Skip to content
IeDEA International epidemiology Databases to Evaluate AIDS

IeDEA International epidemiology Databases to Evaluate AIDS

0Countries
0Sites
>0People living with and at risk for HIV
  • Home
    • Who We Are
  • Regions
    • Asia-Pacific
    • CCASAnet
    • Central Africa
    • East Africa
    • NA-ACCORD
    • Southern Africa
    • West Africa
  • Working Groups
    • Executive Committee
    • Adolescent and Young Adult Network of IeDEA (AYANI)
    • Cancer
    • Data Harmonization
    • Fogarty-IeDEA Mentorship Program (FIMP)
    • Hepatitis
    • Mental Health
    • Mother and Infant
    • Pediatrics
    • Sentinel Research Network (SRN)
    • Site Assessment
    • Strategic Data
    • Substance Use
    • Tuberculosis and Lung Health
  • Publications
    • Asia-Pacific
    • CCASAnet
    • Central Africa
    • East Africa
    • NA-ACCORD
    • Southern Africa
    • West Africa
    • Multi-regional
    • All publications
  • Resources
    • Fogarty-IeDEA Mentorship Program (FIMP)
    • Multiregional research SOPs, templates
    • Funding Acknowledgements
    • Consortium accomplishments
    • Meeting reports and presentations
      • CROI 2022 – IeDEA presentations
  • News
IeDEA International epidemiology Databases to Evaluate AIDS > Resources

Resources

– Multiregional research SOPs, templates

– Funding Acknowledgements

– Consortium accomplishments

– Meeting reports and presentations

– Fogarty-IeDEA Mentorship Program (FIMP)

 

News

  • Global Newsletter – JulyJuly 19, 2024
  • Global Newsletter – AprilApril 2, 2024
  • Global Newsletter – JanuaryJanuary 24, 2024
  • New Fogarty-IeDEA Mentorship Program (FIMP) traineesDecember 8, 2023
  • AIDS 2024December 1, 2023

Quick access

  • Who We Are
  • Regions
  • Working Groups
  • Publications
  • Resources

News

Global Newsletter – July

Read our latest global newsletter here.

Global Newsletter – April

Read our latest global newsletter here.

Global Newsletter – January

Read our latest global newsletter here.

New Fogarty-IeDEA Mentorship Program (FIMP) trainees

IeDEA has selected 13 new FIMP trainees from 13 countries to join our regional programs in January 2024. 

