22%2C%228IRGNQWZ%22%2C%22BH3MKZCS%22%2C%22D9WC3N3V%22%2C%22F2Y6PLUL%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A37%3A35Z%22%7D%7D%2C%7B%22key%22%3A%226W8UR2R7%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Boisson-Walsh%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoisson-Walsh%2C%20Alix%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNgimbi%2C%20Patrick%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMorgan%2C%20Camille%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStover%2C%20Angela%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMbonze%2C%20Nana%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Perceived%20shifts%20in%20routine%20vaccine%20confidence%20during%20the%20COVID-19%20pandemic%20in%20Kinshasa%20Province%2C%20DRC%3A%20A%20mixed-methods%20approach.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B5%26lt%3B%5C%2Fi%26gt%3B%20%287%29%2C%20S.%20e0004755.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0004755%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0004755%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Perceived%20shifts%20in%20routine%20vaccine%20confidence%20during%20the%20COVID-19%20pandemic%20in%20Kinshasa%20Province%2C%20DRC%3A%20A%20mixed-methods%20approach%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alix%22%2C%22lastName%22%3A%22Boisson-Walsh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Ngimbi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%20E.%22%2C%22lastName%22%3A%22Morgan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Stover%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Mbonze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Ntambua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jolie%22%2C%22lastName%22%3A%22Matondo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melchior%20M.%22%2C%22lastName%22%3A%22Kashamuka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20B.%22%2C%22lastName%22%3A%22Parr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Mampunza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peyton%22%2C%22lastName%22%3A%22Thompson%22%7D%5D%2C%22abstractNote%22%3A%22The%20COVID-19%20pandemic%20negatively%20impacted%20routine%20immunizations%20worldwide%2C%20decreasing%20confidence%20in%20vaccination%20programs.%20We%20used%20mixed%20methods%20to%20examine%20changes%20in%20vaccine%20confidence%20from%20before%20to%20during%20the%20pandemic%20in%20HBV-negative%20adults%20in%20Kinshasa%20who%20were%20exposed%20to%20HBV%20in%20the%20household%2C%20and%20eligible%20for%20HBV%20vaccination.%20We%20measured%20changes%20in%20routine%20HBV%20vaccine%20confidence%20with%20a%20previously%20validated%20Shift%20in%20Vaccine%20Confidence%20%28SVC%29%20self-report%20measure%20that%20was%20verbally%20administered%20in%20Lingala%20%28local%20language%29.%20We%20compared%20vaccination%20confidence%20before%20versus%20during%20the%20pandemic%20using%20Chi-square%20tests.%20We%20also%20interviewed%20participants%20and%20coded%20open-ended%20responses%20to%20the%20SVC%20scale%20to%20explore%20context-specific%20perceptions.%20From%20April%202022%20to%20February%202023%2C%20we%20administered%20the%20SVC%20tool%20to%20a%20purposive%20sample%20of%2041%20participants%3A%207%20vaccinees%2C%2023%20willing%20to%20receive%20HBV%20vaccine%2C%20and%2011%20refusers.%20Participants%20had%20a%20median%20age%20of%2032%20years%2C%20were%20predominantly%20affiliated%20with%20Revivalist%20churches%2C%20and%20most%20reported%20unemployment%20and%20no%20education%20beyond%20secondary%20school.%20We%20observed%20statistically%20significant%20declines%20across%20all%20five%20vaccine%20confidence%20domains%20when%20comparing%20responses%20before%20and%20during%20the%20pandemic%20%28p%5Cu2009%26lt%3B%5Cu20090.01%29%3A%20vaccines%20prevent%20diseases%20%2885.4%25-68.3%25%29%2C%20are%20safe%20%2880.5%25-46.3%25%29%2C%20important%20for%20a%20child%26%23039%3Bs%20health%20%2892.7%25-87.8%25%29%20and%20one%26%23039%3Bs%20own%20health%20%2887.8%25-68.3%25%29%2C%20and%20new%20vaccines%20carry%20no%20more%20risk%20than%20routine%20vaccines%20%2878.1%25-63.5%25%29.%20Qualitative%20analysis%20identified%20four%20themes%20impacting%20uptake%20decisions%3A%20vaccine%20confidence%2C%20knowledge%2C%20risks%2C%20and%20external%20influences.%20Rising%20uncertainty%20about%20efficacy%2C%20safety%2C%20and%20distrust%20in%20the%20COVID-19%20vaccine%20undermined%20vaccine%20confidence%20among%20our%20participants.%20Factors%20such%20as%20distrust%20in%20manufacturers%20and%20government%2C%20fear%20of%20side%20effects%2C%20perceived%20low%20illness%20risk%2C%20and%20inconvenient%20healthcare%20access%20contributed%20to%20low%20vaccine%20uptake.%20These%20insights%20underscore%20the%20pandemic%26%23039%3Bs%20impact%20on%20routine%20immunization%20and%20emphasize%20the%20need%20for%20consideration%20in%20future%20vaccination%20campaigns.%22%2C%22date%22%3A%222025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0004755%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222767-3375%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A18%3A32Z%22%7D%7D%2C%7B%22key%22%3A%229ZV4YK5S%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kimmel%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKimmel%2C%20April%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPan%2C%20Zhongzhe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMurenzi%2C%20Gad%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMujwara%2C%20Deo%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Development%20and%20calibration%20of%20a%20mathematical%20model%20of%20HIV%20outcomes%20among%20Rwandan%20adults%3A%20Informing%20achievement%20of%20global%20targets%20across%20sub-populations%20in%20Rwanda.%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B20%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20e0310662.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0310662%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0310662%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20and%20calibration%20of%20a%20mathematical%20model%20of%20HIV%20outcomes%20among%20Rwandan%20adults%3A%20Informing%20achievement%20of%20global%20targets%20across%20sub-populations%20in%20Rwanda%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22April%20D.%22%2C%22lastName%22%3A%22Kimmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhongzhe%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deo%22%2C%22lastName%22%3A%22Mujwara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Muhoza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Central%20Africa%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28CA-IeDEA%29%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20We%20developed%20and%20calibrated%20the%20Central%20Africa-International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28CA-IeDEA%29%20HIV%20policy%20model%20to%20inform%20achievement%20of%20global%20goals%2C%20overall%20and%20across%20all%20sub-populations%2C%20in%20Rwanda.%5CnMETHODS%3A%20We%20created%20a%20deterministic%20dynamic%20model%20to%20project%20adult%20HIV%20epidemic%20and%20care%20continuum%20outcomes%2C%20overall%20and%20for%2035%20subpopulations%20%28age%20group%2C%20sex%2C%20HIV%20acquisition%20risk%2C%20urbanicity%29.%20Data%20came%20from%20the%20Rwanda%20cohort%20of%20CA-IeDEA%2C%202004-2020%3B%20Rwanda%20Demographic%20and%20Health%20Surveys%2C%202005%2C%202010%2C%202015%3B%20Rwanda%20Population-based%20HIV%20Impact%20Assessment%2C%202019%3B%20and%20literature%20and%20reports.%20We%20calibrated%20the%20model%20to%2047%20targets%20by%20selecting%2050%20best-fitting%20parameter%20sets.%20Targets%20reflected%20epidemic%2C%20global%20goals%20and%20other%20indicators.%20Best-fitting%20sets%20minimized%20the%20summed%20absolute%20value%20of%20the%20percentage%20deviation%20%28AVPD%29%20between%20projections%20and%20targets.%20Good%20performance%20was%20mean%20AVPD%20%5Cu22645%25%20across%20best-fitting%20sets%20and%5C%2For%20projections%20within%20target%20confidence%20intervals%3B%20acceptable%20was%20mean%20AVPD%20%26gt%3B5%25-15%25.%5CnRESULTS%3A%20Across%20indicators%2C%201%2C843%20of%202%2C350%20%2878.4%25%29%20model%20projections%20were%20a%20good%20or%20acceptable%20fit%20to%20calibration%20targets.%20For%20HIV%20epidemic%20indicators%2C%20247%20of%20300%20%2882.3%25%29%20projections%20were%20a%20good%20fit%20to%20targets%2C%20with%20the%20model%20performing%20better%20for%20women%20%2880.3%25%20a%20good%20fit%29%20than%20for%20men%20%2862.3%25%20a%20good%20fit%29.%20For%20global%20goals%20indicators%2C%2097%20of%20100%20%2897.0%25%29%20projections%20were%20a%20good%20fit%3B%20model%20performance%20was%20similar%20for%20women%20and%20men.%20For%20other%20indicators%2C%20708%20of%20950%20%2874.5%25%29%20projections%20were%20a%20good%20or%20acceptable%20fit.%20Fit%20was%20better%20for%20women%20than%20for%20men%20%28percentage%20virally%20suppressed%20only%29%20and%20when%20restricting%20targets%20for%20number%20on%20ART%20to%202013%20and%20beyond.%5CnCONCLUSIONS%3A%20The%20CA-IeDEA%20HIV%20policy%20model%20fits%20historical%20data%20and%20can%20inform%20policy%20solutions%20for%20achieving%20global%20goals%20across%20all%20sub-populations%20in%20Rwanda.%20High-quality%20population-based%20data%20and%20novel%20approaches%20that%20account%20for%20calibration%20target%20quality%20are%20critical%20to%20ongoing%20use%20of%20mathematical%20models%20for%20programmatic%20planning.