Link to all Southern Africa Publications in PubMed
2775998
TCMBXKKM
2025
1
padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe
50
date
desc
year
254
https://www.iedea.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22KHYDH9MU%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMureithi%2C%20Fiona%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEvans%2C%20Denise%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHuwa%2C%20Jacqueline%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Mental%2C%20physical%2C%20and%20respiratory%20health%20in%20people%20with%20tuberculosis%20in%20Southern%20Africa%3A%20a%20multi-country%20cohort%20analysis.%20%26lt%3Bi%26gt%3BBMC%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B23%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20485.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12916-025-04321-6%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12916-025-04321-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mental%2C%20physical%2C%20and%20respiratory%20health%20in%20people%20with%20tuberculosis%20in%20Southern%20Africa%3A%20a%20multi-country%20cohort%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fiona%22%2C%22lastName%22%3A%22Mureithi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denise%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelly%22%2C%22lastName%22%3A%22Jinga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amina%22%2C%22lastName%22%3A%22Fernando%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agness%22%2C%22lastName%22%3A%22Thawani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%20C.%22%2C%22lastName%22%3A%22Sweetland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Southern%20Africa%20%28IeDEA-SA%29%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Tuberculosis%20%28TB%29%20affects%20people%26%23039%3Bs%20quality%20of%20life%20%28QoL%29.%20We%20prospectively%20monitored%20physical%20and%20mental%20health-related%20QoL%20over%20time%20in%20people%20with%20TB%20in%20the%20Southern%20African%20region%20with%20a%20high%20HIV%20and%20TB%20burden.%5CnMETHODS%3A%20Adults%20aged%5Cu2009%5Cu2265%5Cu200915%20years%20with%20pulmonary%20TB%20were%20enrolled%20in%20five%20cohorts%20in%20Malawi%2C%20Mozambique%2C%20South%20Africa%2C%20Zambia%2C%20and%20Zimbabwe%20from%20October%202022%20to%20September%202024.%20We%20assessed%20six%20QoL%20outcomes%20using%20validated%20instruments%20at%20the%20start%20%28baseline%29%2C%20end%20of%20treatment%2C%20and%206%20months%20post-treatment%3A%20symptoms%20of%20depression%20%28PHQ-9%29%2C%20mental%20and%20physical%20health%20%28SF-12%20mental%2C%20SF12-MC%2C%20SF-12%20physical%20component%2C%20SF12-PC%29%2C%20physical%20fitness%20%286-Minute%20Walk%20Test%2C%206MWT%3B%201-min%20Sit-To-Stand%20Test%2C%20STST%29%2C%20and%20respiratory%20health%20%28Saint-George-Respiratory-Questionnaire%2C%20SGRQ%29.%20Missing%20QoL%20scores%20were%20imputed%20with%20multivariate%20imputation%20by%20chained%20equations.%20We%20compared%20the%20proportion%20of%20participants%20with%20impaired%20QoL%2C%20defining%20impairment%20based%20on%20outcome-specific%20cut-off%20values.%20We%20also%20estimated%20changes%20in%20QoL%20scores%20and%20examined%20their%20associations%20with%20baseline%20characteristics%20using%20Bayesian%20multivariable%20regression%20models.%5CnRESULTS%3A%20We%20included%201438%20participants%20with%20a%20median%20follow-up%20of%20344%20days%20%28interquartile%20range%20%5BIQR%5D%20183-373%29.%20The%20median%20age%20was%2039%20years%20%28IQR%2030-50%29%3B%2067%25%20were%20male%2C%20and%2039%25%20living%20with%20HIV.%20At%20baseline%2C%2049%25%20had%20symptoms%20of%20depression%2C%2073%25%20had%20impaired%20mental%20health%20and%2092%25%20impaired%20physical%20health-related%20QoL%2C%2068-74%25%20had%20reduced%20physical%20fitness%20%2868%25%3A%206MWT%2C%2074%25%3A%20STST%29%2C%20and%2078%25%20impaired%20respiratory%20health.%20All%20QoL%20outcomes%20improved%20by%20the%20end%20of%20treatment%2C%20notably%20depressive%20symptoms%20%2848%25%20to%205%25%29%2C%20mental%20health-related%20QoL%20%2873%25%20to%2028%25%29%2C%20and%20respiratory%20health%20%2878%25%20to%2011%25%29.%20Most%20QoL%20impairments%20continued%20to%20decrease%20post-treatment%2C%20especially%20physical%20and%20respiratory%20health%3B%20depressive%20symptoms%20remained%20below%205%25.%20Across%20QoL%20domains%20and%20study%20visits%2C%20better%20outcomes%20were%20associated%20with%20age%5Cu2009%26lt%3B%5Cu200930%20%2883%25%20probability%29%2C%20and%20worse%20outcomes%20with%20female%20gender%20%2886%25%29%20and%20a%20prior%20TB%20history%20%2889%25%29.%20Living%20with%20HIV%20and%20alcohol%20drinking%20were%20associated%20with%20worse%20QoL%20only%20at%20baseline%20%2888%25%20and%2087%25%29.%5CnCONCLUSIONS%3A%20TB%20negatively%20impacts%20QoL%20across%20physical%2C%20mental%2C%20and%20social%20domains%2C%20including%20post-treatment.%20The%20study%20highlights%20the%20need%20for%20integrated%20mental%20and%20physical%20healthcare%20and%20rehabilitation%20during%20TB%20treatment%20and%20beyond%2C%20especially%20for%20high-risk%20populations%2C%20to%20address%20the%20long-term%20impact%20of%20TB%20on%20QoL.%22%2C%22date%22%3A%222025-08-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12916-025-04321-6%22%2C%22ISSN%22%3A%221741-7015%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-01T11%3A39%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22WFQNLBC3%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Benade%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBenade%2C%20Mariet%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaskew%2C%20Mhairi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChilembo%2C%20Phillip%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWa%20Mwansa%2C%20Mwansa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSavory%2C%20Theodora%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Patterns%20of%20engagement%20in%20care%20during%20clients%26%23x2019%3B%20first%2012%20months%20after%20HIV%20treatment%20initiation%20in%20Zambia%3A%20a%20retrospective%20cohort%20analysis%20using%20routinely%20collected%20data.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e017930.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017930%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017930%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patterns%20of%20engagement%20in%20care%20during%20clients%27%20first%2012%20months%20after%20HIV%20treatment%20initiation%20in%20Zambia%3A%20a%20retrospective%20cohort%20analysis%20using%20routinely%20collected%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariet%22%2C%22lastName%22%3A%22Benade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mhairi%22%2C%22lastName%22%3A%22Maskew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Phillip%22%2C%22lastName%22%3A%22Chilembo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mwansa%22%2C%22lastName%22%3A%22Wa%20Mwansa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodora%22%2C%22lastName%22%3A%22Savory%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brooke%22%2C%22lastName%22%3A%22Nichols%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lloyd%20B.%22%2C%22lastName%22%3A%22Mulenga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suilanji%22%2C%22lastName%22%3A%22Sivile%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khozya%20Davie%22%2C%22lastName%22%3A%22Zyambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sydney%22%2C%22lastName%22%3A%22Rosen%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20first%20year%20after%20HIV%20treatment%20initiation%20or%20re-initiation%20is%20the%20period%20of%20highest%20risk%20of%20a%20treatment%20interruption%20or%20disengagement%2C%20yet%20little%20is%20known%20about%20the%20timing%2C%20patterns%20and%20effects%20of%20interruptions%20in%20the%20early%20treatment%20period.%5CnMETHODS%3A%20Using%20routinely%20collected%20electronic%20medical%20record%20data%20from%20543%20Zambian%20facilities%20from%202018%20to%202023%2C%20we%20described%20patterns%20of%20engagement%20during%20the%20first%20year%20of%20HIV%20treatment.%20We%20defined%20engagement%20patterns%20for%20months%200-6%20and%20months%207-12%20after%20initiation%20or%20reinitiation%20as%20%281%29%20continuous%20%28attended%20all%20scheduled%20clinic%20and%20medication%20pickup%20visits%20as%20planned%3B%20%282%29%20cyclical%20%28attended%20%5Cu22651%20visits%20late%20%26gt%3B28%5Cu2009days%20but%20returned%20to%20and%20remained%20in%20care%29%20or%20%283%29%20disengaged%20%28missed%20a%20scheduled%20visit%20by%20%26gt%3B28%5Cu2009days%20and%20had%20no%20evidence%20of%20return%29.%5CnRESULTS%3A%20Our%20sample%20population%20comprised%20159%5Cu2009429%20adult%20participants%20%2861%25%20female%2C%20median%20age%2033%29.%20Of%20the%20513%5Cu2009322%20interactions%20observed%20%5Cu226412%20months%20after%20initiation%2C%2053%25%20occurred%20as%20planned%2C%2022%25%20were%20late%20%5Cu226428%20days%20late%2C%209%25%20were%20%26gt%3B28%5Cu2009days%20late%2C%20and%2017%25%20were%20scheduled%20but%20never%20attended.%20In%200-6%20months%20after%20initiation%2C%2051%25%20clients%20were%20continuously%20engaged%2C%2012%25%20cyclically%20engaged%20and%2033%25%20disengaged.%20Two-thirds%20of%20disengagers%20%2821%25%20of%20cohort%29%20did%20not%20return%20after%20the%20initiation%20visit.%20During%20months%207-12%2C%20most%20clients%20who%20had%20been%20continuously%20engaged%20in%20months%200-6%20%2854%25%29%20remained%20continuous%2C%20while%2018%25%20moved%20to%20cyclical%20engagement.%20Among%20cyclical%20engagers%20in%20months%200-6%2C%20nearly%20half%20%2847%25%29%20moved%20to%20being%20continuously%20engaged%20by%20month%2012.%20Only%2034%25%20of%20the%20study%20population%20remained%20engaged%20continuously%20by%20the%20end%20of%20the%2012-month%20period.%5CnCONCLUSIONS%3A%20Fewer%20than%2060%25%20of%20clients%20initiating%20antiretroviral%20therapy%20care%20between%202018%20and%202022%20at%20Zambian%20facilities%20remained%20continuously%20engaged%20at%20month%206%20and%2034%25%20at%20month%2012.%20Cyclical%20engagement%20and%20frequent%20interruptions%20should%20be%20accepted%20as%20the%20norm%20and%20models%20of%20service%20delivery%20designed%20to%20accommodate%20them.%22%2C%22date%22%3A%222025-08-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2024-017930%22%2C%22ISSN%22%3A%222059-7908%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-01T07%3A54%3A31Z%22%7D%7D%2C%7B%22key%22%3A%225Q9NZZF9%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222025-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJoska%2C%20John%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLang%2C%20Raynell%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZheng%2C%20Chunyan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Life-years%20lost%20associated%20with%20mental%20disorders%20in%20people%20with%20HIV%3A%20a%20cohort%20study%20in%20South%20Africa%2C%20Canada%20and%20the%20United%20States.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e70023.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.70023%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.70023%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Life-years%20lost%20associated%20with%20mental%20disorders%20in%20people%20with%20HIV%3A%20a%20cohort%20study%20in%20South%20Africa%2C%20Canada%20and%20the%20United%20States%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raynell%22%2C%22lastName%22%3A%22Lang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunyan%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20D.%22%2C%22lastName%22%3A%22Kirk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Silverberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonia%22%2C%22lastName%22%3A%22Napravnik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelly%22%2C%22lastName%22%3A%22Gebo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20J.%20Eron%22%2C%22lastName%22%3A%22Jr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brenna%20C.%22%2C%22lastName%22%3A%22Hogan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Grelotti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mona%22%2C%22lastName%22%3A%22Loutfy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20F.%22%2C%22lastName%22%3A%22Rebeiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20People%20with%20HIV%20%28PWH%29%20have%20a%20high%20burden%20of%20mental%20health%20disorders%2C%20which%20contribute%20to%20increased%20mortality%20due%20to%20elevated%20rates%20of%20physical%20illness%2C%20suicide%20or%20fatal%20accidents.%20Additionally%2C%20mental%20health%20disorders%20can%20adversely%20affect%20antiretroviral%20therapy%20%28ART%29%20adherence%2C%20leading%20to%20increased%20HIV-related%20mortality.%20This%20study%20aims%20to%20quantify%20the%20difference%20in%20mortality%20between%20PWH%20who%20have%20a%20mental%20health%20disorder%20and%20PWH%20without%20mental%20health%20disorders%20in%20South%20Africa%20%28SA%29%20and%20North%20America%20%28NA%29.%5CnMETHODS%3A%20This%20cohort%20study%20includes%20PWH%20aged%2018%20years%20or%20older%20who%20initiated%20ART%20between%202000%20and%202021%20at%20a%20national%20private-sector%20HIV%20programme%20in%20SA%20and%2013%20programmes%20in%20the%20United%20States%20and%20Canada.%20Mental%20health%20disorders%20were%20diagnosed%20according%20to%20ICD-10%20codes%20F10-F99%2C%20which%20include%20psychotic%20disorders%2C%20bipolar%20disorders%2C%20depression%2C%20anxiety%20and%20substance%20use%20disorders.%20We%20estimated%20life-years%20lost%20%28LYL%29%20associated%20with%20mental%20health%20disorders%2C%20quantifying%20the%20average%20difference%20in%20remaining%20life%20expectancy%20between%20individuals%20diagnosed%20with%20a%20mental%20health%20disorder%20and%20those%20without%20such%20diagnoses.%5CnRESULTS%3A%20The%20study%20included%20119%2C785%20participants%20from%20SA%20%2857.4%25%20female%2C%20median%20age%2039%20years%29%20and%20142%2C044%20from%20NA%20%2885.0%25%20male%2C%20median%20age%2043%20years%29.%20In%20SA%2C%2057%2C999%20%2848.4%25%29%20were%20diagnosed%20with%20a%20mental%20health%20disorder%2C%20compared%20with%2093%2C518%20%2865.8%25%29%20in%20NA.%20In%20SA%2C%20the%20LYL%20associated%20with%20any%20mental%20health%20disorder%20were%203.42%20years%20%2895%25%20CI%202.42-4.28%29%20in%20males%20and%202.95%20years%20%280.67-5.95%29%20in%20females.%20Corresponding%20figures%20for%20NA%20were%204.16%20years%20%283.71-4.59%29%20in%20males%20and%204.64%20years%20%282.93-6.05%29%20in%20females.%20In%20both%20regions%2C%20LYL%20were%20higher%20for%20psychotic%20and%20substance%20use%20disorders%20than%20for%20depression%20and%20anxiety.%20Losses%20were%20primarily%20due%20to%20natural%20deaths%20at%20CD4%20counts%20%5Cu2265200%20cells%5C%2F%5Cu00b5l%2C%20with%20considerable%20contributions%20at%20CD4%20counts%20%26lt%3B200%20cells%5C%2F%5Cu00b5l.%20Unnatural%20causes%20also%20contributed%20to%20the%20loss%20of%20life-years%20in%20males%20from%20SA%20and%20males%20and%20females%20from%20NA.%5CnCONCLUSIONS%3A%20PWH%20affected%20by%20mental%20health%20disorders%20experience%20higher%20mortality%2C%20primarily%20from%20natural%20causes.%20LYL%20were%20associated%20with%20both%20immunosuppression%20and%20higher%20CD4%20levels.%20Improved%20management%20of%20HIV%20and%20physical%20comorbidities%20among%20PWH%20affected%20by%20mental%20health%20disorders%20may%20enhance%20their%20prognosis.%22%2C%22date%22%3A%222025-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.70023%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22369YB7BV%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%5D%2C%22dateModified%22%3A%222025-09-01T11%3A41%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22DFDZ7RMR%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gastaldon%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-29%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGastaldon%2C%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWhitesell%20Skrivankova%2C%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchoretsanitis%2C%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Diagnosis%20of%20postpartum%20depression%20and%20associated%20factors%20in%20South%20Africa%3A%20a%20cohort%20study%20of%2047%2C697%20women.%20%26lt%3Bi%26gt%3BEpidemiology%20and%20Psychiatric%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B34%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20e41.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS2045796025100103%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS2045796025100103%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Diagnosis%20of%20postpartum%20depression%20and%20associated%20factors%20in%20South%20Africa%3A%20a%20cohort%20study%20of%2047%2C697%20women%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Gastaldon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Whitesell%20Skrivankova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Schoretsanitis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Salanti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Mesa%20Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22AIMS%3A%20About%20one-third%20of%20South%20African%20women%20have%20clinically%20significant%20symptoms%20of%20postpartum%20depression%20%28PPD%29.%20Several%20socio-demographic%20risk%20factors%20for%20PPD%20exist%2C%20but%20data%20on%20medical%20and%20obstetric%20risk%20factors%20remain%20scarce%20for%20low-%20and%20middle-income%20countries%20and%20particularly%20in%20sub-Saharan%20Africa.%20We%20aimed%20to%20estimate%20the%20proportion%20of%20women%20with%20PPD%20and%20investigate%20socio-demographic%2C%20medical%20and%20obstetric%20risk%20factors%20for%20PPD%20among%20women%20receiving%20private%20medical%20care%20in%20South%20Africa%20%28SA%29.%5CnMETHODS%3A%20In%20this%20longitudinal%20cohort%20study%2C%20we%20analysed%20reimbursement%20claims%20from%20beneficiaries%20of%20an%20SA%20medical%20insurance%20scheme%20who%20delivered%20a%20child%20between%202011%20and%202020.%20PPD%20was%20defined%20as%20a%20new%20International%20Classification%20of%20Diseases%2C%2010th%20Revision%20diagnosis%20of%20depression%20within%20365%5Cu00a0days%20postpartum.%20We%20estimated%20the%20frequency%20of%20women%20with%20a%20diagnosis%20of%20PPD.%20We%20explored%20several%20medical%20and%20obstetric%20risk%20factors%20for%20PPD%2C%20including%20pre-existing%20conditions%2C%20such%20as%20HIV%20and%20polycystic%20ovary%20syndrome%2C%20and%20conditions%20diagnosed%20during%20pregnancy%20and%20labour%2C%20such%20as%20gestational%20diabetes%2C%20pre-term%20delivery%20and%20postpartum%20haemorrhage.%20Using%20a%20multivariable%20modified%20Poisson%20model%2C%20we%20estimated%20adjusted%20risk%20ratios%20%28aRRs%29%20and%2095%25%20confidence%20intervals%20%28CIs%29%20for%20factors%20associated%20with%20PPD.%5CnRESULTS%3A%20Of%20the%2047%2C697%20participants%2C%202%2C380%20%285.0%25%29%20were%20diagnosed%20with%20PPD.%20The%20cumulative%20incidence%20of%20PPD%20increased%20from%200.8%25%20%2895%25%20CI%200.7-0.9%29%20at%206%20weeks%20to%205.5%25%20%285.3-5.7%29%20at%2012%5Cu00a0months%20postpartum.%20PPD%20risk%20was%20higher%20in%20individuals%20with%20history%20of%20depression%20%28aRR%203.47%2C%2095%25%20CI%20%5B3.14-3.85%5D%29%2C%20preterm%20delivery%20%281.47%20%5B1.30-1.66%5D%29%2C%20PCOS%20%281.37%20%5B1.09-1.72%5D%29%2C%20hyperemesis%20gravidarum%20%281.32%20%5B1.11-1.57%5D%29%2C%20gestational%20hypertension%20%281.30%20%5B1.03-1.66%5D%29%20and%20postpartum%20haemorrhage%20%281.29%20%5B0.91-1.85%5D%29.%20Endometriosis%2C%20HIV%2C%20gestational%20diabetes%2C%20foetal%20stress%2C%20perineal%20laceration%2C%20elective%20or%20emergency%20C-section%20and%20preeclampsia%20were%20not%20associated%20with%20a%20higher%20risk%20of%20PPD.%5CnCONCLUSIONS%3A%20The%20PPD%20diagnosis%20rate%20was%20lower%20than%20anticipated%2C%20based%20on%20the%20PPD%20prevalence%20of%20previous%20studies%2C%20indicating%20a%20potential%20diagnostic%20gap%20in%20SA%26%23039%3Bs%20private%20sector.%20Identified%20risk%20factors%20could%20inform%20targeted%20PPD%20screening%20strategies.%22%2C%22date%22%3A%222025-07-29%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1017%5C%2FS2045796025100103%22%2C%22ISSN%22%3A%222045-7979%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-01T11%3A40%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22C2TMM3CP%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fern%5Cu00e1ndez%20Villalobos%20et%20al.%22%2C%22parsedDate%22%3A%222025-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFern%26%23xE1%3Bndez%20Villalobos%2C%20Nathalie%20Ver%26%23xF3%3Bnica%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHelfenstein%2C%20Fabrice%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKhol%2C%20Vohith%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTwizere%2C%20Christella%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSecco%2C%20Mayara%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Scale%20of%20differentiated%20service%20delivery%20implementation%20in%20HIV%20care%20facilities%20in%20low-%20and%20middle-income%20countries%3A%20a%20global%20facility%20survey.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%20Suppl%203%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20e26477.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26477%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26477%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Scale%20of%20differentiated%20service%20delivery%20implementation%20in%20HIV%20care%20facilities%20in%20low-%20and%20middle-income%20countries%3A%20a%20global%20facility%20survey%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20Ver%5Cu00f3nica%22%2C%22lastName%22%3A%22Fern%5Cu00e1ndez%20Villalobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Helfenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vohith%22%2C%22lastName%22%3A%22Khol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mayara%22%2C%22lastName%22%3A%22Secco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Castelnuovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Tiendredbeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20William%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Siew%20Moy%22%2C%22lastName%22%3A%22Fong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanink%22%2C%22lastName%22%3A%22Caro-Vega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%20Elias%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovinio%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Djimon%20Marcel%22%2C%22lastName%22%3A%22Zannou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathy%22%2C%22lastName%22%3A%22Petoumenos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambou%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%20Bolton%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ounoo%20Elom%22%2C%22lastName%22%3A%22Takassi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sasisopin%22%2C%22lastName%22%3A%22Kiertiburanakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogers%20Ajeh%22%2C%22lastName%22%3A%22Awoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shamim%20M.%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Malateste%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Zaniewski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20In%202016%2C%20the%20World%20Health%20Organization%20recommended%20differentiated%20service%20delivery%20%28DSD%29%20as%20a%20client-centred%20approach%20to%20simplify%20HIV%20care%20in%20frequency%20and%20intensity%2C%20thus%20reducing%20the%20clinic%20visit%20burden%20on%20individuals%20and%20HIV%20programmes.%20We%20describe%20the%20scale%20of%20DSD%20implementation%20among%20HIV%20facilities%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29%20in%20Latin%20America%2C%20Africa%20and%20the%20Asia-Pacific%20before%20the%20COVID-19%20pandemic.%5CnMETHODS%3A%20We%20analysed%20facility-level%20survey%20data%20from%20HIV%20care%20facilities%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20consortium%20in%202019.%20We%20used%20descriptive%20statistics%20to%20summarise%20the%20availability%20of%20DSD%2C%20multi-month%20dispensing%20%28MMD%29%20and%20DSD%20for%20HIV%20treatment%20models.%20We%20explored%20factors%20associated%20with%20DSD%20implementation%20using%20multivariable%20models.%5CnRESULTS%3A%20We%20included%20175%20facilities%20in%20the%20Asia-Pacific%20%28n%20%3D%2030%29%2C%20Latin%20America%20%28n%20%3D%208%29%2C%20Central%20Africa%20%28n%20%3D%2021%29%2C%20East%20Africa%20%28n%20%3D%2074%29%2C%20Southern%20Africa%20%28n%20%3D%2028%29%20and%20West%20Africa%20%28n%20%3D%2014%29.%20Overall%2C%20133%20facilities%20%2876%25%29%20reported%20implementing%20DSD.%20Of%20these%2C%2091%25%20offered%20DSD%20for%20HIV%20treatment%2C%2061%25%20for%20HIV%20testing%20and%2059%25%20for%20antiretroviral%20therapy%20%28ART%29%20initiation.%20The%20most%20common%20duration%20of%20ART%20refills%20for%20clinically%20stable%20clients%20was%203MMD%2C%20%2870%25%29%2C%20followed%20by%20monthly%20%2814%25%29%20and%206MMD%20%2810%25%29.%20Facility-based%20individual%20models%20were%20the%20most%20frequently%20available%20DSD%20for%20the%20HIV%20treatment%20model%20%2882%25%29%2C%20followed%20by%20client-managed%20group%20models%20%2860%25%29.%20Out-of-facility%20individual%20models%20were%20available%20at%2048%25%20of%20facilities.%20Facility-based%20individual%20models%20were%20particularly%20common%20among%20facilities%20in%20East%20%2892%25%29%20and%20Southern%20Africa%20%2896%25%29.%20Facilities%20in%20medium%20and%20high%20HIV%20prevalence%20countries%2C%20and%20those%20with%203MMD%2C%20were%20more%20likely%20to%20implement%20DSD.%5CnCONCLUSIONS%3A%20In%202019%2C%20DSD%20was%20available%20in%20most%20HIV%20care%20facilities%20globally%20but%20was%20not%20evenly%20implemented%20across%20regions%20and%20HIV%20services.%20Most%20offered%20facility-based%20DSD%20for%20HIV%20treatment%20models%20and%203MMD%20for%20clinically%20stable%20clients.%20Efforts%20to%20expand%20DSD%20for%20HIV%20testing%20and%20ART%20initiation%20and%20to%20offer%20longer%20MMD%20can%20improve%20long-term%20retention%20in%20care%20of%20people%20living%20with%20HIV%20in%20LMICs%2C%20while%20further%20alleviating%20the%20operational%20burden%20on%20healthcare%20services.%20These%20findings%20from%20the%20pre-COVID-19%20era%20underline%20the%20need%20for%20strengthening%20DSD%20in%20HIV%20care%2C%20which%20remains%20at%20the%20centre%20of%20current%20efforts%20towards%20client-centred%20care.%22%2C%22date%22%3A%222025-07%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26477%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-09-01T11%3A40%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22QC4E5AK2%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222025-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMiddelkoop%2C%20Keren%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchmutz%2C%20Remo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLeukes%2C%20Juane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZ%26%23xFC%3Brcher%2C%20Kathrin%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Infection%20prevention%20and%20control%20measures%20during%20the%20COVID-19%20pandemic%20and%20airborne%20tuberculosis%20transmission%20during%20primary%20care%20visits%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Infectious%20Diseases%3A%20IJID%3A%20Official%20Publication%20of%20the%20International%20Society%20for%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B156%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20107921.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2025.107921%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2025.107921%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infection%20prevention%20and%20control%20measures%20during%20the%20COVID-19%20pandemic%20and%20airborne%20tuberculosis%20transmission%20during%20primary%20care%20visits%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keren%22%2C%22lastName%22%3A%22Middelkoop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juane%22%2C%22lastName%22%3A%22Leukes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Z%5Cu00fcrcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Tuberculosis%20%28TB%29%20transmission%20in%20crowded%20health%20care%20settings%20poses%20considerable%20risks%20in%20high-burden%20regions.%20We%20assessed%20how%20COVID-19%20pandemic-related%20infection%20prevention%20and%20control%20%28IPC%29%20measures%20might%20impact%20TB%20transmission%20in%20a%20South%20African%20primary%20care%20clinic.%5CnMETHODS%3A%20In%202019%20%28prepandemic%29%20and%202021%20%28pandemic%29%2C%20we%20collected%20clinical%20data%2C%20patient%20tracking%20data%20%28person-time%20and%20spatial%20density%29%2C%20indoor%20CO2%20levels%2C%20and%20concentrations%20of%20Mycobacterium%20tuberculosis%20%28Mtb%29%20DNA%20in%20bio-aerosol%20samples.%20We%20estimated%20the%20risk%20of%20Mtb%20transmission%20during%20a%201-hour%20visit%20based%20on%20ventilation%20rate%20and%20duration%20of%20exposure.%5CnRESULTS%3A%20During%20the%20pandemic%2C%20clinics%20were%20less%20crowded%2C%20with%20lower%20mean%20person-time%20per%20day%20%28209%20vs%20258%20hours%3B%20P%20%26lt%3B%200.001%29.%20TB%20prevalence%20among%20patients%20also%20declined%20%281.1%25%20vs%204.7%25%3B%20P%20%3D%200.052%29.%20Environmental%20indicators%20suggested%20improved%20air%20quality%2C%20with%20lower%20CO%5Cu2082%20levels%20%28555%20vs%20856%20parts-per-million%3B%20P%20%26lt%3B%200.001%29%20and%20higher%20ventilation%20rates%20%2815.8%20vs%206.3%20air%20changes%20per%20hour%3B%20P%20%26lt%3B%200.001%29.%20These%20changes%20corresponded%20with%20a%20reduction%20in%20modeled%20Mtb%20transmission%20risk%20%280.04%25%20vs%201.36%25%3B%20P%20%3D%200.046%29.%20Airborne%20Mtb%20DNA%20was%20detected%20in%20both%20periods.%5CnCONCLUSION%3A%20Pandemic-related%20IPC%20measures%20to%20control%20COVID-19%20transmission%20were%20rigorously%20implemented%20and%20likely%20reduced%20transmission%20of%20airborne%20respiratory%20infections%2C%20supporting%20their%20continued%20implementation%20in%20healthcare%20settings%20postpandemic.%22%2C%22date%22%3A%222025-07%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijid.2025.107921%22%2C%22ISSN%22%3A%221878-3511%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A52%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22ZDQLEHPI%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20Gabriela%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Mary-Ann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Association%20between%20changes%20in%20script%20renewal%20periods%20and%20HIV%20viral%20non-suppression%3A%20a%20cohort%20study%20of%20a%20South%20African%20private-sector%20HIV%20program.%20%26lt%3Bi%26gt%3BJournal%20of%20Acquired%20Immune%20Deficiency%20Syndromes%20%281999%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003697%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003697%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20changes%20in%20script%20renewal%20periods%20and%20HIV%20viral%20non-suppression%3A%20a%20cohort%20study%20of%20a%20South%20African%20private-sector%20HIV%20program%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Evidence%20is%20needed%20to%20inform%20differentiated%20service%20delivery%20models%20for%20people%20with%20HIV%20%28PWH%29.%20During%20the%20COVID-19%20pandemic%2C%20South%20Africa%20temporarily%20changed%20the%20validity%20of%20repeat%20prescriptions%20for%20ART%20from%206%20to%2012%20months.%20We%20evaluated%20the%20association%20between%20these%20changes%20and%20HIV%20viral%20non-suppression%20in%20the%20private%20health%20sector.%5CnMETHODS%3A%20We%20analysed%20routine%20claims%20data%20from%20a%20large%20private-sector%20HIV%20management%20programme.%20PWH%20aged%20%26gt%3B15%20years%20from%204%20months%20after%20first%20ART%20evidence%20were%20included.%20We%20conducted%20an%20interrupted%20time-series%20analysis%20comparing%20trends%20in%20the%20proportions%20of%20PWH%20with%20viral%20non-suppression%20%28viral%20load%20%5Cu226550%20copies%5C%2FmL%29%20during%20three%20periods%3A%20January%201%2C%202019%20to%20April%2023%2C%202020%20%28conventional%206-monthly%20script%20renewal%29%3B%20April%2024%2C%202020%20to%20September%2025%2C%202021%20%2812-monthly%20renewal%29%3B%20and%20September%2026%2C%202021%20to%20November%2030%2C%202022%20%286-monthly%20renewal%20re-instated%29.%20We%20used%20weighting%20to%20maintain%20the%20age%2C%20sex%2C%20ART%20regimen%20and%20medical%20scheme%20distributions%20of%20our%20study%20population%20over%20time.%5CnRESULTS%3A%20Monthly%20odds%20of%20viral%20non-suppression%20initially%20decreased%20by%204%25%20per%20annum%20%28adjusted%20odds%20ratio%20%28aOR%29%200.96%2C%2095%25%20confidence%20interval%20%28CI%29%200.93-0.99%29.%20During%2012-monthly%20renewal%2C%20there%20were%20steeper%20declines%20of%2011%25%20per%20annum%20%28aOR%200.89%2C%2095%25%20CI%200.87-0.91%29.%20After%206-monthly%20renewal%20was%20re-introduced%2C%20viral%20non-suppression%20instead%20increased%20by%206%25%20per%20annum%20%28aOR%201.06%2095%25%20CI%201.03-1.09%29.%20Changes%20in%20slopes%20were%20significant%20%28p-values%20%26lt%3B0.001%29.%5CnCONCLUSION%3A%20Measures%20implemented%20during%20COVID-19%20to%20ensure%20continued%20access%20to%20chronic%20medication%20provided%20unique%20evidence%20for%20models%20involving%20less%20frequent%20clinical%20visits.%20Extending%20prescription%20renewal%20periods%20was%20not%20associated%20with%20worse%20virologic%20outcomes%20among%20privately-insured%20PWH.%22%2C%22date%22%3A%222025-05-14%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003697%22%2C%22ISSN%22%3A%221944-7884%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A53%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22Z4MLM4QG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFrigati%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNuttall%2C%20James%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20High%20Incidence%20of%20Tuberculosis%20in%20Young%20Children%20Living%20With%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BJournal%20of%20Acquired%20Immune%20Deficiency%20Syndromes%20%281999%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B98%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20506%26%23x2013%3B514.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003591%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003591%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High%20Incidence%20of%20Tuberculosis%20in%20Young%20Children%20Living%20With%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariette%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Data%20on%20tuberculosis%20%28TB%29%20incidence%20and%20risk%20factors%20among%20children%20living%20with%20HIV%20%28CLHIV%29%20in%20the%20universal%20ART%20era%20are%20limited.%5CnMETHODS%3A%20We%20analyzed%20routinely%20collected%20data%20on%20TB%20diagnoses%20for%20CLHIV%20age%20%5Cu22645%20years%2C%20born%202018-2022%2C%20in%20the%20Westen%20Cape%2C%20South%20Africa.%20We%20examined%20factors%20associated%20with%20TB%20diagnosis%2C%20with%20death%20and%20loss%20to%20follow-up%20as%20competing%20events.%5CnRESULTS%3A%20Among%202219%20CLHIV%2C%2030%25%20were%20diagnosed%20with%20HIV%20at%20birth.%20Median%20follow-up%20from%20birth%20was%2038%20months%20%5Binterquartile%20range%20%28IQR%3A%2024-50%29%3B%2090%25%20started%20antiretroviral%20therapy%20%28ART%29.%20TB%20was%20diagnosed%20in%2028%25%20of%20CLHIV%20%28n%20%3D%20626%5C%2F2219%29%3B%2062%25%20were%20first%20diagnosed%20before%5C%2Fwithin%203%20months%20of%20ART%20start%20%28%26quot%3BTB%20before%20ART%26quot%3B%29%20and%2038%25%20%26gt%3B3%20months%20after%20ART%20start%20%28%26quot%3BTB%20after%20ART%26quot%3B%29.%20Of%20those%20with%20%26quot%3BTB%20before%20ART%26quot%3B%20%28n%20%3D%20390%29%2C%20median%20age%20at%20HIV%20diagnosis%20was%2013%20months%20%28IQR%3A%206-22%29%3B%20median%20time%20between%20HIV%20and%20TB%20diagnoses%20was%205%20days%20%28IQR%3A%200-31%29.%20%26quot%3BTB%20before%20ART%26quot%3B%20was%20associated%20with%20older%20age%20at%20HIV%20diagnosis%20and%20advanced%5C%2Fsevere%20immunodeficiency.%20Of%20those%20with%20%26quot%3BTB%20after%20ART%26quot%3B%20%28n%20%3D%20258%29%2C%20median%20age%20at%20HIV%20diagnosis%20was%202%20months%20%28IQR%3A%200-8%29%20and%20median%20time%20from%20ART%20start%20to%20TB%20diagnosis%20was%2012%20months%20%28IQR%3A%207-21%29.%20%26quot%3BTB%20after%20ART%26quot%3B%20was%20associated%20with%20increased%20viral%20load%20and%20advanced%5C%2Fsevere%20immunosuppression%20%28time%20updated%29.%20Overall%2C%205%25%20%28n%20%3D%20112%5C%2F2219%29%20of%20CLHIV%20died%2C%2036%25%20of%20whom%20were%20diagnosed%20with%20TB%20%28median%20time%20from%20TB%20diagnosis%20to%20death%3A%2058%20days%3B%20IQR%3A%2017-191%29.%5CnCONCLUSIONS%3A%20Young%20CLHIV%20in%20this%20setting%20have%20high%20TB-associated%20morbidity%20and%20mortality.%20Efforts%20to%20improve%20early%20HIV%20and%20TB%20diagnosis%2C%20viral%20suppression%2C%20and%20TB%20preventive%20therapy%20are%20needed.%22%2C%22date%22%3A%222025-04-15%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003591%22%2C%22ISSN%22%3A%221944-7884%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-08-05T13%3A53%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22BS29FRDB%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20Gabriela%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMalateste%2C%20Karen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBolton%20Moore%2C%20Carolyn%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSipambo%2C%20Nosisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMokone%2C%20Limpho%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Global%20Trends%20in%20CD4%20Measurement%20and%20Immunosuppression%20at%20ART%20Initiation%20Among%20Children%20With%20HIV.%20%26lt%3Bi%26gt%3BThe%20Pediatric%20Infectious%20Disease%20Journal%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004819%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004819%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20Trends%20in%20CD4%20Measurement%20and%20Immunosuppression%20at%20ART%20Initiation%20Among%20Children%20With%20HIV%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Malateste%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%20Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nosisa%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Limpho%22%2C%22lastName%22%3A%22Mokone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denna%22%2C%22lastName%22%3A%22Michael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Desmonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dewi%22%2C%22lastName%22%3A%22Kumara%20Wati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Revathy%22%2C%22lastName%22%3A%22Nallusamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aarti%22%2C%22lastName%22%3A%22Kinikar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Du%20Tuan%22%2C%22lastName%22%3A%22Quy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20Vanes%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nel%20Jason%22%2C%22lastName%22%3A%22Haw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20collaboration%22%7D%5D%2C%22abstractNote%22%3A%22Eligibility%20for%20antiretroviral%20therapy%20is%20no%20longer%20based%20on%20immune%20criteria.%20In%20a%20global%20cohort%20of%2097%2C453%20children%2C%20between%202005%20and%202021%2C%20we%20observed%20large%20declines%20in%20CD4%20measurement%2C%20from%2051%25%20to%2012%25%20among%20%26lt%3B5%20seconds%2C%20and%20from%2074%25%20to%2020%25%20among%20those%205-14%20years%20of%20age.%20Lack%20of%20CD4%20testing%20may%20negatively%20affect%20clinical%20care%20and%20surveillance%20of%20severe%20immune%20suppression.%22%2C%22date%22%3A%222025-04-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FINF.0000000000004819%22%2C%22ISSN%22%3A%221532-0987%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22369YB7BV%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-09-01T11%3A41%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22CGJDXP9C%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Embleton%20et%20al.%22%2C%22parsedDate%22%3A%222025-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEmbleton%2C%20Lonnie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSudjaritruk%2C%20Tavitiya%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMachado%2C%20Daisy%20Maria%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChihota%2C%20Belinda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusabyimana%2C%20Fran%26%23xE7%3Boise%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Characterizing%20adolescent%20and%20youth-friendly%20HIV%20services%3A%20a%20cross-sectional%20assessment%20across%2016%20global%20sites.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e26437.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26437%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26437%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Characterizing%20adolescent%20and%20youth-friendly%20HIV%20services%3A%20a%20cross-sectional%20assessment%20across%2016%20global%20sites%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lonnie%22%2C%22lastName%22%3A%22Embleton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tavitiya%22%2C%22lastName%22%3A%22Sudjaritruk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Musabyimana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Jesson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%22%2C%22lastName%22%3A%22Apondi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thanyawee%22%2C%22lastName%22%3A%22Puthanakit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%20Tulio%22%2C%22lastName%22%3A%22Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%20Ellen%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zachary%22%2C%22lastName%22%3A%22Kwena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Perreras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Batya%22%2C%22lastName%22%3A%22Elul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxanne%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Vreeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Adolescent%20and%20youth-friendly%20health%20services%20%28AYFHS%29%20have%20been%20promoted%20as%20a%20best%20practice%20for%20adolescents%20and%20young%20people%20living%20with%20HIV%20%28AYLH%29.%20However%2C%20thorough%20descriptions%20of%20AYFHS%20for%20AYLH%20remain%20scarce.%20We%20sought%20to%20characterize%20adolescent-friendly%20HIV%20services%20in%20a%20global%20paediatric%20research%20consortium.%5CnMETHODS%3A%20Cross-sectional%20data%20were%20collected%20from%2016%20global%20sites%20in%20the%20Adolescent%20and%20Young%20Adult%20Network%20of%20IeDEA%20%28AYANI%29%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20consortium%20between%20August%202020%20and%20October%202022%20using%20a%20standardized%20site%20assessment%20tool%20that%20collected%20data%20on%20clinic%2C%20patient%20and%20provider%20characteristics%2C%20differentiated%20care%2C%20and%20transition%20to%20adult%20services%20processes.%20Descriptive%20analyses%20characterized%20the%20health%20services%20available%20across%20the%20participating%20sites%2C%20using%20frequencies%20and%20proportions%20for%20categorical%20variables%20and%20medians%20and%20interquartile%20range%20for%20continuous%20variables.%20Data%20were%20analysed%20using%20RStudio.%5CnRESULTS%3A%20Overall%2C%2013%20of%2016%20sites%20%2881%25%29%20reported%20having%20dedicated%20adolescent%20services%2C%20which%20most%20often%20consisted%20of%20dedicated%20clinic%20days%20%2862%25%2C%20n%20%3D%208%5C%2F13%29%2C%20primarily%20offered%20on%20weekdays.%20Across%20all%20sites%2C%20nurses%20and%20counsellors%20delivered%20services%20to%20adolescents.%20Over%20half%20of%20all%20clinics%20%2869%25%2C%20n%20%3D%2011%5C%2F16%29%20reported%20offering%20health%20education%20to%20adolescents%20to%20facilitate%20adolescent%20health%20literacy.%20Peer%20educators%20and%20navigators%20were%20involved%20in%20delivering%20services%20at%2062%25%20of%20sites%2C%20primarily%20in%20those%20with%20dedicated%20adolescent%20services%20%2869%25%2C%20n%20%3D%209%5C%2F13%29.%20There%20was%20limited%20integration%20of%20sexual%20and%20reproductive%20health%20services%20into%20HIV%20clinics%20for%20adolescents.%20With%2063%25%20of%20clinics%20conducting%20pregnancy%20screening%2C%2050%25%20providing%20family%20planning%20methods%20and%2038%25%20providing%20cervical%20cancer%20screening.