AIDS 2024

July 22-26, 2024 in Munich, Germany

Tweets by @iedeaglobal

Tweets by iedeaglobal

Recent publications

2775998 369YB7BV 1 padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe 3 desc 10 https://www.iedea.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-a13771dcad3923d955fea3b1607ce7e6%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22EUYZJYMH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tsondai%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3E%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3ETsondai%2C%20Priscilla%20R.%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EDavies%2C%20Mary-Ann%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3ESingtoroj%2C%20Thida%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EMaxwell%2C%20Nicola%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3ETechnau%2C%20Karl-G%26%23xFC%3Bnter%3C%5C%2Fspan%3E%20et%20al.%3C%5C%2Fspan%3E%20%282024%29.%20Creating%20a%20data%20collection%20and%20management%20platform%20to%20support%20measurement%20of%20adolescent%20HIV%20care%20transition%20processes%20within%20low-%20and%20middle-income%20countries%3A%20The%20GRADUATE%20project.%20%3Ci%3EPLOS%20Global%20Public%20Health%3C%5C%2Fi%3E%2C%20%3Ci%3E4%3C%5C%2Fi%3E%20%288%29%2C%20S.%20e0002705.%20%3Ca%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002705%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002705%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Creating%20a%20data%20collection%20and%20management%20platform%20to%20support%20measurement%20of%20adolescent%20HIV%20care%20transition%20processes%20within%20low-%20and%20middle-income%20countries%3A%20The%20GRADUATE%20project%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Priscilla%20R.%22%2C%22lastName%22%3A%22Tsondai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thida%22%2C%22lastName%22%3A%22Singtoroj%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Maxwell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kulkanya%22%2C%22lastName%22%3A%22Chokephaibulkit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pagakrong%22%2C%22lastName%22%3A%22Lumbiganon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%20H.%22%2C%22lastName%22%3A%22Sohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Global%20fRAmework%20of%20Data%20collection%20Used%20for%20Adolescent%20HIV%20Transition%20Evaluation%20%28GRADUATE%29%20Advisory%20Group%22%7D%5D%2C%22abstractNote%22%3A%22Few%20national%20programs%20and%20research%20cohorts%20within%20low-%20and%20middle-income%20countries%20%28LMICs%29%20document%20transition-related%20processes%20and%20outcomes%20for%20adolescents%20and%20young%20adults%20living%20with%20HIV%20%28AYLH%29%20transitioning%20to%20adulthood.%20Between%202017-2020%2C%20The%20Global%20fRAmework%20of%20Data%20collection%20Used%20for%20Adolescent%20HIV%20Transition%20Evaluation%20%28GRADUATE%29%20project%20convened%20a%20collaborative%20advisory%20group%20to%20identify%20key%20variables%20and%20definitions%20capturing%20the%20process%2C%20predictors%2C%20and%20outcomes%20across%20the%20transition%20period.%20In%20total%2C%20114%20variables%20identified%20as%20essential%20to%20measuring%20AYLH%20transition-related%20data%20were%20identified%20and%20formatted%20into%20a%20GRADUATE%20Data%20Exchange%20Standard%20%28DES%29%2C%20which%20was%20added%20to%20and%20harmonized%20with%20the%20existing%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20DES.%20In%202019%2C%20the%20GRADUATE%20DES%20was%20pilot%20tested%20at%20four%20IeDEA%20facilities%20in%20Malawi%2C%20South%20Africa%2C%20and%20Thailand%20through%20a%20cross-sectional%20study.%20Upon%20comparing%20the%20variables%20to%20routine%20medical%20records%2C%20available%20data%20were%20too%20limited%20to%20adequately%20capture%20transition-related%20processes%20and%20outcomes.%20However%2C%20additional%20data%20collection%20using%20GRADUATE%20tools%20was%20feasible%20and%20improved%20completeness.%20Of%20the%20100%20%2852%25%20female%29%20AYLH%20included%20in%20the%20pilot%20study%2C%2071%25%20had%20transitioned%5C%2Ftransferred%20to%20adult%20care%2C%20with%2042%25%20transitioning%20from%20an%20adolescent-specific%20model%20of%20care%20within%20an%20integrated%20family%20clinic%20to%20having%20their%20clinic%20visits%20scheduled%20on%20a%20different%20day%20of%20the%20week%20while%2058%25%20transferred%20from%20a%20pediatric%20facility%20to%20one%20offering%20adult%20HIV%20care.