%22%2C%22date%22%3A%222025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0310662%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A12%3A29Z%22%7D%7D%2C%7B%22key%22%3A%224NQ3HLS2%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ross%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoss%2C%20Jonathan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGasana%2C%20Josephine%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZotova%2C%20Natalia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNdabakuranye%2C%20Giovanni%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMabano%2C%20Fabiola%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20PrEP%20in%20the%20key%20population%20community%3A%20A%20qualitative%20study%20of%20perspectives%20on%20pre-exposure%20prophylaxis%20by%20gay%2C%20bisexual%20and%20other%20men%20who%20have%20sex%20with%20men%20and%20female%20sex%20workers%20in%20Kigali%2C%20Rwanda.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B5%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e0004538.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0004538%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0004538%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22PrEP%20in%20the%20key%20population%20community%3A%20A%20qualitative%20study%20of%20perspectives%20on%20pre-exposure%20prophylaxis%20by%20gay%2C%20bisexual%20and%20other%20men%20who%20have%20sex%20with%20men%20and%20female%20sex%20workers%20in%20Kigali%2C%20Rwanda%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josephine%22%2C%22lastName%22%3A%22Gasana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Zotova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giovanni%22%2C%22lastName%22%3A%22Ndabakuranye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabiola%22%2C%22lastName%22%3A%22Mabano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Ingabire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adebola%22%2C%22lastName%22%3A%22Adedimeji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viraj%20V.%22%2C%22lastName%22%3A%22Patel%22%7D%5D%2C%22abstractNote%22%3A%22Gay%2C%20bisexual%20and%20other%20men%20who%20have%20sex%20with%20men%20%28GBMSM%29%20and%20cisgender%20female%20sex%20workers%20%28FSW%29%20are%20increasingly%20and%20disproportionately%20impacted%20by%20HIV%20in%20sub-Saharan%20Africa%2C%20yet%20current%20PrEP%20care%20models%20in%20this%20region%20are%20not%20optimized%20for%20these%20communities.%20Limited%20data%20exist%20describing%20experiences%20and%20preferences%20of%20GBMSM%20and%20FSW%20with%20respect%20to%20accessing%20and%20using%20PrEP.%20We%20conducted%20qualitative%2C%20semi-structured%20interviews%20with%20GBMSM%20and%20FSW%20recruited%20from%20three%20health%20centers%20and%20seven%20community%20organizations%20in%20Kigali%2C%20Rwanda.%20Data%20were%20analyzed%20using%20a%20mixed%20deductive%20and%20inductive%20approach%20to%20describe%20key%20themes%20related%20to%20initiating%20and%20adhering%20to%20PrEP.%20Participants%20included%2018%20GBMSM%20and%2014%20FSW%3B%2012%20were%20using%20PrEP%20at%20the%20time%20of%20interview%2C%209%20had%20previously%20used%20PrEP%2C%20and%2011%20had%20never%20used%20it.%20Participants%20highlighted%20the%20central%20role%20of%20their%20social%20networks%20as%20key%20sources%20of%20information%20about%20and%20support%20for%20PrEP%20use%2C%20and%20described%20a%20strong%20motivation%20to%20use%20PrEP%20as%20a%20way%20to%20protect%20both%20themselves%20and%20their%20communities%20from%20HIV.%20While%20stigma%20and%20discrimination%20were%20pervasive%2C%20these%20were%20experienced%20differently%20by%20GBMSM%20and%20FSW.%20Participants%20suggested%20community%20access%20points%20that%20allowed%20more%20discreet%20and%20less%20frequent%20contact%20with%20health%20care%20workers%20as%20important%20and%20desired%20strategies%20to%20improve%20engagement.%20These%20findings%20suggest%20that%20leveraging%20community%20resources%20for%20disseminating%20information%20about%20HIV%20prevention%20and%20delivering%20PrEP%20could%20contribute%20to%20successful%20implementation%20of%20PrEP%20for%20GBMSM%20and%20FSW%20in%20Rwanda%20and%20other%20settings%20in%20SSA.%22%2C%22date%22%3A%222025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0004538%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222767-3375%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T12%3A08%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22HYVZWN6R%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zotova%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZotova%2C%20Natalia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMunyaneza%2C%20Athanase%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMurenzi%2C%20Gad%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKubwimana%2C%20Gallican%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAdedimeji%2C%20Adebola%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Low%20birth%20weight%20and%20adverse%20pregnancy%20outcomes%20among%20women%20living%20with%20HIV%20and%20HIV-uninfected%20in%20Rwanda.%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B20%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e0329312.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0329312%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0329312%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Low%20birth%20weight%20and%20adverse%20pregnancy%20outcomes%20among%20women%20living%20with%20HIV%20and%20HIV-uninfected%20in%20Rwanda%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Zotova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Athanase%22%2C%22lastName%22%3A%22Munyaneza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gallican%22%2C%22lastName%22%3A%22Kubwimana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adebola%22%2C%22lastName%22%3A%22Adedimeji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22CA-IeDEA%20consortium%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20In%20utero%20exposure%20to%20HIV%20and%5C%2For%20antiretroviral%20therapy%20%28ART%29%20has%20been%20shown%20to%20be%20associated%20with%20stillbirth%2C%20preterm%20births%2C%20and%20low%20birth%20weight%20%28LBW%29%2C%20but%20data%20from%20low-resource%2C%20high-%20HIV-burden%20settings%20remain%20limited.%20This%20study%20describes%20adverse%20pregnancy%20outcomes%20among%20Rwandan%20women%20living%20with%20HIV%20%28WLWH%29%20and%20HIV-uninfected%20women%20and%20examines%20associations%20between%20HIV%2C%20ART%20timing%2C%20and%20LBW.%5CnMETHODS%3A%20This%20retrospective%20cohort%20study%20used%20antenatal%20care%2C%20delivery%2C%20and%20PMTCT%20registry%20data%20from%20the%20Central%20Africa%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28CA-IeDEA%29.%20Women%20with%20documented%20HIV%20status%20and%20recorded%20birth%20weights%20were%20included.%20Adverse%20outcomes%20were%20defined%20as%20LBW%20%28%26lt%3B2%2C500%20g%29%2C%20stillbirth%2C%20and%20preterm%20birth%20%28%26lt%3B37%20weeks%20gestation%29.%20Logistic%20regression%20was%20used%20to%20assess%20associations%20between%20maternal%20HIV%20status%2C%20ART%20timing%2C%20and%20LBW%2C%20adjusting%20for%20relevant%20covariates.%5CnRESULTS%20AND%20DISCUSSION%3A%20Among%2010%2C191%20women%20with%20known%20HIV%20status%20and%20babies%26%23039%3B%20birth%20weights%2C%2012.7%25%20%28n%5Cu2009%3D%5Cu20091%2C293%29%20were%20WLWH.%20There%20were%2047%20stillbirths%20%280.5%25%29%20and%2070%20preterm%20births%20%280.7%25%29.%20Among%2010%2C037%20term%20births%2C%20366%20%283.6%25%29%20were%20LBW.%20WLWH%20had%20significantly%20higher%20rates%20of%20stillbirth%20%280.6%25%20vs.%200.4%25%2C%20p%5Cu2009%26lt%3B%5Cu20090.05%29%20and%20LBW%20%286.5%25%20vs.%202.9%25%2C%20p%5Cu2009%26lt%3B%5Cu20090.001%29%20compared%20to%20HIV-uninfected%20women%3B%20preterm%20birth%20rates%20did%20not%20differ%20significantly.%20The%20adjusted%20odds%20of%20LBW%20among%20WLWH%20were%201.61%20%2895%25%20CI%3A%201.08%2C%202.39%29%2C%20controlling%20for%20marital%20status%2C%20primigravidae%2C%20and%20maternal%20weight%20at%20admission.%20Among%20WLWH%20%28n%5Cu2009%3D%5Cu20091%2C274%29%2C%20ART%20initiation%20prior%20to%20pregnancy%20was%20associated%20with%2050%25%20lower%20odds%20of%20LBW%20after%20adjusting%20for%20age%20and%20WHO%20stage.%5CnCONCLUSIONS%3A%20Even%20among%20relatively%20healthy%20uncomplicated%20pregnancies%20in%20low-risk%20delivery%20settings%20and%20universal%20ART%2C%20WLWH%20experienced%20significantly%20higher%20rates%20of%20stillbirth%20and%20LBW.%20Among%20WLWH%2C%20initiation%20of%20ART%20prior%20to%20current%20pregnancy%20had%20a%20protective%20effect%20against%20LBW.%20This%20underscores%20the%20importance%20of%20early%20HIV%20diagnosis%20and%20initiation%20of%20ART.%22%2C%22date%22%3A%222025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0329312%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22BH3MKZCS%22%2C%22ZVWK2Q45%22%5D%2C%22dateModified%22%3A%222026-02-12T11%3A27%3A45Z%22%7D%7D%5D%7D
Parcesepe, Angela M.; Filiatreau, Lindsey M.; Ebasone, Peter Vanes; Dzudie, Anastase; Yotebieng, Marcel et al. (2025). Gender, mental health symptoms, loss to clinic, and viral non-suppression 6 months after HIV care initiation among a cohort of people with HIV in Cameroon.
