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Research Highlights 2022

Check out the IeDEA Global Research Highlights from 2022!

Zürcher, Kathrin; Reichmuth, Martina L.; Ballif, Marie; Loiseau, Chloé; Borrell, Sonia et al. (2021). Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study. The Lancet Microbe, 2 (7), S. e320–e330. http://doi.org/10.1016/S2666-5247(21)00044-6.

Yiannoutsos, Constantin T.; An, Ming-Wen; Frangakis, Constantine E.; Musick, Beverly S.; Braitstein, Paula et al. (2008). Sampling-Based Approaches to Improve Estimation of Mortality among Patient Dropouts: Experience from a Large PEPFAR-Funded Program in Western Kenya. PLoS ONE, 3 (12), S. e3843. http://doi.org/10.1371/journal.pone.0003843.

Coelho, Lara E.; Jenkins, Cathy A.; Shepherd, Bryan E.; Pape, Jean W.; Mejia Cordero, Fernando et al. (2022). Weight gain post-ART in HIV+ Latinos/as differs in the USA, Haiti, and Latin America. Lancet Regional Health. Americas, 8, S. 100173. http://doi.org/10.1016/j.lana.2021.100173.

Sack, Daniel E.; Gange, Stephen J.; Althoff, Keri N.; Pettit, April C.; Kheshti, Asghar N. et al. (2021). Visualizing the geography of HIV observational cohorts with density-adjusted cartograms. Journal of Acquired Immune Deficiency Syndromes (1999). http://doi.org/10.1097/QAI.0000000000002903.

Antimycobacterial Susceptibility Testing Group (2022). Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment. The European Respiratory Journal, 59 (4), S. 2200166. http://doi.org/10.1183/13993003.00166-2022.

Parcesepe, Angela M.; Remch, Molly; Dzudie, Anastase; Ajeh, Rogers; Nash, Denis et al. (2021). Depressive Symptoms, Gender, Disclosure, and HIV Care Stage Among People Living with HIV in Cameroon. AIDS and Behavior. http://doi.org/10.1007/s10461-021-03425-3.

Justice, Amy C.; Goetz, Matthew B.; Stewart, Cameron N.; Hogan, Brenna C.; Humes, Elizabeth et al. (2022). Delayed presentation of HIV among older individuals: a growing problem. The Lancet HIV, S. S2352301822000030. http://doi.org/10.1016/S2352-3018(22)00003-0.

Staub, Kaspar; Panczak, Radoslaw; Matthes, Katarina L.; Floris, Joël; Berlin, Claudia et al. (2022). Historically High Excess Mortality During the COVID-19 Pandemic in Switzerland, Sweden, and Spain. Annals of Internal Medicine, 175 (4), S. 523–532. http://doi.org/10.7326/M21-3824.

Castilho, Jessica L.; Bian, Aihua; Jenkins, Cathy A.; Shepherd, Bryan E.; Sigel, Keith et al. (2022). CD4/CD8 Ratio and Cancer Risk among Adults with HIV. Journal of the National Cancer Institute, S. djac053. http://doi.org/10.1093/jnci/djac053.

Myers, Courtney; Apondi, Edith; Toromo, Judith J.; Omollo, Mark; Bakari, Salim et al. (2022). “Who am I going to stay with? Who will accept me?”: family-level domains influencing HIV care engagement among disengaged adolescents in Kenya. Journal of the International AIDS Society, 25 (2), S. e25890. http://doi.org/10.1002/jia2.25890.

McMahon, Devon E.; Chemtai, Linda; Grant, Merridy; Singh, Rhea; Semeere, Aggrey et al. (2022). Understanding Diagnostic Delays for Kaposi Sarcoma in Kenya: A Qualitative Study. Journal of Acquired Immune Deficiency Syndromes (1999). http://doi.org/10.1097/QAI.0000000000003011.

Leite, Pedro H. A. C.; Coelho, Lara E.; Cardoso, Sandra W.; Moreira, Ronaldo I.; Veloso, Valdilea G. et al. (2022). Early mortality in a cohort of people living with HIV in Rio de Janeiro, Brazil, 2004-2015: a persisting problem. BMC Infectious Diseases, 22 (1), S. 475. http://doi.org/10.1186/s12879-022-07451-x.

Kim, Jung Ho; Jiamsakul, Awachana; Kiertiburanakul, Sasisopin; Huy, Bui Vu; Khusuwan, Suwimon et al. (2022). Patterns and prognosis of holding regimens for people living with HIV in Asian countries. PloS One, 17 (3), S. e0264157. http://doi.org/10.1371/journal.pone.0264157.