%20While%20almost%20all%20%2894%25%29%20had%20a%20transition-related%20discussion%20with%20their%20healthcare%20providers%20prior%20to%20the%20transition%2C%20we%20found%20that%2069%25%20%2895%25%20CI%2049-85%25%29%20were%20somewhat%20or%20very%20satisfied%5C%2Fcomfortable%20with%20the%20post-transfer%20clinic%20and%20the%20staff.%20Utilization%20of%20the%20GRADUATE%20DES%20better%20characterized%20AYLH%20transitioning%20to%20adulthood%20across%20LMICs%2C%20and%20optimally%20measured%20transition%20preparation%20activities%20and%20outcomes.%20Utilization%20of%20the%20GRADUATE%20DES%20in%20other%20settings%20could%20facilitate%20comparisons%20and%20identify%20gaps%20in%20the%20care%20of%20transitioning%20adolescents%20that%20need%20to%20be%20addressed.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0002705%22%2C%22ISSN%22%3A%222767-3375%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22369YB7BV%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%5D%2C%22dateModified%22%3A%222024-09-02T06%3A45%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22ZEPBWGGW%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rupasinghe%20et%20al.%22%2C%22parsedDate%22%3A%222024-08-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3E%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3ERupasinghe%2C%20Dhanushi%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EChoi%2C%20Jun%20Yong%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EKumarasamy%2C%20Nagalingeswaran%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EPujari%2C%20Sanjay%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EKhol%2C%20Vohith%3C%5C%2Fspan%3E%20et%20al.%3C%5C%2Fspan%3E%20%282024%29.%20Post-Diagnosis%20HCV%20RNA%20Testing%20Rates%20Prior%20to%20HCV%20Treatment%20Among%20People%20Living%20With%20HIV%20With%20HCV%20Antibody%20Positivity%20in%20the%20Asia-Pacific%20Region.%20%3Ci%3EJournal%20of%20Viral%20Hepatitis%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjvh.13993%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjvh.13993%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Post-Diagnosis%20HCV%20RNA%20Testing%20Rates%20Prior%20to%20HCV%20Treatment%20Among%20People%20Living%20With%20HIV%20With%20HCV%20Antibody%20Positivity%20in%20the%20Asia-Pacific%20Region%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dhanushi%22%2C%22lastName%22%3A%22Rupasinghe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%20Yong%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nagalingeswaran%22%2C%22lastName%22%3A%22Kumarasamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjay%22%2C%22lastName%22%3A%22Pujari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vohith%22%2C%22lastName%22%3A%22Khol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%20Ketut%20Agus%22%2C%22lastName%22%3A%22Somia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Man%20Po%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thach%20Ngoc%22%2C%22lastName%22%3A%22Pham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sasisopin%22%2C%22lastName%22%3A%22Kiertiburanakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cuong%20Duy%22%2C%22lastName%22%3A%22Do%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anchalee%22%2C%22lastName%22%3A%22Avihingsanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Awachana%22%2C%22lastName%22%3A%22Jiamsakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22on%20behalf%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Asia%5Cu2010Pacific%22%7D%5D%2C%22abstractNote%22%3A%22HCV%20RNA%20test%20determines%20current%20active%20infection%20and%20is%20a%20requirement%20prior%20to%20initiating%20HCV%20treatment.%20We%20investigated%20trends%20and%20factors%20associated%20with%20post-diagnosis%20HCV%20RNA%20testing%20rates%20prior%20to%20HCV%20treatment%2C%20and%20risk%20factors%20for%20first%20positive%20HCV%20RNA%20among%20people%20living%20with%20HIV%20%28PLHIV%29%20with%20HCV%20in%20the%20Asia-Pacific%20region.%20PLHIV%20with%20positive%20HCV%20antibody%20and%20in%20follow-up%20after%202010%20were%20included.%20Patients%20were%20considered%20HCV-antibody%20positive%20if%20they%20ever%20tested%20positive%20for%20HCV%20antibody%20%28HCVAb%29.%20Repeated%20measures%20Poisson%20regression%20model%20was%20used%20to%20analyse%20factors%20associated%20with%20post-diagnosis%20HCV%20RNA%20testing%20rates%20from%20positive%20HCVAb%20test.%20Factors%20associated%20with%20time%20to%20first%20positive%20HCV%20RNA%20from%20positive%20HCVAb%20test%20were%20analysed%20using%20Cox%20regression%20model.