%20Under%20half%20of%20all%20HIV%20clinics%20screened%20for%20physical%20abuse%20or%20violence%20%2844%25%2C%20n%20%3D%207%5C%2F16%29%20and%20sexual%20abuse%20or%20rape%20%2838%25%2C%20n%20%3D%206%5C%2F16%29.%20A%20low%20proportion%20of%20clinics%20screened%20for%20risk%20factors%20related%20to%20young%20key%20populations%2C%20including%20drug%20use%20%2856%25%2C%20n%20%3D%209%5C%2F16%29%2C%20homelessness%20%2838%25%2C%20n%20%3D%206%5C%2F16%29%20young%20men%20having%20sex%20with%20men%20%2831%25%2C%20n%20%3D%205%5C%2F16%29%20and%20transactional%20sex%20%2831%25%2C%20n%20%3D%205%5C%2F16%29.%20Mental%20health%20screening%20for%20concerns%20was%20variable.%5CnCONCLUSIONS%3A%20Findings%20suggest%20gaps%20in%20AYFHS%20for%20AYLH%20across%20the%20HIV%20clinics%20included%20in%20this%20analysis.%20There%20is%20a%20vital%20need%20to%20design%20health%20services%20for%20AYLH%20that%20are%20accessible%2C%20equitable%2C%20and%20effective%20and%20meet%20the%20global%20standards%20for%20delivering%20high-quality%20healthcare%20to%20adolescents.%22%2C%22date%22%3A%222025-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26437%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-08-05T13%3A54%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22JVIGBFUD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ballif%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBallif%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPerrig%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAvihingsanon%2C%20Anchalee%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNsonde%2C%20Dominique%20Mahambu%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20long-term%20impact%20of%20the%20COVID-19%20pandemic%20on%20tuberculosis%20care%20and%20infection%20control%20measures%20in%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20low-%20and%20middle-income%20countries%3A%20a%20multiregional%20site%20survey%20in%20Asia%20and%20Africa.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e017828.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017828%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017828%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20long-term%20impact%20of%20the%20COVID-19%20pandemic%20on%20tuberculosis%20care%20and%20infection%20control%20measures%20in%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20low-%20and%20middle-income%20countries%3A%20a%20multiregional%20site%20survey%20in%20Asia%20and%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Perrig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anchalee%22%2C%22lastName%22%3A%22Avihingsanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambu%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Obatsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Komena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haruka%22%2C%22lastName%22%3A%22Uemura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Otaalo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrice%22%2C%22lastName%22%3A%22Gou%5Cu00e9ss%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nagalingeswaran%22%2C%22lastName%22%3A%22Kumarasamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denna%22%2C%22lastName%22%3A%22Michael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Ramd%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%20Ketut%20Agus%22%2C%22lastName%22%3A%22Somia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Global%20IeDEA%20consortium%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20COVID-19%20pandemic%20challenged%20healthcare%20systems%2C%20particularly%20in%20settings%20with%20high%20infectious%20disease%20burden.%20We%20examined%20the%20postpandemic%20long-term%20impacts%20of%20COVID-19%20on%20tuberculosis%20%28TB%29%20services%20at%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20lower-income%20countries.%5CnMETHODS%3A%20Using%20standardised%20online%20questionnaires%2C%20we%20conducted%20a%20cross-sectional%20site%20survey%20among%20ART%20clinics%20providing%20TB%20services%20in%20Africa%20and%20Asia%20from%20July%20to%20September%202023%20%28site-level%20information%20and%20number%20of%20TB%20diagnoses%20and%20tests%29.%5CnRESULTS%3A%20Of%2045%20participating%20ART%20clinics%2C%2032%20%2871%25%29%20were%20in%20Africa%20and%2013%20%2829%25%29%20in%20Asia.%20During%20the%20COVID-19%20pandemic%20%282020-2022%29%2C%2043%20%2896%25%29%20clinics%20reported%20implementing%20social%20distancing%20or%20separation%20measures%2C%2039%20%2887%25%29%20personal%20protections%20for%20staff%20members%20and%2032%20%2871%25%29%20protections%20for%20patients.%20Infection%20control%20measures%20were%20in%20place%20in%2045%25%20of%20the%20clinics%20before%20the%20pandemic%20%28until%202019%29%2C%2023%25%20introduced%20measures%20during%20the%20pandemic%20and%2015%25%20maintained%20them%20after%20the%20pandemic%20%28after%202022%29.%20Service%20provision%20was%20affected%20during%20the%20pandemic%20in%2033%20%2873%25%29%20clinics%2C%20including%20TB%20services%20in%2022%20%2849%25%29%20clinics.%20TB%20service%20restrictions%20were%20addressed%20by%20introducing%20changes%20in%20directly%20observed%20therapy%20provision%20in%208%20%2818%25%29%20clinics%2C%20multimonth%20TB%20drug%20dispensing%20in%2023%20%2851%25%29%2C%20telehealth%20services%20in%2025%20%2856%25%29%20and%20differentiated%20service%20delivery%20in%2019%20%2842%25%29.%20These%20changes%20were%20sustained%20after%20the%20pandemic%20at%204%20%289%25%29%2C%2011%20%2824%25%29%2C%2017%20%2838%25%29%20and%2012%20%2827%25%29%20clinics%2C%20respectively.%20Compared%20with%202018-2019%2C%20the%20number%20of%20TB%20diagnoses%20decreased%20sharply%20in%202020-2021%20and%20improved%20after%20the%20pandemic.%5CnCONCLUSIONS%3A%20COVID-19%20affected%20TB%20care%20services%20in%20ART%20clinics%20in%20Africa%20and%20Asia.%20This%20was%20paralleled%20by%20a%20reduction%20in%20TB%20diagnoses%2C%20which%20partly%20resumed%20after%20the%20pandemic.%20Infection%20control%20measures%20and%20alternative%20modes%20of%20service%20delivery%20were%20adopted%20during%20the%20pandemic%20and%20only%20partially%20maintained.%20Efforts%20should%20be%20made%20to%20sustain%20the%20lessons%20learnt%20during%20the%20COVID-19%20pandemic%2C%20particularly%20approaches%20that%20reduce%20the%20risk%20of%20transmission%20of%20infectious%20diseases%2C%20including%20TB%2C%20in%20ART%20clinics.%22%2C%22date%22%3A%222025-03-24%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2024-017828%22%2C%22ISSN%22%3A%222059-7908%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-07-08T08%3A12%3A52Z%22%7D%7D%2C%7B%22key%22%3A%224TA3Y9W8%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuloiwa%2C%20Rudzani%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNuttall%2C%20James%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Hospitalisation%20incidence%20among%20young%20children%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004156%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004156%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hospitalisation%20incidence%20among%20young%20children%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudzani%22%2C%22lastName%22%3A%22Muloiwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20M.%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thandi%22%2C%22lastName%22%3A%22Wessels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaco%22%2C%22lastName%22%3A%22Murray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gayathri%22%2C%22lastName%22%3A%22Sridhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Ragone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vani%22%2C%22lastName%22%3A%22Vannappagari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Studies%20examining%20hospitalization%20among%20young%20children%20with%20HIV%20in%20resource-limited%20settings%2C%20in%20the%20context%20of%20early%20infant%20diagnosis%20and%20early%20antiretroviral%20therapy%20%28ART%29%20initiation%2C%20are%20limited.%5CnMETHODS%3A%20We%20used%20routinely%20collected%20data%20to%20describe%20hospitalization%20patterns%20among%20children%20%28age%20%5Cu22645%5Cu200ayears%29%2C%20born%202018-2022%2C%20who%20were%20diagnosed%20with%20HIV%20%28Western%20Cape%20province%2C%20South%20Africa%29.%20We%20used%20mixed-effects%20Poisson%20models%20to%20examine%20factors%20associated%20with%20overall%20hospitalization%20and%20hospitalization%20after%20ART%20initiation.%5CnRESULTS%3A%20We%20included%202219%20children%2C%2030%25%20were%20diagnosed%20with%20HIV%20at%20birth%20%28%5Cu22647%5Cu200adays%29%2C%20an%20additional%2041%25%20before%20age%201%5Cu200ayear%2C%20and%2029%25%20at%20age%20%5Cu22651%5Cu200ayear.%20Median%20follow-up%20from%20birth%20was%2038%5Cu200amonths%20%28interquartile%20range%2024-50%29.%20Overall%2C%2067%25%20of%20children%20were%20hospitalized%2C%20of%20whom%2050%25%20had%20%26gt%3B1%20hospitalization.%20Excluding%20birth%20admissions%2C%2035%25%20of%20children%20were%20hospitalized%20before%20ART%20start%20%28n%5Cu200a%3D%5Cu200a781%5C%2F2219%29.%20Among%20children%20who%20started%20ART%2C%2038%25%20%28n%5Cu200a%3D%5Cu200a747%5C%2F1990%29%20had%20admissions%20after%20ART%20start.%20Compared%20to%20children%20diagnosed%20with%20HIV%20at%20birth%2C%20overall%20hospitalization%20rates%20%28excluding%20birth%20admissions%29%20increased%20by%2067%25%20%5B95%25%20confidence%20interval%20%28CI%29%3A%2039-101%5D%2C%2074%25%20%2895%25%20CI%3A%2045-109%29%20and%2029%25%20%2895%25%20CI%3A%209-51%25%29%20among%20those%20diagnosed%20at%20age%201%5Cu200aweek%20to%203%5Cu200amonths%2C%20%26gt%3B3%20to%209%5Cu200amonths%2C%20and%20%26gt%3B9%5Cu200amonths%2C%20respectively.%20Hospitalization%20rates%20after%20ART%20start%20were%20twice%20as%20high%20%28103%25%20increase%3B%2095%25%20CI%3A%2068-146%25%29%20among%20children%20who%20had%20unsuppressed%20viral%20load%20%28%5Cu22651000%5Cu200acopies%5C%2Fml%29%20at%204%20or%2012%5Cu200amonths%20after%20ART%20start.%5CnCONCLUSIONS%3A%20High%20hospitalization%20rates%20occur%20among%20young%20children%20with%20HIV.%20Earlier%20HIV%20diagnosis%2C%20enabling%20earlier%20ART%20initiation%2C%20is%20associated%20with%20lower%20overall%20hospitalization%20rates.%20Unsuppressed%20viral%20load%20is%20associated%20with%20higher%20post-ART%20hospitalization%20rates.%22%2C%22date%22%3A%222025-03-18%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000004156%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A43%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22HXCBRY88%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schwab%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchwab%2C%20Tiana%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJoseph%2C%20Lavania%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMoono%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BG%26%23xF6%3Bller%2C%20Pauline%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMotsei%2C%20Mamello%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Field%20evaluation%20of%20nanopore%20targeted%20next-generation%20sequencing%20to%20predict%20drug-resistant%20tuberculosis%20from%20native%20sputum%20in%20South%20Africa%20and%20Zambia.%20%26lt%3Bi%26gt%3BJournal%20of%20Clinical%20Microbiology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B63%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e0139024.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01390-24%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01390-24%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Field%20evaluation%20of%20nanopore%20targeted%20next-generation%20sequencing%20to%20predict%20drug-resistant%20tuberculosis%20from%20native%20sputum%20in%20South%20Africa%20and%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiana%20C.%22%2C%22lastName%22%3A%22Schwab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lavania%22%2C%22lastName%22%3A%22Joseph%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Moono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pauline%20C.%22%2C%22lastName%22%3A%22G%5Cu00f6ller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamello%22%2C%22lastName%22%3A%22Motsei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denise%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Neuenschwander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20M.%22%2C%22lastName%22%3A%22Keller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Ramette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaheed%20V.%22%2C%22lastName%22%3A%22Omar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Southern%20Africa%20%28IeDEA-SA%29%22%7D%5D%2C%22abstractNote%22%3A%22Rapid%20and%20comprehensive%20drug%20susceptibility%20testing%20%28DST%29%20is%20essential%20for%20diagnosing%20and%20treating%20drug-resistant%20tuberculosis%20effectively%2C%20and%20next-generation%20sequencing%20can%20be%20an%20effective%20genotypic%20DST%20method.%20We%20implemented%20and%20evaluated%20the%20performance%20of%20a%20nanopore%20targeted%20sequencing%20assay%2C%20called%20the%20Tuberculosis%20Drug%20Resistance%20Test%20%28TBDR%2C%20Oxford%20Nanopore%20Diagnostics%2C%20Ltd.%2C%20United%20Kingdom%29%2C%20which%20predicts%20drug%20resistance%20to%2016%20TB%20drugs%2C%20at%20a%20South%20African%20reference%20laboratory%20and%20a%20district%20diagnostic%20laboratory%20in%20Zambia.%20We%20compared%20the%20sequencing%20success%20rates%20between%20unprocessed%20and%20decontaminated%20sputum%20samples%20and%20determined%20the%20diagnostic%20accuracy%20against%20local%20DST%20%28Xpert%20MTB%5C%2FRIF%20Ultra%2C%20Xpert%20MTB%5C%2FXDR%2C%20and%20BD%20BACTEC%20MGIT%20phenotypic%20DST%29.%20We%20prospectively%20sequenced%20236%20samples%20and%20have%20148%20samples%20with%20sequencing%20results%20from%20unprocessed%20and%20decontaminated%20sputum.%20We%20obtained%20successful%20sequencing%20results%20from%2066.4%25%20%2894%5C%2F148%29%20unprocessed%20sputum%20samples%20and%2075%25%20%28111%5C%2F148%29%20decontaminated%20samples.%20Sequencing%20success%20rates%20at%20the%20two%20sites%20differed%2C%20with%2050.7%25%20%2836%5C%2F71%29%20successful%20sequencing%20results%20from%20unprocessed%20sputum%20in%20Zambia%20and%2075.3%25%20%2858%5C%2F77%29%20in%20South%20Africa.%20Samples%20with%20%26quot%3Blow%26quot%3B%20bacterial%20load%2C%20measured%20by%20Xpert%20MTB%5C%2FRIF%20Ultra%2C%20tended%20to%20produce%20fewer%20successful%20sequencing%20results.%20TBDR%20sequencing%20predicted%20resistances%20in%2048%20samples%2C%20detecting%20resistance%20for%20rifampicin%20%28n%20%3D%2041%29%20and%20isoniazid%20%28n%20%3D%2020%29%2C%20as%20well%20as%2010%20second-line%20drugs%20%28n%20%3D%2015%29.%20Sensitivity%20was%20variable%20compared%20to%20phenotypic%20DST%2C%20ranging%20from%2033%20%28ethionamide%29%20to%2094%25%20%28rifampicin%29%2C%20while%20specificity%20remained%20above%2090%25%20for%20all%20drugs%2C%20except%20clofazimine.%20The%20TBDR%20assay%20can%20provide%20rapid%2C%20comprehensive%20genotypic%20DST.%20Technical%20and%20operational%20challenges%20need%20to%20be%20addressed%20for%20its%20broader%20implementation%20in%20high%20tuberculosis-burden%20settings.IMPORTANCEThis%20study%20illustrates%20the%20use%20of%20the%20Tuberculosis%20Drug%20Resistance%20Test%20%28TBDR%2C%20Oxford%20Nanopore%20Diagnostics%2C%20Ltd.%2C%20United%20Kingdom%29%20as%20a%20rapid%20drug%20susceptibility%20testing%20%28DST%29%20approach%20for%20diagnosing%20drug-resistant%20TB%20in%20the%20high%20TB-burden%20countries%20of%20South%20Africa%20and%20Zambia.%20The%20TBDR%20assay%20predicts%20resistance%20to%2016%20TB%20drugs%2C%20including%20first-%20and%20second-line%20treatments.%20By%20implementing%20the%20TBDR%20assay%20in%20a%20national%20reference%20laboratory%20in%20South%20Africa%20and%20a%20district%20diagnostic%20laboratory%20in%20Zambia%2C%20we%20demonstrate%20how%20this%20technology%20can%20provide%20faster%20diagnostic%20results%20%28days%29%20compared%20to%20traditional%20phenotypic%20DST%20methods%20%28~2%20months%29%2C%20with%20adequate%20sensitivity.%20Missed%20resistances%20compared%20to%20phenotypic%20DST%20indicate%20that%20technical%20improvements%20are%20needed.%20Successful%20sequencing%20from%20unprocessed%20and%20decontaminated%20sputum%20samples%20at%20different%20sites%20suggests%20feasibility%20in%20diverse%20settings%2C%20though%20operational%20challenges%20remain.%20Implementing%20this%20rapid%2C%20comprehensive%20DST%20approach%20could%20enhance%20drug-resistant%20tuberculosis%20diagnosis%20and%20treatment%2C%20ultimately%20improving%20patient%20outcomes%20and%20helping%20to%20combat%20tuberculosis%20in%20high-burden%20regions.%22%2C%22date%22%3A%222025-03-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1128%5C%2Fjcm.01390-24%22%2C%22ISSN%22%3A%221098-660X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T12%3A32%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22FWC57YQB%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chihota%20et%20al.%22%2C%22parsedDate%22%3A%222025-02-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChihota%2C%20Belinda%20Varaidzo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMandiriri%2C%20Ardele%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanda%2C%20Esau%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShamu%2C%20Tinei%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Cohort%20profile%3A%20Noncommunicable%20diseases%20and%20ideal%20cardiovascular%20health%20among%20people%20living%20with%20and%20without%20HIV%20in%20Zambia%20and%20Zimbabwe%20%28NCDzz%20cohort%29.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B15%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e088706.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-088706%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-088706%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cohort%20profile%3A%20Noncommunicable%20diseases%20and%20ideal%20cardiovascular%20health%20among%20people%20living%20with%20and%20without%20HIV%20in%20Zambia%20and%20Zimbabwe%20%28NCDzz%20cohort%29.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%20Varaidzo%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ardele%22%2C%22lastName%22%3A%22Mandiriri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esau%22%2C%22lastName%22%3A%22Banda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tinei%22%2C%22lastName%22%3A%22Shamu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton-Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cleophas%22%2C%22lastName%22%3A%22Chimbetete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20The%20NCDzz%20study%20is%20a%20prospective%20cohort%20of%20people%20living%20with%20and%20without%20HIV%20attending%20primary%20care%20clinics%20in%20Zambia%20and%20Zimbabwe%20and%20was%20established%20in%202019%20to%20understand%20the%20intersection%20between%20noncommunicable%20diseases%20%28NCDs%29%20and%20HIV%20in%20Southern%20Africa.%20Here%2C%20we%20describe%20the%20study%20design%20and%20population%20and%20evaluate%20their%20ideal%20cardiovascular%20health%20%28ICVH%29%20using%20the%20Life%26%23039%3Bs%20Simple%207%20%28LS7%29%20score%20according%20to%20the%20American%20Heart%20Association.%20PARTICIPANTS%3A%20Antiretroviral%20therapy-naive%20people%20living%20with%20HIV%20%28PLWH%29%20and%20people%20living%20without%20HIV%20%28PLWOH%29%2030%20years%20or%20older%20were%20recruited%20from%20three%20primary%20care%20clinics%20in%20Lusaka%20and%20Harare%2C%20and%20underwent%20comprehensive%20clinical%2C%20laboratory%20and%20behavioural%20assessments.%20All%20study%20measurements%20are%20repeated%20during%20yearly%20follow-up%20visits.%20PLWOH%20were%20recruited%20from%20the%20same%20neighbourhoods%20and%20had%20similar%20socioeconomic%20conditions%20as%20PLWH.%20FINDINGS%20TO%20DATE%3A%20Between%20August%202019%20and%20March%202023%2C%20we%20included%201100%20adults%2C%20of%20whom%20618%20%2856%25%29%20were%20females%20and%20539%20%2849%25%29%20were%20PLWH.%20The%20median%20age%20at%20enrolment%20was%2039%20years%20%28IQR%2034-46%20years%29.%20Among%201013%20participants%20%2892%25%29%20with%20complete%20data%2C%20the%20median%20LS7%20score%20was%2011%5C%2F14%20%28IQR%2010-12%29.%20Overall%2C%2060%25%20of%20participants%20met%20the%20criteria%20of%20ICVH%20metrics%20%285-7%20ideal%20components%29%20and%20among%20individual%20components%20of%20the%20LS7%2C%20more%20females%20had%20poor%20body%20mass%20index%20%28BMI%29%20than%20males%2C%20regardless%20of%20HIV%20status%20%2827%25%20vs%203%25%2C%20p%26lt%3B0.001%29.%20Our%20data%20show%20no%20apparent%20difference%20in%20cardiovascular%20health%20determinants%20between%20men%20and%20women%2C%20but%20high%20BMI%20in%20women%20and%20overall%20high%20hypertension%20prevalence%20need%20detailed%20investigation.%20Untreated%20HIV%20%28OR%3A%201.36%20%28IQR%201.05-1.78%29%29%20and%20being%20a%20Zambian%20participant%20%28OR%3A%201.81%20%28IQR%201.31-2.51%29%29%20were%20associated%20with%20having%20ICVH%20metrics%2C%20whereas%20age%20older%20than%2050%20years%20%28OR%3A%200.46%20%28IQR%200.32-0.65%29%29%20was%20associated%20with%20not%20having%20ICVH%20metrics.%20FUTURE%20PLANS%3A%20Our%20study%20will%20be%20regularly%20updated%20with%20upcoming%20analyses%20using%20prospective%20data%20including%20a%20focus%20on%20arterial%20hypertension%20and%20vascular%20function.%20We%20plan%20to%20enrich%20the%20work%20through%20conducting%20in-depth%20assessments%20on%20the%20determinants%20of%20cardiovascular%2C%20liver%20and%20kidney%20end-organ%20disease%20outcomes%20yearly.%20Additionally%2C%20we%20seek%20to%20pilot%20NCD%20interventions%20using%20novel%20methodologies%20like%20the%20trials%20within%20cohorts.%20Beyond%20the%20initial%20funding%20support%2C%20we%20aim%20to%20collect%20at%20minimum%20yearly%20data%20for%20an%20additional%205-year%20period.%22%2C%22date%22%3A%222025%20Feb%207%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2024-088706%22%2C%22ISSN%22%3A%222044-6055%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A56Z%22%7D%7D%2C%7B%22key%22%3A%224H6RFYTE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ford%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A7%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFord%2C%20Nathan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20Reshma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStelzle%2C%20Dominik%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJarvis%2C%20Joseph%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSued%2C%20Omar%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Global%20prevalence%20of%20advanced%20HIV%20disease%20in%20healthcare%20settings%3A%20a%20rapid%20review.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e26415.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26415%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26415%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20prevalence%20of%20advanced%20HIV%20disease%20in%20healthcare%20settings%3A%20a%20rapid%20review.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Stelzle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20N.%22%2C%22lastName%22%3A%22Jarvis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Omar%22%2C%22lastName%22%3A%22Sued%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georges%22%2C%22lastName%22%3A%22Perrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meg%22%2C%22lastName%22%3A%22Doherty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajay%22%2C%22lastName%22%3A%22Rangaraj%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Recent%20studies%20have%20indicated%20a%20high%20enduring%20burden%20of%20advanced%20HIV%20disease%2C%20but%20estimates%20across%20regions%20and%20settings%20are%20lacking.%20The%20aim%20of%20this%20study%20was%20to%20estimate%20the%20prevalence%20of%20advanced%20HIV%20disease%20since%202015%20among%20those%20people%20with%20CD4%20measured%20in%20healthcare%20settings%2C%20disaggregated%20by%20age%20group%2C%20level%20of%20healthcare%20and%20region.%20METHODS%3A%20We%20searched%20MedLine%20via%20Pubmed%20and%20Hinari%20for%20studies%20that%20reported%20the%20proportion%20of%20individuals%20with%20advanced%20HIV%20disease%20%28defined%20as%20CD4%20cell%20count%20%26lt%3B200%20cells%5C%2Fmm%283%29%29%20in%20healthcare%20settings%20since%202015%3B%20this%20search%20was%20complemented%20by%20conference%20abstracts%20and%20data%20from%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20Consortium%20%28IeDEA%29.%20We%20estimated%20pooled%20prevalence%20of%20advanced%20HIV%20disease%20using%20random-%20effects%20models%20and%20performed%20subgroup%20and%20sensitivity%20analyses%20to%20explore%20heterogeneity.%20RESULTS%3A%20We%20obtained%20data%20from%20117%20cohorts%2C%20representing%201%2C814%2C362%20individuals%20from%2052%20countries%20across%20all%20six%20World%20Health%20Organization%20regions.%20The%20majority%20of%20studies%20%28n%20%3D%2083%29%20were%20conducted%20among%20adults%20and%20recorded%20CD4%20cell%20count%20among%20treatment%20naive%20individuals%20at%20antiretroviral%20therapy%20start%20%28n%20%3D%2086%29.%20Studies%20included%20data%20reported%20up%20to%202023.%20The%20proportion%20of%20individuals%20with%20advanced%20HIV%20disease%20was%20higher%20in%20inpatient%20settings%20%2844.3%25%2C%2095%25%20CI%2039.1-49.6%25%29%20compared%20to%20outpatient%20settings%20%2833.5%25%2C%2095%25%20CI%2031.5-35.4%25%29.%20Prevalence%20was%20similar%20across%20age%20groups%2C%20time%20since%20HIV%20diagnosis%20and%20treatment%20status%2C%20and%20highest%20in%20West%20and%20Central%20Africa%2C%20South-East%20Asia%20and%20the%20Eastern%20Mediterranean%20region.%20DISCUSSION%3A%20This%20review%20finds%20that%20at%20least%20a%20third%20of%20people%20presenting%20to%20healthcare%20settings%20have%20advanced%20HIV%20disease%2C%20with%20no%20evidence%20that%20this%20has%20changed%20in%20recent%20years.%20Screening%20for%20advanced%20HIV%20remains%20important%20to%20be%20able%20to%20direct%20appropriate%20preventive%2C%20diagnostic%20and%20therapeutic%20interventions%20to%20prevent%20progression%20to%20severe%20illness%20and%20death.%20CONCLUSIONS%3A%20This%20review%20summarizes%20recent%20evidence%20of%20the%20continued%20high%20proportion%20of%20individuals%20who%20%28re%29present%20to%20care%20with%20advanced%20HIV%20disease.%20These%20findings%20underscore%20the%20urgent%20need%20to%20reinforce%20programme%20capacity%20to%20diagnose%2C%20prevent%20and%20treat%20advanced%20HIV%20disease%20as%20an%20essential%20pillar%20of%20the%20global%20AIDS%20response.%22%2C%22date%22%3A%222025%20Feb%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26415%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-07-08T08%3A12%3A21Z%22%7D%7D%2C%7B%22key%22%3A%227NGNKLUM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMiddelkoop%2C%20Keren%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLeukes%2C%20Juane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWeingartner%2C%20Ernest%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchmutz%2C%20Remo%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Estimating%20Mycobacterium%20tuberculosis%20transmission%20in%20a%20South%20African%20clinic%3A%20Spatiotemporal%20model%20based%20on%20person%20movements.%20%26lt%3Bi%26gt%3BPLoS%20Computational%20Biology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B21%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e1012823.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pcbi.1012823%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pcbi.1012823%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Estimating%20Mycobacterium%20tuberculosis%20transmission%20in%20a%20South%20African%20clinic%3A%20Spatiotemporal%20model%20based%20on%20person%20movements.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keren%22%2C%22lastName%22%3A%22Middelkoop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juane%22%2C%22lastName%22%3A%22Leukes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ernest%22%2C%22lastName%22%3A%22Weingartner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Zurcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22The%20risk%20of%20Mycobacterium%20tuberculosis%20%28Mtb%29%20transmission%20can%20be%20high%20in%20crowded%20clinics.%20We%20developed%20a%20spatiotemporal%20model%20of%20airborne%20Mtb%20transmission%20based%20on%20the%20Wells-Riley%20equation.%20We%20collected%20environmental%2C%20clinical%20and%20person-tracking%20data%20in%20a%20South%20African%20clinic%20during%20COVID-19%2C%20when%20community%20or%20surgical%20masks%20were%20compulsory%20and%20ventilation%20was%20increased.%20We%20matched%20person%20movements%20with%20clinical%20records%20to%20identify%20the%20spatiotemporal%20location%20of%20infectious%20TB%20patients.%20We%20modeled%20the%20concentration%20of%20infectious%20doses%20%28quanta%29%20and%20estimated%20the%20individual%20risk%20of%20infection.%20Over%20five%20days%2C%20video%20sensors%20tracked%201%2C438%20clinic%20attendees.%20CO2%20levels%20were%20low%20%28median%20431%20ppm%2C%20IQR%20406%20ppm-458%20ppm%29%3B%20the%20quanta%20concentration%20was%20higher%20in%20the%20morning%20than%20in%20the%20afternoon%2C%20and%20highest%20in%20the%20waiting%20room.%20The%20estimated%20risk%20of%20infection%20per%20clinic%20attendee%20was%200.05%25%20%2880%25-credible%20interval%20%28CrI%29%200.01%25-0.06%25%29.%20It%20increased%20with%20the%20number%20of%20close%20contacts%20with%20infectious%20patients%20and%20the%20time%20spent%20in%20the%20clinic%2C%20and%20was%201.3-fold%20%2895%25-CrI%201.2-1.4%29%20higher%20in%20scenarios%20without%20mask%20use%20and%202.1-fold%20%2895%25-CrI%200.9-5.0%29%20higher%20with%20pre-pandemic%20ventilation%20rates%2C%20emphasizing%20the%20importance%20of%20ventilation.%20Spatiotemporal%20modeling%20can%20identify%20high-%20risk%20areas%20and%20evaluate%20the%20impact%20of%20infection%20control%20measures%20in%20clinics.%22%2C%22date%22%3A%222025%20Feb%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pcbi.1012823%22%2C%22ISSN%22%3A%221553-7358%201553-734X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A43%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22SCPEDY7T%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFrigati%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNuttall%2C%20James%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Mother-child%20dyads%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20Undetectable%20%3D%20Undetectable%3F%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e26418.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26418%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26418%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mother-child%20dyads%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20Undetectable%20%3D%20Undetectable%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gayathri%22%2C%22lastName%22%3A%22Sridhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Ragone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vani%22%2C%22lastName%22%3A%22Vannappagari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Globally%2C%20children%20living%20with%20HIV%20continue%20to%20lag%20behind%20UNAIDS%20targets%20for%20viral%20suppression%20%28VS%29.%20Because%20studies%20with%20linked%20mother-child%20data%20are%20limited%2C%20we%20describe%20VS%20and%20associated%20factors%20among%20young%20children%20in%20a%20setting%20with%20early%20infant%20HIV%20testing%20%28at%20birth%2C%20age%2010%20weeks%20and%206%20months%29%20and%20early%20protease%20inhibitor-based%20first-line%20antiretroviral%20therapy%20%28ART%29.%20METHODS%3A%20We%20analysed%20routinely%20collected%20mother-child%20data%20for%20children%20living%20with%20HIV%20born%202018-2022%20in%20Western%20Cape%20province%2C%20South%20Africa%20%28followed%20through%20mid-2023%29.%20We%20assessed%20associations%20between%20child%20and%20maternal%20viral%20load%20%28VL%29%20results%20at%2012%20and%2024%20months%20after%20child%20ART%20start%20using%20logistic%20regression%2C%20adjusted%20for%20child%20sex%2C%20birthyear%2C%20severity%20of%20child%20immunodeficiency%20at%20ART%20start%2C%20maternal%20age%20and%20timing%20of%20maternal%20HIV%20diagnosis.%20RESULTS%3A%20Among%202219%20children%20living%20with%20HIV%3B%2030%25%20were%20diagnosed%20at%20birth%20%28%26lt%3B%5C%2F%3D7%20days%29%2C%2041%25%20before%20age%201%20year%20%288-365%20days%29%20and%2029%25%20at%20age%20%26gt%3B1%20year.%20Overall%2C%205%25%20%28n%20%3D%20112%5C%2F2219%29%20of%20children%20died%2C%20a%20third%20of%20whom%20had%20not%20started%20ART%3B%2090%25%20of%20children%20%28n%20%3D%201990%29%20started%20ART%2C%20at%20median%20age%205%20months%20%28IQR%201-16%29.%20Median%20follow-up%20from%20ART%20start%20was%2026%20months%20%28IQR%2014-40%29.%20Among%20children%20with%20available%20VL%20at%2012%20months%20%28n%20%3D%20853%5C%2F1582%29%2C%2024%20months%20%28n%20%3D%20614%5C%2F1129%29%20and%2036%20months%20%28n%20%3D%20350%5C%2F658%29%20after%20ART%20start%2C%2036%25%2C%2043%25%20and%2048%25%20were%20virally%20suppressed%2C%20respectively%20%28VL%26lt%3B100%20copies%5C%2Fml%29.%20VS%20among%20children%20at%2012%20and%2024%20months%20was%20more%20likely%20if%20maternal%20VL%20was%20%26lt%3B100%20versus%20%26gt%3B%5C%2F%3D100%20copies%5C%2Fml%20at%2012%20months%20%28adjusted%20odds%20ratio%20%5BaOR%5D%20%3D%203.5%3B%2095%25%20CI%201.9-6.5%29%20and%2024%20months%20%28aOR%20%3D%206.1%3B%2095%25%20CI%202.8-13.1%29%20after%20child%20ART%20start.%20Children%20with%20no%5C%2Fmild%20versus%20advanced%5C%2Fsevere%20immunodeficiency%20at%20ART%20start%20were%20more%20likely%20to%20achieve%20VS%20at%2012%20months%20%28aOR%20%3D%202.3%3B%2095%25%20CI%201.3-4.2%29%20but%20not%20at%2024%20months.%20Eligible%20children%20with%20missing%20VL%20at%2024%20months%20%2839%25%29%20were%20more%20likely%20to%20have%20gaps%20in%20care%20of%20%26gt%3B6%20months%20than%20those%20with%20VL%26gt%3B%5C%2F%3D100%20or%20VL%26lt%3B100%20copies%5C%2Fml%20%2884%25%20vs.%2028%25%20vs.%2014%25%2C%20respectively%3B%20p%26lt%3B0.001%29.%20CONCLUSIONS%3A%20Less%20than%20half%20of%20children%20on%20ART%20achieved%20VS%2C%20and%20children%20were%20more%20likely%20to%20achieve%20VS%20if%20their%20mothers%20were%20also%20virally%20suppressed.%20Significant%20efforts%20are%20needed%20to%20support%20mother-child%20dyads%20to%20achieve%20optimal%20VS.%22%2C%22date%22%3A%222025%20Feb%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26418%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A49%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22LQ46ZRQH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Didden%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDidden%2C%20Christiane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRohner%2C%20Eliane%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20Contribution%20of%20Noncommunicable%20and%20Infectious%20Diseases%20to%20the%20Effect%20of%20Depression%20on%20Mortality%3A%20A%20Longitudinal%20Causal%20Mediation%20Analysis.%20%26lt%3Bi%26gt%3BEpidemiology%20%28Cambridge%2C%20Mass.%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B36%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%2088%26%23x2013%3B98.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FEDE.0000000000001804%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FEDE.0000000000001804%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Contribution%20of%20Noncommunicable%20and%20Infectious%20Diseases%20to%20the%20Effect%20of%20Depression%20on%20Mortality%3A%20A%20Longitudinal%20Causal%20Mediation%20Analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Mesa-Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayesha%22%2C%22lastName%22%3A%22Kriel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soraya%22%2C%22lastName%22%3A%22Seedat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20increased%20prevalence%20of%20physical%20diseases%20among%20individuals%20with%20mental%20illness%20contributes%20to%20their%20increased%20risk%20of%20mortality.%20However%2C%20the%20mediating%20role%20of%20specific%20diseases%20in%20the%20effect%20of%20mental%20illness%20on%20mortality%20is%20not%20well%20understood.%5CnMETHOD%3A%20We%20conducted%20a%20longitudinal%20causal%20mediation%20analysis%20using%20data%20from%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme%20from%202011%20to%202020.%20We%20estimated%20the%20overall%20effect%20of%20major%20depressive%20disorder%20%28MDD%29%20on%20mortality%20and%20evaluated%20reductions%20in%20this%20overall%20effect%20through%20hypothetical%20interventions%20on%20the%20risks%20of%20mediating%20physical%20diseases%20using%20an%20interventional%20effects%20approach.%20Monte%20Carlo%20simulation-based%20g-computation%20was%20used%20for%20estimation.%5CnRESULTS%3A%20Among%20981%2C540%20individuals%2C%20143%2C314%20%2814.6%25%29%20were%20diagnosed%20with%20MDD.%20Mortality%20risk%20after%208%20years%20was%206.5%25%20under%20MDD%2C%20and%205.3%25%20under%20no%20MDD%20%28risk%20ratio%201.23%2C%2095%25%20CI%20%3D%201.19%2C%201.26%29.%20Overall%2C%2043.4%25%20of%20this%20disparity%20could%20be%20attributed%20to%20higher%20rates%20of%20physical%20comorbidities%20due%20to%20MDD.%20Cardiovascular%20diseases%20accounted%20for%2017.8%25%2C%20followed%20by%20chronic%20respiratory%20diseases%20%288.6%25%29%2C%20cancers%20%287.5%25%29%2C%20diabetes%20and%20chronic%20kidney%20disease%20%285.8%25%29%2C%20tuberculosis%20%284.3%25%29%2C%20and%20HIV%20%282.7%25%29.%5CnCONCLUSION%3A%20Within%20the%20privately%20insured%20population%20of%20South%20Africa%2C%20MDD%20is%20associated%20with%20increased%20mortality.%20We%20found%20that%20noncommunicable%20diseases%2C%20rather%20than%20infectious%20diseases%2C%20are%20important%20mediators%20of%20the%20effect%20of%20MDD%20on%20mortality.%22%2C%22date%22%3A%222025-01-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FEDE.0000000000001804%22%2C%22ISSN%22%3A%221531-5487%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A50Z%22%7D%7D%2C%7B%22key%22%3A%222XD6TBKQ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Samim%20et%20al.%22%2C%22parsedDate%22%3A%222025-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSamim%2C%20Daryoush%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChibomba%2C%20Douglas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BXulu%2C%20Sihle%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Cardiovascular%20Involvement%20in%20Tuberculosis%20Patients%20Treated%20in%20Southern%20Africa.%20%26lt%3Bi%26gt%3BJACC.%20Advances%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20101427.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacadv.2024.101427%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacadv.2024.101427%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cardiovascular%20Involvement%20in%20Tuberculosis%20Patients%20Treated%20in%20Southern%20Africa.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daryoush%22%2C%22lastName%22%3A%22Samim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Douglas%22%2C%22lastName%22%3A%22Chibomba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sihle%22%2C%22lastName%22%3A%22Xulu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denise%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Perrig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22De%20Marchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22Gunther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Pilgrim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20Tuberculosis%20%28TB%29%20is%20the%20leading%20cause%20of%20death%20among%20people%20with%20HIV%20and%20a%20major%20global%20health%20challenge.%20Subclinical%20cardiovascular%20manifestations%20of%20TB%20are%20poorly%20documented%20in%20high%20TB%20and%20HIV%20burden%20countries.%20Objectives%3A%20The%20purpose%20of%20this%20study%20was%20to%20quantify%20the%20prevalence%20of%20cardiovascular%20involvement%20in%20TB%20patients%20and%20investigate%20changes%20after%20completion%20of%20anti-TB%20treatment.%20Methods%3A%20HIV-positive%20and%20HIV-negative%20patients%20diagnosed%20with%20pulmonary%20TB%20between%20October%202022%20and%20November%202023%20were%20enrolled%20from%202%20tertiary%20care%20hospitals%20in%20Zambia%20and%20South%20Africa.%20Standardized%20transthoracic%20echocardiography%20%28TTE%29%20was%20conducted%20at%20TB%20diagnosis%20and%20after%206%20months%20of%20anti-TB%20treatment.%20Cross-%20sectional%20and%20longitudinal%20analyses%20assessed%20pericardial%20effusion%2C%20thickening%2C%20or%20calcification%2C%20with%20and%20without%20signs%20of%20pericardial%20constriction.%20Results%3A%20A%20total%20of%20286%20TB%20patients%20%28218%20%5B76%25%5D%20men%2C%20109%20%5B38%25%5D%20people%20with%20HIV%2C%20median%20age%2035%20years%29%20underwent%20TTE%20at%20TB%20diagnosis%2C%20of%20whom%20105%20participants%20had%20a%20second%20TTE%20after%20completion%20of%20treatment.%20At%20TB%20diagnosis%2C%20134%20%2847%25%29%20had%20pericardial%20effusions%2C%2086%20%2830%25%29%20thickening%2C%207%20%282%25%29%20calcifications%2C%20103%20%2842%25%29%20signs%20of%20constriction%2C%20and%2013%20%2812%25%29%20had%20definite%20diagnosis%20of%20constriction.%20After%20TB%20treatment%2C%20pericardial%20effusions%20%2847%25%20vs%2016%25%2C%20P%20%26lt%3B%200.001%29%20and%20pericardial%20thickenings%20%2830%25%20vs%2015%25%2C%20P%20%3D%200.002%29%20became%20less%20prevalent.%20Pericardial%20calcifications%20%282%25%20vs%201%25%2C%20P%20%3D%200.4%29%2C%20signs%20of%20constrictions%20%2842%25%20vs%2038%25%2C%20P%20%3D%200.4%29%2C%20and%20definite%20diagnosis%20of%20constriction%20%2812%25%20vs%2014%25%2C%20P%20%3D%200.8%29%20were%20similar.%20Conclusions%3A%20Cardiac%20involvement%20is%20frequent%20in%20newly%20diagnosed%20TB%20patients.%20Early%20pericardial%20changes%20may%20be%20reversed%20with%20anti-TB%20treatment.%20Echocardiographic%20screening%20facilitates%20early%20detection%20and%20timely%20management%20of%20cardiovascular%20involvement%20in%20TB%20patients.%22%2C%22date%22%3A%222025%20Jan%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jacadv.2024.101427%22%2C%22ISSN%22%3A%222772-963X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A31Z%22%7D%7D%2C%7B%22key%22%3A%22KDE2A62W%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTlali%2C%20Mpho%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Stephan%26lt%3B%5C%2Fspan%26gt%3B%20%26amp%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Is%20suicide%20risk%20100-fold%20higher%20in%20people%20with%20HIV%3F%20A%20critical%20appraisal%20of%20a%20meta-analysis.%20%26lt%3Bi%26gt%3BGeneral%20Psychiatry%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e102210.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fgpsych-2025-102210%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fgpsych-2025-102210%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Is%20suicide%20risk%20100-fold%20higher%20in%20people%20with%20HIV%3F%20A%20critical%20appraisal%20of%20a%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fgpsych-2025-102210%22%2C%22ISSN%22%3A%222517-729X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-01T11%3A40%3A10Z%22%7D%7D%2C%7B%22key%22%3A%22FG32B8TS%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Metekoua%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMetekoua%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMwansa-Kambafwile%2C%20Judith%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKellett%2C%20Peter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Patterns%20of%20incident%20Burkitt%20lymphoma%20during%20the%20HIV%20epidemic%20among%20the%20Black%20African%20and%20White%20population%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BBr%20J%20Cancer%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41416-024-02937-8%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41416-024-02937-8%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patterns%20of%20incident%20Burkitt%20lymphoma%20during%20the%20HIV%20epidemic%20among%20the%20Black%20African%20and%20White%20population%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Metekoua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Mwansa-Kambafwile%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Kellett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Muchengeti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tracey%22%2C%22lastName%22%3A%22Wiggill%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41416-024-02937-8%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A36Z%22%7D%7D%5D%7D
Banholzer, Nicolas; Muula, Guy; Mureithi, Fiona; Evans, Denise; Huwa, Jacqueline et al. (2025). Mental, physical, and respiratory health in people with tuberculosis in Southern Africa: a multi-country cohort analysis.