BMC Public Health,
25 (1), S. 4374.
http://doi.org/10.1186/s12889-025-24668-y.
Pan, Zhongzhe; Brazier, Ellen; Duda, Stephany N.; Ross, Jeremy; Templeton, David J. et al. (2025). Limited user fees for adult HIV diagnosis and routine laboratory monitoring in the global IeDEA consortium: analysis in 42 countries.
medRxiv: The Preprint Server for Health Sciences, S. 2025.12.05.25341715.
http://doi.org/10.64898/2025.12.05.25341715.
Curcio, Evan J.; Xu, Kai; Sahakyan, Harutyun; Wolf, Yuri I.; Kelvin, Elizabeth A. et al. (2025). Mosquito vector ecologies are destabilizing as a result of climate change.
Research Square, S. rs.3.rs-7776054.
http://doi.org/10.21203/rs.3.rs-7776054/v1.
Brazier, Ellen; Berry, Amanda; Katz, Benjamin; Lewis, Judith T.; Duda, Stephany N. et al. (2025). The development of IeDEA’s Treat All Dashboard on HIV care outcomes at participating clinics in Sub-Saharan Africa.
medRxiv: The Preprint Server for Health Sciences, S. 2025.11.20.25340413.
http://doi.org/10.1101/2025.11.20.25340413.
He, Jiawei; Brewer, Edmond; Novotney, Amanda; Carter, Austin; Paul, Hilary et al. (2025). HIV-related mortality time trends among children and young adolescents on antiretroviral therapy by age, treatment duration, and region: a systematic review and meta-regression analysis.
The Lancet. HIV,
12 (11), S. e774–e788.
http://doi.org/10.1016/S2352-3018(25)00168-7.
Mabou, Gabriel Tchatchouang; Brazier, Ellen; Ebasone, Peter; Dzudie, Anastase; Hoover, Donald et al. (2025). Factors associated with HIV status non-disclosure among people entering care at IeDEA sites in Cameroon: a cross-sectional study.
AIDS Research and Therapy,
22 (1), S. 100.
http://doi.org/10.1186/s12981-025-00765-1.
Vreeman, Rachel C.; Yiannoutsos, Constantin T.; Edmonds, Andrew; Leroy, Valériane; Fatti, Geoffrey et al. (2025). Rates of adherence, adherence measurement, and support services for children and adolescents living with HIV followed in global sites of the International Epidemiology Databases to Evaluate AIDS (IeDEA).
BMC Pediatrics,
25 (1), S. 706.
http://doi.org/10.1186/s12887-025-05939-4.
Corry, Jacqueline; Zotova, Natalia; Tabala, Martine; Cotrone, Christina K.; Kasindi, Fidéle Lumande et al. (2025). Dynamics of Cytokines and Chemokines During the Peripartum Period in People Living With Human Immunodeficiency Virus.
American Journal of Reproductive Immunology (New York, N.Y.: 1989),
94 (2), S. e70147.
http://doi.org/10.1111/aji.70147.
de Waal, Reneé; Wools-Kaloustian, Kara; Brazier, Ellen; Althoff, Keri N.; Jaquet, Antoine et al. (2025). Global Trends in CD4 Count Measurement and Distribution at First Antiretroviral Treatment Initiation.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America,
80 (6), S. 1332–1336.
http://doi.org/10.1093/cid/ciae548.
Zotova, Natalia; Shongo, Alisho; Lelo, Patricia; Mbonze, Nana; Kaba, Didine et al. (2025). Attrition from Care and Barriers to PrEP Use Among Key Populations in Kinshasa, DRC: A Multiple Methods Study.
AIDS and Behavior.
http://doi.org/10.1007/s10461-025-04809-5.
Fernández Villalobos, Nathalie Verónica; Helfenstein, Fabrice; Khol, Vohith; Twizere, Christella; Secco, Mayara et al. (2025). Scale of differentiated service delivery implementation in HIV care facilities in low- and middle-income countries: a global facility survey.
Journal of the International AIDS Society,
28 Suppl 3, S. e26477.
http://doi.org/10.1002/jia2.26477.
Laycock, Katherine; Technau, Karl-Günter; Lelo, Patricia; Jantarabenjakul, Watsamon; Yonaba, Caroline et al. (2025). Tuberculosis Diagnosis, Treatment, and Prevention Services for Children Living with HIV in Low- and Middle-Income Countries: A Multiregional Site Survey.
Journal of the Pediatric Infectious Diseases Society,
14 (6), S. piaf050.
http://doi.org/10.1093/jpids/piaf050.
Brazier, Ellen; Romo, Matthew L.; Ciaranello, Andrea; Odhiambo, Francesca; Pujari, Sanjay et al. (2025). Lingering sex and age disparities in dolutegravir uptake among adults with HIV: A multi-country observational cohort study.
medRxiv: The Preprint Server for Health Sciences, S. 2025.05.23.25325682.
http://doi.org/10.1101/2025.05.23.25325682.
Kimmel, April D.; Pan, Zhongzhe; Murenzi, Gad; Brazier, Ellen; Elul, Batya et al. (2025). Sustaining Rwanda’s HIV response after elimination of PEPFAR funding: a modeling analysis.
medRxiv: The Preprint Server for Health Sciences, S. 2025.04.25.25326450.
http://doi.org/10.1101/2025.04.25.25326450.
Patten, Gabriela; Malateste, Karen; Bolton Moore, Carolyn; Sipambo, Nosisa; Mokone, Limpho et al. (2025). Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.
The Pediatric Infectious Disease Journal.
http://doi.org/10.1097/INF.0000000000004819.
Embleton, Lonnie; Sudjaritruk, Tavitiya; Machado, Daisy Maria; Chihota, Belinda; Musabyimana, Françoise et al. (2025). Characterizing adolescent and youth-friendly HIV services: a cross-sectional assessment across 16 global sites.
Journal of the International AIDS Society,
28 (4), S. e26437.
http://doi.org/10.1002/jia2.26437.
Ballif, Marie; Banholzer, Nicolas; Perrig, Lisa; Avihingsanon, Anchalee; Nsonde, Dominique Mahambu et al. (2025). The long-term impact of the COVID-19 pandemic on tuberculosis care and infection control measures in anti-retroviral therapy (ART) clinics in low- and middle-income countries: a multiregional site survey in Asia and Africa.
BMJ Global Health,
10 (3), S. e017828.
http://doi.org/10.1136/bmjgh-2024-017828.
Bernard, Charlotte; Font, Hélène; Zotova, Natalia; Wools-Kaloustian, Kara; Goodrich, Suzanne et al. (2025). Accuracy of Alternative PHQ-9 Scoring Algorithms to Screen for Depression in People Living With HIV in Sub-Saharan Africa.
Journal of Acquired Immune Deficiency Syndromes (1999),
98 (2), S. 143–149.
http://doi.org/10.1097/QAI.0000000000003551.
Ford, Nathan; Kassanjee, Reshma; Stelzle, Dominik; Jarvis, Joseph N.; Sued, Omar et al. (2025). Global prevalence of advanced HIV disease in healthcare settings: a rapid review.
Journal of the International AIDS Society,
28 (2), S. e26415.
http://doi.org/10.1002/jia2.26415.
Zumla, Alimuddin; Rosenthal, Philip J.; Sam-Agudu, Nada A.; Ogoina, Dimie; Mbala-Kingebeni, Placide et al. (2025). The 2024 Public Health Emergency of International Concern: A Global Failure to Control Mpox.
The American Journal of Tropical Medicine and Hygiene,
112 (1), S. 17–20.
http://doi.org/10.4269/ajtmh.24-0606.
Kuniholm, Mark H.; Murenzi, Gad; Shumbusho, Fabienne; Brazier, Ellen; Plaisy, Marie K. et al. (2025). Association of cardiovascular disease risk with liver steatosis and fibrosis in people with HIV in low- and middle-income countries.
AIDS,
39 (1), S. 11–21.
http://doi.org/10.1097/QAD.0000000000004012.
Boisson-Walsh, Alix; Ngimbi, Patrick; Morgan, Camille E.; Stover, Angela M.; Mbonze, Nana et al. (2025). Perceived shifts in routine vaccine confidence during the COVID-19 pandemic in Kinshasa Province, DRC: A mixed-methods approach.