%20There%20were%20767%20HCVAb%20positive%20participants%20included%20%2887%25%20from%20LMICs%29%20of%20whom%2011%25%20had%20HCV%20RNA%20tests.%20With%20163%20HCV%20RNA%20tests%20post%20positive%20HCVAb%20test%2C%20the%20overall%20testing%20rate%20was%205.05%20per%20100%20person-years.%20Factors%20associated%20with%20increased%20testing%20rates%20included%20later%20calendar%20years%20of%20follow-up%2C%20HIV%20viral%20load%20%5Cu22651000%5Cu2009copies%5C%2FmL%20and%20higher%20income%20countries.%20Later%20calendar%20years%20of%20follow-up%2C%20ALT%20%3E5%20times%20its%20upper%20limit%20of%20normal%2C%20and%20higher%20income%20countries%20were%20associated%20with%20shorter%20time%20to%20first%20positive%20HCV%20RNA%20test.%20Testing%20patterns%20indicated%20that%20uptake%20was%20predominantly%20in%20high%20income%20countries%20possibly%20due%20to%20different%20strategies%20used%20to%20determine%20testing%20in%20LMICs.%20Expanding%20access%20to%20HCV%20RNA%2C%20such%20as%20through%20lower-cost%20point%20of%20care%20assays%2C%20will%20be%20required%20to%20achieve%20elimination%20of%20HCV%20as%20a%20public%20health%20issue.%22%2C%22date%22%3A%222024-08-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fjvh.13993%22%2C%22ISSN%22%3A%221365-2893%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22369YB7BV%22%2C%228IRGNQWZ%22%5D%2C%22dateModified%22%3A%222024-09-02T06%3A42%3A43Z%22%7D%7D%2C%7B%22key%22%3A%22XY975M2U%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Egger%20et%20al.%22%2C%22parsedDate%22%3A%222024-08-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3E%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EEgger%2C%20Matthias%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3ESauermann%2C%20Mamatha%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3ELoosli%2C%20Tom%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3EHossmann%2C%20Stefanie%3C%5C%2Fspan%3E%3B%20%3Cspan%20style%3D%5C%22text-decoration%3Anone%3B%5C%22%3ERiedo%2C%20Selma%3C%5C%2Fspan%3E%20et%20al.%3C%5C%2Fspan%3E%20%282024%29.%20HIV-1%20subtype-specific%20drug%20resistance%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20protocol%20for%20a%20multicentre%20study%20%28DTG%20RESIST%29.%20%3Ci%3EBMJ%20Open%3C%5C%2Fi%3E%2C%20%3Ci%3E14%3C%5C%2Fi%3E%20%288%29%2C%20S.%20e085819.%20%3Ca%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-085819%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-085819%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV-1%20subtype-specific%20drug%20resistance%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20protocol%20for%20a%20multicentre%20study%20%28DTG%20RESIST%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamatha%22%2C%22lastName%22%3A%22Sauermann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Loosli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Selma%22%2C%22lastName%22%3A%22Riedo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niko%22%2C%22lastName%22%3A%22Beerenwinkel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Giandhari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20D.%22%2C%22lastName%22%3A%22Kouyos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Lessells%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20HIV%20drug%20resistance%20poses%20a%20challenge%20to%20the%20United%20Nation%27s%20goal%20of%20ending%20the%20HIV%5C%2FAIDS%20epidemic.%20The%20integrase%20strand%20transfer%20inhibitor%20%28InSTI%29%20dolutegravir%2C%20which%20has%20a%20higher%20resistance%20barrier%2C%20was%20endorsed%20by%20the%20WHO%20in%202019%20for%20first-line%2C%20second-line%20and%20third-line%20antiretroviral%20therapy%20%28ART%29.%20This%20multiplicity%20of%20roles%20of%20dolutegravir%20in%20ART%20may%20facilitate%20the%20emergence%20of%20dolutegravir%20resistance.%5CnMETHODS%20AND%20ANALYSIS%3A%20Nested%20within%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%2C%20DTG%20RESIST%20is%20a%20multicentre%20study%20of%20adults%20and%20adolescents%20living%20with%20HIV%20in%20sub-Saharan%20Africa%2C%20Asia%2C%20and%20South%20and%20Central%20America%20who%20experienced%20virological%20failure%20on%20dolutegravir-based%20ART.%20At%20the%20time%20of%20virological%20failure%2C%20whole%20blood%20will%20be%20collected%20and%20processed%20to%20prepare%20plasma%20or%20dried%20blood%20spots.%20Laboratories%20in%20Durban%2C%20Mexico%20City%20and%20Bangkok%20will%20perform%20genotyping.