BMC Medicine,
23 (1), S. 485.
http://doi.org/10.1186/s12916-025-04321-6.
Benade, Mariet; Maskew, Mhairi; Chilembo, Phillip; Wa Mwansa, Mwansa; Savory, Theodora et al. (2025). Patterns of engagement in care during clients’ first 12 months after HIV treatment initiation in Zambia: a retrospective cohort analysis using routinely collected data.
BMJ Global Health,
10 (8), S. e017930.
http://doi.org/10.1136/bmjgh-2024-017930.
Ruffieux, Yann; Joska, John A.; Lang, Raynell; Zheng, Chunyan; Folb, Naomi et al. (2025). Life-years lost associated with mental disorders in people with HIV: a cohort study in South Africa, Canada and the United States.
Journal of the International AIDS Society,
28 (8), S. e70023.
http://doi.org/10.1002/jia2.70023.
Gastaldon, C.; Whitesell Skrivankova, V.; Schoretsanitis, G.; Folb, N.; Taghavi, K. et al. (2025). Diagnosis of postpartum depression and associated factors in South Africa: a cohort study of 47,697 women.
Epidemiology and Psychiatric Sciences,
34, S. e41.
http://doi.org/10.1017/S2045796025100103.
Fernández Villalobos, Nathalie Verónica; Helfenstein, Fabrice; Khol, Vohith; Twizere, Christella; Secco, Mayara et al. (2025). Scale of differentiated service delivery implementation in HIV care facilities in low- and middle-income countries: a global facility survey.
Journal of the International AIDS Society,
28 Suppl 3, S. e26477.
http://doi.org/10.1002/jia2.26477.
Banholzer, Nicolas; Middelkoop, Keren; Schmutz, Remo; Leukes, Juane; Zürcher, Kathrin et al. (2025). Infection prevention and control measures during the COVID-19 pandemic and airborne tuberculosis transmission during primary care visits in South Africa.
International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases,
156, S. 107921.
http://doi.org/10.1016/j.ijid.2025.107921.
Patten, Gabriela; Haas, Andreas D.; Davies, Mary-Ann; Maartens, Gary; Chinogurei, Chido et al. (2025). Association between changes in script renewal periods and HIV viral non-suppression: a cohort study of a South African private-sector HIV program.
Journal of Acquired Immune Deficiency Syndromes (1999).
http://doi.org/10.1097/QAI.0000000000003697.
Anderson, Kim; Rabie, Helena; Eley, Brian S.; Frigati, Lisa; Nuttall, James et al. (2025). High Incidence of Tuberculosis in Young Children Living With HIV in the Western Cape, South Africa.
Journal of Acquired Immune Deficiency Syndromes (1999),
98 (5), S. 506–514.
http://doi.org/10.1097/QAI.0000000000003591.
Patten, Gabriela; Malateste, Karen; Bolton Moore, Carolyn; Sipambo, Nosisa; Mokone, Limpho et al. (2025). Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.
The Pediatric Infectious Disease Journal.
http://doi.org/10.1097/INF.0000000000004819.
Embleton, Lonnie; Sudjaritruk, Tavitiya; Machado, Daisy Maria; Chihota, Belinda; Musabyimana, Françoise et al. (2025). Characterizing adolescent and youth-friendly HIV services: a cross-sectional assessment across 16 global sites.
Journal of the International AIDS Society,
28 (4), S. e26437.
http://doi.org/10.1002/jia2.26437.
Ballif, Marie; Banholzer, Nicolas; Perrig, Lisa; Avihingsanon, Anchalee; Nsonde, Dominique Mahambu et al. (2025). The long-term impact of the COVID-19 pandemic on tuberculosis care and infection control measures in anti-retroviral therapy (ART) clinics in low- and middle-income countries: a multiregional site survey in Asia and Africa.
BMJ Global Health,
10 (3), S. e017828.
http://doi.org/10.1136/bmjgh-2024-017828.
Anderson, Kim; Eley, Brian S.; Rabie, Helena; Muloiwa, Rudzani; Nuttall, James et al. (2025). Hospitalisation incidence among young children living with HIV in the Western Cape, South Africa.
AIDS (London, England).
http://doi.org/10.1097/QAD.0000000000004156.
Schwab, Tiana C.; Joseph, Lavania; Moono, Andrew; Göller, Pauline C.; Motsei, Mamello et al. (2025). Field evaluation of nanopore targeted next-generation sequencing to predict drug-resistant tuberculosis from native sputum in South Africa and Zambia.
Journal of Clinical Microbiology,
63 (3), S. e0139024.
http://doi.org/10.1128/jcm.01390-24.
Chihota, Belinda Varaidzo; Mandiriri, Ardele; Muula, Guy; Banda, Esau; Shamu, Tinei et al. (2025). Cohort profile: Noncommunicable diseases and ideal cardiovascular health among people living with and without HIV in Zambia and Zimbabwe (NCDzz cohort).
BMJ Open,
15 (2), S. e088706.
http://doi.org/10.1136/bmjopen-2024-088706.
Ford, Nathan; Kassanjee, Reshma; Stelzle, Dominik; Jarvis, Joseph N.; Sued, Omar et al. (2025). Global prevalence of advanced HIV disease in healthcare settings: a rapid review.
Journal of the International AIDS Society,
28 (2), S. e26415.
http://doi.org/10.1002/jia2.26415.
Banholzer, Nicolas; Middelkoop, Keren; Leukes, Juane; Weingartner, Ernest; Schmutz, Remo et al. (2025). Estimating Mycobacterium tuberculosis transmission in a South African clinic: Spatiotemporal model based on person movements.
PLoS Computational Biology,
21 (2), S. e1012823.
http://doi.org/10.1371/journal.pcbi.1012823.
Anderson, Kim; Rabie, Helena; Eley, Brian S.; Frigati, Lisa; Nuttall, James et al. (2025). Mother-child dyads living with HIV in the Western Cape, South Africa: Undetectable = Undetectable?
Journal of the International AIDS Society,
28 (2), S. e26418.
http://doi.org/10.1002/jia2.26418.
Didden, Christiane; Egger, Matthias; Folb, Naomi; Maartens, Gary; Rohner, Eliane et al. (2025). The Contribution of Noncommunicable and Infectious Diseases to the Effect of Depression on Mortality: A Longitudinal Causal Mediation Analysis.
Epidemiology (Cambridge, Mass.),
36 (1), S. 88–98.
http://doi.org/10.1097/EDE.0000000000001804.
Samim, Daryoush; Muula, Guy; Banholzer, Nicolas; Chibomba, Douglas; Xulu, Sihle et al. (2025). Cardiovascular Involvement in Tuberculosis Patients Treated in Southern Africa.
JACC. Advances,
4 (1), S. 101427.
http://doi.org/10.1016/j.jacadv.2024.101427.
Haas, Andreas D.;
Ruffieux, Yann;
Tlali, Mpho;
Rabie, Stephan &
Egger, Matthias (2025). Is suicide risk 100-fold higher in people with HIV? A critical appraisal of a meta-analysis.
General Psychiatry,
38 (4), S. e102210.
http://doi.org/10.1136/gpsych-2025-102210.
Metekoua, Carole; Ruffieux, Yann; Mwansa-Kambafwile, Judith; Kellett, Peter; Egger, Matthias et al. (2025). Patterns of incident Burkitt lymphoma during the HIV epidemic among the Black African and White population in South Africa.
Br J Cancer.
http://doi.org/10.1038/s41416-024-02937-8.
2775998
TCMBXKKM
2024
1
padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe
50
date
desc
year
254
https://www.iedea.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22WGDWSC39%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-30%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMwansa-Kambafwile%2C%20Judith%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMetekoua%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTombe-Nyahuma%2C%20Tinashe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBohlius%2C%20Julia%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20HIV-1%20Viremia%20and%20Cancer%20Risk%20in%202.8%20Million%20People%3A%20the%20South%20African%20HIV%20Cancer%20Match%20Study.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20ciae652.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae652%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae652%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV-1%20Viremia%20and%20Cancer%20Risk%20in%202.8%20Million%20People%3A%20the%20South%20African%20HIV%20Cancer%20Match%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Mwansa-Kambafwile%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Metekoua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tinashe%22%2C%22lastName%22%3A%22Tombe-Nyahuma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Muchengeti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Most%20research%20on%20HIV-1%20viremia%20and%20cancer%20risk%20is%20from%20high-income%20countries.%20We%20evaluated%20the%20association%20between%20HIV-1%20viremia%20and%20the%20risk%20of%20various%20cancer%20types%20among%20people%20with%20HIV%20%28PWH%29%20in%20South%20Africa.%5CnMETHODS%3A%20We%20analysed%20data%20from%20the%20South%20African%20HIV%20Cancer%20Match%20study%2C%20based%20on%20laboratory%20measurements%20from%20the%20National%20Health%20Laboratory%20Services%20and%20cancer%20records%20from%20the%20National%20Cancer%20Registry%20from%202004-2014.%20Using%20Cox%20proportional%20hazards%20models%2C%20we%20estimated%20hazard%20ratios%20%28HR%29%20for%20cancer%20incidence%20per%20unit%20increase%20in%20time-updated%20Log10%20HIV-1%20RNA%20viral%20load%20copies%5C%2FmL.%20We%20created%20partially%20adjusted%20%28sex%2C%20age%2C%20calendar%20year%29%20and%20fully%20adjusted%20models%20%28additionally%20including%20time-updated%20CD4%20count%29.%5CnRESULTS%3A%20We%20included%202%2C770%2C200%20PWH%20with%2010%2C175%20incident%20cancers%3B%20most%20common%20were%20cervical%20cancer%20%28N%3D2%2C481%29%2C%20Kaposi%20sarcoma%20%28N%3D1%2C902%29%2C%20breast%20cancer%20%28N%3D1%2C063%29%2C%20and%20non-Hodgkin%20lymphoma%20%28N%3D863%29.%20Hazard%20ratios%20for%20the%20association%20of%20HIV-1%20viremia%20and%20cancer%20risk%20changed%20after%20partial%20and%20full%20adjustment%20and%20were%20generally%20attenuated%20for%20infection-related%20cancers%20but%20tended%20to%20increase%20for%20infection-unrelated%20cancers.%20In%20the%20fully%20adjusted%20model%2C%20HIV-1%20viremia%20was%20associated%20with%20an%20increased%20risk%20of%20Kaposi%20sarcoma%20%28HR%20per%20unit%20increase%20in%20Log10%20HIV-1%20RNA%20viral%20load%3A%201.38%2C%2095%25%20CI%201.35-1.42%29%2C%20leukemia%20%28HR%3A%201.28%2C%2095%25%20CI%201.13-1.45%29%2C%20non-Hodgkin%20lymphoma%20%28HR%3A%201.24%2C%2095%25%20CI%201.19-1.29%29%2C%20conjunctival%20cancer%20%28HR%3A%201.19%2C%2095%25%20CI%201.11-1.25%29%2C%20and%20colorectal%20cancer%20%28HR%3A%201.11%2C%2095%25%20CI%201.02-1.21%29.%20Associations%20with%20other%20cancer%20types%20were%20weaker%20or%20absent.%5CnCONCLUSIONS%3A%20Our%20findings%20underline%20the%20importance%20of%20sustained%20viral%20suppression%20for%20cancer%20prevention%20among%20PWH%20in%20South%20Africa.%22%2C%22date%22%3A%222024-12-30%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciae652%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-14T13%3A34%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22243VDCVH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Siedentop%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-20%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSiedentop%2C%20Berit%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKachalov%2C%20Viacheslav%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWitzany%2C%20Christopher%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKouyos%2C%20Roger%20D.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20The%20effect%20of%20combining%20antibiotics%20on%20resistance%3A%20A%20systematic%20review%20and%20meta-analysis.%20%26lt%3Bi%26gt%3BeLife%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20RP93740.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7554%5C%2FeLife.93740%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7554%5C%2FeLife.93740%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effect%20of%20combining%20antibiotics%20on%20resistance%3A%20A%20systematic%20review%20and%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Siedentop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viacheslav%20N.%22%2C%22lastName%22%3A%22Kachalov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Witzany%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20D.%22%2C%22lastName%22%3A%22Kouyos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Bonhoeffer%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Under%20which%20conditions%20antibiotic%20combination%20therapy%20decelerates%20rather%20than%20accelerates%20resistance%20evolution%20is%20not%20well%20understood.%20We%20examined%20the%20effect%20of%20combining%20antibiotics%20on%20within-patient%20resistance%20development%20across%20various%20bacterial%20pathogens%20and%20antibiotics.%5CnMETHODS%3A%20We%20searched%20CENTRAL%2C%20EMBASE%2C%20and%20PubMed%20for%20%28quasi%29-randomised%20controlled%20trials%20%28RCTs%29%20published%20from%20database%20inception%20to%2024%20November%202022.%20Trials%20comparing%20antibiotic%20treatments%20with%20different%20numbers%20of%20antibiotics%20were%20included.%20Patients%20were%20considered%20to%20have%20acquired%20resistance%20if%2C%20at%20the%20follow-up%20culture%2C%20a%20resistant%20bacterium%20%28as%20defined%20by%20the%20study%20authors%29%20was%20detected%20that%20had%20not%20been%20present%20in%20the%20baseline%20culture.%20We%20combined%20results%20using%20a%20random%20effects%20model%20and%20performed%20meta-regression%20and%20stratified%20analyses.%20The%20trials%26%23039%3B%20risk%20of%20bias%20was%20assessed%20with%20the%20Cochrane%20tool.%5CnRESULTS%3A%2042%20trials%20were%20eligible%20and%2029%2C%20including%205054%20patients%2C%20qualified%20for%20statistical%20analysis.%20In%20most%20trials%2C%20resistance%20development%20was%20not%20the%20primary%20outcome%20and%20studies%20lacked%20power.%20The%20combined%20odds%20ratio%20for%20the%20acquisition%20of%20resistance%20comparing%20the%20group%20with%20the%20higher%20number%20of%20antibiotics%20with%20the%20comparison%20group%20was%201.23%20%2895%25%20CI%200.68-2.25%29%2C%20with%20substantial%20between-study%20heterogeneity%20%28I2%3D77%25%29.%20We%20identified%20tentative%20evidence%20for%20potential%20beneficial%20or%20detrimental%20effects%20of%20antibiotic%20combination%20therapy%20for%20specific%20pathogens%20or%20medical%20conditions.%5CnCONCLUSIONS%3A%20The%20evidence%20for%20combining%20a%20higher%20number%20of%20antibiotics%20compared%20to%20fewer%20from%20RCTs%20is%20scarce%20and%20overall%20compatible%20with%20both%20benefit%20or%20harm.%20Trials%20powered%20to%20detect%20differences%20in%20resistance%20development%20or%20well-designed%20observational%20studies%20are%20required%20to%20clarify%20the%20impact%20of%20combination%20therapy%20on%20resistance.%5CnFUNDING%3A%20Support%20from%20the%20Swiss%20National%20Science%20Foundation%20%28grant%20310030B_176401%20%28SB%2C%20BS%2C%20CW%29%2C%20grant%2032FP30-174281%20%28ME%29%2C%20grant%20324730_207957%20%28RDK%29%29%20and%20from%20the%20National%20Institute%20of%20Allergy%20and%20Infectious%20Diseases%20%28NIAID%2C%20cooperative%20agreement%20AI069924%20%28ME%29%29%20is%20gratefully%20acknowledged.%22%2C%22date%22%3A%222024-12-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.7554%5C%2FeLife.93740%22%2C%22ISSN%22%3A%222050-084X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A35%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22SGP6MQZU%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Carlucci%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-17%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCarlucci%2C%20James%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHuntington%2C%20Thomas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-Gunter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYotebieng%2C%20Marcel%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLeroy%2C%20Valeriane%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20High%20Prevalence%20of%20Unconfirmed%20Positive%20HIV%20Polymerase%20Chain%20Reaction%20Test%20Results%20Among%20African%20Infants%20With%20HIV%20Exposure%20in%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20Consortium.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%26%23x202F%3B%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B79%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%201475%26%23x2013%3B1478.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae251%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae251%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High%20Prevalence%20of%20Unconfirmed%20Positive%20HIV%20Polymerase%20Chain%20Reaction%20Test%20Results%20Among%20African%20Infants%20With%20HIV%20Exposure%20in%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20Consortium.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20G.%22%2C%22lastName%22%3A%22Carlucci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Huntington%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Gunter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valeriane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Edmonds%22%7D%5D%2C%22abstractNote%22%3A%22In%20a%20large%2C%20multiregional%20cohort%20of%20African%20infants%20with%20human%20immunodeficiency%20virus%20%28HIV%29%20exposure%2C%2044%25%20of%20those%20with%20a%20positive%20HIV%20polymerase%20chain%20reaction%20test%20lacked%20a%20confirmatory%20positive%20test.%20Efforts%20are%20needed%20to%20ensure%20high-fidelity%20implementation%20of%20HIV%20testing%20algorithms%20so%20that%20all%20positive%20results%20are%20confirmed.%22%2C%22date%22%3A%222024%20Dec%2017%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciae251%22%2C%22ISSN%22%3A%221537-6591%201058-4838%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-10T15%3A22%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22N6HZL79Q%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Phillips%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhillips%2C%20Tamsin%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGomba%2C%20Yolanda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMogoba%2C%20Pheposadi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhelanyane%2C%20Florence%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Routine%20Electronic%20Mother-Infant%20Data%20%28REMInD%29%3A%20a%20proof-of-concept%20Data%20to%20Care%20study%20to%20support%20retention%20in%20maternal%20HIV%20treatment%20and%20infant%20HIV%20testing%20in%20Cape%20Town%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BResearch%20Square%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20rs.3.rs-5626699.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21203%5C%2Frs.3.rs-5626699%5C%2Fv1%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21203%5C%2Frs.3.rs-5626699%5C%2Fv1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Routine%20Electronic%20Mother-Infant%20Data%20%28REMInD%29%3A%20a%20proof-of-concept%20Data%20to%20Care%20study%20to%20support%20retention%20in%20maternal%20HIV%20treatment%20and%20infant%20HIV%20testing%20in%20Cape%20Town%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamsin%20K.%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yolanda%22%2C%22lastName%22%3A%22Gomba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pheposadi%22%2C%22lastName%22%3A%22Mogoba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20H.%22%2C%22lastName%22%3A%22Chi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kate%22%2C%22lastName%22%3A%22Clouse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucia%22%2C%22lastName%22%3A%22Knight%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Landon%22%2C%22lastName%22%3A%22Myer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elaine%20J.%22%2C%22lastName%22%3A%22Abrams%22%7D%5D%2C%22abstractNote%22%3A%22Data%20to%20Care%20%28D2C%29%20strategies%20-%20using%20routine%20data%20to%20facilitate%20identification%20and%20linkage%20back%20to%20care%20of%20people%20living%20with%20HIV%20who%20are%20not%20in%20care%20-%20have%20shown%20promise%20in%20high-income%20settings%20but%20received%20little%20attention%20in%20lower%20resourced%20or%20vertical%20HIV%20transmission%20prevention%20%28VTP%29%20contexts.%20In%20this%20proof-of-concept%20study%2C%20we%20monitored%20existing%20linked%20electronic%20medical%20records%20in%20near%20real-time%20to%20identify%20key%20gaps%20in%20postpartum%20VTP%20steps%20among%20336%20mothers%20living%20with%20HIV%20and%20their%20infants%20in%20Cape%20Town%2C%20South%20Africa%20%28recruited%20March%202021%20-%20April%202022%29.%20We%20attempted%20to%20confirm%20observed%20gaps%20through%20source%20data%20systems%20and%20telephonic%20tracing%2C%20and%20facilitated%20re-engagement%20in%20care%20where%20needed.%20There%20were%20302%20gaps%20observed%20in%20the%20routine%20data%3B%20123%20%2841%25%29%20were%20false%20gaps%20and%20179%20%2859%25%29%20were%20considered%20probable%20gaps%20%28133%20mother-infant%20pairs%29.%20Overall%2C%2054%20mothers%20%2816%25%29%20did%20not%20link%20to%20HIV%20care%20within%2012%20weeks%20of%20delivery%2C%2043%20mothers%20%2813%25%29%20linked%20to%20care%20but%20had%20a%20gap%20in%20ART%20dispensing%20by%20nine%20months%20postpartum%2C%2025%20infants%20%2810%25%29%20did%20not%20have%20an%20HIV%20test%20around%2010%20weeks%20and%2057%20%2817%25%29%20had%20no%20HIV%20test%20around%206%20months%20of%20age.%20Only%20100%20of%20the%20probable%20gaps%20%2856%25%29%20could%20be%20confirmed%20through%20telephonic%20tracing%20and%2C%20of%20those%2C%20only%2047%20were%20successfully%20re-linked%20to%20care.%20Mobility%20and%20clinic%20transfer%2C%20fear%20of%20stigma%20and%20employment-related%20challenges%20were%20commonly%20reported%20reasons%20for%20gaps%20in%20VTP%20steps.%20This%20study%20highlights%20that%20linked%20routine%20data%20sources%20linking%20mother-infant%20pairs%20across%20health%20facilities%20has%20the%20potential%20to%20streamline%20tracing%20efforts%3B%20however%2C%20implementation%20is%20challenging%20and%2C%20even%20when%20gaps%20are%20identified%2C%20re-engagement%20in%20care%20may%20be%20difficult.%20Further%20research%20is%20needed%20to%20combine%20D2C%20strategies%20with%20interventions%20addressing%20broader%20social%20and%20structural%20determinants%20of%20health%2C%20and%20to%20tailor%20D2C%20strategies%20to%20fit%20available%20resources%20and%20data%20sources%20in%20low-resource%20settings.%22%2C%22date%22%3A%222024-12-13%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.21203%5C%2Frs.3.rs-5626699%5C%2Fv1%22%2C%22ISSN%22%3A%222693-5015%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A27%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22TSITSWJA%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brenner%20et%20al.%22%2C%22parsedDate%22%3A%222024-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrenner%2C%20Isaac%20Ravi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFlanagan%2C%20Clare%20F.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPenazzato%2C%20Martina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWebb%2C%20Karen%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHorsfall%2C%20Stephanie%20B.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Cost-effectiveness%20of%20viral%20load%20testing%20for%20transitioning%20antiretroviral%20therapy-experienced%20children%20to%20dolutegravir%20in%20South%20Africa%3A%20a%20modelling%20analysis.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%20e2068%26%23x2013%3Be2079.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2214-109X%2824%2900381-4%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2214-109X%2824%2900381-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cost-effectiveness%20of%20viral%20load%20testing%20for%20transitioning%20antiretroviral%20therapy-experienced%20children%20to%20dolutegravir%20in%20South%20Africa%3A%20a%20modelling%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isaac%20Ravi%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clare%20F.%22%2C%22lastName%22%3A%22Flanagan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martina%22%2C%22lastName%22%3A%22Penazzato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%20A.%22%2C%22lastName%22%3A%22Webb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20B.%22%2C%22lastName%22%3A%22Horsfall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%20P.%22%2C%22lastName%22%3A%22Hyle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elaine%22%2C%22lastName%22%3A%22Abrams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%22%2C%22lastName%22%3A%22Bacha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20M.%22%2C%22lastName%22%3A%22Neilan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Intira%20Jeannie%22%2C%22lastName%22%3A%22Collins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Desmonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Siobhan%22%2C%22lastName%22%3A%22Crichton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20A.%22%2C%22lastName%22%3A%22Freedberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%20L.%22%2C%22lastName%22%3A%22Ciaranello%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20For%20children%20with%20HIV%20on%20antiretroviral%20therapy%20%28ART%29%2C%20transitioning%20to%20dolutegravir-containing%20regimens%20is%20recommended.%20The%20aim%20of%20this%20study%20was%20to%20assess%20whether%20introducing%20viral%20load%20testing%20to%20inform%20new%20nucleoside%20or%20nucleotide%20reverse%20transcriptase%20inhibitors%20%28NRTIs%29%20for%20children%20with%20HIV%20and%20viraemia%20alongside%20dolutegravir-based%20ART%20is%20beneficial%20and%20of%20good%20economic%20value.%5CnMETHODS%3A%20We%20used%20the%20Cost-Effectiveness%20of%20Preventing%20AIDS%20Complications-Pediatric%20model%20to%20project%20clinical%20and%20cost%20implications%20of%20three%20strategies%20among%20a%20simulated%20cohort%20of%20South%20African%20children%20aged%208%20years%20with%20HIV%20receiving%20abacavir-lamivudine-efavirenz%3A%20%281%29%20continue%20current%20ART%20%28no%20dolutegravir%3B%20abacavir-lamivudine-efavirenz%29%3B%20%282%29%20transition%20all%20children%20with%20HIV%20to%20dolutegravir%2C%20keeping%20current%20NRTIs%20%28dolutegravir%3B%20abacavir-lamivudine-dolutegravir%29%3B%20or%20%283%29%20transition%20to%20dolutegravir%20based%20on%20viral%20load%20testing%20%28viral%20load%20plus%20dolutegravir%29%2C%20keeping%20current%20NRTIs%20if%20virologically%20suppressed%20%28abacavir-lamivudine-dolutegravir%2C%2070%25%20of%20cohort%29%20or%20switching%20abacavir%20to%20zidovudine%20%28zidovudine%29%20if%20viraemic%20%28zidovudine-lamivudine-dolutegravir%2C%2030%25%29.%20We%20assumed%2050%25%20of%20children%20who%20had%20viraemia%20after%20abacavir-lamivudine%20exposure%20had%20NRTI%20resistance%3B%20with%20resistance%2C%20we%20assumed%20zidovudine-lamivudine-dolutegravir%20was%20more%20effective%20than%20abacavir-lamivudine-dolutegravir.%20We%20designated%20a%20strategy%20as%20preferred%20if%20it%20was%20most%20effective%20and%20least%20costly%20or%20had%20an%20incremental%20cost-effectiveness%20ratio%20less%20than%20half%20the%20South%20African%202020%20gross%20domestic%20product%20per%20capita.%5CnFINDINGS%3A%20Under%20base-case%20assumptions%2C%20the%20viral%20load%20plus%20dolutegravir%20strategy%20would%20be%20the%20most%20effective%20%28projected%20undiscounted%20life%20expectancy%20of%2039%5Cu00b772%20life-years%29%20and%20least%20costly%20strategy%20%28US%2424%5Cu2009600%20per%20person%29%3B%20the%20no%20dolutegravir%20strategy%20was%20the%20least%20effective%20%2834%5Cu00b749%20life-years%29%20and%20most%20expensive%20%28%2426%5Cu2009480%20per%20person%29.%20In%20sensitivity%20analyses%2C%20the%2024-week%20virological%20suppression%20probability%20and%20subsequent%20monthly%20virological%20failure%20risks%20%28ie%2C%20late%20failure%29%20were%20most%20influential%20on%20cost-effectiveness.%20Only%20with%20a%20high%20late-failure%20risk%20for%20zidovudine-lamivudine-dolutegravir%20%28ie%2C%20%5Cu22650%5Cu00b73%25%20per%20month%20in%20the%20base%20case%20or%20%26gt%3B0%5Cu00b75%25%20per%20month%20if%20abacavir%20also%20confers%20low%20virological%20suppression%20probability%20in%20the%20presence%20of%20NRTI%20resistance%20%5B65%25%5D%29%20would%20the%20dolutegravir%20strategy%20become%20preferred%20above%20the%20viral%20load%20plus%20dolutegravir%20strategy.%5CnINTERPRETATION%3A%20For%20programmes%20transitioning%20to%20dolutegravir-based%20regimens%2C%20our%20model%20predicted%20that%20doing%20so%20would%20be%20more%20effective%20and%20less%20costly%20than%20continuing%20current%20ART%20regimens%2C%20regardless%20of%20NRTI%20choice.%20Whether%20viral%20load%20testing%20for%20children%20with%20HIV%20is%20necessary%20to%20inform%20NRTI%20choice%20depends%20substantially%20on%20the%20comparative%20outcomes%20of%20abacavir%20and%20zidovudine%20after%20switching%20to%20dolutegravir-containing%20ART.%5CnFUNDING%3A%20The%20Eunice%20Kennedy%20Shriver%20Institute%20for%20Child%20Health%20and%20Human%20Development%2C%20the%20National%20Institute%20of%20Allergy%20and%20Infectious%20Diseases%2C%20the%20Massachusetts%20General%20Hospital%20Executive%20Committee%20on%20Research%2C%20the%20Massachusetts%20General%20Hospital%2C%20and%20the%20Medical%20Research%20Council.%22%2C%22date%22%3A%222024-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2FS2214-109X%2824%2900381-4%22%2C%22ISSN%22%3A%222214-109X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-10T15%3A49%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22P4JBXGFH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Musonda%20et%20al.%22%2C%22parsedDate%22%3A%222024-11-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusonda%2C%20Taonga%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWallace%2C%20Michael%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatel%2C%20Hailey%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMartin%2C%20Owen%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOetheimer%2C%20Christopher%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20New%20Window%20Into%20Hepatitis%20B%20in%20Africa%3A%20Liver%20Sampling%20Combined%20With%20Single-Cell%20Omics%20Enables%20Deep%20and%20Longitudinal%20Assessment%20of%20Intrahepatic%20Immunity%20in%20Zambia.%20%26lt%3Bi%26gt%3BThe%20Journal%20of%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B230%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20e1171%26%23x2013%3Be1175.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiae054%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiae054%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22New%20Window%20Into%20Hepatitis%20B%20in%20Africa%3A%20Liver%20Sampling%20Combined%20With%20Single-Cell%20Omics%20Enables%20Deep%20and%20Longitudinal%20Assessment%20of%20Intrahepatic%20Immunity%20in%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taonga%22%2C%22lastName%22%3A%22Musonda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20S.%22%2C%22lastName%22%3A%22Wallace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hailey%22%2C%22lastName%22%3A%22Patel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Owen%20P.%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Oetheimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simutanyi%22%2C%22lastName%22%3A%22Mwakamui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edford%22%2C%22lastName%22%3A%22Sinkala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bright%22%2C%22lastName%22%3A%22Nsokolo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annie%22%2C%22lastName%22%3A%22Kanunga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georg%22%2C%22lastName%22%3A%22Lauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%20T.%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debika%22%2C%22lastName%22%3A%22Bhattacharya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Kelly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Alatrakchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Vinikoor%22%7D%5D%2C%22abstractNote%22%3A%22In%20Lusaka%2C%20Zambia%2C%20we%20introduced%20liver%20fine-needle%20aspiration%20biopsy%20%28FNAB%29%20into%20a%20research%20cohort%20of%20adults%20with%20treatment-naive%20chronic%20hepatitis%20B%20virus%20%28HBV%29%20infection%2C%20with%20and%20without%20human%20immunodeficiency%20virus%20%28HIV%29%20coinfection%2C%20as%20well%20as%20with%20acute%20HBV%20infection.%20From%20117%20enrollment%20and%2047%20longitudinal%20FNABs%20%28at%201-year%20follow-up%29%2C%20we%20established%20participant%20acceptability%20and%20safety.%20We%20also%20demonstrated%20the%20quality%20of%20the%20material%20through%20single-cell%20RNA%20sequencing%20of%20selected%20enrollment%20FNAs%2C%20which%20revealed%20a%20range%20of%20immune%20cells.%20This%20approach%20can%20drive%20new%20insights%20into%20HBV%20immunology%2C%20informing%20cure%20strategies%2C%20and%20can%20improve%20our%20understanding%20of%20HBV%20natural%20history%20in%20Africa.%22%2C%22date%22%3A%222024-11-15%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Finfdis%5C%2Fjiae054%22%2C%22ISSN%22%3A%221537-6613%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A16%3A13Z%22%7D%7D%2C%7B%22key%22%3A%227GP8K3Y5%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Waal%20et%20al.%22%2C%22parsedDate%22%3A%222024-11-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Waal%2C%20Rene%26%23xE9%3B%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWools-Kaloustian%2C%20Kara%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAlthoff%2C%20Keri%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJaquet%2C%20Antoine%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Global%20trends%20in%20CD4%20count%20measurement%20and%20distribution%20at%20first%20antiretroviral%20treatment%20initiation.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20ciae548.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae548%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae548%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20trends%20in%20CD4%20count%20measurement%20and%20distribution%20at%20first%20antiretroviral%20treatment%20initiation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rene%5Cu00e9%22%2C%22lastName%22%3A%22de%20Waal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nagalingeswaran%22%2C%22lastName%22%3A%22Kumarasamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodora%22%2C%22lastName%22%3A%22Savory%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22Byakwaga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%22%2C%22lastName%22%3A%22Justice%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%20K.%22%2C%22lastName%22%3A%22Ekouevi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Cesar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20K.%20U.%22%2C%22lastName%22%3A%22Pasayan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agness%22%2C%22lastName%22%3A%22Thawani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pelagie%22%2C%22lastName%22%3A%22Babakazo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maile%22%2C%22lastName%22%3A%22Karris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%22%2C%22lastName%22%3A%22Messou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%20P.%22%2C%22lastName%22%3A%22Cortes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%20Yong%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noela%20C.%22%2C%22lastName%22%3A%22Owarwo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annabelle%22%2C%22lastName%22%3A%22Niyongabo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%20C.%22%2C%22lastName%22%3A%22Marconi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%20L.%22%2C%22lastName%22%3A%22Castilho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathy%22%2C%22lastName%22%3A%22Petoumenos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20While%20people%20with%20HIV%20%28PWH%29%20start%20antiretroviral%20treatment%20%28ART%29%20regardless%20of%20CD4%20count%2C%20CD4%20measurement%20remains%20crucial%20for%20detecting%20advanced%20HIV%20disease%20and%20evaluating%20ART%20programmes.%20We%20explored%20CD4%20measurement%20%28proportion%20of%20PWH%20with%20a%20CD4%20result%20available%29%20and%20prevalence%20of%20CD4%20%26lt%3B200%20cells%5C%2F%5Cu00b5L%20at%20ART%20initiation%20within%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20global%20collaboration.%5CnMETHODS%3A%20We%20included%20PWH%20at%20participating%20ART%20programmes%20who%20first%20initiated%20ART%20at%20age%2015-80%20years%20during%202005-2019.%20We%20described%20proportions%20of%20PWH%20%28i%29%20with%20CD4%20%28measured%20within%206%20months%20before%20to%202%20weeks%20after%20ART%20initiation%29%3B%20and%20%28ii%29%20among%20those%20with%20a%20CD4%2C%20with%20CD4%20%26lt%3B200%3B%20by%20year%20of%20ART%20initiation%20and%20region.%5CnRESULTS%3A%20We%20included%201%2C355%2C104%20PWH%20from%2042%20countries%20in%207%20regions%3B%2063%25%20were%20female.%20Median%20%28interquartile%20range%29%20age%20at%20ART%20initiation%20was%2037%20%2831-44%29%20in%20men%20and%2032%20%2826-39%29%20in%20women.%20CD4%20measurement%20initially%20increased%2C%20or%20remained%20stable%20over%20time%20until%20around%202013%2C%20but%20then%20declined%20to%20low%20levels%20in%20some%20regions%20%28Southern%20Africa%2C%20except%20South%20Africa%3A%20from%2054%20to%2013%25%3B%20East%20Africa%2085%20to%2031%25%3B%20Central%20Africa%2072%20to%2020%25%3B%20West%20Africa%3A%2091%20to%2053%25%3B%20and%20Latin%20America%3A%2087%20to%2056%25%29.%20Prevalence%20of%20CD4%26lt%3B200%20declined%20over%20time%20in%20all%20regions%2C%20but%20plateaued%20after%202015%20at%20%5Cu226530%25.%5CnCONCLUSIONS%3A%20CD4%20measurement%20has%20declined%20sharply%20in%20recent%20years%2C%20especially%20in%20sub-Saharan%20Africa.%20Among%20those%20with%20a%20CD4%2C%20the%20prevalence%20of%20CD4%20%26lt%3B200%20remains%20concerningly%20high.%20Scaling%20up%20CD4%20testing%20and%20securing%20adequate%20funding%20are%20urgent%20priorities.%22%2C%22date%22%3A%222024-11-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciae548%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-04-14T13%3A33%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22TKZ5KNTG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Yotebieng%20et%20al.%22%2C%22parsedDate%22%3A%222024-10-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYotebieng%2C%20Marcel%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZotova%2C%20Natalia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBernard%2C%20Charlotte%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGoodrich%2C%20Suzanne%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAwoh%2C%20Ajeh%20Rogers%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Accuracy%20of%20nine-item%20Patient%20Health%20Questionnaire%20against%20psychiatric%20diagnosis%20for%20depression%20among%20people%20with%20HIV.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%201765%26%23x2013%3B1773.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003963%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003963%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Accuracy%20of%20nine-item%20Patient%20Health%20Questionnaire%20against%20psychiatric%20diagnosis%20for%20depression%20among%20people%20with%20HIV%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Zotova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%22%2C%22lastName%22%3A%22Goodrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajeh%20Rogers%22%2C%22lastName%22%3A%22Awoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dana%22%2C%22lastName%22%3A%22Watnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambu%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%20Flore%20Tchiengang%22%2C%22lastName%22%3A%22Moungang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%20Laure%20Nguemo%22%2C%22lastName%22%3A%22Noumedem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%20Calvin%20Nko%27o%22%2C%22lastName%22%3A%22Mbongo%27o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moussa%22%2C%22lastName%22%3A%22Seydi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Gandou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%20Kamaru%22%2C%22lastName%22%3A%22Kwobah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukoye%22%2C%22lastName%22%3A%22Atwoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Consortium%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20The%20aim%20of%20this%20study%20was%20to%20assess%20the%20performance%20of%20the%20nine-item%20Patient%20Health%20Questionnaire%20%28PHQ-9%29%20against%20psychiatrist%20diagnosis%20in%20people%20with%20HIV%20%28PWH%29.