PLOS Global Public Health,
5 (7), S. e0004755.
http://doi.org/10.1371/journal.pgph.0004755.
Kimmel, April D.; Pan, Zhongzhe; Brazier, Ellen; Murenzi, Gad; Mujwara, Deo et al. (2025). Development and calibration of a mathematical model of HIV outcomes among Rwandan adults: Informing achievement of global targets across sub-populations in Rwanda.
PloS One,
20 (5), S. e0310662.
http://doi.org/10.1371/journal.pone.0310662.
Ross, Jonathan; Gasana, Josephine; Zotova, Natalia; Ndabakuranye, Giovanni; Mabano, Fabiola et al. (2025). PrEP in the key population community: A qualitative study of perspectives on pre-exposure prophylaxis by gay, bisexual and other men who have sex with men and female sex workers in Kigali, Rwanda.
PLOS Global Public Health,
5 (4), S. e0004538.
http://doi.org/10.1371/journal.pgph.0004538.
Zotova, Natalia; Munyaneza, Athanase; Murenzi, Gad; Kubwimana, Gallican; Adedimeji, Adebola et al. (2025). Low birth weight and adverse pregnancy outcomes among women living with HIV and HIV-uninfected in Rwanda.
PloS One,
20 (8), S. e0329312.
http://doi.org/10.1371/journal.pone.0329312.
2024
Carlucci, J. G. et al. (2024). High Prevalence of Unconfirmed Positive HIV Polymerase Chain Reaction Test Results Among African Infants With HIV Exposure in the International Epidemiology Databases to Evaluate AIDS Consortium. Clin Infect Dis 79, 1475–1478. http://doi.org/10.1093/cid/ciae251.
Dusingize, J. C. et al. (2024). Cancer risk among people living with Human Immunodeficiency Virus (HIV) in Rwanda from 2007 to 2018. Int J Cancer 155, 2149–2158. http://doi.org/10.1002/ijc.35091.
Zotova, N. et al. (2024). Understanding depression and the PHQ-9 items among people living with HIV: A multiple methods qualitative study in Yaoundé, Cameroon. SSM Ment Health 6, 100353. http://doi.org/10.1016/j.ssmmh.2024.100353.
Rosenberg, N. E. et al. (2024). A Human Immunodeficiency Virus Type 1 Risk Assessment Tool for Women Aged 15-49 Years in African Countries: A Pooled Analysis Across 15 Nationally Representative Surveys. Clin Infect Dis 79, 1223–1232. http://doi.org/10.1093/cid/ciae211.
Thahir, S. et al. (2024). Promoting Antiviral Access and Adherence in the Expansion of Hepatitis B Prevention Programs: Insights From the Democratic Republic of Congo. J Pediatric Infect Dis Soc 13, S148–S152. http://doi.org/10.1093/jpids/piae081.
Munyaneza, A. et al. (2024). High retention among key populations initiated on HIV pre-exposure prophylaxis in Kigali City, Rwanda. J Int AIDS Soc 27, e26392. http://doi.org/10.1002/jia2.26392.
Yotebieng, M. et al. (2024). Accuracy of nine-item Patient Health Questionnaire against psychiatric diagnosis for depression among people with HIV. AIDS 38, 1765–1773. http://doi.org/10.1097/QAD.0000000000003963.
Parcesepe, A. M. et al. (2024). Prevalence and co-occurrence of symptoms of mental and substance use disorders among people with HIV age 40 and older in low- and middle-income countries: a cross-sectional study. J Int AIDS Soc 27, e26359. http://doi.org/10.1002/jia2.26359.
Tulenko, S. E. et al. (2024). Immunogenicity of a Birth Dose of Hepatitis B Vaccine in Kinshasa, Democratic Republic of Congo: A Randomised, Controlled Trial. J Viral Hepat https://doi.org/10.1111/jvh.14003.
Kimmel, A. D. et al. (2024). Development and calibration of a mathematical model of HIV outcomes among Rwandan adults: informing equitable achievement of targets in Rwanda. medRxiv. http://doi.org/10.1101/2024.09.06.24313223.
Zaniewski, E. et al. (2024). Transition to dolutegravir-based ART in 35 low- and middle-income countries: a global survey of HIV care clinics. AIDS. http://doi.org/10.1097/QAD.0000000000004007.
Filiatreau, L. M. et al. (2024). Intersectional HIV- and Depression-Related Stigma Among People with HIV Entering HIV Care in Cameroon. AIDS Behav 28, 2950–2960. http://doi.org/10.1007/s10461-024-04375-2.
Ross, J. et al. (2024). PrEP in the key population community: a qualitative study of perspectives on pre-exposure prophylaxis by men who have sex with men and female sex workers in Kigali, Rwanda. medRxiv. http://doi.org/10.1101/2024.08.20.24311545.
Asangbeh-Kerman, S. L. et al. (2024). Cervical cancer prevention and care in HIV clinics across sub-Saharan Africa: results of a facility-based survey. J Int AIDS Soc 27, e26303. http://doi.org/10.1002/jia2.26303.
Vakaniaki, E. H. et al. (2024). Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo. Nat Med. http://doi.org/10.1038/s41591-024-03130-3.
Ebasone, P. V. et al. (2024). Coprevalence and associations of diabetes mellitus and hypertension among people living with HIV/AIDS in Cameroon. AIDS Res Ther 21, 36. http://doi.org/10.1186/s12981-024-00624-5.
Yan, L. D. et al. (2024). Spectrum of prevalent cardiovascular diseases in urban Port-au-Prince, Haiti: a population-based cross-sectional study. Lancet Reg Health Am 33, 100729. http://doi.org/10.1016/j.lana.2024.100729.
Ross, J. et al. (2024). Reducing time to differentiated service delivery for newly-diagnosed people living with HIV in Kigali, Rwanda: a pilot, unblinded, randomized controlled trial. BMC Health Serv Res 24, 555. http://doi.org/10.1186/s12913-024-10950-z.
Grimes, K. E. L. et al. (2024). Factors influencing integration of mental health screening and treatment at HIV clinic settings in Cameroon: a qualitative study of health providers’ perspectives. BMC Health Serv Res 24, 519. http://doi.org/10.1186/s12913-024-10775-w.
Mujwara, D. et al. (2024). The economic costs and cost-effectiveness of HIV self-testing among truck drivers in Kenya. Health Policy Plan 39, 355–362. http://doi.org/10.1093/heapol/czae013.
Kebede, S. et al. (2024). Preexposure prophylaxis availability among health facilities participating in the global International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. AIDS 38, 751–756. http://doi.org/10.1097/QAD.0000000000003824.
Plaisy, M. K. et al. (2024). Metabolic causes of liver disease among adults living with HIV from low- and middle-income countries: a cross-sectional study. J Int AIDS Soc 27, e26238. http://doi.org/10.1002/jia2.26238.
Cohen, M. H., Benekigeri, C. & Anastos, K. (2024). Bringing together the pieces: the need for holistic care for women with HIV. J Int AIDS Soc 27, e26228. http://doi.org/10.1002/jia2.26228.
Brazier, E. et al. (2024). Long-term HIV care outcomes under universal HIV treatment guidelines: A retrospective cohort study in 25 countries. PLoS Med 21, e1004367. http://doi.org/10.1371/journal.pmed.1004367
Davidović, M. et al. (2024). Facility-Based Indicators to Manage and Scale Up Cervical Cancer Prevention and Care Services for Women Living With HIV in Sub-Saharan Africa: a Three-Round Online Delphi Consensus Method. J Acquir Immune Defic Syndr 95, 170–178. http://doi.org/10.1097/QAI.0000000000003343.
Lancaster, K. E. et al. (2024). Availability of substance use screening and treatment within HIV clinical sites across seven geographic regions within the IeDEA consortium. Int J Drug Policy 124, 104309. http://doi.org/10.1016/j.drugpo.2023.104309.
Enane, L. A. et al. (2024). The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America. BMJ Open 14, e079138. http://doi.org/10.1136/bmjopen-2023-079138.
Munyaneza, A. et al. (2024). Awareness and willingness to use pre-exposure prophylaxis for HIV prevention among men who have sex with men in Rwanda: findings from a web-based survey. Front Public Health 12, 1325029. http://doi.org/10.3389/fpubh.2024.1325029.
Grimes, K. E. L. et al. (2024). Intimate partner violence, depression, hazardous alcohol use, and social support among people with HIV initiating HIV care in Cameroon. PLoS One 19, e0304114. http://doi.org/10.1371/journal.pone.0304114.
2023
Hill, S. E. et al. (2023). Association Between Clinical Encounter Frequency and HIV-Related Stigma Among Newly-Diagnosed People Living with HIV in Rwanda. AIDS Behav. https://doi.org/10.1007/s10461-023-04226-6.