Hussey, Hannah; Davies, Mary-Ann; Heekes, Alexa; Williamson, Carolyn; Valley-Omar, Ziyaad et al. (2022). Assessing the clinical severity of the Omicron variant in the Western Cape Province, South Africa, using the diagnostic PCR proxy marker of RdRp target delay to distinguish between Omicron and Delta infections - a survival analysis. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, 118, S. 150–154. http://doi.org/10.1016/j.ijid.2022.02.051.

McNeil, Candice J.; Lee, Jennifer S.; Cole, Stephen R.; Patel, Shivani A.; Martin, Jeffrey et al. (2022). Anal cancer incidence in men with HIV who have sex with men: are black men at higher risk? AIDS (London, England), 36 (5), S. 657–664. http://doi.org/10.1097/QAD.0000000000003151.

Oyungu, Eren; El Kebbi, Ola; Vreeman, Rachel; Nyandiko, Winstone; Monahan, Patrick O. et al. (2022). Predicting neurodevelopmental risk in children born to mothers living with HIV in Kenya: protocol for a prospective cohort study (Tabiri Study). BMJ Open, 12 (4), S. e061051. http://doi.org/10.1136/bmjopen-2022-061051.

Zhou, Wenxian; Bakoyannis, Giorgos; Zhang, Ying & Yiannoutsos, Constantin T. (2022). Semiparametric marginal regression for clustered competing risks data with missing cause of failure. Biostatistics (Oxford, England), S. kxac012. http://doi.org/10.1093/biostatistics/kxac012.

Humphrey, John M.; Songok, Julia; Ofner, Susan; Musick, Beverly; Alera, Marsha et al. (2022). Retention in care and viral suppression in the PMTCT continuum at a large referral facility in western Kenya. AIDS and Behavior. http://doi.org/10.1007/s10461-022-03666-w.

Filiatreau, Lindsey M.; Ebasone, Peter Vanes; Dzudie, Anastase; Ajeh, Rogers; Pence, Brian W. et al. (2022). Prevalence of stressful life events and associations with symptoms of depression, anxiety, and post-traumatic stress disorder among people entering care for HIV in Cameroon. Journal of Affective Disorders, 308, S. 421–431. http://doi.org/10.1016/j.jad.2022.04.061.

Muchengeti, Mazvita; Bartels, Lina; Olago, Victor; Dhokotera, Tafadzwa; Chen, Wenlong Carl et al. (2022). Cohort profile: the South African HIV Cancer Match (SAM) Study, a national population-based cohort. BMJ Open, 12 (4), S. e053460. http://doi.org/10.1136/bmjopen-2021-053460.

Crabtree-Ramirez, Brenda; Jenkins, Cathy A.; Shepherd, Bryan E.; Jayathilake, Karu; Veloso, Valdilea G. et al. (2022). Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy. BMC Infectious Diseases, 22 (1), S. 341. http://doi.org/10.1186/s12879-022-07330-5.

Vreeman, Rachel C.; Scanlon, Michael L.; Inui, Thomas S.; McAteer, Carole I.; Fischer, Lydia J. et al. (2015). Why did you not tell me?’: Perspectives of caregivers and children on the social environment surrounding child HIV disclosure in Kenya. AIDS, 29, S. S47–S55. http://doi.org/10.1097/QAD.0000000000000669.

Braitstein, Paula; Songok, Julia; Vreeman, Rachel C.; Wools-Kaloustian, Kara K.; Koskei, Pamela et al. (2011). “Wamepotea” (They Have Become Lost): Outcomes of HIV-Positive and HIV-Exposed Children Lost to Follow-Up From a Large HIV Treatment Program in Western Kenya. JAIDS Journal of Acquired Immune Deficiency Syndromes, 57 (3), S. e40–e46. http://doi.org/10.1097/QAI.0b013e3182167f0d.

Tierney, William M.; Nyandiko, Winstone N.; Siika, Abraham M.; Wools-Kaloustian, Kara; Sidle, John E. et al. (2013). “These are good problems to have...”: Establishing a collaborative research partnership in east Africa. Journal of General Internal Medicine, 28 (SUPPL.3), S. 625–625. http://doi.org/10.1007/s11606-013-2459-4.

Renju, Jenny; Moshabela, Mosa; McLean, Estelle; Ddaaki, William; Skovdal, Morten et al. (2017). “Side effects” are “central effects” that challenge retention in HIV treatment programmes in six sub-Saharan African countries: a multicountry qualitative study. Sexually Transmitted Infections, 93 (Suppl 3), S. e052971–e052971. http://doi.org/10.1136/sextrans-2016-052971.

McLean, Estelle; Renju, Jenny; Wamoyi, Joyce; Bukenya, Dominic; Ddaaki, William et al. (2017). “I wanted to safeguard the baby”: A qualitative study to understand the experiences of Option B+ for pregnant women and the potential implications for “test-And-Treat” in four sub-Saharan African settings. Sexually Transmitted Infections, 93 (Suppl 3). http://doi.org/10.1136/sextrans-2016-052972.