%5CnDESIGN%3A%20Cross-sectional%20analysis%20of%20data%20collected%20between%20January%202018%20and%20July%202022%20across%20five%20sites%20in%20Cameroon%2C%20Cote%20d%26%23039%3BIvoire%2C%20Kenya%2C%20Senegal%2C%20and%20the%20Republic%20of%20Congo.%20Participants%20were%20%5Cu226518%5Cu200ayears%20and%20receiving%20HIV%20care%20at%20the%20participating%20site.%20PHQ-9%20was%20administered%20by%20study%20staff%20followed%20by%20a%20psychiatrist%26%23039%3Bs%20evaluation%20within%203%5Cu200adays.%5CnRESULTS%3A%20Overall%2C%20778%20participants%20with%20complete%20data%20were%20included%3A%20297%20%2838.2%25%29%20in%20Cameroon%2C%20132%20%2817.0%25%29%20in%20Congo%2C%20148%20%2819.0%25%29%20in%20Cote%20d%26%23039%3BIvoire%2C%2098%20%2812.6%25%29%20in%20Kenya%2C%20and%20103%20%2813.2%25%29%20in%20Senegal.%20The%20area%20under%20the%20curve%20for%20PHQ-9%20score%20was%20generally%20high%20ranging%20from%200.935%20%5B95%25%20confidence%20interval%20%28CI%29%3A%200.893%2C%200.977%5D%20in%20Cote%20d%26%23039%3BIvoire%20to%200.768%20%2895%25%20CI%3A%200.589%2C%200.947%29%20in%20Congo.%20However%2C%20for%20the%20common%20cut-off%20score%20%5Cu226510%2C%20sensitivity%20was%20low%3A%2050%25%20or%20lower%20in%20Cameroon%2C%20Congo%20and%20Senegal%2C%2066.7%25%20in%20Kenya%20and%2070.6%25%20in%20Cote%20d%26%23039%3BIvoire.%20But%20negative%20predictive%20values%20%28NPV%29%20were%20high%3A%2098.9%25%20%2895%25%20CI%3A%2096.9%25%2C%2099.8%25%29%20in%20Cameroon%2C%2096.1%20%2895%25%20CI%3A%2091.1%2C%2098.7%29%20in%20Cote%20d%26%23039%3BIvoire%2C%2096.3%25%20%2895%25%20CI%3A%2089.7%25%2C%2099.2%25%29%20in%20Kenya%2C%2095.7%25%20%2895%25%20CI%3A%2090.2%25%2C%2098.6%25%29%20in%20Congo%2C%20and%2089.0%25%20%2895%25%20CI%3A%2081.2%25%2C%2094.4%25%29%20in%20Senegal.%5CnINTERPRETATION%3A%20Across%20all%20countries%2C%20PHQ-9%20score%20%5Cu226510%20performed%20very%20poorly%20%28low%20sensitivity%29%20as%20a%20tool%20to%20identify%20psychiatrist%20diagnosed%20depression.%20However%2C%20the%20observed%20high%20NPV%20suggests%20it%20can%20be%20used%20to%20rule%20out%20depression.%22%2C%22date%22%3A%222024-10-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003963%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A14%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22B454NC8K%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222024-10-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bvan%20Zyl%2C%20Gert%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHsiao%2C%20Nei-Yuan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BClaassen%2C%20Mathilda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMudaly%2C%20Vanessa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20HIV%20Drug%20Resistance%20in%20Newly%20Diagnosed%20Young%20Children%20in%20the%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BThe%20Pediatric%20Infectious%20Disease%20Journal%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B43%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%20970%26%23x2013%3B976.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004482%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004482%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV%20Drug%20Resistance%20in%20Newly%20Diagnosed%20Young%20Children%20in%20the%20Western%20Cape%2C%20South%20Africa.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gert%22%2C%22lastName%22%3A%22van%20Zyl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nei-Yuan%22%2C%22lastName%22%3A%22Hsiao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilda%22%2C%22lastName%22%3A%22Claassen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Voget%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gayathri%22%2C%22lastName%22%3A%22Sridhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Ragone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vani%22%2C%22lastName%22%3A%22Vannappagari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Pretreatment%20of%20HIV%20drug%20resistance%20among%20children%20living%20with%20HIV%20%28CLHIV%29%20can%20compromise%20antiretroviral%20therapy%20%28ART%29%20effectiveness.%20Resistance%20may%20be%20transmitted%20directly%20from%20mothers%20or%20acquired%20following%20exposure%20to%20antiretrovirals%20consumed%20through%20breastfeeding%20or%20administered%20as%20prophylaxis.%20METHODS%3A%20We%20performed%20resistance%20testing%20in%20children%20aged%20%26lt%3B3%20years%2C%20newly%20diagnosed%20with%20HIV%20in%20Western%20Cape%2C%20South%20Africa%20%282021-2022%29%2C%20who%20either%20%281%29%20acquired%20HIV%20via%20possible%20breastfeeding%20transmission%20from%20mothers%20who%20received%20ART%20%28any%20regimen%29%20during%20pregnancy%5C%2Fpostpartum%20and%5C%2For%20%282%29%20were%20exposed%20to%20protease%20inhibitors%20or%20integrase%20strand%20transfer%20inhibitors%20%28INSTIs%29%20in%20utero.%20Possible%20breastfeeding%20transmission%20was%20defined%20as%20testing%20HIV-polymerase%20chain%20reaction%20positive%20at%20age%20%26gt%3B28%20days%2C%20after%20previously%20testing%20negative.%20We%20used%20surveillance%20drug-resistance%20mutation%20lists%20to%20define%20mutations.%20RESULTS%3A%20We%20included%20135%20CLHIV.%20Most%20mothers%20started%20ART%20prepregnancy%20%2873%25%29.%20Overall%2C%2057%25%20%2877%5C%2F135%29%20of%20children%20had%20resistance%20mutations%20detected.%20Nonnucleoside%20reverse%20transcriptase%20inhibitor-%20associated%2C%20nucleoside%20reverse%20transcriptase%20inhibitor-associated%2C%20protease%20inhibitor-associated%20and%20INSTI-associated%20mutations%20were%20found%20in%2055%25%20%2874%5C%2F135%29%2C%2010%25%20%2813%5C%2F135%29%2C%20%26lt%3B1%25%20%281%5C%2F135%29%20and%20%26lt%3B1%25%20%281%5C%2F122%29%20of%20children%20tested%2C%20respectively.%20One%20child%20with%20breastfeeding%20transmission%20had%20high-%20level%20INSTI%20resistance%20detected%20at%20HIV%20diagnosis%2C%20aged%2018%20months%20%28E138K%20and%20G118R%20mutations%29.%20CONCLUSIONS%3A%20Although%20not%20clinically%20relevant%2C%20nonnucleoside%20reverse%20transcriptase%20inhibitor-associated%20mutations%20were%20common.%20Dolutegravir%20is%20currently%20the%20preferred%20first-line%20treatment%20for%20adults%20and%20CLHIV%20age%20%26gt%3B%5C%2F%3D4%20weeks%2C%20and%20although%20very%20low%20INSTI%20resistance%20levels%20have%20been%20observed%20in%20adults%2C%20limited%20data%20exist%20on%20genotyping%20the%20integrase%20region%20in%20children.%20Pretreatment%20INSTI%20resistance%20in%20children%20is%20likely%20to%20be%20unusual%2C%20but%20future%20surveillance%2C%20including%20longitudinal%20studies%20with%20paired%20mother-child%20resistance%20testing%2C%20is%20needed.%22%2C%22date%22%3A%222024%20Oct%201%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FINF.0000000000004482%22%2C%22ISSN%22%3A%221532-0987%200891-3668%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%224HQSQPK4%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Parcesepe%20et%20al.%22%2C%22parsedDate%22%3A%222024-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BParcesepe%2C%20Angela%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStockton%2C%20Melissa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBernard%2C%20Charlotte%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKanguya%2C%20Tukiya%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKwobah%2C%20Edith%20Kamaru%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Prevalence%20and%20co-occurrence%20of%20symptoms%20of%20mental%20and%20substance%20use%20disorders%20among%20people%20with%20HIV%20age%2040%20and%20older%20in%20low-%20and%20middle-income%20countries%3A%20a%20cross-sectional%20study.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%20e26359.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26359%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26359%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prevalence%20and%20co-occurrence%20of%20symptoms%20of%20mental%20and%20substance%20use%20disorders%20among%20people%20with%20HIV%20age%2040%20and%20older%20in%20low-%20and%20middle-income%20countries%3A%20a%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Stockton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tukiya%22%2C%22lastName%22%3A%22Kanguya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%20Kamaru%22%2C%22lastName%22%3A%22Kwobah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alvaro%22%2C%22lastName%22%3A%22Lopez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%22%2C%22lastName%22%3A%22Goodrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Perazzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Musabyimana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Smita%22%2C%22lastName%22%3A%22Nimkar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22IeDEA%22%2C%22lastName%22%3A%22Consortium%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Due%20to%20the%20increased%20effectiveness%20of%20and%20access%20to%20antiretroviral%20therapy%20%28ART%29%2C%20people%20with%20HIV%20%28PWH%29%20are%20living%20longer.%20As%20a%20result%2C%20the%20population%20of%20older%20PWH%20has%20increased.%20Mental%20and%20substance%20use%20disorders%20%28MSDs%29%20are%20common%20and%20frequently%20co-occurring%20among%20PWH%20and%20are%20associated%20with%20poor%20HIV%20care%20outcomes.%20Research%20into%20the%20prevalence%20and%20co-occurrence%20of%20MSDs%20among%20ageing%20PWH%20remains%20limited%2C%20particularly%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29.%5CnMETHODS%3A%20We%20analysed%20data%20collected%20between%202020%20and%202022%20from%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Sentinel%20Research%20Network%20cohort%20of%20PWH%20aged%2040%20years%20or%20older%20on%20ART%20at%2011%20HIV%20clinics%20in%20Brazil%2C%20C%5Cu00f4te%20d%26%23039%3BIvoire%2C%20India%2C%20Kenya%2C%20Mexico%2C%20Uganda%2C%20Rwanda%2C%20Togo%2C%20Vietnam%2C%20Zambia%20and%20Zimbabwe.%20We%20estimated%20the%20prevalence%20and%20co-occurrence%20of%20unhealthy%20alcohol%20use%20%28AUDIT-C%20%5Cu22653%20for%20women%2C%20%5Cu22654%20for%20men%29%2C%20unhealthy%20drug%20use%20%28ASSIST%20%26gt%3B3%20for%20cannabis%2C%20cocaine%2C%20amphetamines%2C%20inhalants%2C%20sedatives%2C%20hallucinogens%20and%5C%2For%20opioids%29%2C%20and%20moderate%20to%20severe%20symptoms%20of%20depression%20%28PHQ-9%20%5Cu226510%29%2C%20anxiety%20%28GAD-7%20%5Cu226510%29%20and%20post-traumatic%20stress%20disorder%20%28PTSD%29%20%28PCL-5%20%5Cu226533%29.%20Psychiatric%20multimorbidity%20was%20defined%20as%20having%20symptoms%20of%20two%20or%20more%20disorders%20assessed.%20Log%20binomial%20models%20assessed%20the%20association%20between%20socio-demographic%20and%20HIV%20care%20characteristics%20and%20symptoms%20of%20anxiety%2C%20depression%2C%20PTSD%20or%20unhealthy%20substance%20use.%5CnRESULTS%3A%20Of%202821%20participants%2C%20the%20prevalence%20of%20unhealthy%20alcohol%20and%20drug%20use%20was%2021%25%20and%205%25%2C%20respectively.%20The%20prevalence%20of%20moderate%20to%20severe%20symptoms%20of%20depression%2C%20anxiety%20and%20PTSD%20was%2014%25%2C%209%25%20and%206%25%2C%20respectively.%20Overall%2C%20the%20prevalence%20of%20psychiatric%20multimorbidity%20was%2011%25.%20Among%20those%20with%20symptoms%20of%20at%20least%20one%20mental%20health%20or%20substance%20use%20outcome%20assessed%20%28n%20%3D%201036%29%2C%20the%20prevalence%20of%20psychiatric%20multimorbidity%20was%2031%25.%20In%20binomial%20models%2C%20the%20prevalence%20of%20symptoms%20of%20depression%20and%20anxiety%20was%20higher%2C%20while%20the%20prevalence%20of%20unhealthy%20alcohol%20and%20drug%20use%20was%20lower%20among%20women%20than%20men.%5CnCONCLUSIONS%3A%20Unhealthy%20alcohol%20use%20and%20symptoms%20of%20depression%20were%20most%20commonly%20reported%2C%20among%20this%20cohort%20of%20PWH%20aged%2040%20or%20older%20across%2011%20LMICs.%20Integration%20of%20MSD%20screening%20and%20treatment%20into%20HIV%20care%20should%20be%20prioritized.%20The%20effectiveness%20and%20implementation%20of%20transdiagnostic%20or%20multi-focus%20mental%20health%20treatment%20approaches%20in%20HIV%20care%20settings%20should%20be%20examined.%22%2C%22date%22%3A%222024-10%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26359%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-10T15%3A35%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22HR94XNMG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schwab%20et%20al.%22%2C%22parsedDate%22%3A%222024-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchwab%2C%20Tiana%20Carina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPerrig%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGoller%2C%20Pauline%20Carlotta%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGuebely%20De%20la%20Hoz%2C%20Freddy%20Fernando%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLahousse%2C%20Adrien%20Philippe%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Targeted%20next-generation%20sequencing%20to%20diagnose%20drug-resistant%20tuberculosis%3A%20a%20systematic%20review%20and%20meta-analysis.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B24%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%201162%26%23x2013%3B1176.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2824%2900263-9%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2824%2900263-9%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Targeted%20next-generation%20sequencing%20to%20diagnose%20drug-resistant%20tuberculosis%3A%20a%20systematic%20review%20and%20meta-analysis.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiana%20Carina%22%2C%22lastName%22%3A%22Schwab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Perrig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pauline%20Carlotta%22%2C%22lastName%22%3A%22Goller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Freddy%20Fernando%22%2C%22lastName%22%3A%22Guebely%20De%20la%20Hoz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrien%20Philippe%22%2C%22lastName%22%3A%22Lahousse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatrice%22%2C%22lastName%22%3A%22Minder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22Gunther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Orestis%22%2C%22lastName%22%3A%22Efthimiou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaheed%20Vally%22%2C%22lastName%22%3A%22Omar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Targeted%20next-generation%20sequencing%20%28NGS%29%20can%20rapidly%20and%20simultaneously%20detect%20mutations%20associated%20with%20resistance%20to%20tuberculosis%20drugs%20across%20multiple%20gene%20targets.%20The%20use%20of%20targeted%20NGS%20to%20diagnose%20drug-resistant%20tuberculosis%2C%20as%20described%20in%20publicly%20available%20data%2C%20has%20not%20been%20comprehensively%20reviewed.%20We%20aimed%20to%20identify%20targeted%20NGS%20assays%20that%20diagnose%20drug-resistant%20tuberculosis%2C%20determine%20how%20widely%20this%20technology%20has%20been%20used%2C%20and%20assess%20the%20diagnostic%20accuracy%20of%20these%20assays.%20METHODS%3A%20In%20this%20systematic%20review%20and%20meta-analysis%2C%20we%20searched%20MEDLINE%2C%20Embase%2C%20Cochrane%20Library%2C%20Web%20of%20Science%20Core%20Collection%2C%20Global%20Index%20Medicus%2C%20Google%20Scholar%2C%20ClinicalTrials.gov%2C%20and%20the%20WHO%20International%20Clinical%20Trials%20Registry%20Platform%20for%20published%20and%20unpublished%20reports%20on%20targeted%20NGS%20for%20drug-%20resistant%20tuberculosis%20from%20Jan%201%2C%202005%2C%20to%20Oct%2014%2C%202022%2C%20with%20updates%20to%20our%20search%20in%20Embase%20and%20Google%20Scholar%20until%20Feb%2013%2C%202024.%20Studies%20eligible%20for%20the%20systematic%20review%20described%20targeted%20NGS%20approaches%20to%20predict%20drug%20resistance%20in%20Mycobacterium%20tuberculosis%20infections%20using%20primary%20samples%2C%20reference%20strain%20collections%2C%20or%20cultured%20isolates%20from%20individuals%20with%20presumed%20or%20confirmed%20tuberculosis.%20Our%20search%20had%20no%20limitations%20on%20study%20type%20or%20language%2C%20although%20only%20reports%20in%20English%2C%20German%2C%20and%20French%20were%20screened%20for%20eligibility.%20For%20the%20meta-analysis%2C%20we%20included%20test%20accuracy%20studies%20that%20used%20any%20reference%20standard%2C%20and%20we%20assessed%20risk%20of%20bias%20using%20the%20Quality%20Assessment%20of%20Diagnostic%20Accuracy%20Studies-2%20tool.%20The%20primary%20outcomes%20for%20the%20meta-analysis%20were%20sensitivity%20and%20specificity%20of%20targeted%20NGS%20to%20diagnose%20drug-resistant%20tuberculosis%20compared%20to%20phenotypic%20and%20genotypic%20drug%20susceptibility%20testing.%20We%20used%20a%20Bayesian%20bivariate%20model%20to%20generate%20summary%20receiver%20operating%20characteristic%20plots%20and%20diagnostic%20accuracy%20measures%2C%20overall%20and%20stratified%20by%20drug%20and%20sample%20type.%20This%20study%20is%20registered%20with%20PROSPERO%2C%20CRD42022368707.%20FINDINGS%3A%20We%20identified%20and%20screened%202920%20reports%2C%20of%20which%20124%20were%20eligible%20for%20our%20systematic%20review%2C%20including%2037%20review%20articles%20and%2087%20reports%20of%20studies%20collecting%20samples%20for%20targeted%20NGS.%20Sequencing%20was%20mainly%20done%20in%20the%20USA%20%2814%20%5B16%25%5D%20of%2087%29%2C%20western%20Europe%20%28ten%20%5B11%25%5D%29%2C%20India%20%28ten%20%5B11%25%5D%29%2C%20and%20China%20%28nine%20%5B10%25%5D%29.%20We%20included%2024%20test%20accuracy%20studies%20in%20the%20meta-analysis%2C%20in%20which%2023%20different%20tuberculosis%20drugs%20or%20drug%20groups%20were%20assessed%2C%20covering%20first-line%20drugs%2C%20injectable%20drugs%2C%20and%20fluoroquinolones%20and%20predominantly%20comparing%20targeted%20NGS%20with%20phenotypic%20drug%20susceptibility%20testing.%20The%20combined%20sensitivity%20of%20targeted%20NGS%20across%20all%20drugs%20was%2094.1%25%20%2895%25%20credible%20interval%20%5BCrI%5D%2090.9-96.3%29%20and%20specificity%20was%2098.1%25%20%2897.0-98.9%29.%20Sensitivity%20for%20individual%20drugs%20ranged%20from%2076.5%25%20%2852.5-92.3%29%20for%20capreomycin%20to%2099.1%25%20%2898.3-99.7%29%20for%20rifampicin%3B%20specificity%20ranged%20from%2093.1%25%20%2888.0-96.3%29%20for%20ethambutol%20to%2099.4%25%20%2898.3-99.8%29%20for%20amikacin.%20Diagnostic%20accuracy%20was%20similar%20for%20primary%20clinical%20samples%20and%20culture%20isolates%20overall%20and%20for%20rifampicin%2C%20isoniazid%2C%20ethambutol%2C%20streptomycin%2C%20and%20fluoroquinolones%2C%20and%20similar%20after%20excluding%20studies%20at%20high%20risk%20of%20bias%20%28overall%20sensitivity%2095.2%25%20%5B95%25%20CrI%2091.7-97.1%5D%20and%20specificity%2098.6%25%20%5B97.4-99.3%5D%29.%20INTERPRETATION%3A%20Targeted%20NGS%20is%20highly%20sensitive%20and%20specific%20for%20detecting%20drug%20resistance%20across%20panels%20of%20tuberculosis%20drugs%20and%20can%20be%20performed%20directly%20on%20clinical%20samples.%20There%20is%20a%20paucity%20of%20data%20on%20performance%20for%20some%20currently%20recommended%20drugs.%20The%20barriers%20preventing%20the%20use%20of%20targeted%20NGS%20to%20diagnose%20drug-resistant%20tuberculosis%20in%20high-burden%20countries%20need%20to%20be%20addressed.%20FUNDING%3A%20National%20Institutes%20of%20Allergy%20and%20Infectious%20Diseases%20and%20Swiss%20National%20Science%20Foundation.%22%2C%22date%22%3A%222024%20Oct%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2FS1473-3099%2824%2900263-9%22%2C%22ISSN%22%3A%221474-4457%201473-3099%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22S5ZQS6AG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Technau%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-G%26%23xFC%3Bnter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaskew%2C%20Mhairi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNattey%2C%20Cornelius%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHwang%2C%20Candice%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bvan%20Dongen%2C%20Nicola%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Cohort%20profile%3A%20Rahima%20Moosa%20Mother%20and%20Child%20Hospital%20maternal%20HIV%20cohort%2C%20Johannesburg%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B14%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20e085082.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-085082%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-085082%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cohort%20profile%3A%20Rahima%20Moosa%20Mother%20and%20Child%20Hospital%20maternal%20HIV%20cohort%2C%20Johannesburg%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mhairi%22%2C%22lastName%22%3A%22Maskew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelius%22%2C%22lastName%22%3A%22Nattey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Candice%22%2C%22lastName%22%3A%22Hwang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thalia%22%2C%22lastName%22%3A%22Ferreira%20Brizido%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%22%2C%22lastName%22%3A%22Wise%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20The%20Rahima%20Moosa%20Mother%20and%20Child%20Hospital%20%28RMMCH%29%20maternal%20HIV%20cohort%20originated%20from%20data%20systems%20that%20were%20developed%20to%20support%20HIV-related%20birth%20care%20and%20track%20outcomes%20of%20a%20complete%20birth%20cohort%20of%20HIV-exposed%20infants%20at%20Rahima%20Moosa%20Hospital%20and%20their%20mothers%20living%20with%20HIV.%5CnPARTICIPANTS%3A%20Supported%20by%20the%20Empilweni%20Services%20and%20Research%20Unit%2C%20maternal%20and%20infant%20data%20from%2013%5Cu2009654%20pregnant%20women%20living%20with%20HIV%20who%20delivered%20their%20infants%20%28and%20a%20subset%20also%20attended%20antenatal%20care%29%20were%20collected%20at%20RMMCH%20in%20Johannesburg%2C%20South%20Africa%20since%202013.%20Maternal%20data%20were%20collected%20using%20counsellor-administered%20interviews%20and%20the%202013-2018%20subset%20of%20this%20cohort%20was%20linked%20to%20the%20National%20Health%20Laboratory%20Services%20%28NHLS%29%20national%20HIV%20cohort-a%20longitudinal%20cohort%20of%20people%20living%20with%20HIV%20accessing%20care%20in%20the%20public%20sector%20antiretroviral%20therapy%20programme%20in%20South%20Africa%20that%20can%20observe%20national%20access%20to%20HIV%20care%20through%20laboratory%20testing%20data.%5CnFINDINGS%20TO%20DATE%3A%20Topics%20addressed%20by%20the%20cohort%20include%20antenatal%20care%20history%2C%20HIV%20treatment%20exposure%2C%20delivery%5C%2Fbirth%20management%2C%20prophylaxis%20and%20maternal%20blood%20results%20relevant%20to%20HIV%20captured%20at%20delivery.%20The%20cohort%20was%20also%20one%20of%20the%20first%20to%20describe%20implementation%20of%20early%20infant%20diagnosis%20procedures%20in%20South%20Africa%20including%20evaluations%20of%20novel%20point-of-care%20testing%20strategies%20demonstrating%20improvements%20in%20uptake%20of%20HIV%20care%20among%20infants%20accessing%20point-of-care%20services.%5CnFUTURE%20PLANS%3A%20Annual%20linkage%20of%20infant%20delivery%20and%20testing%20data%20to%20longitudinal%20laboratory%20test%20data%20in%20the%20NHLS%20national%20HIV%20cohort%20is%20planned%20to%20allow%20for%20analysis%20of%20both%20infant%20continuity%20of%20care%20outcomes%20and%20as%20well%20as%20evaluation%20of%20maternal-infant%20pair%20treatment%20and%20mobility%20outcomes%20in%20the%20post%20partum%20and%20later%20period.%22%2C%22date%22%3A%222024-09-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2024-085082%22%2C%22ISSN%22%3A%222044-6055%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A14%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22CTS44ZKW%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kuniholm%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKuniholm%2C%20Mark%20H.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMurenzi%2C%20Gad%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShumbusho%2C%20Fabienne%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPlaisy%2C%20Marie%20K.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Association%20of%20cardiovascular%20disease%20risk%20with%20liver%20steatosis%20and%20fibrosis%20in%20people%20living%20with%20hiv%20in%20low-%20and%20middle-income%20countries.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004012%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004012%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20cardiovascular%20disease%20risk%20with%20liver%20steatosis%20and%20fibrosis%20in%20people%20living%20with%20hiv%20in%20low-%20and%20middle-income%20countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20H.%22%2C%22lastName%22%3A%22Kuniholm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabienne%22%2C%22lastName%22%3A%22Shumbusho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20K.%22%2C%22lastName%22%3A%22Plaisy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ephrem%22%2C%22lastName%22%3A%22Mensah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlotta%22%2C%22lastName%22%3A%22Riebensahm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%20V.%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niharika%22%2C%22lastName%22%3A%22Samala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aggrey%20S.%22%2C%22lastName%22%3A%22Semeere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thida%22%2C%22lastName%22%3A%22Chanyachukul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rohidas%22%2C%22lastName%22%3A%22Borse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dung%20T.%20H.%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Perazzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alvaro%22%2C%22lastName%22%3A%22Lopez-Iniguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%20L.%22%2C%22lastName%22%3A%22Castilho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20understand%20the%20relationship%20between%20cardiovascular%20disease%20%28CVD%29%20risk%20and%20liver%20steatosis%20and%20fibrosis%20among%20people%20living%20with%20HIV%20%28PLWH%29%20%5Cu226540%5Cu200ayears%20on%20antiretroviral%20therapy%20%28ART%29%20in%20low-%20and%20middle-income%20countries%20%28LMIC%29.%5CnDESIGN%3A%20We%20used%20cross-sectional%20behavioral%20and%20clinical%20data%20collected%20during%20study%20enrollment%20visits%20in%202020-2022%20for%20the%20Sentinel%20Research%20Network%20of%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28SRN%20of%20IeDEA%29.%5CnMETHODS%3A%20Ten-year%20CVD%20risk%20was%20calculated%20using%202019%20World%20Health%20Organization%20non-laboratory%20and%20laboratory%20models.%20Transient%20elastography%20%28TE%29%20was%20used%20to%20assess%20liver%20disease.%20Presence%20of%20steatosis%20and%20significant%20fibrosis%20were%20defined%20by%20Controlled%20Attenuation%20Parameter%20%28CAP%29%20%5Cu2265248%5Cu200adB%5C%2Fm%20and%20liver%20stiffness%20measurement%20%28LSM%29%20%5Cu22657.1%5Cu200akPa%2C%20respectively.%20Participants%20with%20viral%20hepatitis%2C%20hazardous%20alcohol%20consumption%20and%20unsuppressed%20HIV%20viral%20load%20were%20excluded%20from%20the%20analysis.%20Logistic%20regression%20was%20used%20to%20estimate%20odds%20ratios%2C%20adjusting%20for%20study%20site%2C%20CD4%5Cu200aT%20cell%20count%2C%20stavudine%20and%20didanosine%20exposure%2C%20and%20in%20models%20stratified%20by%20sex%20and%20geographic%20region.%5CnRESULTS%3A%20There%20were%201%2C750%20participants%20from%20nine%20LMIC.%20Median%20CVD%20risk%20was%203%25%20for%20both%20non-laboratory%20and%20laboratory-based%20models.%20Adjusted%20odds%20ratios%20%28ORs%29%20for%20steatosis%20and%20significant%20fibrosis%20associated%20with%20laboratory%20CVD%20risk%20%28%5Cu226510%25%20vs.%20%26lt%3B5%25%29%20were%20OR%5Cu200a%3D%5Cu200a1.83%20%2895%25%20confidence%20interval%3A%28CI%29%5Cu200a%3D%5Cu200a1.21-2.76%3B%20P%5Cu200a%3D%5Cu200a0.004%29%20and%20OR%5Cu200a%3D%5Cu200a1.62%20%2895%25%20CI%5Cu200a%3D%5Cu200a0.85-3.07%3B%20P%5Cu200a%3D%5Cu200a0.14%29%2C%20respectively.%20Associations%20of%20CVD%20risk%20with%20steatosis%20were%20stronger%20in%20males%20and%20among%20participants%20at%20study%20sites%20outside%20Africa.%5CnCONCLUSIONS%3A%20Higher%20CVD%20risk%20was%20associated%20with%20steatosis%20but%20not%20with%20significant%20fibrosis%20in%20PLWH%20in%20our%20LMIC%20cohort.%22%2C%22date%22%3A%222024-09-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000004012%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-07-15T14%3A52%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22DH7Q539B%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zaniewski%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZaniewski%2C%20Elizabeth%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSkrivankova%2C%20Veronika%20Whitesell%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAvihingsanon%2C%20Anchalee%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCardoso%2C%20Sandra%20Wagner%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Transition%20to%20dolutegravir-based%20ART%20in%2035%20low-%20and%20middle-income%20countries%3A%20a%20global%20survey%20of%20HIV%20care%20clinics.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004007%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004007%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Transition%20to%20dolutegravir-based%20ART%20in%2035%20low-%20and%20middle-income%20countries%3A%20a%20global%20survey%20of%20HIV%20care%20clinics%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Zaniewski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronika%20Whitesell%22%2C%22lastName%22%3A%22Skrivankova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anchalee%22%2C%22lastName%22%3A%22Avihingsanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%20Wagner%22%2C%22lastName%22%3A%22Cardoso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Cesar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henri%22%2C%22lastName%22%3A%22Chenal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brenda%20E.%22%2C%22lastName%22%3A%22Crabtree-Ram%5Cu00edrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rossana%20A.%22%2C%22lastName%22%3A%22Ditangco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20Vanes%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20George%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%20Madalitso%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%20Kouassi%22%2C%22lastName%22%3A%22Messou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%20Kla%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Muleebwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjay%22%2C%22lastName%22%3A%22Mundhe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winnie%20R.%22%2C%22lastName%22%3A%22Muyindike%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambou%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20M.%22%2C%22lastName%22%3A%22Obatsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20Walter%22%2C%22lastName%22%3A%22Prozesky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Supattra%22%2C%22lastName%22%3A%22Rungmaitree%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aggrey%20Semwendero%22%2C%22lastName%22%3A%22Semeere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moussa%22%2C%22lastName%22%3A%22Seydi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nosisa%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tavitiya%22%2C%22lastName%22%3A%22Sudjaritruk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Tiendrebeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christelle%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20We%20studied%20the%20transition%20to%20dolutegravir-containing%20antiretroviral%20therapy%20%28ART%29%20at%20HIV%20treatment%20clinics%20within%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29.%5CnDESIGN%3A%20Site-level%20survey%20conducted%20in%202020-2021%20among%20HIV%20clinics%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29.%5CnMETHODS%3A%20We%20assessed%20the%20status%20of%20dolutegravir%20rollout%20and%20viral%20load%20and%20drug%20resistance%20testing%20practices%20for%20patients%20on%20ART%20switching%20to%20dolutegravir-based%20regimens.%20We%20used%20generalized%20estimating%20equations%20to%20assess%20associations%20between%20clinic%20rollout%20of%20both%20first-%20and%20second-line%20dolutegravir-based%20ART%20regimens%20%28dual%20rollout%29%20and%20site-level%20factors.%5CnRESULTS%3A%20Of%20179%20surveyed%20clinics%2C%20175%20%2898%25%29%20participated%3B%20137%20%2878%25%29%20from%20Africa%2C%2030%20%2817%25%29%20from%20the%20Asia-Pacific%2C%20and%208%20%285%25%29%20from%20Latin%20America.%20Most%20clinics%20%2880%25%29%20were%20in%20low-%20or%20lower-middle-income%20countries%2C%20and%20there%20were%20a%20mix%20of%20primary-%2C%20secondary-%20and%20tertiary-level%20clinics.%20Ninety%20percent%20reported%20rollout%20of%20first-line%20dolutegravir%2C%2059%25%20of%20second-line%2C%2094%25%20of%20first-%20or%20second-line%20and%2055%25%20of%20dual%20rollout.%20The%20adjusted%20odds%20of%20dual%20rollout%20were%20higher%20among%20tertiary-level%20%28aOR%204.00%3B%2095%25%20CI%201.39%20to%2011.47%29%20and%20secondary-level%20clinics%20%28aOR%203.66%3B%2095%25%20CI%202.19%20to%206.11%29%20than%20in%20primary-level%20clinics.%20Over%20half%20%2859%25%29%20of%20clinics%20that%20introduced%20first-%20or%20second-line%20dolutegravir-based%20ART%20required%20recent%20viral%20load%20testing%20before%20switching%20to%20dolutegravir%2C%20and%2015%25%20performed%20genotypic%20resistance%20testing%20at%20switch.%5CnCONCLUSIONS%3A%20Dolutegravir-based%20ART%20was%20rolled%20out%20at%20nearly%20all%20IeDEA%20clinics%20in%20LMICs%2C%20yet%20many%20switched%20patients%20to%20dolutegravir%20without%20recent%20viral%20load%20testing%20and%20drug%20resistance%20testing%20was%20rarely%20performed.%20Without%20such%20testing%2C%20drug%20resistance%20among%20patient%20switching%20to%20dolutegravir%20may%20go%20undetected.%22%2C%22date%22%3A%222024-09-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000004007%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-10T15%3A22%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22NHTU387L%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222024-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGrimsrud%2C%20Anna%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHislop%2C%20Michael%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDunn%2C%20Liezl%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Courier%20delivery%20of%20antiretroviral%20therapy%3A%20a%20cohort%20study%20of%20a%20South%20African%20private-sector%20HIV%20programme.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20e26360.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26360%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26360%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Courier%20delivery%20of%20antiretroviral%20therapy%3A%20a%20cohort%20study%20of%20a%20South%20African%20private-sector%20HIV%20programme.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Grimsrud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Hislop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liezl%22%2C%22lastName%22%3A%22Dunn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20Maria%22%2C%22lastName%22%3A%22Namubiru%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Courier%20delivery%20has%20become%20a%20popular%20antiretroviral%20therapy%20%28ART%29%20distribution%20method%20in%20some%20HIV%20care%20settings%2C%20yet%20data%20on%20ART%20courier%20delivery%20and%20how%20it%20relates%20to%20ART%20outcomes%20are%20scarce.%20We%20studied%20the%20differences%20in%20viral%20suppression%20rates%20between%20individuals%20from%20a%20South%20African%20private%20sector%20HIV%20programme%20receiving%20ART%20by%20courier%20delivery%20and%20those%20receiving%20ART%20through%20traditional%20retail%20dispensing.%20METHODS%3A%20Individuals%20aged%2015%20years%20or%20older%20who%20were%20actively%20enrolled%20in%20the%20Aid%20for%20AIDS%20programme%20between%20January%202011%20and%20July%202022%20were%20eligible%20for%20the%20analysis.%20The%20outcome%20of%20interest%20was%20viral%20suppression%20defined%20as%20a%20viral%20load%20%28VL%29%20%26lt%3B400%20copies%20per%20ml.%20We%20calculated%20adjusted%20odds%20ratios%20%28OR%29%20for%20the%20association%20between%20the%20ART%20distribution%20method%20and%20viral%20suppression%2C%20comparing%20those%20receiving%20refills%20through%20courier%20pharmacies%20versus%20retail%20dispensing%20at%20the%20time%20of%20the%20VL%20testing.%20We%20used%20generalized%20estimating%20equations%20to%20account%20for%20repeated%20VL%20testing%20of%20the%20same%20individual.%20The%20models%20were%20adjusted%20for%20age%2C%20sex%2C%20calendar%20year%2C%20ART%20regimen%2C%20history%20of%20mental%20illness%20and%20medical%20insurance%20scheme.%20We%20computed%20adjusted%20ORs%20for%20the%20calendar%20periods%202011-2013%2C%202014-2016%2C%202017-2019%2C%202020-2022%20and%20overall.%20RESULTS%3A%20We%20extracted%20442%2C619%20VL%20measurements%20from%2068%2C720%20eligible%20individuals%2C%2039%2C406%20%2857.3%25%29%20were%20women.%20The%20median%20number%20of%20VL%20measurements%20per%20individual%20was%206%20%28IQR%203-10%29.%20VL%20suppression%20was%20detected%20in%20398%2C901%20%2890.1%25%29%20tests%2C%20and%20185%2C701%20%2842.0%25%29%20of%20the%20tests%20were%20taken%20while%20the%20individual%20was%20receiving%20ART%20by%20courier%20delivery.%20Overall%2C%20courier%20delivery%20was%20associated%20with%205%25%20higher%20odds%20of%20viral%20suppression%20than%20retail%20dispensing%20%28adjusted%20OR%201.05%2C%2095%25%20CI%201.02-1.08%29.%20The%20strength%20and%20direction%20of%20this%20association%20varied%20by%20calendar%20period%2C%20with%20an%20adjusted%20OR%20of%201.37%20%2895%25%20CI%201.27-1.48%29%20in%202011-2013%20and%201.02%20%2895%25%20CI%200.97-1.07%29%20in%202020-2022.%20CONCLUSIONS%3A%20Courier%20delivery%20of%20ART%20is%20a%20viable%20alternative%20to%20retail%20dispensing%20in%20the%20South%20African%20private%20sector%2C%20as%20it%20was%20associated%20with%20higher%20viral%20suppression%20until%202016%20and%20similar%20suppression%20rates%20in%20recent%20years.%20Further%20research%20is%20needed%20to%20investigate%20the%20potential%20benefits%20and%20drawbacks%20of%20courier%20delivery%20of%20ART%20in%20both%20private%20and%20public%20healthcare%20settings.%22%2C%22date%22%3A%222024%20Sep%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26360%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22XY975M2U%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Egger%20et%20al.%22%2C%22parsedDate%22%3A%222024-08-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSauermann%2C%20Mamatha%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLoosli%2C%20Tom%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRiedo%2C%20Selma%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20HIV-1%20subtype-specific%20drug%20resistance%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20protocol%20for%20a%20multicentre%20study%20%28DTG%20RESIST%29.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B14%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e085819.