Boisson-Walsh, A. et al. (2023). Childhood immunization uptake determinants in Kinshasa, Democratic Republic of the Congo: ordered regressions to assess timely infant vaccines administered at birth and 6-weeks. Glob Health Res Policy 8, 50. http://doi.org/10.1186/s41256-023-00338-7.
Morgan, C. E. et al. (2023). Hepatitis B virus prevalence and transmission in the households of pregnant women in Kinshasa, Democratic Republic of Congo. medRxiv. http://doi.org/10.1101/2023.11.27.23298863.
Zotova, N. et al. (2023). Low birth weight among infants and pregnancy outcomes among women living with HIV and HIV-negative women in Rwanda. Res Sq rs.3.rs-3467879. http://doi10.21203/rs.3.rs-3467879/v1.
Ingabire, C. et al. (2023). Experiences of stigma and HIV care engagement in the context of Treat All in Rwanda: a qualitative study. BMC Public Health 23, 1817. http://doi.org/10.1186/s12889-023-16752-y.
Nachega, J. B. et al. (2023). Global HIV control: is the glass half empty or half full? Lancet HIV 10, e617–e622. http://doi.org/10.1016/S2352-3018(23)00150-9.
Parcesepe, A. M. et al. (2023). Availability of screening and treatment for common mental disorders in HIV clinic settings: data from the global International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium, 2016-2017 and 2020. J Int AIDS Soc 26, e26147. http://doi.org/10.1002/jia2.26147.
Chiarappa, J. A., Hoover, D. R. & Pedley, A. (2023). Economizing comparative Poisson clinical trials of multiple experimental treatments by testing against the same control. Stat Methods Med Res 32, 1604–1615. http://doi.org/10.1177/09622802231181235
Parcesepe, A. M. et al. (2023). Coping Strategies and Symptoms of Mental Health Disorders Among People with HIV Initiating HIV Care in Cameroon. AIDS Behav 27, 2360–2369. http://doi.org/10.1007/s10461-022-03963-4.
Lancaster, K. E. et al. (2023). Age-varying Associations of Depressive Symptoms and Heavy Episodic Drinking Throughout Adulthood Among People with HIV and Receiving care in Cameroon Within a National ‘treat all’ Policy. AIDS Behav 27, 2070–2078. http://doi.org/10.1007/s10461-022-03939-4.
Nachega, J. B. et al. (2023). Long-acting antiretrovirals and HIV treatment adherence. Lancet HIV 10, e332–e342. http://doi.org/10.1016/S2352-3018(23)00051-6.
Nachega, J. B. et al. (2023). Advancing detection and response capacities for emerging and re-emerging pathogens in Africa. Lancet Infect Dis 23, e185–e189. http://doi.org/10.1016/S1473-3099(22)00723-X.
Murenzi, G. et al. (2023). Association Between Time to Antiretroviral Therapy and Loss to Care Among Newly Diagnosed Rwandan People Living with Human Immunodeficiency Virus. AIDS Res Hum Retroviruses 39, 253–261. http://doi.org/10.1089/AID.2022.0023.
Vreeman, R. C. et al. (2023). Global HIV prevention, care and treatment services for children: a cross-sectional survey from the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium. BMJ Open 13, e069399. http://doi.org/10.1136/bmjopen-2022-069399.
Parcesepe, A. M. et al. (2023). Prevalence of potentially traumatic events and symptoms of depression, anxiety, hazardous alcohol use, and post-traumatic stress disorder among people with HIV initiating HIV care in Cameroon. BMC Psychiatry 23, 150. http://doi.org/10.1186/s12888-023-04630-1.
Parcesepe, A. M. et al. (2023). HIV-Related Stigma, Social Support, and Symptoms of Mental Health Disorders Among People with HIV Initiating HIV Care in Cameroon. AIDS Patient Care STDS 37, 146–154. http://doi.org/10.1089/apc.2022.0187.
Masiano, S. P. et al. (2023). Economic costs and cost-effectiveness of conditional cash transfers for the uptake of services for the prevention of vertical HIV transmissions in a resource-limited setting. Soc Sci Med 320, 115684. http://doi.org/10.1016/j.socscimed.2023.115684.
Ross, J. et al. (2023). Same-Day Antiretroviral Therapy Initiation as a Predictor of Loss to Follow-up and Viral Suppression Among People With Human Immunodeficiency Virus in Sub-Saharan Africa. Clin Infect Dis 76, 39–47. http://doi.org/10.1093/cid/ciac759.
Humphrey, J. et al. (2023). Integration of HIV care into maternal and child health services in the global IeDEA consortium. Front Glob Womens Health 4, 1066297. http://doi.org/10.3389/fgwh.2023.1066297.
Chabikuli, O. N. et al. (2023). Advanced HIV Disease at Antiretroviral Therapy Initiation and Treatment Outcomes Among Children and Adolescents Compared to Adults Living With HIV in Kinshasa, Democratic Republic of the Congo. J Int Assoc Provid AIDS Care 22, 23259582231221955. http://doi.org/10.1177/23259582231221955.
Brazier, E. et al. (2023). Design and implementation of a global site assessment survey among HIV clinics participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium. PLoS One 18, e0268167. http://doi.org/10.1371/journal.pone.0268167.
2022
Thompson, P.; Mpody, C.; Sayre, W.; Rigney, C.; Tabala, M. et al. (2022). Hepatitis C prevalence and quality of health services among HIV-positive mothers in the Democratic Republic of the Congo. Sci Rep, 12 (1), S. 1384. http://doi.org/10.1038/s41598-022-05014-3.
Romo, M. L.; Patel, R. C.; Edwards, J. K.; Humphrey, J. M.; Musick, B. S. et al. (2022). Disparities in Dolutegravir Uptake Affecting Females of Reproductive Age With HIV in Low- and Middle-Income Countries After Initial Concerns About Teratogenicity : An Observational Study. Ann Intern Med, 175 (1), S. 84–94. http://doi.org/10.7326/M21-3037.
Shaikh, K.; Bhondoekhan, F.; Haberlen, S.; Nakanishi, R.; Roy, S. K. et al. (2022). Coronary artery plaque progression and cardiovascular risk scores in men with and without HIV-infection. AIDS, 36 (2), S. 215–224. http://doi.org/10.1097/QAD.0000000000003093.
Sam-Agudu, N. A.; Quakyi, N. K.; Masekela, R.; Zumla, A. & Nachega, J. B. (2022). Children and adolescents in African countries should also be vaccinated for COVID-19. BMJ Glob Health, 7 (2), S. e008315. http://doi.org/10.1136/bmjgh-2021-008315.
Zotova, N.; Familiar, I.; Kawende, B.; Kasindi, F. L.; Ravelomanana, N. et al. (2022). HIV disclosure and depressive symptoms among pregnant women living with HIV: a cross-sectional study in the Democratic Republic of Congo. J Int AIDS Soc, 25 (2), S. e25865. http://doi.org/10.1002/jia2.25865.
Collaborative Initiative for Paediatric, H. I. V. Education; Research Global Cohort, Collaboration; Jesson, J.; Crichton, S.; Quartagno, M. et al. (2022). Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis. J Int AIDS Soc, 25 (3), S. e25871. http://doi.org/10.1002/jia2.25871.
Parcesepe, A. M.; Remch, M.; Dzudie, A.; Ajeh, R.; Nash, D. et al. (2022). Depressive Symptoms, Gender, Disclosure, and HIV Care Stage Among People Living with HIV in Cameroon. AIDS Behav, 26 (3), S. 651–661. http://doi.org/10.1007/s10461-021-03425-3.
Antimycobacterial Susceptibility Testing, Group (2022). Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment. Eur Respir J, 59 (4), S. 2200166. http://doi.org/10.1183/13993003.00166-2022.
Justice, A. C.; Goetz, M. B.; Stewart, C. N.; Hogan, B. C.; Humes, E. et al. (2022). Delayed presentation of HIV among older individuals: a growing problem. Lancet HIV, 9 (4), S. e269–e280. http://doi.org/10.1016/S2352-3018(22)00003-0.
Lewis, J. T.; Brazier, E.; Katz, B.; Nash, D. & Duda, S. N. (2022). A Method for Generating Dashboard Aggregations in an International HIV Consortium. Stud Health Technol Inform, 290, S. 1048–1049. http://doi.org/10.3233/SHTI220261.
Filiatreau, L. M.; Ebasone, P. V.; Dzudie, A.; Ajeh, R.; Pence, B. W. et al. (2022). Prevalence of stressful life events and associations with symptoms of depression, anxiety, and post-traumatic stress disorder among people entering care for HIV in Cameroon. J Affect Disord, 308, S. 421–431. http://doi.org/10.1016/j.jad.2022.04.061.
Lewis, J. T.; Stephens, J.; Musick, B.; Brown, S.; Malateste, K. et al. (2022). The IeDEA harmonist data toolkit: A data quality and data sharing solution for a global HIV research consortium. J Biomed Inform, 131, S. 104110. http://doi.org/10.1016/j.jbi.2022.104110.