%20Analyses%20will%20focus%20on%20%281%29%20individuals%20who%20experienced%20virological%20failure%20on%20dolutegravir%20and%20%282%29%20those%20who%20started%20or%20switched%20to%20such%20a%20regimen%20and%20were%20at%20risk%20of%20virological%20failure.%20For%20population%20%281%29%2C%20the%20outcome%20will%20be%20any%20InSTI%20drug%20resistance%20mutations%2C%20and%20for%20population%20%282%29%20virological%20failure%20is%20defined%20as%20a%20viral%20load%20%3E1000%20copies%5C%2FmL.%20Phenotypic%20testing%20will%20focus%20on%20non-B%20subtype%20viruses%20with%20major%20InSTI%20resistance%20mutations.%20Bayesian%20evolutionary%20models%20will%20explore%20and%20predict%20treatment%20failure%20genotypes.%20The%20study%20will%20have%20intermediate%20statistical%20power%20to%20detect%20differences%20in%20resistance%20mutation%20prevalence%20between%20major%20HIV-1%20subtypes%3B%20ample%20power%20to%20identify%20risk%20factors%20for%20virological%20failure%20and%20limited%20power%20for%20analysing%20factors%20associated%20with%20individual%20InSTI%20drug%20resistance%20mutations.%5CnETHICS%20AND%20DISSEMINATION%3A%20The%20research%20protocol%20was%20approved%20by%20the%20Biomedical%20Research%20Ethics%20Committee%20at%20the%20University%20of%20KwaZulu-Natal%2C%20South%20Africa%20and%20the%20Ethics%20Committee%20of%20the%20Canton%20of%20Bern%2C%20Switzerland.%20All%20sites%20participate%20in%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20and%20have%20obtained%20ethics%20approval%20from%20their%20local%20ethics%20committee%20to%20collect%20additional%20data.%5CnTRIAL%20REGISTRATION%20NUMBER%3A%20NCT06285110.%22%2C%22date%22%3A%222024-08-21%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2024-085819%22%2C%22ISSN%22%3A%222044-6055%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22369YB7BV%22%2C%22NMNPNZRP%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222024-09-02T06%3A39%3A18Z%22%7D%7D%5D%7D
Tsondai, Priscilla R.; Davies, Mary-Ann; Singtoroj, Thida; Maxwell, Nicola; Technau, Karl-Günter et al. (2024). Creating a data collection and management platform to support measurement of adolescent HIV care transition processes within low- and middle-income countries: The GRADUATE project. PLOS Global Public Health, 4 (8), S. e0002705. http://doi.org/10.1371/journal.pgph.0002705.
Rupasinghe, Dhanushi; Choi, Jun Yong; Kumarasamy, Nagalingeswaran; Pujari, Sanjay; Khol, Vohith et al. (2024). Post-Diagnosis HCV RNA Testing Rates Prior to HCV Treatment Among People Living With HIV With HCV Antibody Positivity in the Asia-Pacific Region. Journal of Viral Hepatitis. http://doi.org/10.1111/jvh.13993.
Egger, Matthias; Sauermann, Mamatha; Loosli, Tom; Hossmann, Stefanie; Riedo, Selma et al. (2024). HIV-1 subtype-specific drug resistance on dolutegravir-based antiretroviral therapy: protocol for a multicentre study (DTG RESIST). BMJ Open, 14 (8), S. e085819. http://doi.org/10.1136/bmjopen-2024-085819.
  • Home
    • Who We Are
  • Regions
    • Asia-Pacific
    • CCASAnet
    • Central Africa
    • East Africa
    • NA-ACCORD
    • Southern Africa
    • West Africa
  • Working Groups
    • Executive Committee
    • Adolescent and Young Adult Network of IeDEA (AYANI)
    • Cancer
    • Data Harmonization
    • Fogarty-IeDEA Mentorship Program (FIMP)
    • Hepatitis
    • Mental Health
    • Mother and Infant
    • Pediatrics
    • Sentinel Research Network (SRN)
    • Site Assessment
    • Strategic Data
    • Substance Use
    • Tuberculosis and Lung Health
  • Publications
    • Asia-Pacific
    • CCASAnet
    • Central Africa
    • East Africa
    • NA-ACCORD
    • Southern Africa
    • West Africa
    • Multi-regional
    • All publications
  • Resources
    • Fogarty-IeDEA Mentorship Program (FIMP)
    • Multiregional research SOPs, templates
    • Funding Acknowledgements
    • Consortium accomplishments
    • Meeting reports and presentations
      • CROI 2022 – IeDEA presentations
  • News
IeDEA International epidemiology Databases to Evaluate AIDS Proudly powered by WordPress

This site was developed by the Institute of Social and Preventive Medicine (ISPM) at the University of Bern for NIAID, under cooperative agreement number U01AI069924. The opinions expressed herein are those of the authors and do not necessarily reflect the views of the NIAID or the U.S. Government.
Sponsored by: NIAID, NCI, NICHD, NIMH, NHLBI, NIDDK, NLM, NIAAA, FIC and NIDA.

We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.Ok