Gourlay, Annabelle; Wringe, Alison; Birdthistle, Isolde; Mshana, Gerry; Michael, Denna et al. (2014). “It is like that, we didn’t understand each other”: exploring the influence of patient-provider interactions on prevention of mother-to-child transmission of HIV service use in rural Tanzania. PloS One, 9 (9), S. e106325–e106325. http://doi.org/10.1371/journal.pone.0106325.

Ondenge, Ken; Renju, Jenny; Bonnington, Oliver; Moshabela, Mosa; Wamoyi, Joyce et al. (2017). “I am treated well if I adhere to my HIV medication”: putting patient-provider interactions in context through insights from qualitative research in five sub-Saharan African countries. Sexually Transmitted Infections, 93 (Suppl 3), S. e052973–e052973. http://doi.org/10.1136/sextrans-2016-052973.

Ruffieux, Yann; Dhokotera, Tafadzwa; Muchengeti, Mazvita; Bartels, Lina; Olago, Victor et al. (2021). Cancer risk in adolescents and young adults living with HIV in South Africa: a nationwide cohort study. The Lancet HIV, S. S2352301821001582. http://doi.org/10.1016/S2352-3018(21)00158-2.

IeDEA and COHERE Cohort Collaborations (2018). Global Trends in CD4 Cell Count at the Start of Antiretroviral Therapy: Collaborative Study of Treatment Programs. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. http://doi.org/10.1093/cid/cix915.

Humphrey, John M.; Genberg, Becky L.; Keter, Alfred; Musick, Beverly; Apondi, Edith et al. (2019). Viral suppression among children and their caregivers living with HIV in western Kenya. Journal of the International AIDS Society, 22 (4), S. e25272–e25272. http://doi.org/10.1002/jia2.25272.

Wools-Kaloustian, Kara; Kimaiyo, Silvester; Diero, Lameck; Siika, Abraham; Sidle, John et al. (2006). Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: Experience from western Kenya. AIDS, 20 (1), S. 41–48. http://doi.org/10.1097/01.aids.0000196177.65551.ea.

Parcesepe, Angela M.; Bernard, Charlotte; Agler, Robert; Ross, Jeremy; Yotebieng, Marcel et al. (2018). Mental health and HIV: research priorities related to the implementation and scale up of “treat all” in sub-Saharan Africa. Journal of Virus Eradication, 4 (Suppl 2), S. 16–25. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/30515310

Clouse, Kate; Blevins, Meridith; Lindegren, Mary Lou; Yotebieng, Marcel; Nguyen, Dung Thi et al. (2017). Low implementation of Xpert MTB/RIF among HIV/TB co-infected adults in the International epidemiologic Databases to Evaluate AIDS (IeDEA) program. PloS One, 12 (2), S. e0171384–e0171384. http://doi.org/10.1371/journal.pone.0171384.

Vreeman, Rachel C.; Nyandiko, Winstone M.; Liu, Hai; Tu, Wanzhu; Scanlon, Michael L. et al. (2014). Measuring adherence to antiretroviral therapy in children and adolescents in western Kenya. Journal of the International AIDS Society, 17 (1). http://doi.org/10.7448/IAS.17.1.19227.

Yu, Menggang & Yiannoutsos, Constantin T. (2015). Marginal and Conditional Distribution Estimation from Double-sampled Semi-competing Risks Data: Double-sampled semi-competing risks data. Scandinavian Journal of Statistics, 42 (1), S. 87–103. http://doi.org/10.1111/sjos.12096.

Morrow, Carl; Munro, Alison; Wilke, Marisa; Stark, Ruth & Wood, Robin (2012). Remote sensing of HIV care programmes using centrally collected laboratory results: can we monitor ART programme effectiveness? South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 102 (6), S. 501–505. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22668950

Bukenya, Dominic; Wringe, Alison; Moshabela, Mosa; Skovdal, Morten; Ssekubugu, Robert et al. (2017). Where are we now? A multicountry qualitative study to explore access to pre-antiretroviral care services: a precursor to antiretroviral therapy initiation. Sexually Transmitted Infections, 93 (Suppl 3), S. e052970–e052970. http://doi.org/10.1136/sextrans-2016-052970.

Geng, Elvin H.; Bwana, Mwebesa B.; Kabakyenga, Jerome; Muyindike, Winnie; Emenyonu, Nneka I. et al. (2010). Diminishing availability of publicly funded slots for antiretroviral initiation among HIV-infected ART-eligible patients in Uganda. PloS One, 5 (11), S. e14098–e14098. http://doi.org/10.1371/journal.pone.0014098.