Romo, M. L.; Brazier, E.; Mahambou-Nsonde, D.; De Waal, R.; Sekaggya-Wiltshire, C. et al. (2022). Real-world use and outcomes of dolutegravir-containing antiretroviral therapy in HIV and tuberculosis co-infection: a site survey and cohort study in sub-Saharan Africa. J Int AIDS Soc, 25 (7), S. e25961. http://doi.org/10.1002/jia2.25961.
Murenzi, G.; Shumbusho, F.; Hansen, N.; Munyaneza, A.; Gage, J. C. et al. (2022). Long-term human papillomavirus vaccination effectiveness and immunity in Rwandan women living with and without HIV: a study protocol. BMJ Open, 12 (8), S. e061650. http://doi.org/10.1136/bmjopen-2022-061650.
Edmonds, A.; Brazier, E.; Musick, B. S.; Yotebieng, M.; Humphrey, J. et al. (2022). Clinical and programmatic outcomes of HIV-exposed infants enrolled in care at geographically diverse clinics, 1997-2021: A cohort study. PLoS Med, 19 (9), S. e1004089. http://doi.org/10.1371/journal.pmed.1004089.
Wada, P. Y.; Kim, A.; Jayathilake, K.; Duda, S. N.; Abo, Y. et al. (2022). Site-Level Comprehensiveness of Care Is Associated with Individual Clinical Retention Among Adults Living with HIV in International Epidemiology Databases to Evaluate AIDS, a Global HIV Cohort Collaboration, 2000-2016. AIDS Patient Care STDS, 36 (9), S. 343–355. http://doi.org/10.1089/apc.2022.0042.
Brazier, E.; Ajeh, R.; Maruri, F.; Musick, B.; Freeman, A. et al. (2022). Service delivery challenges in HIV care during the first year of the COVID-19 pandemic: results from a site assessment survey across the global IeDEA consortium. J Int AIDS Soc, 25 (12), S. e26036. http://doi.org/10.1002/jia2.26036.
Parcesepe, A. M.; Filiatreau, L. M.; Ebasone, P. V.; Dzudie, A.; Pence, B. W. et al. (2022). Psychiatric comorbidity and psychosocial stressors among people initiating HIV care in Cameroon. PLoS One, 17 (6), S. e0270042. http://doi.org/10.1371/journal.pone.0270042.
Rogers, A.; Brazier, E.; Dzudie, A.; Adedimeji, A.; Yotebieng, M. et al. (2022). COVID-19 associated changes in HIV service delivery over time in Central Africa: Results from facility surveys during the first and second waves of the pandemic. PLoS One, 17 (11), S. e0275429. http://doi.org/10.1371/journal.pone.0275429.
Zurcher, K.; Cox, S. R.; Ballif, M.; Enane, L. A.; Marcy, O. et al. (2022). Integrating services for HIV and multidrug-resistant tuberculosis: A global cross-sectional survey among ART clinics in low- and middle-income countries. PLOS Glob Public Health, 2 (3), S. e0000180. http://doi.org/10.1371/journal.pgph.0000180.
2021
Agler, Robert A.; Zivich, Paul N.; Kawende, Bienvenu; Behets, Frieda & Yotebieng, Marcel (2021). Postpartum depressive symptoms following implementation of the 10 steps to successful breastfeeding program in Kinshasa, Democratic Republic of Congo: A cohort study. PLOS Medicine, 18 (1), S. e1003465–e1003465. http://doi.org/10.1371/journal.pmed.1003465.
Pierz, Amanda J.; Ajeh, Rogers; Fuhngwa, Norbert; Nasah, Judith; Dzudie, Anastase et al. (2021). Acceptability of Self-Sampling for Cervical Cancer Screening Among Women Living With HIV and HIV-Negative Women in Limbé, Cameroon. Frontiers in Reproductive Health, 2, S. 561202–561202. http://doi.org/10.3389/frph.2020.561202.
Tsondai, Priscilla Ruvimbo; Davies, Mary-Ann; Singtoroj, Thida; Maxwell, Nicola; McGowan, Catherine C. et al. (2021). Improving Methods to Classify Perinatal versus Nonperinatal HIV Acquisition in Young Adolescents 10-14 Years of Age. The Pediatric Infectious Disease Journal. http://doi.org/10.1097/INF.0000000000003059.
Mageras, Anna; Brazier, Ellen; Niyongabo, Théodore; Murenzi, Gad; D’Amour Sinayobye, Jean et al. (2021). Comparison of cohort characteristics in Central Africa International Epidemiology Databases to Evaluate AIDS and Demographic Health Surveys: Rwanda and Burundi. International Journal of STD & AIDS, S. 956462420983783. http://doi.org/10.1177/0956462420983783.
Adedimeji, Adebola; Ajeh, Rogers; Pierz, Amanda; Nkeng, Relindis; Ndenkeh, Jackson Jr et al. (2021). Challenges and opportunities associated with cervical cancer screening programs in a low income, high HIV prevalence context. BMC Women’s Health, 21 (1), S. 74. http://doi.org/10.1186/s12905-021-01211-w.
Chiarappa, Joseph A. & Hoover, Donald R. (2021). Comparative poisson clinical trials of multiple experimental treatments vs a single control using the negative multinomial distribution. Statistics in Medicine. http://doi.org/10.1002/sim.8914.
Brazier, Ellen; Tymejczyk, Olga; Zaniewski, Elizabeth; Egger, Matthias; Wools-Kaloustian, Kara et al. (2021). Effects of national adoption of Treat-All guidelines on pre-ART CD4 testing and viral load monitoring after ART initiation: A regression discontinuity analysis. Clinical Infectious Diseases, S. ciab222. http://doi.org/10.1093/cid/ciab222.
McMahon, Devon E.; Semeere, Aggrey; Laker-Oketta, Miriam; Byakwaga, Helen; Mugglin, Catrina et al. (2021). Global disparities in skin cancer services at HIV treatment centers across 29 countries. The Journal of Investigative Dermatology. http://doi.org/10.1016/j.jid.2021.02.758.
Ross, Jonathan; Murenzi, Gad; Hill, Sarah; Remera, Eric; Ingabire, Charles et al. (2021). Reducing time to differentiated service delivery for newly diagnosed people living with HIV in Kigali, Rwanda: study protocol for a pilot, unblinded, randomised controlled study. BMJ Open, 11 (4), S. e047443. http://doi.org/10.1136/bmjopen-2020-047443.
Iyun, Victoria; Technau, Karl-Gunter; Vinikoor, Michael; Yotebieng, Marcel; Vreeman, Rachel et al. (2021). Variations in the characteristics and outcomes of children living with HIV following universal ART in sub-Saharan Africa (2006-17): a retrospective cohort study. The Lancet. HIV. http://doi.org/10.1016/S2352-3018(21)00004-7.
Yumo, Habakkuk A.; Ndenkeh, Jackson N.; Sieleunou, Isidore; Nsame, Denis N.; Kuwoh, Pius B. et al. (2021). Human immunodeficiency virus case detection and antiretroviral therapy enrollment among children below and above 18 months old: A comparative analysis from Cameroon. Medicine, 100 (17), S. e25510. http://doi.org/10.1097/MD.0000000000025510.
Fouda, Genevieve G. A.; Kwiek, Jesse J. & Yotebieng, Marcel (2021). Safety of Breastfeeding by Mothers With COVID-19: New Evidence From Israel. Pediatrics, 147 (5). http://doi.org/10.1542/peds.2020-049772.
Filiatreau, Lindsey M.; Ebasone, Peter Vanes; Dzudie, Anastase; Ajeh, Rogers; Pence, Brian et al. (2021). Correlates of self-reported history of mental health help-seeking: a cross-sectional study among individuals with symptoms of a mental or substance use disorder initiating care for HIV in Cameroon. BMC Psychiatry, 21 (1), S. 293. http://doi.org/10.1186/s12888-021-03306-y.
Parcesepe, Angela M.; Filiatreau, Lindsey M.; Ebasone, Peter Vanes; Dzudie, Anastase; Ajeh, Rogers et al. (2021). Gender, Mental Health, and Entry Into Care with Advanced HIV Among People Living with HIV in Cameroon Under a National “Treat All” Policy. AIDS and Behavior. http://doi.org/10.1007/s10461-021-03328-3.
Adedimeji, Adebola A.; Hoover, Donald R.; Shi, Qiuhu; Kim, Hae-Young; Brazier, Ellen et al. (2021). Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018. Journal of the International AIDS Society, 24 (6), S. e25672. http://doi.org/10.1002/jia2.25672.
Parcesepe, Angela M.; Remch, Molly; Dzudie, Anastase; Ajeh, Rogers; Nash, Denis et al. (2021). Depressive Symptoms, Gender, Disclosure, and HIV Care Stage Among People Living with HIV in Cameroon. AIDS and Behavior. http://doi.org/10.1007/s10461-021-03425-3.