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-085819%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-085819%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV-1%20subtype-specific%20drug%20resistance%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20protocol%20for%20a%20multicentre%20study%20%28DTG%20RESIST%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamatha%22%2C%22lastName%22%3A%22Sauermann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Loosli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Selma%22%2C%22lastName%22%3A%22Riedo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niko%22%2C%22lastName%22%3A%22Beerenwinkel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Giandhari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20D.%22%2C%22lastName%22%3A%22Kouyos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Lessells%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20HIV%20drug%20resistance%20poses%20a%20challenge%20to%20the%20United%20Nation%26%23039%3Bs%20goal%20of%20ending%20the%20HIV%5C%2FAIDS%20epidemic.%20The%20integrase%20strand%20transfer%20inhibitor%20%28InSTI%29%20dolutegravir%2C%20which%20has%20a%20higher%20resistance%20barrier%2C%20was%20endorsed%20by%20the%20WHO%20in%202019%20for%20first-line%2C%20second-line%20and%20third-line%20antiretroviral%20therapy%20%28ART%29.%20This%20multiplicity%20of%20roles%20of%20dolutegravir%20in%20ART%20may%20facilitate%20the%20emergence%20of%20dolutegravir%20resistance.%5CnMETHODS%20AND%20ANALYSIS%3A%20Nested%20within%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%2C%20DTG%20RESIST%20is%20a%20multicentre%20study%20of%20adults%20and%20adolescents%20living%20with%20HIV%20in%20sub-Saharan%20Africa%2C%20Asia%2C%20and%20South%20and%20Central%20America%20who%20experienced%20virological%20failure%20on%20dolutegravir-based%20ART.%20At%20the%20time%20of%20virological%20failure%2C%20whole%20blood%20will%20be%20collected%20and%20processed%20to%20prepare%20plasma%20or%20dried%20blood%20spots.%20Laboratories%20in%20Durban%2C%20Mexico%20City%20and%20Bangkok%20will%20perform%20genotyping.%20Analyses%20will%20focus%20on%20%281%29%20individuals%20who%20experienced%20virological%20failure%20on%20dolutegravir%20and%20%282%29%20those%20who%20started%20or%20switched%20to%20such%20a%20regimen%20and%20were%20at%20risk%20of%20virological%20failure.%20For%20population%20%281%29%2C%20the%20outcome%20will%20be%20any%20InSTI%20drug%20resistance%20mutations%2C%20and%20for%20population%20%282%29%20virological%20failure%20is%20defined%20as%20a%20viral%20load%20%26gt%3B1000%20copies%5C%2FmL.%20Phenotypic%20testing%20will%20focus%20on%20non-B%20subtype%20viruses%20with%20major%20InSTI%20resistance%20mutations.%20Bayesian%20evolutionary%20models%20will%20explore%20and%20predict%20treatment%20failure%20genotypes.%20The%20study%20will%20have%20intermediate%20statistical%20power%20to%20detect%20differences%20in%20resistance%20mutation%20prevalence%20between%20major%20HIV-1%20subtypes%3B%20ample%20power%20to%20identify%20risk%20factors%20for%20virological%20failure%20and%20limited%20power%20for%20analysing%20factors%20associated%20with%20individual%20InSTI%20drug%20resistance%20mutations.%5CnETHICS%20AND%20DISSEMINATION%3A%20The%20research%20protocol%20was%20approved%20by%20the%20Biomedical%20Research%20Ethics%20Committee%20at%20the%20University%20of%20KwaZulu-Natal%2C%20South%20Africa%20and%20the%20Ethics%20Committee%20of%20the%20Canton%20of%20Bern%2C%20Switzerland.%20All%20sites%20participate%20in%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20and%20have%20obtained%20ethics%20approval%20from%20their%20local%20ethics%20committee%20to%20collect%20additional%20data.%5CnTRIAL%20REGISTRATION%20NUMBER%3A%20NCT06285110.%22%2C%22date%22%3A%222024-08-21%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2024-085819%22%2C%22ISSN%22%3A%222044-6055%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22ZF8VXG2C%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222024-08-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFernandez%20Villalobos%2C%20Nathalie%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDidden%2C%20Christiane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Prostate%20Cancer%20Diagnosis%20Rates%20among%20Insured%20Men%20with%20and%20without%20HIV%20in%20South%20Africa%3A%20A%20Cohort%20Study.%20%26lt%3Bi%26gt%3BCancer%20Epidemiology%2C%20Biomarkers%20%26amp%3B%20Prevention%26%23x202F%3B%3A%20A%20Publication%20of%20the%20American%20Association%20for%20Cancer%20Research%2C%20Cosponsored%20by%20the%20American%20Society%20of%20Preventive%20Oncology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B33%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%201057%26%23x2013%3B1064.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1158%5C%2F1055-9965.EPI-24-0137%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1158%5C%2F1055-9965.EPI-24-0137%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prostate%20Cancer%20Diagnosis%20Rates%20among%20Insured%20Men%20with%20and%20without%20HIV%20in%20South%20Africa%3A%20A%20Cohort%20Study.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20V.%22%2C%22lastName%22%3A%22Fernandez%20Villalobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Several%20studies%20have%20found%20lower%20prostate%20cancer%20diagnosis%20rates%20among%20men%20with%20human%20immunodeficiency%20virus%20%28HIV%3B%20MWH%29%20than%20men%20without%20HIV%20but%20reasons%20for%20this%20finding%20remain%20unclear.%20METHODS%3A%20We%20used%20claims%20data%20from%20a%20South%20African%20private%20medical%20insurance%20scheme%20%28July%202017-%20July%202020%29%20to%20assess%20prostate%20cancer%20diagnosis%20rates%20among%20men%20aged%20%26gt%3B%5C%2F%3D%2018%20years%20with%20and%20without%20HIV.%20Using%20flexible%20parametric%20survival%20models%2C%20we%20estimated%20hazard%20ratios%20%28HR%29%20for%20the%20association%20between%20HIV%20and%20incident%20prostate%20cancer%20diagnoses.%20We%20accounted%20for%20potential%20confounding%20by%20age%2C%20population%20group%2C%20and%20sexually%20transmitted%20infections%20%28confounder-adjusted%20model%29%20and%20additionally%20for%20potential%20mediation%20by%20prostatitis%20diagnoses%2C%20prostate-specific%20antigen%20testing%2C%20and%20prostate%20biopsies%20%28fully%20adjusted%20model%29.%20RESULTS%3A%20We%20included%20288%2C194%20men%2C%20of%20whom%2020%2C074%20%287%25%29%20were%20living%20with%20HIV.%20Prostate%20cancer%20was%20diagnosed%20in%201%2C614%20men%20without%20HIV%20%28median%20age%20at%20diagnosis%3A%2067%20years%29%20and%20in%2082%20MWH%20%28median%20age%20at%20diagnosis%3A%2060%20years%29.%20In%20the%20unadjusted%20analysis%2C%20prostate%20cancer%20diagnosis%20rates%20were%2035%25%20lower%20among%20MWH%20than%20men%20without%20HIV%20%5BHR%2C%200.65%3B%2095%25%20confidence%20interval%20%28CI%29%2C%200.52-0.82%5D.%20However%2C%20this%20association%20was%20no%20longer%20evident%20in%20the%20confounder-adjusted%20model%20%28HR%2C%201.03%3B%2095%25%20CI%2C%200.82-1.30%29%20or%20in%20the%20fully%20adjusted%20model%20%28HR%2C%201.14%3B%2095%25%20CI%2C%200.91-1.44%29.%20CONCLUSIONS%3A%20When%20accounting%20for%20potential%20confounders%20and%20mediators%2C%20our%20analysis%20found%20no%20evidence%20of%20lower%20prostate%20cancer%20diagnosis%20rates%20among%20MWH%20than%20men%20without%20HIV%20in%20South%20Africa.%20IMPACT%3A%20Our%20results%20do%20not%20support%20the%20hypothesis%20that%20HIV%20decreases%20the%20risk%20of%20prostate%20cancer.%22%2C%22date%22%3A%222024%20Aug%201%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1158%5C%2F1055-9965.EPI-24-0137%22%2C%22ISSN%22%3A%221538-7755%201055-9965%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22MK8Q7EQF%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kalk%20et%20al.%22%2C%22parsedDate%22%3A%222024-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKalk%2C%20Emma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHeekes%2C%20Alexa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLavies%2C%20Diane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJacobs%2C%20Lizel%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSpencer%2C%20Careni%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Population-based%20prevalence%20of%20congenital%20defects%20in%20a%20routine%20sentinel%20site-based%20surveillance%20system%20in%20the%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BBirth%20Defects%20Research%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B116%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e2388.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fbdr2.2388%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fbdr2.2388%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Population-based%20prevalence%20of%20congenital%20defects%20in%20a%20routine%20sentinel%20site-based%20surveillance%20system%20in%20the%20Western%20Cape%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diane%22%2C%22lastName%22%3A%22Lavies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lizel%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Careni%22%2C%22lastName%22%3A%22Spencer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alison%22%2C%22lastName%22%3A%22Boutall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayesha%22%2C%22lastName%22%3A%22Osman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Stewart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anika%22%2C%22lastName%22%3A%22van%20Niekerk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Fieggen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ushma%22%2C%22lastName%22%3A%22Mehta%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Lack%20of%20data%20on%20the%20burden%20and%20scope%20of%20congenital%20disorders%20%28CDs%29%20in%20South%20Africa%20undermines%20resource%20allocation%20and%20limits%20the%20ability%20to%20detect%20signals%20from%20potentially%20teratogenic%20pregnancy%20exposures.%5CnMETHODS%3A%20We%20used%20routine%20electronic%20data%20in%20the%20Western%20Cape%20Pregnancy%20Exposure%20Registry%20%28PER%29%20to%20determine%20the%20overall%20and%20individual%20prevalence%20of%20CD%20identified%20on%20neonatal%20surface%20examination%20at%20birth%20in%20the%20Western%20Cape%2C%20South%20Africa%2C%202016-2022.%20CD%20was%20confirmed%20by%20record%20review.%20The%20contribution%20of%20late%20%28%5Cu226424%5Cu2009months%29%20and%20antenatal%20diagnoses%20was%20assessed.%20We%20compared%20demographic%20and%20obstetric%20characteristics%20between%20women%20with%5C%2Fwithout%20pregnancies%20affected%20by%20CD.%5CnRESULTS%3A%20Women%20with%20a%20viable%20pregnancy%20%28%26gt%3B22%5Cu2009weeks%20gestation%3B%20birth%20weight%5Cu2009%5Cu2265%5Cu2009500%5Cu2009g%29%20%28n%5Cu2009%3D%5Cu200932%2C494%29%20were%20included.%20Of%201106%20potential%20CD%20identified%2C%2056.1%25%20were%20confirmed%20on%20folder%20review.%20When%20internal%20and%20minor%20CD%20were%20excluded%20the%20prevalence%20of%20major%20CD%20identified%20on%20surface%20examination%20at%20birth%20was%207.2%5C%2F1000%20births.%20When%20missed%5C%2Flate%20diagnoses%20on%20examination%20%2816.8%25%29%20and%20ultrasound%20%286.8%25%29%20were%20included%2C%20the%20prevalence%20was%209.2%5C%2F1000%20births%3A%208.9%5C%2F1000%20livebirths%20and%2021.5%5C%2F1000%20stillbirths.%20The%20PER%20did%20not%20detect%2021.5%25%20of%20major%20CD%20visible%20at%20birth.%20Older%20maternal%20age%20and%20diabetes%20mellitus%20were%20associated%20with%20an%20increased%20prevalence%20of%20CD.%20Women%20living%20with%5C%2Fwithout%20HIV%20%28or%20the%20timing%20of%20antiretroviral%20therapy%2C%20before%5C%2Fafter%20conception%29%2C%20hypertension%20or%20obesity%20did%20not%20significantly%20affect%20prevalence%20of%20CD.%5CnCONCLUSIONS%3A%20A%20surveillance%20system%20based%20on%20routine%20data%20successfully%20determined%20the%20prevalence%20of%20major%20CD%20identified%20on%20surface%20examination%20at%20birth%20at%20rates%20slightly%20higher%20than%20in%20equivalent%20studies.%20Overall%20rates%2C%20modeled%20at%20~2%25%2C%20are%20likely%20underestimated.%20Strengthening%20routine%20neonatal%20examination%20and%20clinical%20record-keeping%20could%20improve%20CD%20ascertainment.%22%2C%22date%22%3A%222024-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fbdr2.2388%22%2C%22ISSN%22%3A%222472-1727%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A02%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22SIYFL2NM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nyakato%20et%20al.%22%2C%22parsedDate%22%3A%222024-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNyakato%2C%20Patience%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchomaker%2C%20Michael%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoulle%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEuvrard%2C%20Jonathan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWood%2C%20Robin%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Correcting%20mortality%20estimates%20among%20children%20and%20youth%20on%20antiretroviral%20therapy%20in%20southern%20Africa%3A%20A%20comparative%20analysis%20between%20a%20multi-country%20tracing%20study%20and%20linkage%20to%20a%20health%20information%20exchange.%20%26lt%3Bi%26gt%3BTropical%20Medicine%20%26amp%3B%20International%20Health%3A%20TM%20%26amp%3B%20IH%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B29%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20739%26%23x2013%3B751.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ftmi.14030%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ftmi.14030%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Correcting%20mortality%20estimates%20among%20children%20and%20youth%20on%20antiretroviral%20therapy%20in%20southern%20Africa%3A%20A%20comparative%20analysis%20between%20a%20multi-country%20tracing%20study%20and%20linkage%20to%20a%20health%20information%20exchange%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patience%22%2C%22lastName%22%3A%22Nyakato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Schomaker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%22%2C%22lastName%22%3A%22Prozesky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benedikt%22%2C%22lastName%22%3A%22Christ%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%22%2C%22lastName%22%3A%22Ayakaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%20B.%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22van%20Lettow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cleophas%22%2C%22lastName%22%3A%22Chimbetete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Safari%22%2C%22lastName%22%3A%22Mbewe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constantin%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20The%20objective%20of%20this%20study%20is%20to%20assess%20the%20outcomes%20of%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%20reported%20as%20lost%20to%20follow-up%2C%20correct%20mortality%20estimates%20for%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%20for%20unascertained%20outcomes%20in%20those%20loss%20to%20follow-up%20%28LTFU%29%20based%20on%20tracing%20and%20linkage%20data%20separately%20using%20data%20from%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20in%20Southern%20Africa.%5CnMETHODS%3A%20We%20included%20data%20from%20two%20different%20populations%20of%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%3B%20%281%29%20clinical%20data%20from%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%20aged%20%5Cu226424%5Cu2009years%20from%20Lesotho%2C%20Malawi%2C%20Mozambique%2C%20Zambia%20and%20Zimbabwe%3B%20%282%29%20clinical%20data%20from%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%20aged%20%5Cu226414%5Cu2009years%20from%20the%20Western%20Cape%20%28WC%29%20in%20South%20Africa.%20Outcomes%20of%20patients%20lost%20to%20follow-up%20were%20available%20from%20%281%29%20a%20tracing%20study%20and%20%282%29%20linkage%20to%20a%20health%20information%20exchange.%20For%20both%20populations%2C%20we%20compared%20six%20methods%20for%20correcting%20mortality%20estimates%20for%20all%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV.%5CnRESULTS%3A%20We%20found%20substantial%20variations%20of%20mortality%20estimates%20among%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%20reported%20as%20lost%20to%20follow-up%20versus%20those%20retained%20in%20care.%20Ascertained%20mortality%20was%20higher%20among%20lost%20and%20traceable%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%20and%20lower%20among%20lost%20and%20linkable%20than%20those%20retained%20in%20care%20%28mortality%3A%2013.4%25%20%5Btraced%5D%20vs.%2012.6%25%20%5Bretained-other%20Southern%20Africa%20countries%5D%3B%203.4%25%20%5Blinked%5D%20vs.%209.4%25%20%5Bretained-WC%5D%29.%20A%20high%20proportion%20of%20lost%20to%20follow-up%20children%2C%20adolescents%20and%20young%20adults%20with%20HIV%20had%20self-transferred%20%2821.0%25%20and%2047.0%25%29%20in%20the%20traced%20and%20linked%20samples%2C%20respectively.%20The%20uncorrected%20method%20of%20non-informative%20censoring%20yielded%20the%20lowest%20mortality%20estimates%20among%20all%20methods%20for%20both%20tracing%20%286.0%25%29%20and%20linkage%20%284.0%25%29%20approaches%20at%202%5Cu2009years%20from%20ART%20start.%20Among%20corrected%20methods%20using%20ascertained%20data%2C%20multiple%20imputation%2C%20incorporating%20ascertained%20data%20%28MI%28asc.%29%29%20and%20inverse%20probability%20weighting%20with%20logistic%20weights%20were%20most%20robust%20for%20the%20tracing%20approach.%20In%20contrast%2C%20for%20the%20linkage%20approach%2C%20MI%28asc.%29%20was%20the%20most%20robust.%5CnCONCLUSIONS%3A%20Our%20findings%20emphasise%20that%20lost%20to%20follow-up%20is%20non-ignorable%20and%20both%20tracing%20and%20linkage%20improved%20outcome%20ascertainment%3A%20tracing%20identified%20substantial%20mortality%20in%20those%20reported%20as%20lost%20to%20follow-up%2C%20whereas%20linkage%20did%20not%20identify%20out-of-facility%20deaths%2C%20but%20showed%20that%20a%20large%20proportion%20of%20those%20reported%20as%20lost%20to%20follow-up%20were%20self-transfers.%22%2C%22date%22%3A%222024-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Ftmi.14030%22%2C%22ISSN%22%3A%221365-3156%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22P55LJZFF%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Beer%20et%20al.%22%2C%22parsedDate%22%3A%222024-07-24%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Beer%2C%20Shani%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Mary-Ann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhelanyane%2C%20Florence%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJones%2C%20Hayley%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20The%20Retrospective%20Implementation%20of%20Standardized%20In%20Utero%20HIV%20Exposure%20Definitions%20Using%20Routinely%20Collected%20Public%20Sector%20Data%20Across%20the%20Western%20Cape%20Province%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BThe%20Pediatric%20Infectious%20Disease%20Journal%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004486%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004486%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Retrospective%20Implementation%20of%20Standardized%20In%20Utero%20HIV%20Exposure%20Definitions%20Using%20Routinely%20Collected%20Public%20Sector%20Data%20Across%20the%20Western%20Cape%20Province%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shani%20T.%22%2C%22lastName%22%3A%22de%20Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hayley%20E.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Mendelsohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20L.%22%2C%22lastName%22%3A%22Slogrove%22%7D%5D%2C%22abstractNote%22%3A%22Using%20the%20Data%20Evaluation%20and%20Preparation%20for%20HIV-Exposed%20Uninfected%20Child%20Cohorts%20project%26%23039%3Bs%20standardized%20child%20HIV%20exposure%20definitions%2C%2064%25%2C%2064%25%20and%2090%25%20of%20children%20exposed%20to%20HIV%20in%20utero%20could%20be%20classified%20as%20HIV-uninfected%20with%20moderate%20or%20high%20certainty%20at%20the%20ages%20of%201%20and%203%20years%20and%20at%20the%20time%20of%20first%20infectious%20disease%20hospitalization%2C%20respectively.%20These%20definitions%20can%20be%20applied%20retrospectively%20to%20routine%20datasets%20with%20linked%20mother-child%20data.%22%2C%22date%22%3A%222024-07-24%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FINF.0000000000004486%22%2C%22ISSN%22%3A%221532-0987%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A04%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22DT22IEUB%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Moolla%20et%20al.%22%2C%22parsedDate%22%3A%222024-07-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMoolla%2C%20Haroon%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Mary-Ann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Claire%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEuvrard%2C%20Jonathan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BProzesky%2C%20Hans%20W.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20The%20effect%20of%20care%20interruptions%20on%20mortality%20in%20adults%20resuming%20antiretroviral%20therapy.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%201198%26%23x2013%3B1205.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003859%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003859%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effect%20of%20care%20interruptions%20on%20mortality%20in%20adults%20resuming%20antiretroviral%20therapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haroon%22%2C%22lastName%22%3A%22Moolla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20W.%22%2C%22lastName%22%3A%22Prozesky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20P.%22%2C%22lastName%22%3A%22Fox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Orrell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22Von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20Southern%20Africa%20%28IeDEA-SA%29%20Collaboration%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20estimate%20the%20relative%20rate%20of%20all-cause%20mortality%20amongst%20those%20on%20antiretroviral%20treatment%20%28ART%29%20with%20a%20history%20of%20interruptions%20compared%20with%20those%20with%20no%20previous%20interruptions%20in%20care.%5CnDESIGN%3A%20Retrospective%20cohort%20study.%5CnMETHODS%3A%20We%20used%20data%20from%20four%20South%20African%20cohorts%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20Southern%20Africa%20collaboration.%20We%20included%20adults%20who%20started%20ART%20between%202004%20and%202019.%20We%20defined%20a%20care%20interruption%20as%20a%20gap%20in%20contact%20longer%20than%20180%5Cu200adays.%20Observation%20time%20prior%20to%20interruption%20was%20allocated%20to%20a%20%26%23039%3Bno%20interruption%26%23039%3B%20group.%20Observation%20time%20after%20interruption%20was%20allocated%20to%20one%20of%20two%20groups%20based%20on%20whether%20the%20first%20interruption%20started%20before%206%5Cu200amonths%20of%20ART%20%28%26%23039%3Bearly%20interruption%26%23039%3B%29%20or%20later%20%28%26%23039%3Blate%20interruption%26%23039%3B%29.%20We%20used%20Cox%20regression%20to%20estimate%20hazard%20ratios.%5CnRESULTS%3A%20Sixty-three%20thousand%20six%20hundred%20and%20ninety-two%20participants%20contributed%20162%5Cu200a916%20person-years%20of%20observation.%20There%20were%203469%20deaths.%20Most%20participants%20were%20female%20individuals%20%2867.4%25%29%20and%20the%20median%20age%20at%20ART%20initiation%20was%2033.3%5Cu200ayears%20%28interquartile%20range%3A%2027.5-40.7%29.%20Seventeen%20thousand%20and%20eleven%20%2826.7%25%29%20participants%20experienced%20care%20interruptions.%20Those%20resuming%20ART%20experienced%20increased%20mortality%20compared%20with%20those%20with%20no%20interruptions%3A%20early%20interrupters%20had%20a%20hazard%20ratio%20of%204.37%20%2895%25%20confidence%20interval%20%28CI%29%203.87-4.95%29%20and%20late%20interrupters%20had%20a%20hazard%20ratio%20of%202.74%20%2895%25%20CI%202.39-3.15%29.%20In%20sensitivity%20analyses%2C%20effect%20sizes%20were%20found%20to%20be%20proportional%20to%20the%20length%20of%20time%20used%20to%20define%20interruptions.%5CnCONCLUSION%3A%20Our%20findings%20highlight%20the%20need%20to%20improve%20retention%20in%20care%2C%20regardless%20of%20treatment%20duration.%20Programmes%20to%20encourage%20return%20to%20care%20also%20need%20to%20be%20strengthened.%22%2C%22date%22%3A%222024-07-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003859%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22UBNXS76T%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Asangbeh-Kerman%20et%20al.%22%2C%22parsedDate%22%3A%222024-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAsangbeh-Kerman%2C%20Serra%20Lem%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavidovi%26%23x107%3B%2C%20Ma%26%23x161%3Ba%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20Katayoun%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BManasyan%2C%20Albert%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Cervical%20cancer%20prevention%20and%20care%20in%20HIV%20clinics%20across%20sub-Saharan%20Africa%3A%20results%20of%20a%20facility-based%20survey.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%287%29%2C%20S.%20e26303.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26303%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26303%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cervical%20cancer%20prevention%20and%20care%20in%20HIV%20clinics%20across%20sub-Saharan%20Africa%3A%20results%20of%20a%20facility-based%20survey%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serra%20Lem%22%2C%22lastName%22%3A%22Asangbeh-Kerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ma%5Cu0161a%22%2C%22lastName%22%3A%22Davidovi%5Cu0107%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katayoun%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Manasyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anjali%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beverly%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cleophas%22%2C%22lastName%22%3A%22Chimbetete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannock%22%2C%22lastName%22%3A%22Tweya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josephine%22%2C%22lastName%22%3A%22Muhairwe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Gunter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marielle%22%2C%22lastName%22%3A%22Jousse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Omenge%22%2C%22lastName%22%3A%22Orang%27o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Pierre%20Boni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Partha%22%2C%22lastName%22%3A%22Basu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20To%20eliminate%20cervical%20cancer%20%28CC%29%2C%20access%20to%20and%20quality%20of%20prevention%20and%20care%20services%20must%20be%20monitored%2C%20particularly%20for%20women%20living%20with%20HIV%20%28WLHIV%29.%20We%20assessed%20implementation%20practices%20in%20HIV%20clinics%20across%20sub-Saharan%20Africa%20%28SSA%29%20to%20identify%20gaps%20in%20the%20care%20cascade%20and%20used%20aggregated%20patient%20data%20to%20populate%20cascades%20for%20WLHIV%20attending%20HIV%20clinics.%5CnMETHODS%3A%20Our%20facility-based%20survey%20was%20administered%20between%20November%202020%20and%20July%202021%20in%2030%20HIV%20clinics%20across%20SSA%20that%20participate%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20We%20performed%20a%20qualitative%20site-level%20assessment%20of%20CC%20prevention%20and%20care%20services%20and%20analysed%20data%20from%20routine%20care%20of%20WLHIV%20in%20SSA.%5CnRESULTS%3A%20Human%20papillomavirus%20%28HPV%29%20vaccination%20was%20offered%20in%2033%25%20of%20sites.%20Referral%20for%20CC%20diagnosis%20%2842%25%29%20and%20treatment%20%2870%25%29%20was%20common%2C%20but%20not%20free%20at%20about%2050%25%20of%20sites.%20Most%20sites%20had%20electronic%20health%20information%20systems%20%2890%25%29%2C%20but%20data%20to%20inform%20indicators%20to%20monitor%20global%20targets%20for%20CC%20elimination%20in%20WLHIV%20were%20not%20routinely%20collected%20in%20these%20sites.%20Data%20were%20collected%20routinely%20in%20only%2036%25%20of%20sites%20that%20offered%20HPV%20vaccination%2C%2033%25%20of%20sites%20that%20offered%20cervical%20screening%20and%2020%25%20of%20sites%20that%20offered%20pre-cancer%20and%20CC%20treatment.%5CnCONCLUSIONS%3A%20Though%20CC%20prevention%20and%20care%20services%20have%20long%20been%20available%20in%20some%20HIV%20clinics%20across%20SSA%2C%20patient%20and%20programme%20monitoring%20need%20to%20be%20improved.%20Countries%20should%20consider%20leveraging%20their%20existing%20health%20information%20systems%20and%20use%20monitoring%20tools%20provided%20by%20the%20World%20Health%20Organization%20to%20improve%20CC%20prevention%20programmes%20and%20access%2C%20and%20to%20track%20their%20progress%20towards%20the%20goal%20of%20eliminating%20CC.%22%2C%22date%22%3A%222024-07%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26303%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22FCJ7ZZGT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jacobs%20et%20al.%22%2C%22parsedDate%22%3A%222024-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJacobs%2C%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMorden%2C%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSmith%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bvon%20Delft%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20R.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Severe%20outcomes%20among%20adults%20with%20TB%20during%20COVID-19.%20%26lt%3Bi%26gt%3BIJTLD%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B1%26lt%3B%5C%2Fi%26gt%3B%20%287%29%2C%20S.%20292%26%23x2013%3B298.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtldopen.24.0220%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtldopen.24.0220%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Severe%20outcomes%20among%20adults%20with%20TB%20during%20COVID-19.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Morden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22von%20Delft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.-A.%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20COVID-19%20pandemic%20prompted%20strict%20public%20health%20measures%20to%20reduce%20SARS-CoV-2%20transmission%2C%20potentially%20interrupting%20TB%20programmes%20in%20the%20Western%20Cape%2C%20South%20Africa.%20METHODS%3A%20We%20conducted%20a%20retrospective%20cohort%20study%2C%20estimating%20changes%20in%20new%20TB%20case%20rates%20and%20risk%20of%20death%20during%20TB-specific%20admissions%20within%206%20months%20of%20TB%20first%20evidence%2C%20during%20the%20pre-pandemic%20%281%20January%202019-26%20March%202020%29%20and%20after%20the%20implementation%20of%20public%20health%20and%20social%20measures%20%28PHSM%29%20periods%20%2826%20March%202020-30%20September%202021%29%2C%20based%20on%20PHSM%20strictness.%20We%20used%20interrupted%20time%20series%20and%20logistic%20regression%20models%20to%20adjust%20for%20key%20characteristics.%20RESULTS%3A%20We%20found%20an%20average%2022%25%20reduction%20%2895%25%20CI%2019-25%29%20in%20monthly%20TB%20cases%20during%20the%20entire%20PHSM%20implementation%20period.%20Additionally%2C%20the%20risk%20of%20death%20during%20TB-specific%20admissions%20increased%2C%20with%20the%20adjusted%20odds%20ratio%20ranging%20across%20PHSM%20levels%20from%201.36%20%2895%25%20CI%201.17-1.57%29%20on%20Level%201%20to%201.44%20%2895%25%20CI%201.16-1.79%29%20on%20Level%202%20compared%20with%20the%20pre-pandemic%20period.%20CONCLUSIONS%3A%20There%20was%20a%20decline%20in%20the%20number%20of%20diagnosed%20TB%20cases%20and%20an%20increased%20risk%20of%20severe%20outcomes%20from%2026%20March%202020%20to%2030%20September%202021%20in%20the%20Western%20Cape.%20TB%20programme%20recovery%20strategies%20must%20be%20prioritised%2C%20and%20TB%20management%20programmes%20must%20be%20integrated%20into%20future%20pandemic%20responses.%22%2C%22date%22%3A%222024%20Jul%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtldopen.24.0220%22%2C%22ISSN%22%3A%223005-7590%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%225LPDHUNH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Siedentop%20et%20al.%22%2C%22parsedDate%22%3A%222024-06-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSiedentop%2C%20Berit%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKachalov%2C%20Viacheslav%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWitzany%2C%20Christopher%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKouyos%2C%20Roger%20D.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20The%20effect%20of%20combining%20antibiotics%20on%20resistance%3A%20A%20systematic%20review%20and%20meta-analysis.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.07.10.23292374.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.07.10.23292374%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.07.10.23292374%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effect%20of%20combining%20antibiotics%20on%20resistance%3A%20A%20systematic%20review%20and%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Siedentop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viacheslav%20N.%22%2C%22lastName%22%3A%22Kachalov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Witzany%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20D.%22%2C%22lastName%22%3A%22Kouyos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Bonhoeffer%22%7D%5D%2C%22abstractNote%22%3A%22When%20and%20under%20which%20conditions%20antibiotic%20combination%20therapy%20decelerates%20rather%20than%20accelerates%20resistance%20evolution%20is%20not%20well%20understood.%20We%20examined%20the%20effect%20of%20combining%20antibiotics%20on%20within-patient%20resistance%20development%20across%20various%20bacterial%20pathogens%20and%20antibiotics.%20We%20searched%20CENTRAL%2C%20EMBASE%20and%20PubMed%20for%20%28quasi%29-randomised%20controlled%20trials%20%28RCTs%29%20published%20from%20database%20inception%20to%20November%2024th%2C%202022.%20Trials%20comparing%20antibiotic%20treatments%20with%20different%20numbers%20of%20antibiotics%20were%20included.%20A%20patient%20was%20considered%20to%20have%20acquired%20resistance%20if%2C%20at%20the%20follow-up%20culture%2C%20a%20resistant%20bacterium%20%28as%20defined%20by%20the%20study%20authors%29%20was%20detected%20that%20had%20not%20been%20present%20in%20the%20baseline%20culture.%20We%20combined%20results%20using%20a%20random%20effects%20model%20and%20performed%20meta-regression%20and%20stratified%20analyses.%20The%20trials%26%23039%3B%20risk%20of%20bias%20was%20assessed%20with%20the%20Cochrane%20tool.%2042%20trials%20were%20eligible%20and%2029%2C%20including%205054%20patients%2C%20were%20qualified%20for%20statistical%20analysis.%20In%20most%20trials%2C%20resistance%20development%20was%20not%20the%20primary%20outcome%20and%20studies%20lacked%20power.%20The%20combined%20odds%20ratio%20%28OR%29%20for%20the%20acquisition%20of%20resistance%20comparing%20the%20group%20with%20the%20higher%20number%20of%20antibiotics%20with%20the%20comparison%20group%20was%201.23%20%2895%25%20CI%200.68-2.25%29%2C%20with%20substantial%20between-study%20heterogeneity%20%28I%202%20%3D77%25%29.%20We%20identified%20tentative%20evidence%20for%20potential%20beneficial%20or%20detrimental%20effects%20of%20antibiotic%20combination%20therapy%20for%20specific%20pathogens%20or%20medical%20conditions.%20The%20evidence%20for%20combining%20a%20higher%20number%20of%20antibiotics%20compared%20to%20fewer%20from%20RCTs%20is%20scarce%20and%20overall%2C%20is%20compatible%20with%20both%20benefit%20or%20harm.%20Trials%20powered%20to%20detect%20differences%20in%20resistance%20development%20or%20well-designed%20observational%20studies%20are%20required%20to%20clarify%20the%20impact%20of%20combination%20therapy%20on%20resistance.%22%2C%22date%22%3A%222024-06-28%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.07.10.23292374%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A16%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22VNPED45I%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shafi%20et%20al.%22%2C%22parsedDate%22%3A%222024-06-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShafi%2C%20Jenine%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVirk%2C%20Maneet%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKalk%2C%20Emma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCarlucci%2C%20James%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChepkemoi%2C%20Audrey%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Pharmacovigilance%20in%20Pregnancy%20Studies%2C%20Exposures%20and%20Outcomes%20Ascertainment%2C%20and%20Findings%20from%20Low-%20and%20Middle-Income%20Countries%3A%20A%20Scoping%20Review.%20%26lt%3Bi%26gt%3BDrug%20Safety%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs40264-024-01445-1%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs40264-024-01445-1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pharmacovigilance%20in%20Pregnancy%20Studies%2C%20Exposures%20and%20Outcomes%20Ascertainment%2C%20and%20Findings%20from%20Low-%20and%20Middle-Income%20Countries%3A%20A%20Scoping%20Review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenine%22%2C%22lastName%22%3A%22Shafi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maneet%20K.%22%2C%22lastName%22%3A%22Virk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20G.%22%2C%22lastName%22%3A%22Carlucci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22Chepkemoi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caitlin%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megan%20S.%22%2C%22lastName%22%3A%22McHenry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edwin%22%2C%22lastName%22%3A%22Were%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Humphrey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ushma%20C.%22%2C%22lastName%22%3A%22Mehta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rena%20C.%22%2C%22lastName%22%3A%22Patel%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Pharmacovigilance%20%28PV%29%2C%20or%20the%20ongoing%20safety%20monitoring%20after%20a%20medication%20has%20been%20licensed%2C%20plays%20a%20crucial%20role%20in%20pregnancy%2C%20as%20clinical%20trials%20often%20exclude%20pregnant%20people.%20It%20is%20important%20to%20understand%20how%20pregnancy%20PV%20projects%20operate%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29%2C%20where%20there%20is%20a%20disproportionate%20lack%20of%20PV%20data%20yet%20a%5Cu00a0high%20burden%20of%20adverse%20pregnancy%20outcomes.%20We%20conducted%20a%20scoping%20review%20to%20assess%20how%20exposures%20and%20outcomes%20were%20measured%20in%20recently%20published%20pregnancy%20PV%20projects%20in%20LMICs.%5CnMETHODS%3A%20We%20utilized%20a%20search%20string%2C%20secondary%20review%2C%20and%20team%20knowledge%20to%20review%20publications%20focusing%20on%20therapeutic%20or%20vaccine%20exposures%20among%20pregnant%20people%20in%20LMICs.%20We%20screened%20abstracts%20for%20relevance%20before%20conducting%20a%20full%20text%20review%2C%20and%20documented%20measurements%20of%20exposures%20and%20outcomes%20%28categorized%20as%20maternal%2C%20birth%2C%20or%20neonatal%5C%2Finfant%29%20among%20other%20factors%2C%20including%20study%20topic%2C%20setting%2C%20and%20design%2C%20comparator%20groups%2C%20and%20funding%20sources.%5CnRESULTS%3A%20We%20identified%2031%20PV%20publications%20spanning%20at%20least%2024%20LMICs%2C%20all%20focusing%20on%20therapeutics%20or%20vaccines%20for%20infectious%20diseases%2C%20including%20HIV%20%28n%20%3D%2017%29%2C%20tuberculosis%20%28TB%3B%20n%20%3D%209%29%2C%20malaria%20%28n%20%3D%207%29%2C%20pertussis%2C%20tetanus%2C%20and%20diphtheria%20%28n%20%3D%201%29%2C%20and%20influenza%20%28n%20%3D%203%29.