Ciaranello, Andrea L.; Perez, Freddy; Engelsmann, Barbara; Walensky, Rochelle P.; Mushavi, Angela et al. (2013). Cost-effectiveness of World Health Organization 2010 Guidelines for Prevention of Mother-to-Child HIV Transmission in Zimbabwe. Clinical Infectious Diseases, 56 (3), S. 430–446. http://doi.org/10.1093/cid/cis858.

Rebora, Paola; Antolini, Laura; Glidden, David V. & Valsecchi, Maria Grazia (2016). Crude incidence in two-phase designs in the presence of competing risks. BMC Medical Research Methodology, 16 (1), S. 5–5. http://doi.org/10.1186/s12874-015-0103-1.

Wohl, David A.; Barzin, Amir H.; Napravnik, Sonia; Davy-Mendez, Thibaut; Smedberg, Jason R. et al. (2021). COVID-19 symptoms at time of testing and association with positivity among outpatients tested for SARS-CoV-2. PloS One, 16 (12), S. e0260879. http://doi.org/10.1371/journal.pone.0260879.

Ciaranello, Andrea L.; Morris, Bethany L.; Walensky, Rochelle P.; Weinstein, Milton C.; Ayaya, Samuel et al. (2013). Validation and calibration of a computer simulation model of pediatric HIV infection. PloS One, 8 (12), S. e83389–e83389. http://doi.org/10.1371/journal.pone.0083389.

Gourlay, Annabelle; Mshana, Gerry; Birdthistle, Isolde; Bulugu, Grace; Zaba, Basia et al. (2014). Using vignettes in qualitative research to explore barriers and facilitating factors to the uptake of prevention of mother-to-child transmission services in rural Tanzania: a critical analysis. BMC Medical Research Methodology, 14 (1), S. 21–21. http://doi.org/10.1186/1471-2288-14-21.

Skovdal, Morten; Wringe, Alison; Seeley, Janet; Renju, Jenny; Paparini, Sara et al. (2017). Using theories of practice to understand HIV-positive persons varied engagement with HIV services: a qualitative study in six Sub-Saharan African countries. Sexually Transmitted Infections, 93 (Suppl 3), S. e052977–e052977. http://doi.org/10.1136/sextrans-2016-052977.

Gourlay, Annabelle; Wringe, Alison; Todd, Jim; Cawley, Caoimhe; Michael, Denna et al. (2016). Uptake of services for prevention of mother-to-child transmission of HIV in a community cohort in rural Tanzania from 2005 to 2012. BMC Health Services Research, 16 (1), S. 4–4. http://doi.org/10.1186/s12913-015-1249-6.

Semeere, Aggrey; Freeman, Esther; Wenger, Megan; Glidden, David; Bwana, Mwebesa et al. (2017). Updating vital status by tracking in the community among patients with epidemic Kaposi sarcoma who are lost to follow-up in sub-Saharan Africa. BMC Cancer, 17 (1), S. 611–611. http://doi.org/10.1186/s12885-017-3549-1.

Elul, Batya; Wools-Kaloustian, Kara K.; Wu, Yingfeng; Musick, Beverly S.; Nuwagaba-Biribonwoha, Harriet et al. (2016). Untangling the Relationship Between Antiretroviral Therapy Use and Incident Pregnancy: A Marginal Structural Model Analysis Using Data From 47,313 HIV-Positive Women in East Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 72 (3), S. 324–332. http://doi.org/10.1097/QAI.0000000000000963.

Chi, Benjamin H.; Yiannoutsos, Constantin T.; Westfall, Andrew O.; Newman, Jamie E.; Zhou, Jialun et al. (2011). Universal Definition of Loss to Follow-Up in HIV Treatment Programs: A Statistical Analysis of 111 Facilities in Africa, Asia, and Latin America. PLoS Medicine, 8 (10), S. e1001111. http://doi.org/10.1371/journal.pmed.1001111.

Wamoyi, Joyce; Renju, Jenny; Moshabela, Mosa; McLean, Estelle; Nyato, Daniel et al. (2017). Understanding the relationship between couple dynamics and engagement with HIV care services: insights from a qualitative study in Eastern and Southern Africa. Sexually Transmitted Infections, 93 (Suppl 3), S. e052976–e052976. http://doi.org/10.1136/sextrans-2016-052976.

Resources

– Multiregional research SOPs, templates

– Funding Acknowledgements

– Consortium accomplishments

– Meeting reports and presentations

– Fogarty-IeDEA Mentorship Program (FIMP)

Global Newsletter – March

Research Highlights 2022

Global Newsletter – January

Global Newsletter – November

Global Newsletter – September