Johnson, Leigh F.; Kariminia, Azar; Trickey, Adam; Yiannoutsos, Constantin T.; Ekouevi, Didier K. et al. (2021). Achieving consistency in measures of HIV-1 viral suppression across countries: derivation of an adjustment based on international antiretroviral treatment cohort data. Journal of the International AIDS Society, 24 Suppl 5, S. e25776. http://doi.org/10.1002/jia2.25776.
Irvine, Mary K.; Robertson, McKaylee M.; Nash, Denis; Kulkarni, Sarah G.; Braunstein, Sarah L. et al. (2021). HIV Care Coordination promotes care re-engagement and viral suppression among people who have been out of HIV medical care: an observational effectiveness study using a surveillance-based contemporaneous comparison group. AIDS Research and Therapy, 18 (1), S. 70. http://doi.org/10.1186/s12981-021-00398-0.
Parcesepe, Angela M.; Filiatreau, Lindsey M.; Ebasone, Peter Vanes; Dzudie, Anastase; Pence, Brian W. et al. (2021). Mental health and initiation of antiretroviral treatment at enrolment into HIV care in Cameroon under a national “treat all” policy: a cross-sectional analysis. Journal of the International AIDS Society, 24 (11), S. e25842. http://doi.org/10.1002/jia2.25842.
Filiatreau, Lindsey M.; Ebasone, Peter Vanes; Dzudie, Anastase; Ajeh, Rogers; Pence, Brian W. et al. (2021). Underestimation of potentially traumatic events resulting from underreporting of physical and sexual violence among people entering care for HIV in Cameroon. Psychological Trauma: Theory, Research, Practice and Policy. http://doi.org/10.1037/tra0001175.
Lancaster, Kathryn E.; Remch, Molly; Dzudie, Anastase; Ajeh, Rogers; Adedimeji, Adebola et al. (2021). Heavy episodic drinking and HIV disclosure by HIV treatment status among People with HIV in IeDEA Cameroon. The International Journal on Drug Policy, 98, S. 103431. http://doi.org/10.1016/j.drugpo.2021.103431.
Dzudie, Anastase; Hoover, Donald; Kim, Hae-Young; Ajeh, Rogers; Adedimeji, Adebola et al. (2021). Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS. PloS One, 16 (7), S. e0253742. http://doi.org/10.1371/journal.pone.0253742.
Han, Win Min; Law, Matthew G.; Egger, Matthias; Wools-Kaloustian, Kara; Moore, Richard et al. (2021). Global estimates of viral suppression in children and adolescents and adults on antiretroviral therapy adjusted for missing viral load measurements: a multiregional, retrospective cohort study in 31 countries. The Lancet HIV, 8 (12), S. e766–e775. http://doi.org/10.1016/S2352-3018(21)00265-4.
Kassanjee, Reshma; Johnson, Leigh F.; Zaniewski, Elizabeth; Ballif, Marie; Christ, Benedikt et al. (2021). Global HIV mortality trends among children on antiretroviral treatment corrected for under‐reported deaths: an updated analysis of the International epidemiology Databases to Evaluate AIDS collaboration. Journal of the International AIDS Society, 24 (S5). http://doi.org/10.1002/jia2.25780.
Ross, Jonathan; Ingabire, Charles; Umwiza, Francine; Gasana, Josephine; Munyaneza, Athanase et al. (2021). How early is too early? Challenges in ART initiation and engaging in HIV care under Treat All in Rwanda-A qualitative study. PloS One, 16 (5), S. e0251645. http://doi.org/10.1371/journal.pone.0251645.
Zürcher, Kathrin; Reichmuth, Martina L.; Ballif, Marie; Loiseau, Chloé; Borrell, Sonia et al. (2021). Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study. The Lancet Microbe, 2 (7), S. e320–e330. http://doi.org/10.1016/S2666-5247(21)00044-6.
2020
Humphrey, John M.; Mpofu, Philani; Pettit, April C.; Musick, Beverly; Carter, E. Jane et al. (2020). Mortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium. Open Forum Infectious Diseases, 7 (1), S. ofaa006–ofaa006. http://doi.org/10.1093/ofid/ofaa006.
Patel, Kunjal; Smith, Colette; Collins, Intira Jeannie; Goodall, Ruth; Abrams, Elaine J. et al. (2020). Outcomes of second-line antiretroviral therapy among children living with HIV: a global cohort analysis. Journal of the International AIDS Society, 23 (4). http://doi.org/10.1002/jia2.25477.
Yumo, Habakkuk A.; Ajeh, Rogers A.; Sieleunou, Isidore; Ndenkeh, Jackson N.; Jordan, Michael R. et al. (2020). Parental and child-level predictors of HIV testing uptake, seropositivity and treatment initiation among children and adolescents in Cameroon. PLoS ONE, 15 (4). http://doi.org/10.1371/journal.pone.0230988.
Chammartin, Frédérique; Dao Ostinelli, Cam Ha; Anastos, Kathryn; Jaquet, Antoine; Brazier, Ellen et al. (2020). International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019. BMJ Open, 10 (5). http://doi.org/10.1136/bmjopen-2019-035246.
Jesson, Julie; Desmonde, Sophie; Yiannoutsos, Constantin T.; Patten, Gabriela; Malateste, Karen et al. (2020). Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium. BMC Research Notes, 13 (1), S. 249–249. http://doi.org/10.1186/s13104-020-05081-7.
Ross, Jonathan; Ribakare, Muhayimpundu; Remera, Eric; Murenzi, Gad; Munyaneza, Athanase et al. (2020). High levels of viral load monitoring and viral suppression under Treat All in Rwanda – a cross‐sectional study. Journal of the International AIDS Society, 23 (6). http://doi.org/10.1002/jia2.25543.
Loiseau, Chloé; Brites, Daniela; Reinhard, Miriam; Zürcher, Kathrin; Borrell, Sonia et al. (2020). HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. http://doi.org/10.1128/AAC.00782-20.
Adedimeji, Adebola; Ajeh, Rogers; Dzudie, Anastase; Kendowo, Ernestine; Fuhngwa, Norbert et al. (2020). Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon. Journal of Clinical Virology, 128. http://doi.org/10.1016/j.jcv.2020.104445.
Chan, Andrew T.; Drew, David A.; Nguyen, Long H.; Joshi, Amit D.; Ma, Wenjie et al. (2020). The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 29 (7), S. 1283–1289. http://doi.org/10.1158/1055-9965.EPI-20-0606.
Parcesepe, Angela M.; Lancaster, Kathryn; Edelman, E. Jennifer; DeBoni, Raquel; Ross, Jeremy et al. (2020). Substance use service availability in HIV treatment programs: Data from the global IeDEA consortium, 2014-2015 and 2017. PLoS ONE, 15 (8 August), S. e0237772–e0237772. http://doi.org/10.1371/journal.pone.0237772.
Desmonde, Sophie; Neilan, Anne M.; Musick, Beverly; Patten, Gabriela; Chokephaibulkit, Kulkanya et al. (2020). Time-varying age- and CD4-stratified rates of mortality and WHO stage 3 and stage 4 events in children, adolescents and youth 0 to 24 years living with perinatally acquired HIV, before and after antiretroviral therapy initiation in the paediatric IeDEA Gl. Journal of the International AIDS Society, 23 (10), S. e25617–e25617. http://doi.org/10.1002/jia2.25617.
Rebeiro, Peter F.; Duda, Stephany N.; Wools-Kaloustian, Kara K.; Nash, Denis & Althoff, Keri N. (2020). Implications of COVID-19 for HIV Research: data sources, indicators and longitudinal analyses. Journal of the International AIDS Society, 23 (10), S. e25627–e25627. http://doi.org/10.1002/jia2.25627.
Reichmuth, Martina L.; Hömke, Rico; Zürcher, Kathrin; Sander, Peter; Avihingsanon, Anchalee et al. (2020). Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients. Antimicrobial Agents and Chemotherapy, 64 (11). http://doi.org/10.1128/AAC.00513-20.
Castle, Philip E.; Ajeh, Rogers; Dzudie, Anastase; Kendowo, Ernestine; Fuhngwa, Norbert et al. (2020). A comparison of screening tests for detection of high-grade cervical abnormalities in women living with HIV from Cameroon. Infectious Agents and Cancer, 15, S. 45. http://doi.org/10.1186/s13027-020-00311-w.
Edwards, Jessie K.; Lesko, Catherine R.; Herce, Michael E.; Murenzi, Gad; Twizere, Christella et al. (2020). Gone But Not Lost: Implications for Estimating HIV Care Outcomes When Loss to Clinic Is Not Loss to Care. Epidemiology, 31 (4), S. 570–577. http://doi.org/10.1097/EDE.0000000000001201.