%20As%20for%20outcomes%2C%20n%20%3D%2015%2C%20n%20%3D%2031%2C%20and%20n%20%3D%2020%20of%20the%20publications%20covered%20maternal%2C%20birth%2C%20and%20neonatal%5C%2Finfant%20outcomes%2C%20respectively.%20Among%20HIV-specific%20publications%2C%20the%20primary%20exposure-outcome%20relationship%20of%20focus%20was%20exposure%20to%20maternal%20antiretroviral%20therapy%20and%20adverse%20outcomes.%20For%20TB-specific%20publications%2C%20the%20main%20exposures%20of%20interest%20were%20second-line%20drug-resistant%20TB%20and%20isoniazid-based%20prevention%20therapeutics%20for%20pregnant%20people%20living%20with%20HIV.%20For%20malaria-specific%20publications%2C%20the%20primary%20exposure-outcome%20relationship%20of%20interest%20was%20antimalarial%20medication%20exposure%20during%20pregnancy%20and%20adverse%20outcomes.%20Among%20vaccine-focused%20publications%2C%20the%20exposure%20was%20assessed%20during%20a%20specific%20time%20during%20pregnancy%2C%20with%20an%20overall%20interest%20in%20vaccine%20safety%20and%5C%2For%20efficacy.%20The%20study%20settings%20were%20frequently%20from%20Africa%2C%20designs%20varied%20from%20cohort%20or%20cross-sectional%20studies%20to%20clinical%20trials%2C%20and%20funding%20sources%20were%20largely%20from%20high-income%20countries.%5CnCONCLUSION%3A%20The%20published%20pregnancy%20PV%20projects%20were%20largely%20centered%20in%20Africa%20and%20concerned%20with%20infectious%20diseases.%20This%20may%20reflect%20the%20disease%20burden%20in%20LMICs%20but%20also%20funding%20priorities%20from%20high-income%20countries.%20As%20the%20prevalence%20of%20non-communicable%20diseases%20increases%20in%20LMICs%2C%20PV%20projects%20will%20have%20to%20broaden%20their%20scope.%20Birth%20and%20neonatal%5C%2Finfant%20outcomes%20were%20most%20reported%2C%20with%20fewer%20reporting%20on%20maternal%20outcomes%20and%20none%20on%20longer-term%20child%20outcomes%3B%20additionally%2C%20heterogeneity%20existed%20in%20definitions%20and%20ascertainment%20of%20specific%20measures.%20Notably%2C%20almost%20all%20projects%20covered%20a%20single%20therapeutic%20exposure%2C%20missing%20an%20opportunity%20to%20leverage%20their%20projects%20to%20cover%20additional%20exposures%2C%20add%20scientific%20rigor%2C%20create%20uniformity%20across%20health%20services%2C%20and%20bolster%20existing%20health%20systems.%20For%20many%20publications%2C%20the%20timing%20of%20exposure%2C%20specifically%20by%20trimester%2C%20was%20crucial%20to%20maternal%20and%20neonatal%20safety.%20While%20currently%20published%20pregnancy%20PV%20literature%20offer%20insights%20into%20the%20PV%20landscape%20in%20LMICs%2C%20further%20work%20is%20needed%20to%20standardize%20definitions%20and%20measurements%2C%20integrate%20PV%20projects%20across%20health%20services%2C%20and%20establish%20longer-term%20monitoring.%22%2C%22date%22%3A%222024-06-21%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs40264-024-01445-1%22%2C%22ISSN%22%3A%221179-1942%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%5D%2C%22dateModified%22%3A%222025-03-12T10%3A13%3A33Z%22%7D%7D%2C%7B%22key%22%3A%227VDXV6JE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rossouw%20et%20al.%22%2C%22parsedDate%22%3A%222024-06-20%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRossouw%2C%20Laura%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNgcobo%2C%20Nkosinathi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BClouse%2C%20Kate%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNattey%2C%20Cornelius%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-G%26%23xFC%3Bnter%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Augmenting%20maternal%20clinical%20cohort%20data%20with%20administrative%20laboratory%20dataset%20linkages%3A%20a%20validation%20study.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202024.06.19.24309149.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.06.19.24309149%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.06.19.24309149%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Augmenting%20maternal%20clinical%20cohort%20data%20with%20administrative%20laboratory%20dataset%20linkages%3A%20a%20validation%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Rossouw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nkosinathi%22%2C%22lastName%22%3A%22Ngcobo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kate%22%2C%22lastName%22%3A%22Clouse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelius%22%2C%22lastName%22%3A%22Nattey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mhairi%22%2C%22lastName%22%3A%22Maskew%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20use%20of%20big%20data%20and%20large%20language%20models%20in%20healthcare%20can%20play%20a%20key%20role%20in%20improving%20patient%20treatment%20and%20healthcare%20management%2C%20especially%20when%20applied%20to%20large-scale%20administrative%20data.%20A%20major%20challenge%20to%20achieving%20this%20is%20ensuring%20that%20patient%20confidentiality%20and%20personal%20information%20is%20protected.%20One%20way%20to%20overcome%20this%20is%20by%20augmenting%20clinical%20data%20with%20administrative%20laboratory%20dataset%20linkages%20in%20order%20to%20avoid%20the%20use%20of%20demographic%20information.%5CnMETHODS%3A%20We%20explored%20an%20alternative%20method%20to%20examine%20patient%20files%20from%20a%20large%20administrative%20dataset%20in%20South%20Africa%20%28the%20National%20Health%20Laboratory%20Services%2C%20or%20NHLS%29%2C%20by%20linking%20external%20data%20to%20the%20NHLS%20database%20using%20specimen%20barcodes%20associated%20with%20laboratory%20tests.%20This%20offers%20us%20with%20a%20deterministic%20way%20of%20performing%20data%20linkages%20without%20accessing%20demographic%20information.%20In%20this%20paper%2C%20we%20quantify%20the%20performance%20metrics%20of%20this%20approach.%5CnRESULTS%3A%20The%20linkage%20of%20the%20large%20NHLS%20data%20to%20external%20hospital%20data%20using%20specimen%20barcodes%20achieved%20a%2095%25%20success.%20Out%20of%20the%201200%20records%20in%20the%20validation%20sample%2C%2087%25%20were%20exact%20matches%20and%209%25%20were%20matches%20with%20typographic%20correction.%20The%20remaining%205%25%20were%20either%20complete%20mismatches%20or%20were%20due%20to%20duplicates%20in%20the%20administrative%20data.%5CnCONCLUSIONS%3A%20The%20high%20success%20rate%20indicates%20the%20reliability%20of%20using%20barcodes%20for%20linking%20data%20without%20demographic%20identifiers.%20Specimen%20barcodes%20are%20an%20effective%20tool%20for%20deterministic%20linking%20in%20health%20data%2C%20and%20may%20provide%20a%20method%20of%20creating%20large%2C%20linked%20data%20sets%20without%20compromising%20patient%20confidentiality.%22%2C%22date%22%3A%222024-06-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2024.06.19.24309149%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-10T15%3A22%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22QF8IHYPK%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vinikoor%20et%20al.%22%2C%22parsedDate%22%3A%222024-06-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVinikoor%2C%20Michael%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHamusonde%2C%20Kalongo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAsombang%2C%20Mah%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRiebensahm%2C%20Carlotta%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Long-term%20Hepatitis%20B%20and%20Liver%20Outcomes%20Among%20Adults%20Taking%20Tenofovir-Containing%20Antiretroviral%20Therapy%20for%20HBV%5C%2FHIV%20Coinfection%20in%20Zambia.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B78%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%201583%26%23x2013%3B1590.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciad654%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciad654%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Long-term%20Hepatitis%20B%20and%20Liver%20Outcomes%20Among%20Adults%20Taking%20Tenofovir-Containing%20Antiretroviral%20Therapy%20for%20HBV%5C%2FHIV%20Coinfection%20in%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Vinikoor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kalongo%22%2C%22lastName%22%3A%22Hamusonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mah%22%2C%22lastName%22%3A%22Asombang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlotta%22%2C%22lastName%22%3A%22Riebensahm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22Chitundu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronica%22%2C%22lastName%22%3A%22Sunkuntu-Sichizya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debika%22%2C%22lastName%22%3A%22Bhattacharya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edford%22%2C%22lastName%22%3A%22Sinkala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georg%22%2C%22lastName%22%3A%22Lauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wilson%22%2C%22lastName%22%3A%22Mbewe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Long-term%20outcomes%20of%20tenofovir-containing%20antiretroviral%20therapy%20%28ART%29%20for%20hepatitis%20B%20virus%20%28HBV%29%5C%2Fhuman%20immunodeficiency%20virus%20%28HIV%29%20coinfection%20were%20evaluated%20in%20Zambia.%5CnMETHODS%3A%20A%20prospective%20cohort%20of%20adults%20with%20HIV%20and%20hepatitis%20B%20surface%20antigen%20%28HBsAg%29-positivity%20was%20enrolled%20at%20ART%20initiation.%20On%20tenofovir-containing%20ART%2C%20we%20ascertained%20HBV%20viral%20load%20%28VL%29%20non-suppression%2C%20alanine%20aminotransferase%20%28ALT%29%20elevation%2C%20serologic%20end-points%2C%20progression%20of%20liver%20fibrosis%20based%20on%20elastography%2C%20and%20hepatocellular%20carcinoma%20%28HCC%29%20incidence.%20We%20also%20described%20a%20subgroup%20%28low%20HBV%20VL%20and%20no%5C%2Fminimal%20fibrosis%20at%20baseline%29%20that%2C%20under%20current%20international%20guidelines%2C%20would%20not%20have%20been%20treated%20in%20the%20absence%20of%20their%20HIV%20infection.%5CnRESULTS%3A%20Among%20289%20participants%20at%20ART%20start%2C%20median%20age%20was%2034%20years%2C%2040.1%25%20were%20women%2C%20median%20CD4%20count%20was%20191%20cells%5C%2Fmm3%2C%2044.2%25%20were%20hepatitis%20B%20e%20antigen-positive%2C%20and%2028.4%25%20had%20liver%20fibrosis%5C%2Fcirrhosis.%20Over%20median%205.91%20years%20of%20ART%2C%2013.6%25%20developed%20HBV%20viral%20non-suppression%2C%20which%20was%20associated%20with%20advanced%20HIV%20disease.%20ALT%20elevation%20on%20ART%20was%20linked%20with%20HBV%20VL%20non-suppression.%20Regression%20of%20fibrosis%20and%20cirrhosis%20were%20common%2C%20progression%20to%20cirrhosis%20was%20absent%2C%20and%20no%20cases%20of%20HCC%20were%20ascertained.%20HBsAg%20seroclearance%20was%209.4%25%20at%202%20and%2015.4%25%20at%205%20years%2C%20with%20higher%20rates%20among%20patients%20with%20low%20baseline%20HBV%20replication%20markers.%5CnCONCLUSIONS%3A%20Reassuring%20long-term%20liver%20outcomes%20were%20ascertained%20during%20tenofovir-based%20ART%20for%20HBV%5C%2FHIV%20coinfection%20in%20Zambia.%20Higher%20than%20expected%20HBsAg%20seroclearance%20during%20ART%20underscores%20the%20need%20to%20include%20people%20with%20HIV%20in%20HBV%20cure%20research.%22%2C%22date%22%3A%222024-06-14%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciad654%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A14%3A25Z%22%7D%7D%2C%7B%22key%22%3A%22CZI4DY87%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Skrivankova%20et%20al.%22%2C%22parsedDate%22%3A%222024-06-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSkrivankova%2C%20Veronika%20Whitesell%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHuwa%2C%20Jacqueline%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChiwaya%2C%20Geldert%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanda%2C%20Esau%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Virologic%20Failure%20and%20Drug%20Resistance%20After%20Programmatic%20Switching%20to%20Dolutegravir-based%20First-line%20Antiretroviral%20Therapy%20in%20Malawi%20and%20Zambia.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20ciae261.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae261%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciae261%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Virologic%20Failure%20and%20Drug%20Resistance%20After%20Programmatic%20Switching%20to%20Dolutegravir-based%20First-line%20Antiretroviral%20Therapy%20in%20Malawi%20and%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronika%20Whitesell%22%2C%22lastName%22%3A%22Skrivankova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geldert%20D.%22%2C%22lastName%22%3A%22Chiwaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esau%22%2C%22lastName%22%3A%22Banda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shameem%22%2C%22lastName%22%3A%22Buleya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Chintedza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannock%22%2C%22lastName%22%3A%22Tweya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thokozani%22%2C%22lastName%22%3A%22Kalua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%22%2C%22lastName%22%3A%22Kouyos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Lessells%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20People%20with%20human%20immunodeficiency%20virus%20%28PWH%29%20on%20first-line%2C%20nonnucleoside%20reverse-transcriptase%20inhibitor-based%20antiretroviral%20therapy%20%28ART%29%20were%20routinely%20switched%20to%20tenofovir-lamivudine-dolutegravir.%20We%20examined%20virologic%20outcomes%20and%20drug%20resistance%20in%20ART%20programs%20in%20Malawi%2C%20where%20switching%20was%20irrespective%20of%20viral%20load%2C%20and%20Zambia%2C%20where%20switching%20depended%20on%20a%20viral%20load%20%26lt%3B1000%5Cu2005copies%5C%2FmL%20in%20the%20past%20year.%5CnMETHODS%3A%20We%20compared%20the%20risk%20of%20viremia%20%28%5Cu2265400%5Cu2005copies%5C%2FmL%29%20at%201%20and%202%20years%20by%20viral%20load%20at%20switch%20and%20between%20countries%20using%20exact%20methods%20and%20logistic%20regression%20adjusted%20for%20age%20and%20sex.%20We%20performed%20HIV-1%20pol%20Sanger%20sequencing%20on%20plasma%20samples%20with%20viral%20load%20%5Cu22651000%5Cu2005copies%5C%2FmL.%5CnRESULTS%3A%20A%20total%20of%202832%20PWH%20were%20eligible%20%28Malawi%201422%2C%20Zambia%201410%29%3B%20the%20median%20age%20was%2037%20years%2C%20and%202578%20%2891.0%25%29%20were%20women.%20At%20switch%2C%2077%20%285.4%25%29%20were%20viremic%20in%20Malawi%20and%2042%20%283.0%25%29%20in%20Zambia%20%28P%20%3D%20.001%29.%20Viremia%20at%20switch%20was%20associated%20with%20viremia%20at%201%20year%20%28adjusted%20odds%20ratio%20%28OR%29%2C%206.15%3B%2095%25%20confidence%20interval%20%5BCI%5D%2C%203.13-11.4%29%20and%202%20years%20%287.0%3B%2095%25%20CI%2C%203.73-12.6%29.%20Viremia%20was%20less%20likely%20in%20Zambia%20than%20in%20Malawi%20at%201%20year%20%28OR%2C%200.55%3B%200.32-0.94%29%20and%202%20years%20%28OR%2C%200.33%3B%200.18-0.57%29.%20Integrase%20sequencing%20was%20successful%20for%2079%20of%20113%20eligible%20samples.%20Drug%20resistance%20mutations%20were%20found%20in%205%20PWH%20%28Malawi%204%2C%20Zambia%201%29%3B%202%20had%20major%20mutations%20%28G118R%2C%20E138K%2C%20T66A%20and%20G118R%2C%20E138K%29%20leading%20to%20high-level%20dolutegravir%20resistance.%5CnCONCLUSIONS%3A%20Restricting%20switching%20to%20dolutegravir-based%20ART%20to%20PWH%20with%20a%20viral%20load%20%26lt%3B1000%5Cu2005copies%5C%2FmL%20may%20reduce%20subsequent%20viremia%20and%2C%20consequently%2C%20the%20emergence%20of%20dolutegravir%20drug%20resistance%20mutations.%5CnCLINICAL%20TRIALS%20REGISTRATION%3A%20Clinicaltrials.gov%20%28NCT04612452%29.%22%2C%22date%22%3A%222024-06-07%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciae261%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A14%3A32Z%22%7D%7D%2C%7B%22key%22%3A%224VTZ6XT2%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kassanjee%20et%20al.%22%2C%22parsedDate%22%3A%222024-06-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20Reshma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Mary-Ann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHeekes%2C%20Alexa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMahomed%2C%20Hassan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHawkridge%2C%20Anthony%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20COVID-19%20Vaccine%20Uptake%20and%20Effectiveness%20by%20Time%20since%20Vaccination%20in%20the%20Western%20Cape%20Province%2C%20South%20Africa%3A%20An%20Observational%20Cohort%20Study%20during%202020-2022.%20%26lt%3Bi%26gt%3BVaccines%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20628.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fvaccines12060628%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fvaccines12060628%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22COVID-19%20Vaccine%20Uptake%20and%20Effectiveness%20by%20Time%20since%20Vaccination%20in%20the%20Western%20Cape%20Province%2C%20South%20Africa%3A%20An%20Observational%20Cohort%20Study%20during%202020-2022%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hassan%22%2C%22lastName%22%3A%22Mahomed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20J.%22%2C%22lastName%22%3A%22Hawkridge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erna%22%2C%22lastName%22%3A%22Morden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theuns%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cheryl%22%2C%22lastName%22%3A%22Cohen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harry%22%2C%22lastName%22%3A%22Moultrie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Lessells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolette%22%2C%22lastName%22%3A%22Van%20Der%20Walt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juanita%20O.%22%2C%22lastName%22%3A%22Arendse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Wolter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sibongile%22%2C%22lastName%22%3A%22Walaza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Waasila%22%2C%22lastName%22%3A%22Jassat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22von%20Gottberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20L.%22%2C%22lastName%22%3A%22Hannan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20R.%22%2C%22lastName%22%3A%22Feikin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keith%22%2C%22lastName%22%3A%22Cloete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%5D%2C%22abstractNote%22%3A%22There%20are%20few%20data%20on%20the%20real-world%20effectiveness%20of%20COVID-19%20vaccines%20and%20boosting%20in%20Africa%2C%20which%20experienced%20widespread%20SARS-CoV-2%20infection%20before%20vaccine%20availability.%20We%20assessed%20the%20association%20between%20vaccination%20and%20severe%20COVID-19%20in%20the%20Western%20Cape%2C%20South%20Africa%2C%20in%20an%20observational%20cohort%20study%20of%20%26gt%3B2%20million%20adults%20during%202020-2022.%20We%20described%20SARS-CoV-2%20testing%2C%20COVID-19%20outcomes%2C%20and%20vaccine%20uptake%20over%20time.%20We%20used%20multivariable%20cox%20models%20to%20estimate%20the%20association%20of%20BNT162b2%20and%20Ad26.COV2.S%20vaccination%20with%20COVID-19-related%20hospitalization%20and%20death%2C%20adjusting%20for%20demographic%20characteristics%2C%20underlying%20health%20conditions%2C%20socioeconomic%20status%20proxies%2C%20and%20healthcare%20utilization.%20We%20found%20that%20by%20the%20end%20of%202022%2C%2041%25%20of%20surviving%20adults%20had%20completed%20vaccination%20and%208%25%20had%20received%20a%20booster%20dose.%20Recent%20vaccination%20was%20associated%20with%20notable%20reductions%20in%20severe%20COVID-19%20during%20periods%20dominated%20by%20Delta%2C%20and%20Omicron%20BA.1%5C%2F2%20and%20BA.4%5C%2F5%20%28sub%29lineages.%20During%20the%20latest%20Omicron%20BA.4%5C%2F5%20wave%2C%20within%203%20months%20of%20vaccination%20or%20boosting%2C%20BNT162b2%20and%20Ad26.COV2.S%20were%20each%2084%25%20effective%20against%20death%20%2895%25%20CIs%3A%2057-94%20and%2049-95%2C%20respectively%29.%20However%2C%20distinct%20reductions%20of%20effectiveness%20occurred%20at%20longer%20times%20post%20completing%20or%20boosting%20vaccination.%20Results%20highlight%20the%20importance%20of%20continued%20emphasis%20on%20COVID-19%20vaccination%20and%20boosting%20for%20those%20at%20high%20risk%20of%20severe%20COVID-19%2C%20even%20in%20settings%20with%20widespread%20infection-induced%20immunity.%22%2C%22date%22%3A%222024-06-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3390%5C%2Fvaccines12060628%22%2C%22ISSN%22%3A%222076-393X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22FVGYB2LG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nyakato%20et%20al.%22%2C%22parsedDate%22%3A%222024-05-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNyakato%2C%20Patience%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoulle%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWood%2C%20Robin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Self-transfers%2C%20Hospital%20Admissions%20and%20Mortality%20Among%20Children%20and%20Adolescents%20Lost%20to%20Follow-up%20From%20Antiretroviral%20Therapy%20Programs%20in%20the%20Western%20Cape%2C%20South%20Africa%20Between%202004%20and%202019%3A%20Linkage%20to%20Provincial%20Records.%20%26lt%3Bi%26gt%3BThe%20Pediatric%20Infectious%20Disease%20Journal%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B43%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20430%26%23x2013%3B436.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004281%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004281%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Self-transfers%2C%20Hospital%20Admissions%20and%20Mortality%20Among%20Children%20and%20Adolescents%20Lost%20to%20Follow-up%20From%20Antiretroviral%20Therapy%20Programs%20in%20the%20Western%20Cape%2C%20South%20Africa%20Between%202004%20and%202019%3A%20Linkage%20to%20Provincial%20Records%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patience%22%2C%22lastName%22%3A%22Nyakato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constantin%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Pediatric%20programs%20face%20a%20high%20rate%20of%20loss%20to%20follow-up%20%28LTFU%29%20among%20children%20and%20adolescents%20living%20with%20HIV%20%28CAHIV%29.%20We%20assessed%20true%20outcomes%20and%20predictors%20of%20these%20among%20CAHIV%20who%20were%20LTFU%20using%20linkage%20to%20the%20Western%20Cape%20Provincial%20Health%20Data%20Centre%20at%20Western%20Cape%20sites%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS-Southern%20Africa%20collaboration.%5CnMETHODS%3A%20We%20examined%20factors%20associated%20with%20self-transfer%2C%20hospital%20admission%20and%20mortality%20using%20competing%20risks%20regression%20in%20a%20retrospective%20cohort%20of%20CAHIV%20initiating%20antiretroviral%20therapy%20%26lt%3B15%20years%20old%20between%202004%20and%202019%20and%20deemed%20LTFU%20%28no%20recorded%20visit%20at%20the%20original%20facility%20for%20%5Cu2265180%20days%20from%20the%20last%20visit%20date%20before%20database%20closure%20and%20not%20known%20to%20have%20officially%20transferred%20out%20or%20deceased%29.%5CnRESULTS%3A%20Of%20the%201720%20CAHIV%20deemed%20LTFU%2C%20802%20%2846.6%25%29%20had%20self-transferred%20and%20were%20receiving%20care%20elsewhere%20within%20the%20Western%20Cape%2C%20463%20%2826.9%25%29%20had%20been%20hospitalized%20and%2045%20%282.6%25%29%20CAHIV%20had%20died.%20The%20overall%20rates%20of%20self-transfer%2C%20hospitalization%2C%20mortality%20and%20LTFU%20were%209.4%20%5B95%25%20confidence%20interval%20%28CI%29%3A%208.8-10.1%5D%2C%205.4%20%2895%25%20CI%3A%205.0-6.0%29%2C%200.5%20%2895%25%20CI%3A%200.4-0.7%29%20and%204.8%20%2895%25%20CI%3A%204.4-5.3%29%20per%20100%20person-years%20respectively.%20Increasing%20duration%20on%20antiretroviral%20therapy%20before%20LTFU%20was%20associated%20with%20self-transfers%20while%20male%20sex%2C%20older%20age%20at%20last%20visit%20%28%5Cu226510%20years%20vs.%20younger%29%20were%20associated%20with%20hospital%20admission%20and%20immune%20suppression%20at%20last%20visit%20was%20associated%20with%205%20times%20higher%20mortality.%5CnCONCLUSIONS%3A%20Nearly%20half%20of%20CAHIV%20classified%20as%20LTFU%20had%20self-transferred%20to%20another%20health%20facility%2C%20a%20quarter%20had%20been%20hospitalized%20and%20a%20small%20proportion%20had%20died.%22%2C%22date%22%3A%222024-05-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FINF.0000000000004281%22%2C%22ISSN%22%3A%221532-0987%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T12%3A30%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22EDIV7L8F%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kebede%20et%20al.%22%2C%22parsedDate%22%3A%222024-04-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKebede%2C%20Samuel%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFreeman%2C%20Aimee%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuwonge%2C%20Timothy%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChoi%2C%20Jun%20Yong%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Preexposure%20prophylaxis%20availability%20among%20health%20facilities%20participating%20in%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20751%26%23x2013%3B756.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003824%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003824%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Preexposure%20prophylaxis%20availability%20among%20health%20facilities%20participating%20in%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Kebede%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%20M.%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20R.%22%2C%22lastName%22%3A%22Muwonge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%20Yong%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Renee%22%2C%22lastName%22%3A%22de%20Waal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Armel%22%2C%22lastName%22%3A%22Poda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Cesar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Athanase%22%2C%22lastName%22%3A%22Munyaneza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20Kristoffer%20U.%22%2C%22lastName%22%3A%22Pasayan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alisho%22%2C%22lastName%22%3A%22Shongo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%22%2C%22lastName%22%3A%22Ekouevi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valdil%5Cu00e9a%20G.%22%2C%22lastName%22%3A%22Veloso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20While%20recognized%20as%20a%20key%20HIV%20prevention%20strategy%2C%20preexposure%20prophylaxis%20%28PrEP%29%20availability%20and%20accessibility%20are%20not%20well%20documented%20globally.%20We%20aimed%20to%20describe%20PrEP%20drug%20registration%20status%20and%20the%20availability%20of%20PrEP%20services%20across%20HIV%20care%20sites%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20research%20consortium.%5CnMETHODS%3A%20We%20used%20country-level%20PrEP%20drug%20registration%20status%20from%20the%20AIDS%20Vaccine%20Advocacy%20Coalition%20and%20data%20from%20IeDEA%20surveys%20conducted%20in%202014%2C%202017%20and%202020%20among%20participating%20HIV%20clinics%20in%20seven%20global%20regions.%20We%20used%20descriptive%20statistics%20to%20assess%20PrEP%20availability%20across%20IeDEA%20sites%20serving%20adult%20patients%20in%202020%20and%20examined%20trends%20in%20PrEP%20availability%20among%20sites%20that%20responded%20to%20all%20three%20surveys.%5CnRESULTS%3A%20Of%20199%20sites%20that%20completed%20the%202020%20survey%2C%20PrEP%20was%20available%20in%20161%20%2881%25%29.%20PrEP%20availability%20was%20highest%20at%20sites%20in%20North%20America%20%2829%5C%2F30%3B%2097%25%29%20and%20East%20Africa%20%2870%5C%2F74%3B%2095%25%29%20and%20lowest%20at%20sites%20in%20Central%20%2810%5C%2F20%3B%2050%25%29%20and%20West%20Africa%20%281%5C%2F6%3B%2017%25%29.%20PrEP%20availability%20was%20higher%20among%20sites%20in%20countries%20where%20PrEP%20was%20officially%20registered%20%28146%5C%2F161%3B%2091%25%29%20than%20where%20it%20was%20not%20%2814%5C%2F32%3B%2044%25%29.%20Availability%20was%20higher%20at%20health%20centers%20%28109%5C%2F120%3B%2090%25%29%20and%20district%20hospitals%20%2814%5C%2F16%3B%2088%25%29%20compared%20to%20regional%5C%2Fteaching%20hospitals%20%2836%5C%2F63%29.%20Among%20the%2094%20sites%20that%20responded%20to%20all%20three%20surveys%2C%20PrEP%20availability%20increased%20from%2047%25%20in%202014%20to%2060%25%20in%202017%20and%2076%25%20in%202020.%5CnCONCLUSION%3A%20PrEP%20availability%20has%20substantially%20increased%20since%202014%20and%20is%20now%20available%20at%20most%20IeDEA%20sites.%20However%2C%20PrEP%20service%20provision%20varies%20markedly%20across%20global%20regions.%22%2C%22date%22%3A%222024-04-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003824%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22GNS9IMDT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Plaisy%20et%20al.%22%2C%22parsedDate%22%3A%222024-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPlaisy%2C%20Marie%20Kerbie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMinga%2C%20Albert%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWandeler%2C%20Gilles%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMurenzi%2C%20Gad%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSamala%2C%20Niharika%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Metabolic%20causes%20of%20liver%20disease%20among%20adults%20living%20with%20HIV%20from%20low-%20and%20middle-income%20countries%3A%20a%20cross-sectional%20study.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e26238.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26238%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26238%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Metabolic%20causes%20of%20liver%20disease%20among%20adults%20living%20with%20HIV%20from%20low-%20and%20middle-income%20countries%3A%20a%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20Kerbie%22%2C%22lastName%22%3A%22Plaisy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%20K.%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niharika%22%2C%22lastName%22%3A%22Samala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alvaro%22%2C%22lastName%22%3A%22Lopez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ephrem%22%2C%22lastName%22%3A%22Mensah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ren%5Cu00e9e%22%2C%22lastName%22%3A%22de%20Waal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20H.%22%2C%22lastName%22%3A%22Kuniholm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonali%22%2C%22lastName%22%3A%22Salvi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodrigo%22%2C%22lastName%22%3A%22Moreira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Attia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ardele%22%2C%22lastName%22%3A%22Mandiriri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabienne%22%2C%22lastName%22%3A%22Shumbusho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%22%2C%22lastName%22%3A%22Goodrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dhanushi%22%2C%22lastName%22%3A%22Rupasinghe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paola%22%2C%22lastName%22%3A%22Alarcon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Perrazo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Sentinel%20Research%20Network%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Liver%20disease%20is%20a%20leading%20cause%20of%20morbidity%20and%20mortality%20among%20persons%20living%20with%20HIV%20%28PLHIV%29.%20While%20chronic%20viral%20hepatitis%20has%20been%20extensively%20studied%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29%2C%20there%20is%20limited%20information%20about%20the%20burden%20of%20metabolic%20disorders%20on%20liver%20disease%20in%20PLHIV.%5CnMETHODS%3A%20We%20conducted%20a%20cross-sectional%20analysis%20of%20baseline%20data%20collected%20between%20October%202020%20and%20July%202022%20from%20the%20IeDEA-Sentinel%20Research%20Network%2C%20a%20prospective%20cohort%20enrolling%20PLHIV%20%5Cu226540%20years%20on%20antiretroviral%20treatment%20%28ART%29%20for%20%5Cu22656%20months%20from%20eight%20clinics%20in%20Asia%2C%20Americas%2C%20and%20central%2C%20East%2C%20southern%20and%20West%20Africa.%20Clinical%20assessments%2C%20laboratory%20testing%20on%20fasting%20blood%20samples%20and%20liver%20stiffness%20measurement%20%28LSM%29%5C%2Fcontrolled%20attenuation%20parameter%20%28CAP%29%20by%20vibration-controlled%20transient%20elastography%20were%20performed.%20Multivariable%20logistic%20regression%20models%20assessed%20factors%20associated%20with%20liver%20fibrosis%20%28LSM%20%5Cu22657.1%20kPa%29%20and%20steatosis%20%28CAP%20%5Cu2265248%20dB%5C%2Fm%29.%20Population%20attributable%20fraction%20%28PAF%29%20of%20each%20variable%20associated%20with%20significant%20liver%20fibrosis%20was%20estimated%20using%20Levin%26%23039%3Bs%20formula.%5CnRESULTS%3A%20Overall%2C%202120%20PLHIV%20%2856%25%20female%2C%20median%20age%2050%20%5Binterquartile%20range%3A%2045-56%5D%20years%29%20were%20included.%20The%20prevalence%20of%20obesity%20was%2019%25%2C%2012%25%20had%20type%202%20diabetes%20mellitus%20%28T2DM%29%2C%2029%25%20had%20hypertension%20and%2053%25%20had%20dyslipidaemia.%20The%20overall%20prevalence%20of%20liver%20fibrosis%20and%20steatosis%20was%207.6%25%20%2895%25%20confidence%20interval%20%5BCI%5D%206.1-8.4%29%20and%2028.4%25%20%2895%25%20CI%2026.5-30.7%29%2C%20respectively%2C%20with%20regional%20variability.%20Male%20sex%20at%20birth%20%28odds%20ratio%20%5BOR%5D%201.62%2C%20CI%201.10-2.40%29%2C%20overweight%5C%2Fobesity%20%28OR%20%3D%202.50%2C%2095%25%20CI%201.69-3.75%29%2C%20T2DM%20%28OR%202.26%2C%2095%25%20CI%201.46-3.47%29%20and%20prolonged%20exposure%20to%20didanosine%20%28OR%203.13%2C%2095%25%20CI%201.46-6.49%29%20were%20associated%20with%20liver%20fibrosis.%20Overweight%5C%2Fobesity%20and%20T2DM%20accounted%20for%2042%25%20and%2011%25%20of%20the%20PAF%20for%20liver%20fibrosis%2C%20while%20HBsAg%20and%20anti-HCV%20accounted%20for%203%25%20and%201%25%2C%20respectively.%20Factors%20associated%20with%20steatosis%20included%20overweight%5C%2Fobesity%20%28OR%204.25%2C%2095%25%20CI%203.29-5.51%29%2C%20T2DM%20%28OR%202.06%2C%2095%25%20CI%201.47-2.88%29%2C%20prolonged%20exposure%20to%20stavudine%20%28OR%201.69%2C%2095%25%20CI%201.27-2.26%29%20and%20dyslipidaemia%20%28OR%201.68%2C%2095%25%20CI%201.31-2.16%29.%5CnCONCLUSIONS%3A%20Metabolic%20disorders%20were%20significant%20risk%20factors%20for%20liver%20disease%20among%20PLHIV%20in%20LMICs.%20Early%20recognition%20of%20metabolic%20disorders%20risk%20factors%20might%20be%20helpful%20to%20guide%20clinical%20and%20lifestyle%20interventions.%20Further%20prospective%20studies%20are%20needed%20to%20determine%20the%20causative%20natures%20of%20these%20findings.%22%2C%22date%22%3A%222024-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26238%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-17T13%3A02%3A12Z%22%7D%7D%2C%7B%22key%22%3A%22Y6NAACJN%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Phillips%20et%20al.%22%2C%22parsedDate%22%3A%222024-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhillips%2C%20Tamsin%20Kate%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20Reshma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaxwell%2C%20Nicola%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJohnson%2C%20Leigh%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20ART%20history%20prior%20to%20conception%3A%20trends%20and%20association%20with%20postpartum%20disengagement%20from%20HIV%20care%20in%20Khayelitsha%2C%20South%20Africa%20%282013-2019%29%3A%20a%20retrospective%20cohort%20study.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e26236.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26236%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26236%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22ART%20history%20prior%20to%20conception%3A%20trends%20and%20association%20with%20postpartum%20disengagement%20from%20HIV%20care%20in%20Khayelitsha%2C%20South%20Africa%20%282013-2019%29%3A%20a%20retrospective%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamsin%20Kate%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Maxwell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haroon%22%2C%22lastName%22%3A%22Moolla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Landon%22%2C%22lastName%22%3A%22Myer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20H.%22%2C%22lastName%22%3A%22Chi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Renee%22%2C%22lastName%22%3A%22de%20Waal%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20In%20recent%20years%2C%20the%20expansion%20of%20HIV%20treatment%20eligibility%20has%20resulted%20in%20an%20increase%20in%20people%20with%20antiretroviral%20therapy%20%28ART%29%20experience%20prior%20to%20pregnancy%20but%20little%20is%20known%20about%20postpartum%20engagement%20in%20care%20in%20this%20population.%20We%20examined%20differences%20in%20disengagement%20from%20HIV%20care%20after%20delivery%20by%20maternal%20ART%20history%20before%20conception.%5CnMETHODS%3A%20We%20analysed%20data%20from%20people%20living%20with%20HIV%20%28aged%2015-49%29%20in%20Khayelitsha%2C%20South%20Africa%2C%20with%20%5Cu22651%20live%20birth%20between%20April%202013%20and%20March%202019.%20We%20described%20trends%20over%20time%20in%20ART%20history%20prior%20to%20estimated%20conception%2C%20classifying%20ART%20history%20groups%20as%3A%20%28A%29%20on%20ART%20with%20no%20disengagement%20%28%26gt%3B270%20days%20with%20no%20evidence%20of%20HIV%20care%29%3B%20%28B%29%20returned%20before%20pregnancy%20following%20disengagement%3B%20%28C%29%20restarted%20ART%20in%20pregnancy%20after%20disengagement%3B%20and%20%28D%29%20ART%20new%20start%20in%20pregnancy.%20We%20used%20Kaplan-Meier%20curves%20and%20proportional-hazards%20models%20%28adjusted%20for%20maternal%20age%2C%20number%20of%20pregnancy%20records%20and%20year%20of%20delivery%29%20to%20examine%20the%20time%20to%20disengagement%20from%20delivery%20to%202%20years%20postpartum.%5CnRESULTS%3A%20Among%207309%20pregnancies%20%28in%206680%20individuals%29%2C%20the%20proportion%20on%20ART%20%28A%29%20increased%20from%2019%25%20in%202013%20to%2041%25%20in%202019.%20The%20proportions%20of%20those%20who%20returned%20%28B%29%20and%20restarted%20%28C%29%20increased%20from%202%25%20to%2013%25%20and%20from%202%25%20to%2010%25%2C%20respectively.%20There%20was%20a%20corresponding%20decline%20in%20the%20proportion%20of%20new%20starts%20%28D%29%20from%2077%25%20in%202013%20to%2036%25%20in%202019.%20In%20the%20first%20recorded%20pregnancy%20per%20person%20in%20the%20study%20period%2C%2026%25%20%2895%25%20CI%2025-27%25%29%20had%20disengaged%20from%20care%20by%201%20year%20and%2034%25%20%2895%25%20CI%2033-36%25%29%20by%202%20years%20postpartum.%20Individuals%20who%20returned%20%28B%3A%20aHR%202.10%2C%2095%25%20CI%201.70-2.60%29%2C%20restarted%20%28C%3A%20aHR%203.32%2C%2095%25%20CI%202.70-4.09%29%20and%20newly%20started%20ART%20%28D%3A%20aHR%202.41%2C%2095%25%20CI%202.12-2.74%29%20had%20increased%20hazards%20of%20postpartum%20disengagement%20compared%20to%20those%20on%20ART%20%28A%29.%5CnCONCLUSIONS%3A%20There%20is%20a%20growing%20population%20of%20people%20with%20ART%20experience%20prior%20to%20conception%20and%20postpartum%20disengagement%20varies%20substantially%20by%20ART%20history.%20Antenatal%20care%20presents%20an%20important%20opportunity%20to%20understand%20prior%20ART%20experiences%20and%20an%20entry%20into%20interventions%20for%20strengthened%20engagement%20in%20HIV%20care.%22%2C%22date%22%3A%222024-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26236%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A14%3A56Z%22%7D%7D%2C%7B%22key%22%3A%226EZFH9QC%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222024-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKalk%2C%20Emma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHeekes%2C%20Alexa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhelanyane%2C%20Florence%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJacob%2C%20Nisha%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Factors%20associated%20with%20vertical%20transmission%20of%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20a%20retrospective%20cohort%20analysis.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e26235.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26235%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26235%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Factors%20associated%20with%20vertical%20transmission%20of%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20a%20retrospective%20cohort%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nisha%22%2C%22lastName%22%3A%22Jacob%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ushma%22%2C%22lastName%22%3A%22Mehta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gayathri%22%2C%22lastName%22%3A%22Sridhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Ragone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vani%22%2C%22lastName%22%3A%22Vannappagari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Monitoring%20mother-infant%20pairs%20with%20HIV%20exposure%20is%20needed%20to%20assess%20the%20effectiveness%20of%20vertical%20transmission%20%28VT%29%20prevention%20programmes%20and%20progress%20towards%20VT%20elimination.%5CnMETHODS%3A%20We%20used%20routinely%20collected%20data%20on%20infants%20with%20HIV%20exposure%2C%20born%20May%202018-April%202021%20in%20the%20Western%20Cape%2C%20South%20Africa%2C%20with%20follow-up%20through%20mid-2022.%20We%20assessed%20the%20proportion%20of%20infants%20diagnosed%20with%20HIV%20at%20birth%20%28%5Cu22647%20days%29%2C%2010%20weeks%20%28%26gt%3B1%20to%2014%20weeks%29%20and%20%26gt%3B14%20weeks%20as%20proxies%20for%20intrauterine%2C%20intrapartum%5C%2Fearly%20breastfeeding%20and%20late%20breastfeeding%20transmission%2C%20respectively.%20We%20used%20mixed-effects%20Poisson%20regression%20to%20assess%20factors%20associated%20with%20VT%20in%20mothers%20known%20with%20HIV%20by%20delivery.%5CnRESULTS%3A%20We%20included%2050%2C461%20infants%20born%20to%20mothers%20known%20with%20HIV%20by%20delivery.%20HIV%20was%20diagnosed%20in%20894%20%281.8%25%29%20infants.%20Among%20mothers%2C%2051%25%20started%20antiretroviral%20treatment%20%28ART%29%20before%20and%2027%25%20during%20pregnancy%3B%2017%25%20restarted%20during%20pregnancy%20after%20%5Cu22656%20months%20interruption%3B%20and%206%25%20had%20no%20recorded%20ART%20during%20pregnancy.%20Most%20pregnancy%20ART%20regimens%20included%20non-nucleoside%20reverse%20transcriptase%20inhibitors%20%2883%25%29.%20Of%20mothers%20with%20available%20results%20%2890%25%20with%20viral%20load%20%5BVL%5D%3B%2070%25%20with%20CD4%29%2C%20VL%20nearest%20delivery%20was%20%26lt%3B100%20copies%5C%2Fml%20in%2078%25%20and%20CD4%20count%20%5Cu2265350%20cells%5C%2F%5Cu03bcl%20in%2062%25.%20HIV-PCR%20results%20were%20available%20for%2086%25%2C%2067%25%20and%2048%25%20of%20eligible%20infants%20at%20birth%2C%2010%20weeks%20and%20%26gt%3B14%20weeks.%20Among%20these%20infants%2C%200.9%25%2C%200.4%25%20and%201.5%25%20were%20diagnosed%20positive%20at%20birth%2C%2010%20weeks%20and%20%26gt%3B14%20weeks%2C%20respectively.%20Among%20infants%20diagnosed%20with%20HIV%2C%2043%25%2C%2016%25%20and%2041%25%20were%20diagnosed%20at%20these%20respective%20time%20periods.%20Among%20mothers%20with%20VL%26lt%3B100%2C%20100-999%2C%201000-99%2C000%20and%20%5Cu2265100%2C000%20copies%5C%2Fml%20nearest%20delivery%2C%20infant%20HIV%20diagnosis%20incidence%20was%200.4%25%2C%202.3%25%2C%206.6%25%20and%2018.4%25%2C%20respectively.%20Increased%20VT%20was%20strongly%20associated%20with%20recent%20elevated%20maternal%20VL%20with%20a%20seven-fold%20increased%20rate%20with%20even%20modestly%20elevated%20VL%20%28100-999%20vs.%20%26lt%3B100%20copies%5C%2Fml%29.%20VT%20was%20also%20associated%20with%20unknown%5C%2Flow%20maternal%20CD4%2C%20maternal%20age%20%26lt%3B20%20years%2C%20no%20antenatal%20ART%2C%20later%20maternal%20ART%20start%5C%2Frestart%20in%20pregnancy%20and%20ART%20gaps.%5CnCONCLUSIONS%3A%20Despite%20high%20maternal%20ART%20coverage%20and%20routine%20postnatal%20prophylaxis%2C%20ongoing%20VT%20remains%20a%20concern.%20Timing%20of%20infant%20HIV%20diagnoses%20suggests%20intrapartum%20and%5C%2For%20breastfeeding%20transmission%20in%20nearly%2060%25.%20Interventions%20to%20ensure%20retention%20on%20ART%20and%20sustained%20maternal%20viral%20suppression%20are%20needed%20to%20reduce%20VT.%22%2C%22date%22%3A%222024-03%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26235%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22EKX688G4%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222024-03%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTymejczyk%2C%20Olga%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWools-Kaloustian%2C%20Kara%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJiamsakul%2C%20Awachana%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTorres%2C%20Marco%20Tulio%20Luque%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Long-term%20HIV%20care%20outcomes%20under%20universal%20HIV%20treatment%20guidelines%3A%20A%20retrospective%20cohort%20study%20in%2025%20countries.%20%26lt%3Bi%26gt%3BPLoS%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B21%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e1004367.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004367%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004367%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Long-term%20HIV%20care%20outcomes%20under%20universal%20HIV%20treatment%20guidelines%3A%20A%20retrospective%20cohort%20study%20in%2025%20countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Tymejczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Awachana%22%2C%22lastName%22%3A%22Jiamsakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%20Tulio%20Luque%22%2C%22lastName%22%3A%22Torres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%20S.%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Abuogi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vohith%22%2C%22lastName%22%3A%22Khol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%22%2C%22lastName%22%3A%22Mej%5Cu00eda%20Cordero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20G.%22%2C%22lastName%22%3A%22Law%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20While%20national%20adoption%20of%20universal%20HIV%20treatment%20guidelines%20has%20led%20to%20improved%2C%20timely%20uptake%20of%20antiretroviral%20therapy%20%28ART%29%2C%20longer-term%20care%20outcomes%20are%20understudied.%20There%20is%20little%20data%20from%20real-world%20service%20delivery%20settings%20on%20patient%20attrition%2C%20viral%20load%20%28VL%29%20monitoring%2C%20and%20viral%20suppression%20%28VS%29%20at%2024%20and%2036%20months%20after%20HIV%20treatment%20initiation.%5CnMETHODS%20AND%20FINDINGS%3A%20For%20this%20retrospective%20cohort%20analysis%2C%20we%20used%20observational%20data%20from%2025%20countries%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%26%23039%3Bs%20Asia-Pacific%2C%20Central%20Africa%2C%20East%20Africa%2C%20Central%5C%2FSouth%20America%2C%20and%20North%20America%20regions%20for%20patients%20who%20were%20ART%20na%5Cu00efve%20and%20aged%20%5Cu226515%20years%20at%20care%20enrollment%20between%2024%20months%20before%20and%2012%20months%20after%20national%20adoption%20of%20universal%20treatment%20guidelines%2C%20occurring%202012%20to%202018.%20We%20estimated%20crude%20cumulative%20incidence%20of%20loss-to-clinic%20%28CI-LTC%29%20at%2012%2C%2024%2C%20and%2036%20months%20after%20enrollment%20among%20patients%20enrolling%20in%20care%20before%20and%20after%20guideline%20adoption%20using%20competing%20risks%20regression.%20Guideline%20change-associated%20hazard%20ratios%20of%20LTC%20at%20each%20time%20point%20after%20enrollment%20were%20estimated%20via%20cause-specific%20Cox%20proportional%20hazards%20regression%20models.%20Modified%20Poisson%20regression%20was%20used%20to%20estimate%20relative%20risks%20of%20retention%2C%20VL%20monitoring%2C%20and%20VS%20at%2012%2C%2024%2C%20and%2036%20months%20after%20ART%20initiation.%20There%20were%2066%2C963%20patients%20enrolling%20in%20HIV%20care%20at%20109%20clinics%20with%20%5Cu226512%20months%20of%20follow-up%20time%20after%20enrollment%20%2846%2C484%20%5B69.4%25%5D%20enrolling%20before%20guideline%20adoption%20and%2020%2C479%20%5B30.6%25%5D%20enrolling%20afterwards%29.%20More%20than%20half%20%2854.9%25%29%20were%20females%2C%20and%20median%20age%20was%2034%20years%20%28interquartile%20range%20%5BIQR%5D%3A%2027%20to%2043%29.%20Mean%20follow-up%20time%20was%2051%20months%20%28standard%20deviation%3A%2017%20months%3B%20range%3A%2012%2C%20110%20months%29.%20Among%20patients%20enrolling%20before%20guideline%20adoption%2C%20crude%20CI-LTC%20was%2023.8%25%20%2895%25%20confidence%20interval%20%5B95%25%20CI%5D%2023.4%2C%2024.2%29%20at%2012%20months%2C%2031.0%25%20%2895%25%20CI%20%5B30.6%2C%2031.5%5D%29%20at%2024%20months%2C%20and%2037.2%25%20%2895%25%20%5BCI%2036.8%2C%2037.7%5D%29%20at%2036%20months%20after%20enrollment.%20Adjusting%20for%20sex%2C%20age%20group%2C%20enrollment%20CD4%2C%20clinic%20location%20and%20type%2C%20and%20country%20income%20level%2C%20enrolling%20in%20care%20and%20initiating%20ART%20after%20guideline%20adoption%20was%20associated%20with%20increased%20hazard%20of%20LTC%20at%2012%20months%20%28adjusted%20hazard%20ratio%20%5BaHR%5D%201.25%20%5B95%25%20CI%201.08%2C%201.44%5D%3B%20p%20%3D%200.003%29%3B%2024%20months%20%28aHR%201.38%20%5B95%25%20CI%201.19%2C%201.59%5D%3B%20p%20%26lt%3B%20.001%29%3B%20and%2036%20months%20%28aHR%201.34%20%5B95%25%20CI%201.18%2C%201.53%5D%2C%20p%20%26lt%3B%20.001%29%20compared%20with%20enrollment%20before%20guideline%20adoption%2C%20with%20no%20before-after%20differences%20among%20patients%20with%20no%20record%20of%20ART%20initiation%20by%20end%20of%20follow-up.%20Among%20patients%20retained%20after%20ART%20initiation%2C%20VL%20monitoring%20was%20low%2C%20with%20marginal%20improvements%20associated%20with%20guideline%20adoption%20only%20at%2012%20months%20after%20ART%20initiation.%20Among%20those%20with%20VL%20monitoring%2C%20VS%20was%20high%20at%20each%20time%20point%20among%20patients%20enrolling%20before%20guideline%20adoption%20%2886.0%25%20to%2088.8%25%29%20and%20afterwards%20%2886.2%25%20to%2090.3%25%29%2C%20with%20no%20substantive%20difference%20associated%20with%20guideline%20adoption.%20Study%20limitations%20include%20lags%20in%20and%20potential%20underascertainment%20of%20care%20outcomes%20in%20real-world%20service%20delivery%20data%20and%20potential%20lack%20of%20generalizability%20beyond%20IeDEA%20sites%20and%20regions%20included%20in%20this%20analysis.%5CnCONCLUSIONS%3A%20In%20this%20study%2C%20adoption%20of%20universal%20HIV%20treatment%20guidelines%20was%20associated%20with%20lower%20retention%20after%20ART%20initiation%20out%20to%2036%20months%20of%20follow-up%2C%20with%20little%20change%20in%20VL%20monitoring%20or%20VS%20among%20retained%20patients.%20Monitoring%20long-term%20HIV%20care%20outcomes%20remains%20critical%20to%20identify%20and%20address%20causes%20of%20attrition%20and%20gaps%20in%20HIV%20care%20quality.%22%2C%22date%22%3A%222024-03%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pmed.1004367%22%2C%22ISSN%22%3A%221549-1676%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A31Z%22%7D%7D%2C%7B%22key%22%3A%226V46IUCA%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mesa-Vieira%20et%20al.%22%2C%22parsedDate%22%3A%222024-02-05%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMesa-Vieira%2C%20Cristina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDidden%2C%20Christiane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchomaker%2C%20Michael%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMouton%2C%20Johannes%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Post-traumatic%20stress%20disorder%20as%20a%20risk%20factor%20for%20major%20adverse%20cardiovascular%20events%3A%20a%20cohort%20study%20of%20a%20South%20African%20medical%20insurance%20scheme.%20%26lt%3Bi%26gt%3BEpidemiology%20and%20Psychiatric%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B33%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20e5.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS2045796024000052%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS2045796024000052%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Post-traumatic%20stress%20disorder%20as%20a%20risk%20factor%20for%20major%20adverse%20cardiovascular%20events%3A%20a%20cohort%20study%20of%20a%20South%20African%20medical%20insurance%20scheme%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Mesa-Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Schomaker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%20P.%22%2C%22lastName%22%3A%22Mouton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20L.%22%2C%22lastName%22%3A%22van%20den%20Heuvel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chiara%22%2C%22lastName%22%3A%22Gastaldon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oscar%20H.%22%2C%22lastName%22%3A%22Franco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soraya%22%2C%22lastName%22%3A%22Seedat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22AIMS%3A%20Prior%20research%2C%20largely%20focused%20on%20US%20male%20veterans%2C%20indicates%20an%20increased%20risk%20of%20cardiovascular%20disease%20among%20individuals%20with%20post-traumatic%20stress%20disorder%20%28PTSD%29.%20Data%20from%20other%20settings%20and%20populations%20are%20scarce.%20The%20objective%20of%20this%20study%20is%20to%20examine%20PTSD%20as%20a%20risk%20factor%20for%20incident%20major%20adverse%20cardiovascular%20events%20%28MACEs%29%20in%20South%20Africa.%5CnMETHODS%3A%20We%20analysed%20reimbursement%20claims%20%282011-2020%29%20of%20a%20cohort%20of%20South%20African%20medical%20insurance%20scheme%20beneficiaries%20aged%2018%5Cu00a0years%20or%20older.%20We%20calculated%20adjusted%20hazard%20ratios%20%28aHRs%29%20for%20associations%20between%20PTSD%20and%20MACEs%20using%20Cox%20proportional%20hazard%20models%20and%20calculated%20the%20effect%20of%20PTSD%20on%20MACEs%20using%20longitudinal%20targeted%20maximum%20likelihood%20estimation.%5CnRESULTS%3A%20We%20followed%201%2C009%2C113%20beneficiaries%20over%20a%20median%20of%203.0%5Cu00a0years%20%28IQR%201.1-6.0%29.%20During%20follow-up%2C%2012%2C662%20%281.3%25%29%20persons%20were%20diagnosed%20with%20PTSD%20and%2039%2C255%20%283.9%25%29%20had%20a%20MACE.%20After%20adjustment%20for%20sex%2C%20HIV%20status%2C%20age%2C%20population%20group%2C%20substance%20use%20disorders%2C%20psychotic%20disorders%2C%20major%20depressive%20disorder%2C%20sleep%20disorders%20and%20the%20use%20of%20antipsychotic%20medication%2C%20PTSD%20was%20associated%20with%20a%2016%25%20increase%20in%20the%20risk%20of%20MACEs%20%28aHR%201.16%2C%2095%25%20confidence%20interval%20%28CI%29%201.05-1.28%29.%20The%20risk%20ratio%20for%20the%20effect%20of%20PTSD%20on%20MACEs%20decreased%20from%201.59%20%2895%25%20CI%201.49-1.68%29%20after%201%5Cu00a0year%20of%20follow-up%20to%201.14%20%2895%25%20CI%201.11-1.16%29%20after%208%5Cu00a0years%20of%20follow-up.%5CnCONCLUSION%3A%20Our%20study%20provides%20empirical%20support%20for%20an%20increased%20risk%20of%20MACEs%20in%20males%20and%20females%20with%20PTSD%20from%20a%20general%20population%20sample%20in%20South%20Africa.%20These%20findings%20highlight%20the%20importance%20of%20monitoring%20cardiovascular%20risk%20among%20individuals%20diagnosed%20with%20PTSD.%22%2C%22date%22%3A%222024-02-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1017%5C%2FS2045796024000052%22%2C%22ISSN%22%3A%222045-7979%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22VH2UK4RU%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Davidovi%5Cu0107%20et%20al.%22%2C%22parsedDate%22%3A%222024-02-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavidovi%26%23x107%3B%2C%20Ma%26%23x161%3Ba%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAsangbeh%2C%20Serra%20Lem%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20Katayoun%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJaquet%2C%20Antoine%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Facility-Based%20Indicators%20to%20Manage%20and%20Scale%20Up%20Cervical%20Cancer%20Prevention%20and%20Care%20Services%20for%20Women%20Living%20With%20HIV%20in%20Sub-Saharan%20Africa%3A%20a%20Three-Round%20Online%20Delphi%20Consensus%20Method.%20%26lt%3Bi%26gt%3BJournal%20of%20Acquired%20Immune%20Deficiency%20Syndromes%20%281999%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B95%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20170%26%23x2013%3B178.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003343%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003343%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Facility-Based%20Indicators%20to%20Manage%20and%20Scale%20Up%20Cervical%20Cancer%20Prevention%20and%20Care%20Services%20for%20Women%20Living%20With%20HIV%20in%20Sub-Saharan%20Africa%3A%20a%20Three-Round%20Online%20Delphi%20Consensus%20Method%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ma%5Cu0161a%22%2C%22lastName%22%3A%22Davidovi%5Cu0107%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serra%20Lem%22%2C%22lastName%22%3A%22Asangbeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katayoun%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beverly%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cari%22%2C%22lastName%22%3A%22Van%20Schalkwyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Schwappach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Orang%27o%20Elkanah%22%2C%22lastName%22%3A%22Omenge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%20Pierre%22%2C%22lastName%22%3A%22Boni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Of%20women%20with%20cervical%20cancer%20%28CC%29%20and%20HIV%2C%2085%25%20live%20in%20sub-Saharan%20Africa%2C%20where%2021%25%20of%20all%20CC%20cases%20are%20attributable%20to%20HIV%20infection.%20We%20aimed%20to%20generate%20internationally%20acceptable%20facility-based%20indicators%20to%20monitor%20and%20guide%20scale%20up%20of%20CC%20prevention%20and%20care%20services%20offered%20on-site%20or%20off-site%20by%20HIV%20clinics.%5CnMETHODS%3A%20We%20reviewed%20the%20literature%20and%20extracted%20relevant%20indicators%2C%20grouping%20them%20into%20domains%20along%20the%20CC%20control%20continuum.%20From%20February%202021%20to%20March%202022%2C%20we%20conducted%20a%20three-round%2C%20online%20Delphi%20process%20to%20reach%20consensus%20on%20indicators.%20We%20invited%20106%20experts%20to%20participate.%20Through%20an%20anonymous%2C%20iterative%20process%2C%20participants%20adapted%20the%20indicators%20to%20their%20context%20%28round%201%29%2C%20then%20rated%20them%20for%205%20criteria%20on%20a%205-point%20Likert-type%20scale%20%28rounds%202%20and%203%29%20and%20then%20ranked%20their%20importance%20%28round%203%29.%5CnRESULTS%3A%20We%20reviewed%2039%20policies%20from%2021%20African%20countries%20and%207%20from%20international%20organizations%3B%2072%20experts%20from%2015%20sub-Saharan%20Africa%20countries%20or%20international%20organizations%20participated%20in%20our%20Delphi%20process.%20Response%20rates%20were%2034%25%20in%20round%201%2C%2040%25%20in%20round%202%2C%20and%2044%25%20in%20round%203.%20Experts%20reached%20consensus%20for%2017%20indicators%20in%20the%20following%20domains%3A%20primary%20prevention%20%28human%20papillomavirus%20prevention%2C%20n%20%3D%202%29%2C%20secondary%20prevention%20%28screening%2C%20triage%2C%20treatment%20of%20precancerous%20lesions%2C%20n%20%3D%2011%29%2C%20tertiary%20prevention%20%28CC%20diagnosis%20and%20care%2C%20n%20%3D%202%29%2C%20and%20long-term%20impact%20of%20the%20program%20and%20linkage%20to%20HIV%20service%20%28n%20%3D%202%29.%5CnCONCLUSION%3A%20We%20recommend%20that%20HIV%20clinics%20that%20offer%20CC%20control%20services%20in%20sub-Saharan%20Africa%20implement%20the%2017%20indicators%20stepwise%20and%20adapt%20them%20to%20context%20to%20improve%20monitoring%20along%20the%20CC%20control%20cascade.%22%2C%22date%22%3A%222024-02-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003343%22%2C%22ISSN%22%3A%221944-7884%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A29Z%22%7D%7D%2C%7B%22key%22%3A%223K3AFYPR%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lancaster%20et%20al.%22%2C%22parsedDate%22%3A%222024-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLancaster%2C%20Kathryn%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStockton%2C%20Melissa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRemch%2C%20Molly%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWester%2C%20C.%20William%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNash%2C%20Denis%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Availability%20of%20substance%20use%20screening%20and%20treatment%20within%20HIV%20clinical%20sites%20across%20seven%20geographic%20regions%20within%20the%20IeDEA%20consortium.%20%26lt%3Bi%26gt%3BThe%20International%20Journal%20on%20Drug%20Policy%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B124%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20104309.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.drugpo.2023.104309%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.drugpo.2023.104309%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Availability%20of%20substance%20use%20screening%20and%20treatment%20within%20HIV%20clinical%20sites%20across%20seven%20geographic%20regions%20within%20the%20IeDEA%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%20E.%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Stockton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Molly%22%2C%22lastName%22%3A%22Remch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20William%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adebola%22%2C%22lastName%22%3A%22Adedimeji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Finlayson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Breanna%22%2C%22lastName%22%3A%22Hogan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%20Kamaru%22%2C%22lastName%22%3A%22Kwobah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jayne%20Lewis%22%2C%22lastName%22%3A%22Kulzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tuti%22%2C%22lastName%22%3A%22Merati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judiacel%22%2C%22lastName%22%3A%22Tine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Armel%22%2C%22lastName%22%3A%22Poda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Regina%22%2C%22lastName%22%3A%22Succi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christelle%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%20von%22%2C%22lastName%22%3A%22Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20Jennifer%22%2C%22lastName%22%3A%22Edelman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Consortium%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Overwhelming%20evidence%20highlights%20the%20negative%20impact%20of%20substance%20use%20on%20HIV%20care%20and%20treatment%20outcomes.%20Yet%2C%20the%20extent%20to%20which%20alcohol%20use%20disorder%20%28AUD%29%20and%20other%20substance%20use%20disorders%20%28SUD%29%20services%20have%20been%20integrated%20within%20HIV%20clinical%20settings%20is%20limited.%20We%20describe%20AUD%5C%2FSUD%20screening%20and%20treatment%20availability%20in%20HIV%20clinical%20sites%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%5CnMETHODS%3A%20In%202020%2C%20223%20IeDEA%20HIV%20clinical%20sites%20from%2041%20countries%20across%20seven%20geographic%20regions%20completed%20a%20survey%20on%20capacity%20and%20practices%20related%20to%20management%20of%20AUD%5C%2F%20SUD.%20Sites%20provided%20information%20on%20AUD%20and%20other%20SUD%20screening%20and%20treatment%20practices.%5CnRESULTS%3A%20Sites%20were%20from%20low-income%20countries%20%2823%25%29%2C%20lower-middle-income%20countries%20%2838%25%29%2C%20upper-middle%20income%20countries%20%2817%25%29%20and%20high-income%20counties%20%2823%25%29.%20AUD%20and%20SUD%20screening%20using%20validated%20instruments%20were%20reported%20at%2032%25%20%28n%3D71%20located%20in%2012%20countries%29%20and%2012%25%20%28n%3D27%20located%20in%206%20countries%29%20of%20the%20223%20sites%20from%2041%20countries%2C%20respectively.%20The%20North%20American%20region%20had%20the%20highest%20proportion%20of%20clinics%20that%20reported%20AUD%20screening%20%2876%25%29%2C%20followed%20by%20East%20Africa%20%2846%25%29%3B%20none%20of%20the%20sites%20in%20West%20or%20Central%20Africa%20reported%20AUD%20screening.%2031%25%20%28n%3D69%29%20reported%20both%20AUD%20screening%20and%20counseling%2C%20brief%20intervention%2C%20psychotherapy%2C%20or%20Screening%2C%20Brief%20Intervention%2C%20and%20Referral%20to%20Treatment%3B%208%25%20%28n%3D18%29%20reported%20AUD%20screening%20and%20detox%20hospitalization%3B%20and%2010%25%20%28n%3D24%29%20reported%20both%20AUD%20screening%20and%20medication.%20While%20the%20proportion%20of%20clinics%20providing%20treatment%20for%20SUD%20was%20lower%20than%20those%20treating%20AUD%2C%20the%20prevalence%20estimates%20of%20treatment%20availability%20were%20similar.%5CnCONCLUSIONS%3A%20Availability%20of%20screening%20and%20treatment%20for%20AUD%5C%2FSUD%20in%20HIV%20care%20settings%20is%20limited%2C%20leaving%20a%20substantial%20gap%20for%20integration%20into%20ongoing%20HIV%20care.%20A%20critical%20understanding%20is%20needed%20of%20the%20multilevel%20implementation%20factors%20or%20feasible%20implementation%20strategies%20for%20integrating%20screening%20and%20treatment%20of%20AUD%5C%2FSUD%20into%20HIV%20care%20settings%2C%20particularly%20for%20resource-constrained%20regions.%22%2C%22date%22%3A%222024-02%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.drugpo.2023.104309%22%2C%22ISSN%22%3A%221873-4758%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22PXW76NAV%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shamu%20et%20al.%22%2C%22parsedDate%22%3A%222024-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShamu%2C%20Tinei%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMudzviti%2C%20Tinashe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChimbetete%2C%20Cleophas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BManasa%2C%20Justen%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Body%20weight%20and%20blood%20pressure%20changes%20on%20dolutegravir-%2C%20efavirenz-%20or%20atazanavir-based%20antiretroviral%20therapy%20in%20Zimbabwe%3A%20a%20longitudinal%20study.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e26216.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26216%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26216%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Body%20weight%20and%20blood%20pressure%20changes%20on%20dolutegravir-%2C%20efavirenz-%20or%20atazanavir-based%20antiretroviral%20therapy%20in%20Zimbabwe%3A%20a%20longitudinal%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tinei%22%2C%22lastName%22%3A%22Shamu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tinashe%22%2C%22lastName%22%3A%22Mudzviti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cleophas%22%2C%22lastName%22%3A%22Chimbetete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justen%22%2C%22lastName%22%3A%22Manasa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Dolutegravir%20%28DTG%29%20is%20widely%20used%20for%20antiretroviral%20therapy%20%28ART%29.%20We%20compared%20weight%20and%20blood%20pressure%20trends%20and%20examined%20the%20association%20between%20high%20blood%20pressure%20and%20weight%20gain%20among%20people%20living%20with%20HIV%20%28PLHIV%29%20switching%20to%20or%20starting%20DTG-based%2C%20efavirenz%20%28EFV%29-based%20and%20ritonavir-boosted%20atazanavir%20%28ATV%5C%2Fr%29-based%20ART%20in%20Zimbabwe.%5CnMETHODS%3A%20PLHIV%20aged%2018%20years%20or%20older%20who%20started%20or%20switched%20to%20DTG%2C%20EFV%20or%20ATV%5C%2Fr-based%20ART%20between%20January%202004%20and%20June%202022%20at%20Newlands%20Clinic%20in%20Harare%2C%20Zimbabwe%2C%20were%20eligible.%20Weight%20was%20measured%20at%20all%20visits%20%28Seca%20floor%20scales%29%3B%20blood%20pressure%20only%20at%20clinician-led%20visits%20%28Omron%20M2%20sphygmomanometer%29.%20We%20used%20Bayesian%20additive%20models%20to%20estimate%20trends%20in%20weight%20gain%20and%20the%20proportion%20with%20high%20blood%20pressure%20%28systolic%20%26gt%3B140%20mmHg%20or%20diastolic%20%26gt%3B90%20mmHg%29%20in%20the%20first%202%20years%20after%20starting%20or%20switching%20the%20regimen.%20Finally%2C%20we%20examined%20whether%20trends%20in%20the%20proportion%20with%20high%20blood%20pressure%20were%20related%20to%20weight%20change.%5CnRESULTS%3A%20We%20analysed%2099%2C969%20weight%20and%2035%2C449%20blood%20pressure%20records%20from%209487%20adults%20%28DTG%3A%204593%3B%20EFV%3A%203599%3B%20ATV%5C%2Fr%3A%201295%29.%20At%2024%20months%20after%20starting%20or%20switching%20to%20DTG%2C%20estimated%20median%20weight%20gains%20were%204.54%20kg%20%2890%25%20credibility%20interval%203.88-5.28%20kg%29%20in%20women%20and%203.71%20kg%20%283.07-4.45%20kg%29%20in%20men%2C%20around%20twice%20that%20observed%20for%20ATV%5C%2Fr%20and%20over%20four-times%20the%20gain%20observed%20for%20EFV.%20Prevalence%20of%20high%20blood%20pressure%20among%20PLHIV%20receiving%20DTG-based%20ART%20increased%20from%20around%205%25%20at%20baseline%20to%20over%2020%25%20at%2024%20months%2C%20with%20no%20change%20in%20PLHIV%20receiving%20EFV-%20or%20ATV%5C%2Fr-based%20ART.%20High%20blood%20pressure%20in%20PLHIV%20switching%20to%20DTG%20was%20associated%20with%20weight%20gain%2C%20with%20stronger%20increases%20in%20the%20proportion%20with%20high%20blood%20pressure%20for%20larger%20weight%20gains.%5CnCONCLUSIONS%3A%20Among%20PLHIV%20starting%20ART%20or%20switching%20to%20a%20new%20regimen%2C%20DTG-based%20ART%20was%20associated%20with%20larger%20weight%20gains%20and%20a%20substantial%20increase%20in%20the%20prevalence%20of%20high%20blood%20pressure.%20Routine%20weight%20and%20blood%20pressure%20measurement%20and%20interventions%20to%20lower%20blood%20pressure%20could%20benefit%20PLHIV%20on%20DTG-based%20ART.%20Further%20studies%20are%20needed%20to%20elucidate%20the%20mechanisms%20and%20reversibility%20of%20these%20changes%20after%20discontinuation%20of%20DTG.%22%2C%22date%22%3A%222024-02%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26216%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A14%3A49Z%22%7D%7D%2C%7B%22key%22%3A%228S7DKRXA%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kassanjee%20et%20al.%22%2C%22parsedDate%22%3A%222024-01-25%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20Reshma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Mary-Ann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHeekes%2C%20Alexa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMahomed%2C%20Hassan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHawkridge%2C%20Anthony%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20COVID-19%20vaccine%20uptake%20and%20effectiveness%20by%20time%20since%20vaccination%20in%20the%20Western%20Cape%20province%2C%20South%20Africa%3A%20An%20observational%20cohort%20study%20during%202020-2022.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202024.01.24.24301721.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.01.24.24301721%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.01.24.24301721%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22COVID-19%20vaccine%20uptake%20and%20effectiveness%20by%20time%20since%20vaccination%20in%20the%20Western%20Cape%20province%2C%20South%20Africa%3A%20An%20observational%20cohort%20study%20during%202020-2022%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hassan%22%2C%22lastName%22%3A%22Mahomed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20J.%22%2C%22lastName%22%3A%22Hawkridge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milani%22%2C%22lastName%22%3A%22Wolmarans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erna%22%2C%22lastName%22%3A%22Morden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theuns%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cheryl%22%2C%22lastName%22%3A%22Cohen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harry%22%2C%22lastName%22%3A%22Moultrie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Lessells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolette%22%2C%22lastName%22%3A%22Van%20Der%20Walt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juanita%20O.%22%2C%22lastName%22%3A%22Arendse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hilary%22%2C%22lastName%22%3A%22Goeiman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Wolter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sibongile%22%2C%22lastName%22%3A%22Walaza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Waasila%22%2C%22lastName%22%3A%22Jassat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22von%20Gottberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20L.%22%2C%22lastName%22%3A%22Hannan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petro%22%2C%22lastName%22%3A%22Rousseau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Feikin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keith%22%2C%22lastName%22%3A%22Cloete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20There%20are%20few%20data%20on%20the%20real-world%20effectiveness%20of%20COVID-19%20vaccines%20and%20boosting%20in%20Africa%2C%20which%20experienced%20high%20levels%20of%20SARS-CoV-2%20infection%20in%20a%20mostly%20vaccine-na%5Cu00efve%20population%2C%20and%20has%20limited%20vaccine%20coverage%20and%20competing%20health%20service%20priorities.%20We%20assessed%20the%20association%20between%20vaccination%20and%20severe%20COVID-19%20in%20the%20Western%20Cape%2C%20South%20Africa.%5CnMETHODS%3A%20We%20performed%20an%20observational%20cohort%20study%20of%20%26gt%3B2%20million%20adults%20during%202020-2022.%20We%20described%20SARS-CoV-2%20testing%2C%20COVID-19%20outcomes%2C%20and%20vaccine%20uptake%20over%20time.%20We%20used%20multivariable%20cox%20models%20to%20estimate%20the%20association%20of%20BNT162b2%20and%20Ad26.COV2.S%20vaccination%20with%20COVID-19-related%20hospitalisation%20and%20death%2C%20adjusting%20for%20demographic%20characteristics%2C%20underlying%20health%20conditions%2C%20socioeconomic%20status%20proxies%20and%20healthcare%20utilisation.%5CnRESULTS%3A%20By%20end%202022%2C%20only%2041%25%20of%20surviving%20adults%20had%20completed%20vaccination%20and%208%25%20a%20booster%20dose%2C%20despite%20several%20waves%20of%20severe%20COVID-19.%20Recent%20vaccination%20was%20associated%20with%20notable%20reductions%20in%20severe%20COVID-19%20during%20distinct%20analysis%20periods%20dominated%20by%20Delta%2C%20Omicron%20BA.1%5C%2F2%20and%20BA.4%5C%2F5%20%28sub%29lineages%3A%20within%206%20months%20of%20completing%20vaccination%20or%20boosting%2C%20vaccine%20effectiveness%20was%2046-92%25%20for%20death%20%28range%20across%20periods%29%2C%2045-92%25%20for%20admission%20with%20severe%20disease%20or%20death%2C%20and%2025-90%25%20for%20any%20admission%20or%20death.%20During%20the%20Omicron%20BA.4%5C%2F5%20wave%2C%20within%203%20months%20of%20vaccination%20or%20boosting%2C%20BNT162b2%20and%20Ad26.COV2.S%20were%20each%2084%25%20effective%20against%20death%20%2895%25%20CIs%3A%2057-94%20and%2049-95%2C%20respectively%29.%20However%2C%20there%20were%20distinct%20reductions%20of%20VE%20at%20larger%20times%20post%20completing%20or%20boosting%20vaccination.%5CnCONCLUSIONS%3A%20Continued%20emphasis%20on%20regular%20COVID-19%20vaccination%20including%20boosting%20is%20important%20for%20those%20at%20high%20risk%20of%20severe%20COVID-19%20even%20in%20settings%20with%20widespread%20infection-induced%20immunity.%22%2C%22date%22%3A%222024-01-25%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2024.01.24.24301721%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A47%3A11Z%22%7D%7D%2C%7B%22key%22%3A%229C2H29RK%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dhokotera%20et%20al.%22%2C%22parsedDate%22%3A%222024-01-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuchengeti%2C%20Mazvita%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavidovi%26%23x107%3B%2C%20Ma%26%23x161%3Ba%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRohner%2C%20Eliane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20Victor%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Gynaecologic%20and%20breast%20cancers%20in%20women%20living%20with%20HIV%20in%20South%20Africa%3A%20A%20record%20linkage%20study.%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Cancer%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B154%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20284%26%23x2013%3B296.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fijc.34712%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fijc.34712%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Gynaecologic%20and%20breast%20cancers%20in%20women%20living%20with%20HIV%20in%20South%20Africa%3A%20A%20record%20linkage%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%20G.%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Muchengeti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ma%5Cu0161a%22%2C%22lastName%22%3A%22Davidovi%5Cu0107%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%5D%2C%22abstractNote%22%3A%22Breast%20and%20gynaecologic%20cancers%20account%20for%20approximately%20half%20of%20all%20cancers%20diagnosed%20amongst%20women%20in%20South%20Africa%2C%20many%20of%20whom%20also%20live%20with%20HIV.%20We%20aimed%20to%20determine%20the%20incidence%20of%20and%20risk%20factors%20for%20developing%20breast%20and%20gynaecologic%20cancers%20in%20women%20living%20with%20HIV%20%28WLHIV%29%20in%20South%20Africa.%20This%20is%20a%20longitudinal%20analysis%20of%20the%20South%20African%20HIV%20Cancer%20Match%20study%20including%20women%20aged%20%5Cu226515%5Cu2009years%20with%20two%20or%20more%20HIV-related%20laboratory%20tests.%20We%20used%20Cox%20proportional%20hazard%20models%20to%20determine%20the%20association%20of%20Human%20Papilloma%20Virus%20%28HPV%29-related%20and%20hormone-related%20gynaecologic%20cancer%20with%20patient-%20and%20municipal-level%20characteristics.%20From%203%5Cu2009447%5Cu2009908%20women%20and%2010.5%20million%20years%20of%20follow-up%2C%20we%20identified%2011%5Cu2009384%20incident%20and%207612%20prevalent%20gynaecologic%20and%20breast%20cancers.%20The%20overall%20crude%20incidence%20rate%20was%20108%5C%2F1%5Cu200900%5Cu2009000%20person-years%20%28pyears%29%20%2895%25%20confidence%20interval%20%5BCI%5D%3A%20106-110%29%2C%20with%20the%20highest%20incidence%20observed%20for%20cervical%20cancer%20%2870%5C%2F1%5Cu200900%5Cu2009000%20pyears%3B%2095%25%20CI%3A%2068.5-71.7%29.%20Low%20CD4%20cell%20counts%20and%20high%20HIV%20RNA%20viral%20loads%20increased%20the%20risk%20of%20cervical%20and%20other%20HPV-related%20cancers.%20Age%20was%20associated%20with%20both%20HPV-related%20and%20hormone-related%20cancers.%20Women%20accessing%20health%20facilities%20in%20high%20socioeconomic%20position%20%28SEP%29%20municipalities%20were%20more%20likely%20to%20be%20diagnosed%20with%20HPV-related%20cancers%20and%20breast%20cancer%20than%20women%20accessing%20care%20in%20low%20SEP%20municipalities.