2019
Adedimeji, Adebola; Sinayobye, Jean d’Amour; Asiimwe-Kateera, Brenda; Chaudhry, Junaid; Buzinge, Lydia et al. (2019). Social contexts as mediator of risk behaviors in Rwandan men who have sex with men (MSM): Implications for HIV and STI transmission. PLOS ONE, 14 (1), S. e0211099–e0211099. http://doi.org/10.1371/journal.pone.0211099.
Yotebieng, Marcel; Brazier, Ellen; Addison, Diane; Kimmel, April D.; Cornell, Morna et al. (2019). Research priorities to inform “Treat All” policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA). Journal of the International AIDS Society, 22 (1), S. e25218–e25218. http://doi.org/10.1002/jia2.25218.
Gygli, Sebastian M.; Keller, Peter M.; Ballif, Marie; Blöchliger, Nicolas; Hömke, Rico et al. (2019). Whole-Genome Sequencing for Drug Resistance Profile Prediction in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 63 (4). http://doi.org/10.1128/AAC.02175-18.
Ross, Jonathan; Sinayobye, Jean d’Amour; Yotebieng, Marcel; Hoover, Donald R.; Shi, Qiuhu et al. (2019). Early outcomes after implementation of treat all in Rwanda: an interrupted time series study. Journal of the International AIDS Society, 22 (4), S. e25279–e25279. http://doi.org/10.1002/jia2.25279.
Cornejo Castro, Elena M.; Morrison, Brian J.; Marshall, Vickie A.; Labo, Nazzarena; Miley, Wendell J. et al. (2019). Relationship between human leukocyte antigen alleles and risk of Kaposi’s sarcoma in Cameroon. Genes and Immunity. http://doi.org/10.1038/s41435-019-0077-9.
Mpody, Christian; Thompson, Peyton; Tabala, Martine; Ravelomanana, Noro Lantoniaina Rosa; Malongo, Fathy et al. (2019). Hepatitis B infection among pregnant and post-partum women living with HIV and on antiretroviral therapy in Kinshasa, DR Congo: A cross-sectional study. PloS One, 14 (5), S. e0216293–e0216293. http://doi.org/10.1371/journal.pone.0216293.
Mpody, Christian; Reline, Travis; Ravelomanana, Noro Lantoniaina Rosa; Kawende, Bienvenu; Okitolonda, Emile W. et al. (2019). Breastfeeding Support Offered at Delivery is Associated with Higher Prevalence of Exclusive Breastfeeding at 6 Weeks Postpartum Among HIV Exposed Infants: A Cross-Sectional Analysis. Maternal and Child Health Journal. http://doi.org/10.1007/s10995-019-02760-1.
Brazier, Ellen; Maruri, Fernanda; Duda, Stephany N.; Tymejczyk, Olga; Wester, C. William et al. (2019). Implementation of “Treat-all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey. Journal of the International AIDS Society, 22 (7), S. e25331–e25331. http://doi.org/10.1002/jia2.25331.
Muhoza, Benjamin; Remera, Eric; Shi, Qiuhu; Kabahizi, Jules; Brazier, Ellen et al. (2019). Secondary Data Use in Rwanda: Leveraging OpenMRS for Global HIV Research. Studies in Health Technology and Informatics, 264, S. 1732–1732. http://doi.org/10.3233/SHTI190620.
Ngamani, Lionel; Ajeh, Rogers; Mbuh, Akindeh; Dzudie, Anastase & Duda, Stephany N. (2019). Implementation of a REDCap-Based Research Data Collection System in Cameroon. Studies in Health Technology and Informatics, 264, S. 1708–1709. http://doi.org/10.3233/SHTI190608.
Yotebieng, Marcel; Mpody, Christian; Ravelomanana, Noro Lr; Tabala, Martine; Malongo, Fathy et al. (2019). HIV viral suppression among pregnant and breastfeeding women in routine care in the Kinshasa province: a baseline evaluation of participants in CQI-PMTCT study. Journal of the International AIDS Society, 22 (9), S. e25376–e25376. http://doi.org/10.1002/jia2.25376.
Zürcher, Kathrin; Ballif, Marie; Kiertiburanakul, Sasisopin; Chenal, Henri; Yotebieng, Marcel et al. (2019). Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low- and middle-income countries: a multicohort study. Journal of the International AIDS Society, 22 (9), S. e25392–e25392. http://doi.org/10.1002/jia2.25392.
Jesson, Julie; Schomaker, Michael; Malasteste, Karen; Wati, Dewi K.; Kariminia, Azar et al. (2019). Stunting and growth velocity of adolescents with perinatally acquired HIV: differential evolution for males and females. A multiregional analysis from the IeDEA global paediatric collaboration. Journal of the International AIDS Society, 22 (11), S. e25412–e25412. http://doi.org/10.1002/jia2.25412.
Tymejczyk, Olga; Brazier, Ellen; Wools-Kaloustian, Kara; Davies, Mary-Ann; DiLorenzo, Madeline et al. (2019). Impact of universal antiretroviral treatment eligibility on rapid treatment initiation among young adolescents with HIV in sub-Saharan Africa. The Journal of Infectious Diseases. http://doi.org/10.1093/infdis/jiz547.
Brault, Marie A.; Spiegelman, Donna; Hargreaves, James; Nash, Denis & Vermund, Sten H. (2019). Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. Journal of Acquired Immune Deficiency Syndromes (1999), 82 Suppl 2, S. S104–S112. http://doi.org/10.1097/QAI.0000000000002168.
Johnson, Leigh F.; Anderegg, Nanina; Zaniewski, Elizabeth; Eaton, Jeffrey W.; Rebeiro, Peter F. et al. (2019). Global variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration. AIDS (London, England), 33 Suppl 3, S. S283–S294. http://doi.org/10.1097/QAD.0000000000002358.
Pettit, April C.; Jenkins, Cathy A.; Blevins Peratikos, Meridith; Yotebieng, Marcel; Diero, Lameck et al. (2019). Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries. Journal of the International AIDS Society, 22 (12), S. e25423–e25423. http://doi.org/10.1002/jia2.25423.
Stover, John; Glaubius, Robert; Mofenson, Lynne; Dugdale, Caitlin M.; Davies, Mary Ann et al. (2019). Updates to the Spectrum/AIM model for estimating key HIV indicators at national and subnational levels. AIDS, 33, S. S227–S234. http://doi.org/10.1097/QAD.0000000000002357.
2018
Desmonde, Sophie; Tanser, Franck; Vreeman, Rachel; Takassi, Elom; Edmonds, Andrew et al. (2018). Access to antiretroviral therapy in HIV-infected children aged 0-19 years in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Global Cohort Consortium, 2004-2015: A prospective cohort study. PLoS Medicine, 15 (5), S. e1002565–e1002565. http://doi.org/10.1371/journal.pmed.1002565.
Arrivé, Elise; Ayaya, Samuel; Davies, Mary-Ann; Chimbetete, Cleophas; Edmonds, Andrew et al. (2018). Models of support for disclosure of HIV status to HIV-infected children and adolescents in resource-limited settings. Journal of the International AIDS Society, 21 (7), S. e25157–e25157. http://doi.org/10.1002/jia2.25157.
Yumo, Habakkuk Azinyui; Kuaban, Christopher; Ajeh, Rogers Awoh; Nji, Akindeh Mbuh; Nash, Denis et al. (2018). Active case finding: comparison of the acceptability, feasibility and effectiveness of targeted versus blanket provider-initiated-testing and counseling of HIV among children and adolescents in Cameroon. BMC Pediatrics, 18 (1), S. 309–309. http://doi.org/10.1186/s12887-018-1276-7.
Kiefer, E. M.; Hoover, D. R.; Shi, Q.; Dusingize, J. C.; Sinayobye, J. D. et al. (2018). Longitudinal evaluation of markers of inflammation in HIV-positive and HIV-negative Rwandan women. HIV Medicine, 19 (10), S. 734–744. http://doi.org/10.1111/hiv.12665.
Panayidou, Klea; Davies, Mary-Ann; Anderegg, Nanina; Egger, Matthias & IeDEA, COHERE, PHACS and IMPAACT 219C Collaborations Writing Group (2018). Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation. Journal of the International AIDS Society, 21 (11), S. e25200–e25200. http://doi.org/10.1002/jia2.25200.
Kariminia, Azar; Law, Matthew; Davies, Mary‐Ann; Vinikoor, Michael; Wools‐Kaloustian, Kara et al. (2018). Mortality and losses to follow‐up among adolescents living with HIV in the Ie DEA global cohort collaboration. Journal of the International AIDS Society, 21 (12), S. e25215–e25215. http://doi.org/10.1002/jia2.25215.
Zivich, Paul N.; Kawende, Bienvenu; Lapika, Bruno; Behets, Frieda & Yotebieng, Marcel (2018). Effect of Family Planning Counseling After Delivery on Contraceptive Use at 24 Weeks Postpartum in Kinshasa, Democratic Republic of Congo. Maternal and Child Health Journal. http://doi.org/10.1007/s10995-018-2667-y.