%20It%20is%20important%20to%20improve%20the%20immunologic%20status%20of%20WLHIV%20as%20part%20of%20cancer%20prevention%20strategies%20in%20WLHIV.%20Cancer%20prevention%20and%20early%20detection%20programmes%20should%20be%20tailored%20to%20the%20needs%20of%20women%20ageing%20with%20HIV.%20In%20addition%2C%20SEP%20disparities%20in%20cancer%20diagnostic%20services%20have%20to%20be%20addressed.%22%2C%22date%22%3A%222024-01-15%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fijc.34712%22%2C%22ISSN%22%3A%221097-0215%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A04%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22YKFGHM7H%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fern%5Cu00e1ndez%20Villalobos%20et%20al.%22%2C%22parsedDate%22%3A%222024-01-15%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFern%26%23xE1%3Bndez%20Villalobos%2C%20Nathalie%20Ver%26%23xF3%3Bnica%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20Morna%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Cervical%20precancer%20and%20cancer%20incidence%20among%20insured%20women%20with%20and%20without%20HIV%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Cancer%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B154%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20273%26%23x2013%3B283.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fijc.34707%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fijc.34707%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cervical%20precancer%20and%20cancer%20incidence%20among%20insured%20women%20with%20and%20without%20HIV%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20Ver%5Cu00f3nica%22%2C%22lastName%22%3A%22Fern%5Cu00e1ndez%20Villalobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katayoun%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22HIV%20infection%20increases%20the%20risk%20of%20developing%20cervical%20cancer%3B%20however%2C%20longitudinal%20studies%20in%20sub-Saharan%20Africa%20comparing%20cervical%20cancer%20rates%20between%20women%20living%20with%20HIV%20%28WLWH%29%20and%20women%20without%20HIV%20are%20scarce.%20To%20address%20this%20gap%2C%20we%20compared%20cervical%20precancer%20and%20cancer%20incidence%20rates%20between%20WLWH%20and%20women%20without%20HIV%20in%20South%20Africa%20using%20reimbursement%20claims%20data%20from%20a%20medical%20insurance%20scheme%20from%20January%202011%20to%20June%202020.%20We%20used%20Royston-Parmar%20flexible%20parametric%20survival%20models%20to%20estimate%20cervical%20precancer%20and%20cancer%20incidence%20rates%20as%20a%20continuous%20function%20of%20age%2C%20stratified%20by%20HIV%20status.%20Our%20study%20population%20consisted%20of%20518%5Cu2009048%20women%2C%20with%20exclusions%20based%20on%20the%20endpoint%20of%20interest.%20To%20analyse%20cervical%20cancer%20incidence%2C%20we%20included%20517%5Cu2009312%20women%2C%20of%20whom%20564%20developed%20cervical%20cancer.%20WLWH%20had%20an%20~3-fold%20higher%20risk%20of%20developing%20cervical%20precancer%20and%20cancer%20than%20women%20without%20HIV%20%28adjusted%20hazard%20ratio%20for%20cervical%20cancer%3A%202.99%3B%2095%25%20confidence%20interval%20%5BCI%5D%3A%202.40-3.73%29.%20For%20all%20endpoints%20of%20interest%2C%20the%20estimated%20incidence%20rates%20were%20higher%20in%20WLWH%20than%20women%20without%20HIV.%20Cervical%20cancer%20rates%20among%20WLWH%20increased%20at%20early%20ages%20and%20peaked%20at%2049%5Cu2009years%20%28122%5C%2F100%5Cu2009000%20person-years%3B%2095%25%20CI%3A%20100-147%29%2C%20whereas%2C%20in%20women%20without%20HIV%2C%20incidence%20rates%20peaked%20at%2056%5Cu2009years%20%2840%5C%2F100%5Cu2009000%20person-years%3B%2095%25%20CI%3A%2036-45%29.%20Cervical%20precancer%20rates%20peaked%20in%20women%20in%20their%2030s.%20Analyses%20of%20age-specific%20cervical%20cancer%20rates%20by%20HIV%20status%20are%20essential%20to%20inform%20the%20design%20of%20targeted%20cervical%20cancer%20prevention%20policies%20in%20Southern%20Africa%20and%20other%20regions%20with%20a%20double%20burden%20of%20HIV%20and%20cervical%20cancer.%22%2C%22date%22%3A%222024-01-15%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fijc.34707%22%2C%22ISSN%22%3A%221097-0215%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A03%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22JUI8ZCRG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Enane%20et%20al.%22%2C%22parsedDate%22%3A%222024-01-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEnane%2C%20Leslie%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDuda%2C%20Stephany%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChanyachukul%2C%20Thida%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBolton-Moore%2C%20Carolyn%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNavuluri%2C%20Neelima%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20The%20Tuberculosis%20Sentinel%20Research%20Network%20%28TB-SRN%29%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%3A%20protocol%20for%20a%20prospective%20cohort%20study%20in%20Africa%2C%20Southeast%20Asia%20and%20Latin%20America.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B14%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20e079138.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2023-079138%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2023-079138%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Tuberculosis%20Sentinel%20Research%20Network%20%28TB-SRN%29%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%3A%20protocol%20for%20a%20prospective%20cohort%20study%20in%20Africa%2C%20Southeast%20Asia%20and%20Latin%20America%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thida%22%2C%22lastName%22%3A%22Chanyachukul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton-Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neelima%22%2C%22lastName%22%3A%22Navuluri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eug%5Cu00e8ne%22%2C%22lastName%22%3A%22Messou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Mbonze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22LaQuita%20R.%22%2C%22lastName%22%3A%22McDade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marina%20Cruvinel%22%2C%22lastName%22%3A%22Figueiredo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denise%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Akpata%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Zotova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20Flore%22%2C%22lastName%22%3A%22Pierre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dhanushi%22%2C%22lastName%22%3A%22Rupasinghe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22Byakwaga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22de%20Castro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martine%22%2C%22lastName%22%3A%22Tabala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20R.%22%2C%22lastName%22%3A%22Sterling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%20H.%22%2C%22lastName%22%3A%22Sohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Armel%22%2C%22lastName%22%3A%22Poda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Huebner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Marcy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Tuberculosis%20%28TB%29%20is%20a%20leading%20infectious%20cause%20of%20death%20globally.%20It%20is%20the%20most%20common%20opportunistic%20infection%20in%20people%20living%20with%20HIV%2C%20and%20the%20most%20common%20cause%20of%20their%20morbidity%20and%20mortality.%20Following%20TB%20treatment%2C%20surviving%20individuals%20may%20be%20at%20risk%20for%20post-TB%20lung%20disease.%20The%20TB%20Sentinel%20Research%20Network%20%28TB-SRN%29%20provides%20a%20platform%20for%20coordinated%20observational%20TB%20research%20within%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%5CnMETHODS%20AND%20ANALYSIS%3A%20This%20prospective%2C%20observational%20cohort%20study%20will%20assess%20treatment%20and%20post-treatment%20outcomes%20of%20pulmonary%20TB%20%28microbiologically%20confirmed%20or%20clinically%20diagnosed%29%20among%202600%20people%20aged%20%5Cu226515%20years%2C%20with%20and%20without%20HIV%20coinfection%2C%20consecutively%20enrolled%20at%2016%20sites%20in%2011%20countries%2C%20across%206%20of%20IeDEA%26%23039%3Bs%20global%20regions.%20Data%20regarding%20clinical%20and%20sociodemographic%20factors%2C%20mental%20health%2C%20health-related%20quality%20of%20life%2C%20pulmonary%20function%2C%20and%20laboratory%20and%20radiographic%20findings%20will%20be%20collected%20using%20standardised%20questionnaires%20and%20data%20collection%20tools%2C%20beginning%20from%20the%20initiation%20of%20TB%20treatment%20and%20through%2012%20months%20after%20the%20end%20of%20treatment.%20Data%20will%20be%20aggregated%20for%20proposed%20analyses.%5CnETHICS%20AND%20DISSEMINATION%3A%20Ethics%20approval%20was%20obtained%20at%20all%20implementing%20study%20sites%2C%20including%20the%20Vanderbilt%20University%20Medical%20Center%20Human%20Research%20Protections%20Programme.%20Participants%20will%20provide%20informed%20consent%3B%20for%20minors%2C%20this%20includes%20both%20adolescent%20assent%20and%20the%20consent%20of%20their%20parent%20or%20primary%20caregiver.%20Protections%20for%20vulnerable%20groups%20are%20included%2C%20in%20alignment%20with%20local%20standards%20and%20considerations%20at%20sites.%20Procedures%20for%20requesting%20use%20and%20analysis%20of%20TB-SRN%20data%20are%20publicly%20available.%20Findings%20from%20TB-SRN%20analyses%20will%20be%20shared%20with%20national%20TB%20programmes%20to%20inform%20TB%20programming%20and%20policy%2C%20and%20disseminated%20at%20regional%20and%20global%20conferences%20and%20other%20venues.%22%2C%22date%22%3A%222024-01-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2023-079138%22%2C%22ISSN%22%3A%222044-6055%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222024-02-06T15%3A01%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22ENZDPGXT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Olago%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20Victor%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNimako%2C%20Gideon%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBartels%2C%20Lina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBohlius%2C%20Julia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Cancer%20diagnostic%20service%20use%20in%20people%20living%20with%20HIV%20in%20South%20Africa%3A%20A%20cross-sectional%20study.%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20e0291897.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0291897%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0291897%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cancer%20diagnostic%20service%20use%20in%20people%20living%20with%20HIV%20in%20South%20Africa%3A%20A%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gideon%22%2C%22lastName%22%3A%22Nimako%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Bartels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvira%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Sengayi-Muchengeti%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20The%20objective%20of%20this%20study%20was%20to%20map%20place%20of%20cancer%20diagnosis%20in%20relation%20to%20Human%20Immunodeficiency%20Virus%20%28HIV%29%20care%20centre%20among%20people%20living%20with%20HIV%20%28PLHIV%29%20within%20South%20Africa%20%28SA%29%20using%20national%20laboratory%20database.%5CnDESIGN%3A%20We%20linked%20HIV%20and%20cancer%20laboratory%20data%20from%202004-2014%20using%20supervised%20machine-learning%20algorithms.%20We%20performed%20a%20cross-sectional%20analysis%20comparing%20province%20where%20individuals%20accessed%20their%20HIV%20care%20versus%20where%20they%20had%20their%20cancer%20diagnosis.%5CnSETTING%3A%20We%20used%20laboratory%20test%20records%20related%20to%20HIV%20diagnostics%20and%20care%2C%20such%20as%20CD4%20cell%20counts%20and%20percentages%2C%20rapid%20tests%2C%20qualitative%20Polymerase%20Chain%20Reaction%20%28PCR%29%2C%20antibody%20and%20antigen%20tests%20for%20HIV%20data%20that%20was%20documented%20as%20HIV%20positive%20and%20laboratory%20diagnosed%20cancer%20records%20from%20SA.%5CnSTUDY%20POPULATION%3A%20Our%20study%20population%20consisted%20of%20HIV%20records%20from%20the%20National%20Health%20Laboratory%20Service%20%28NHLS%29%20that%20linked%20to%20cancer%20record%20at%20the%20National%20Cancer%20Registry%20%28NCR%29%20between%202004-2014.%5CnPRIMARY%20AND%20SECONDARY%20OUTCOMES%3A%20We%20linked%20HIV%20records%20from%20NHLS%20to%20cancer%20records%20at%20NCR%20in%20order%20to%20study%20the%20inherent%20characteristics%20of%20the%20population%20with%20both%20HIV%20and%20cancer.%5CnRESULTS%3A%20The%20study%20population%20was%2068%2C284%20individuals%20with%20cancer%20and%20documented%20HIV%20related%20laboratory%20test.%20The%20median%20age%20at%20cancer%20diagnosis%20was%2040%20%5BIQR%2C%2033-48%5D%20years%20for%20the%20study%20population%20with%20most%20cancers%20in%20PLHIV%20diagnosed%20in%20females%2070.9%25%20%5Bn%20%3D%2046%2C313%5D.%20Of%20all%20the%20PLHIV%20and%20cancer%2C%2025%25%20%28n%20%3D%2016%2C364%20p%20%26lt%3B%200.001%29%20sought%20treatment%20outside%20their%20province%20of%20residence%20with%2060.7%25%20%28n%20%3D%2010%2C235%29%20travelling%20to%20Gauteng.%20KZN%20had%2046.6%25%20%28n%20%3D%204%2C107%29%20of%20its%20PLHIV%20getting%20cancer%20diagnosis%20in%20Gauteng.%20Western%20Cape%20had%2095%25%20%28n%20%3D%206%2C200%29%20of%20PLHIV%20getting%20cancer%20diagnosis%20within%20the%20province.%5CnCONCLUSIONS%3A%20Our%20results%20showed%20health%20systems%20inequalities%20across%20provinces%20in%20SA%20with%20respect%20to%20cancer%20diagnosis.%20KZN%20for%20example%20had%20nearly%20half%20of%20the%20PLHIV%20getting%20cancer%20diagnosis%20outside%20the%20province%20while%20Western%20Cape%20is%20able%20to%20offer%20cancer%20diagnostic%20services%20to%20most%20of%20the%20PLHIV%20in%20the%20province.%20Gauteng%20is%20getting%20over%20burdened%20with%20referral%20for%20cancer%20diagnosis%20from%20other%20provinces.%20More%20effort%20is%20required%20to%20ensure%20equitable%20access%20to%20cancer%20diagnostic%20services%20within%20the%20country.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0291897%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A15Z%22%7D%7D%2C%7B%22key%22%3A%2269CKNZMW%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Taghavi%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20Katayoun%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMoono%2C%20Misinzo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMwanahamuntu%2C%20Mulindi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoumet%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLimacher%2C%20Andreas%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Accuracy%20of%20screening%20tests%20for%20cervical%20precancer%20in%20women%20living%20with%20HIV%20in%20low-resource%20settings%3A%20a%20paired%20prospective%20study%20in%20Lusaka%2C%20Zambia.%20%26lt%3Bi%26gt%3BBMJ%20Oncology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20e000111.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjonc-2023-000111%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjonc-2023-000111%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Accuracy%20of%20screening%20tests%20for%20cervical%20precancer%20in%20women%20living%20with%20HIV%20in%20low-resource%20settings%3A%20a%20paired%20prospective%20study%20in%20Lusaka%2C%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katayoun%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Misinzo%22%2C%22lastName%22%3A%22Moono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mulindi%22%2C%22lastName%22%3A%22Mwanahamuntu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Roumet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Limacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herbert%22%2C%22lastName%22%3A%22Kapesa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thamsanqa%22%2C%22lastName%22%3A%22Madliwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Rutjes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Partha%22%2C%22lastName%22%3A%22Basu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Manasyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20This%20study%20aimed%20to%20provide%20evidence%20to%20improve%20cervical%20screening%20for%20women%20living%20with%20HIV%20%28WLHIV%29.%20We%20assessed%20the%20accuracy%20of%20screening%20tests%20that%20can%20be%20used%20in%20low-resource%20settings%20and%20give%20results%20at%20the%20same%20visit.%5CnMETHODS%20AND%20ANALYSIS%3A%20We%20conducted%20a%20paired%2C%20prospective%20study%20among%20consecutive%20eligible%20WLHIV%2C%20aged%2018-65%20years%2C%20receiving%20cervical%20cancer%20screening%20at%20one%20hospital%20in%20Lusaka%2C%20Zambia.%20The%20histopathological%20reference%20standard%20was%20multiple%20biopsies%20taken%20at%20two%20time%20points.%20The%20target%20condition%20was%20cervical%20intraepithelial%20neoplasia%20grade%202%20and%20above%20%28CIN2%2B%29.%20The%20index%20tests%20were%20high-risk%20human%20papillomavirus%20detection%20%28hrHPV%2C%20Xpert%20HPV%2C%20Cepheid%29%2C%20portable%20colposcopy%20%28Gynocular%2C%20Gynius%29%20and%20visual%20inspection%20with%20acetic%20acid%20%28VIA%29.%20Accuracy%20of%20stand-alone%20and%20test%20combinations%20were%20calculated%20as%20the%20point%20estimate%20with%2095%25%20CIs.%20A%20sensitivity%20analysis%20considered%20disease%20when%20only%20visible%20lesions%20were%20biopsied.%5CnRESULTS%3A%20Women%20included%20in%20the%20study%20had%20well-controlled%20HIV%20infection%20%28median%20CD4%20count%3D542%20cells%5C%2Fmm3%29%20and%20all%20except%20one%20were%20on%20antiretroviral%20therapy.%20Among%20371%20participants%20with%20histopathological%20results%2C%2027%25%20%28101%5C%2F371%29%20women%20had%20CIN2%2B%20and%2023%25%20%2823%5C%2F101%29%20were%20not%20detected%20by%20any%20index%20test.%20Sensitivity%20and%20specificity%20for%20stand-alone%20tests%20were%3A%20hrHPV%2C%2067.3%25%20%2895%25%20CI%2057.7%25%20to%2075.7%25%29%20and%2065.3%25%20%2895%25%20CI%2059.4%25%20to%2070.7%25%29%3B%20Gynocular%2051.5%25%20%2895%25%20CI%2041.9%25%20to%2061.0%25%29%20and%2080.0%25%20%2895%25%20CI%2074.8%25%20to%2084.3%25%29%3B%20and%20VIA%2022.8%25%20%2895%25%20CI%2015.7%25%20to%2031.9%25%29%20and%2092.6%25%20%2895%25%20CI%2088.8%25%20to%2095.2%25%29%2C%20respectively.%20Combining%20tests%20did%20not%20improve%20test%20accuracy%20measures.%20All%20test%20accuracies%20improved%20in%20sensitivity%20analysis.%5CnCONCLUSION%3A%20The%20low%20accuracy%20of%20screening%20tests%20assessed%20might%20be%20explained%20by%20our%20reference%20standard%2C%20which%20reduced%20verification%20and%20misclassification%20biases.%20Better%20screening%20strategies%20for%20WLHIV%20in%20low-resource%20settings%20are%20urgently%20needed.%5CnTRIAL%20REGISTRATION%20NUMBER%3A%20NCT03931083.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjonc-2023-000111%22%2C%22ISSN%22%3A%222752-7948%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T08%3A46%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22JTJFSID4%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Atkinson%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAtkinson%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKraus%2C%20David%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMiro%2C%20Jose%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BReiss%2C%20Peter%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20HIV%20replication%20and%20tuberculosis%20risk%20among%20people%20living%20with%20HIV%20in%20Europe%3A%20A%20multicohort%20analysis%2C%201983-2015.%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%20e0312035.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0312035%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0312035%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV%20replication%20and%20tuberculosis%20risk%20among%20people%20living%20with%20HIV%20in%20Europe%3A%20A%20multicohort%20analysis%2C%201983-2015.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Atkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Kraus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20M.%22%2C%22lastName%22%3A%22Miro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Reiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ole%22%2C%22lastName%22%3A%22Kirk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Mussini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Morlat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daria%22%2C%22lastName%22%3A%22Podlekareva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alison%20D.%22%2C%22lastName%22%3A%22Grant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Sabin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22van%20der%20Valk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Le%20Moing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurence%22%2C%22lastName%22%3A%22Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remonie%22%2C%22lastName%22%3A%22Seng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonella%22%2C%22lastName%22%3A%22Castagna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niels%22%2C%22lastName%22%3A%22Obel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastasia%22%2C%22lastName%22%3A%22Antoniadou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Salmon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Zwahlen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%22%2C%22lastName%22%3A%22de%20Wit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansjakob%22%2C%22lastName%22%3A%22Furrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20HIV%20replication%20leads%20to%20a%20change%20in%20lymphocyte%20phenotypes%20that%20impairs%20immune%20protection%20against%20opportunistic%20infections.%20We%20examined%20current%20HIV%20replication%20as%20an%20independent%20risk%20factor%20for%20tuberculosis%20%28TB%29.%20METHODS%3A%20We%20included%20people%20living%20with%20HIV%20from%2025%20European%20cohorts%201983-2015.%20Individuals%20%26lt%3B16%20years%20or%20with%20previous%20TB%20were%20excluded.%20Person-time%20was%20calculated%20from%20enrolment%20%28baseline%29%20to%20the%20date%20of%20TB%20diagnosis%20or%20last%20follow-up%20information.%20We%20used%20adjusted%20Poisson%20regression%20and%20general%20additive%20regression%20models.%20RESULTS%3A%20We%20included%20272%2C548%20people%20with%20a%20median%20follow-up%20of%205.9%20years%20%28interquartile%20range%20%5BIQR%5D%202.3-10.9%29.%20At%20baseline%2C%20the%20median%20CD4%20cell%20count%20was%20355%20cells%5C%2FmuL%20%28IQR%20193-540%29%20and%20the%20median%20HIV-RNA%20level%2022%2C000%20copies%5C%2FmL%20%28IQR%201%2C300-103%2C000%29.%20During%201%2C923%2C441%20person-years%20of%20follow-%20up%2C%205%2C956%20%282.2%25%29%20people%20developed%20TB.%20Overall%2C%20TB%20incidence%20was%203.1%20per%201%2C000%20person-years%20%2895%25%20confidence%20interval%20%5BCI%5D%203.02-3.18%29%20and%20was%20four%20times%20higher%20in%20patients%20with%20HIV-RNA%20levels%20of%2010%2C000%20compared%20with%20levels%20%26lt%3B400%20copies%5C%2FmL%20in%20any%20CD4%20stratum.%20CD4%20and%20HIV-RNA%20time-updated%20analyses%20showed%20that%20the%20association%20between%20HIV-RNA%20and%20TB%20incidence%20was%20independent%20of%20CD4.%20The%20TB%20incidence%20rate%20ratio%20for%20people%20born%20in%20TB-%20endemic%20countries%20compared%20with%20those%20born%20in%20Europe%20was%201.8%20%2895%25%20CI%201.5-2.2%29.%20CONCLUSIONS%3A%20Our%20results%20indicate%20that%20ongoing%20HIV%20replication%20%28suboptimal%20HIV%20control%29%20is%20an%20important%20risk%20factor%20for%20TB%2C%20independent%20of%20CD4%20count.%20Those%20at%20highest%20risk%20of%20TB%20are%20people%20from%20TB-endemic%20countries.%20Close%20monitoring%20and%20TB%20preventive%20therapy%20for%20people%20with%20suboptimal%20HIV%20control%20is%20important.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0312035%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22PHYPFD3I%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Davidovic%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavidovic%2C%20Masa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDos-Santos-Silva%2C%20Isabel%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBohlius%2C%20Julia%26lt%3B%5C%2Fspan%26gt%3B%20%26amp%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSengayi-Muchengeti%2C%20Mazvita%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Breast%20cancer%20in%20women%20by%20HIV%20status%3A%20A%20report%20from%20the%20South%20African%20National%20Cancer%20Registry.%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20e0305274.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0305274%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0305274%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Breast%20cancer%20in%20women%20by%20HIV%20status%3A%20A%20report%20from%20the%20South%20African%20National%20Cancer%20Registry.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masa%22%2C%22lastName%22%3A%22Davidovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabel%22%2C%22lastName%22%3A%22Dos-Santos-Silva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Sengayi-Muchengeti%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Breast%20cancer%20%28BC%29%20is%20the%20leading%20cause%20of%20cancer-related%20morbidity%20and%20mortality%20in%20women%20living%20in%20South%20Africa%2C%20a%20country%20with%20a%20high%20HIV%20burden.%20However%2C%20characteristics%20of%20the%20double%20burden%20of%20HIV%20and%20BC%20in%20South%20Africa%20have%20not%20been%20properly%20investigated.%20We%20described%20characteristics%20of%20BC%20cases%20by%20HIV%20status%20in%20South%20Africa.%20METHODS%3A%20In%20this%20nationwide%20South%20African%20study%2C%20we%20obtained%20BC%20records%20for%20women%20aged%20%26gt%3B%5C%2F%3D15%20years%20diagnosed%20in%20the%20public%20health%20sector%20between%20January%202004%20and%20December%202014.%20We%20included%20records%20from%20the%20National%20Cancer%20Registry%20that%20had%20been%20linked%20to%20HIV-related%20laboratory%20records%20from%20the%20National%20Health%20Laboratory%20Service.%20We%20assessed%20the%20odds%20of%20being%20HIV%20positive%20versus%20HIV%20negative%20in%20relation%20to%20patient-%2C%20cancer-%2C%20and%20municipality-related%20characteristics.%20RESULTS%3A%20From%202004-2014%2C%2040%20520%20BC%20cases%20were%20diagnosed%20in%20women%20aged%20%26gt%3B%5C%2F%3D15%20years.%20Of%20these%2C%2073.5%25%20had%20unknown%20HIV%20status%2C%2018.7%25%20were%20HIV%20negative%2C%20and%207.7%25%20were%20HIV%20positive.%20The%20median%20age%20at%20BC%20diagnosis%20was%2043%20years%20%28interquartile%20range%20%5BIQR%5D%3A%2037-52%29%20in%20HIV%20positive%20and%2057%20years%20%28IQR%3A%2046-68%29%20in%20HIV%20negative%20women%2C%20respectively.%20The%20odds%20of%20being%20HIV%20positive%20was%20higher%20for%20women%20who%20were%20aged%2030-34%20years%20compared%20to%20women%20aged%2035-39%20years%20at%20cancer%20diagnosis%20%28odds%20ratio%20%5BOR%5D%201.38%2C%2095%25%20confidence%20interval%20%5BCI%5D%201.10-1.71%29%2C%20Black%20versus%20non-Black%20%28OR%206.41%2C%2095%25%20CI%205.68-7.23%29%2C%20diagnosed%20with%20cancer%20in%20rural%20versus%20urban%20areas%20%28OR%201.59%2C%2095%25%20CI%201.40-1.82%29%20and%20diagnosed%20in%20municipalities%20with%20low%20and%20middle%20%28OR%203.46%2C%2095%25%20CI%202.48-4.82%29%20versus%20high%20socioeconomic%20position%20%28OR%202.69%2C%2095%25%20CI%202.11-3.42%29.%20CONCLUSION%3A%20HIV%20status%20was%20unknown%20for%20the%20majority%20of%20BC%20patients.%20Among%20those%20with%20known%20HIV%20status%2C%20being%20HIV%20positive%20was%20associated%20with%20a%20younger%20age%20at%20cancer%20diagnosis%2C%20being%20Black%20and%20receiving%20care%20in%20municipalities%20of%20poor%20socioeconomic%20position.%20Future%20studies%20should%20examine%20opportunities%20to%20integrate%20HIV%20and%20BC%20control%20programs.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0305274%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22HQ278P6Y%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sharma%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSharma%2C%20Anjali%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMwamba%2C%20Chanda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSt%20Clair-Sullivan%2C%20Natalie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChihota%2C%20Belinda%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPry%2C%20Jake%20M.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20The%20Social%20Construction%20of%20Aging%20Among%20a%20Clinic-Based%20Population%20and%20Their%20Healthcare%20Workers%20in%20Zambia.%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B69%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%201606607.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2024.1606607%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2024.1606607%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Social%20Construction%20of%20Aging%20Among%20a%20Clinic-Based%20Population%20and%20Their%20Healthcare%20Workers%20in%20Zambia.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anjali%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chanda%22%2C%22lastName%22%3A%22Mwamba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalie%22%2C%22lastName%22%3A%22St%20Clair-Sullivan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%20V.%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jake%20M.%22%2C%22lastName%22%3A%22Pry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton-Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Vinikoor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%20K.%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harriet%22%2C%22lastName%22%3A%22Daultrey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joel%22%2C%22lastName%22%3A%22Gittelsohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lloyd%20B.%22%2C%22lastName%22%3A%22Mulenga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Namasiku%22%2C%22lastName%22%3A%22Siyumbwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaime%20H.%22%2C%22lastName%22%3A%22Vera%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%3A%20We%20sought%20to%20understand%20the%20social%20construction%20of%20aging%20in%20a%20clinic-based%20population%2C%20with%20and%20without%20HIV%2C%20to%20address%20gaps%20in%20care%20for%20older%20individuals%20living%20with%20HIV%20in%20Zambia.%20Methods%3A%20Our%20exploratory%20qualitative%20study%20included%2036%20in-depth%20interviews%20with%20clinic%20clients%20and%20four%20focus%20group%20discussions%20with%2036%20professional%20and%20lay%20healthcare%20workers%20providing%20services%20to%20the%20clients.%20We%20identified%20themes%20based%20on%20social%20construction%20theory.%20Results%3A%20At%20the%20individual%20level%2C%20aging%20was%20multidimensional%2C%20perceived%20both%20as%20an%20achievement%20in%20the%20HIV%20era%20and%20as%20a%20period%20of%20cognitive%2C%20physical%2C%20and%20economic%20decline.%20In%20social%20interactions%2C%20older%20individuals%20were%20often%20stereotyped%20and%20treated%20as%20helpless%2C%20poor%2C%20and%20%26quot%3Bwitches.%26quot%3B%20Those%20living%20with%20HIV%20faced%20the%20additional%20stigma%20of%20being%20labeled%20as%20promiscuous.%20Some%20of%20the%20participants%20living%20without%20HIV%20refused%20to%20take%20daily%20medication%20for%20non-communicable%20diseases%20to%20avoid%20being%20mistaken%20for%20taking%20antiretroviral%20therapy%20for%20HIV.%20Older%20individuals%20wanted%20quality%20healthcare%20and%20family%20support%20to%20address%20the%20intersectional%20stigma%20of%20aging%2C%20poverty%2C%20and%20chronic%20illness.%20Conclusion%3A%20Multifaceted%20interventions%20are%20required%20to%20combat%20age-related%20prejudice%2C%20intersectional%20stigma%2C%20and%20discriminatory%20practices%2C%20particularly%20for%20people%20living%20with%20HIV.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3389%5C%2Fijph.2024.1606607%22%2C%22ISSN%22%3A%221661-8564%201661-8556%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T10%3A56%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22EUYZJYMH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tsondai%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTsondai%2C%20Priscilla%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Mary-Ann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSingtoroj%2C%20Thida%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaxwell%2C%20Nicola%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-G%26%23xFC%3Bnter%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Creating%20a%20data%20collection%20and%20management%20platform%20to%20support%20measurement%20of%20adolescent%20HIV%20care%20transition%20processes%20within%20low-%20and%20middle-income%20countries%3A%20The%20GRADUATE%20project.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e0002705.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002705%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002705%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Creating%20a%20data%20collection%20and%20management%20platform%20to%20support%20measurement%20of%20adolescent%20HIV%20care%20transition%20processes%20within%20low-%20and%20middle-income%20countries%3A%20The%20GRADUATE%20project%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Priscilla%20R.%22%2C%22lastName%22%3A%22Tsondai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thida%22%2C%22lastName%22%3A%22Singtoroj%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Maxwell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kulkanya%22%2C%22lastName%22%3A%22Chokephaibulkit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pagakrong%22%2C%22lastName%22%3A%22Lumbiganon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%20H.%22%2C%22lastName%22%3A%22Sohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Global%20fRAmework%20of%20Data%20collection%20Used%20for%20Adolescent%20HIV%20Transition%20Evaluation%20%28GRADUATE%29%20Advisory%20Group%22%7D%5D%2C%22abstractNote%22%3A%22Few%20national%20programs%20and%20research%20cohorts%20within%20low-%20and%20middle-income%20countries%20%28LMICs%29%20document%20transition-related%20processes%20and%20outcomes%20for%20adolescents%20and%20young%20adults%20living%20with%20HIV%20%28AYLH%29%20transitioning%20to%20adulthood.%20Between%202017-2020%2C%20The%20Global%20fRAmework%20of%20Data%20collection%20Used%20for%20Adolescent%20HIV%20Transition%20Evaluation%20%28GRADUATE%29%20project%20convened%20a%20collaborative%20advisory%20group%20to%20identify%20key%20variables%20and%20definitions%20capturing%20the%20process%2C%20predictors%2C%20and%20outcomes%20across%20the%20transition%20period.%20In%20total%2C%20114%20variables%20identified%20as%20essential%20to%20measuring%20AYLH%20transition-related%20data%20were%20identified%20and%20formatted%20into%20a%20GRADUATE%20Data%20Exchange%20Standard%20%28DES%29%2C%20which%20was%20added%20to%20and%20harmonized%20with%20the%20existing%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20DES.%20In%202019%2C%20the%20GRADUATE%20DES%20was%20pilot%20tested%20at%20four%20IeDEA%20facilities%20in%20Malawi%2C%20South%20Africa%2C%20and%20Thailand%20through%20a%20cross-sectional%20study.%20Upon%20comparing%20the%20variables%20to%20routine%20medical%20records%2C%20available%20data%20were%20too%20limited%20to%20adequately%20capture%20transition-related%20processes%20and%20outcomes.%20However%2C%20additional%20data%20collection%20using%20GRADUATE%20tools%20was%20feasible%20and%20improved%20completeness.%20Of%20the%20100%20%2852%25%20female%29%20AYLH%20included%20in%20the%20pilot%20study%2C%2071%25%20had%20transitioned%5C%2Ftransferred%20to%20adult%20care%2C%20with%2042%25%20transitioning%20from%20an%20adolescent-specific%20model%20of%20care%20within%20an%20integrated%20family%20clinic%20to%20having%20their%20clinic%20visits%20scheduled%20on%20a%20different%20day%20of%20the%20week%20while%2058%25%20transferred%20from%20a%20pediatric%20facility%20to%20one%20offering%20adult%20HIV%20care.%20While%20almost%20all%20%2894%25%29%20had%20a%20transition-related%20discussion%20with%20their%20healthcare%20providers%20prior%20to%20the%20transition%2C%20we%20found%20that%2069%25%20%2895%25%20CI%2049-85%25%29%20were%20somewhat%20or%20very%20satisfied%5C%2Fcomfortable%20with%20the%20post-transfer%20clinic%20and%20the%20staff.%20Utilization%20of%20the%20GRADUATE%20DES%20better%20characterized%20AYLH%20transitioning%20to%20adulthood%20across%20LMICs%2C%20and%20optimally%20measured%20transition%20preparation%20activities%20and%20outcomes.%20Utilization%20of%20the%20GRADUATE%20DES%20in%20other%20settings%20could%20facilitate%20comparisons%20and%20identify%20gaps%20in%20the%20care%20of%20transitioning%20adolescents%20that%20need%20to%20be%20addressed.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0002705%22%2C%22ISSN%22%3A%222767-3375%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A14%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22LWE5DNAR%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchmutz%2C%20Remo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMiddelkoop%2C%20Keren%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHella%2C%20Jerry%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282024%29.%20Airborne%20transmission%20risks%20of%20tuberculosis%20and%20COVID-19%20in%20schools%20in%20South%20Africa%2C%20Switzerland%2C%20and%20Tanzania%3A%20Modeling%20of%20environmental%20data.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20e0002800.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002800%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002800%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Airborne%20transmission%20risks%20of%20tuberculosis%20and%20COVID-19%20in%20schools%20in%20South%20Africa%2C%20Switzerland%2C%20and%20Tanzania%3A%20Modeling%20of%20environmental%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keren%22%2C%22lastName%22%3A%22Middelkoop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerry%22%2C%22lastName%22%3A%22Hella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22The%20COVID-19%20pandemic%20renewed%20interest%20in%20airborne%20transmission%20of%20respiratory%20infections%2C%20particularly%20in%20congregate%20indoor%20settings%2C%20such%20as%20schools.%20We%20modeled%20transmission%20risks%20of%20tuberculosis%20%28caused%20by%20Mycobacterium%20tuberculosis%2C%20Mtb%29%20and%20COVID-19%20%28caused%20by%20SARS-CoV-2%29%20in%20South%20African%2C%20Swiss%20and%20Tanzanian%20secondary%20schools.%20We%20estimated%20the%20risks%20of%20infection%20with%20the%20Wells-Riley%20equation%2C%20expressed%20as%20the%20median%20with%202.5%25%20and%2097.5%25%20quantiles%20%28credible%20interval%20%5BCrI%5D%29%2C%20based%20on%20the%20ventilation%20rate%20and%20the%20duration%20of%20exposure%20to%20infectious%20doses%20%28so-called%20quanta%29.%20We%20computed%20the%20air%20change%20rate%20%28ventilation%29%20using%20carbon%20dioxide%20%28CO2%29%20as%20a%20tracer%20gas%20and%20modeled%20the%20quanta%20generation%20rate%20based%20on%20reported%20estimates%20from%20the%20literature.%20The%20share%20of%20infectious%20students%20in%20the%20classroom%20is%20determined%20by%20country-specific%20estimates%20of%20pulmonary%20TB.%20For%20SARS-CoV-2%2C%20the%20number%20of%20infectious%20students%20was%20estimated%20based%20on%20excess%20mortality%20to%20mitigate%20the%20bias%20from%20country-specific%20reporting%20and%20testing.%20Average%20CO2%20concentration%20%28parts%20per%20million%20%5Bppm%5D%29%20was%201%2C610%20ppm%20in%20South%20Africa%2C%201%2C757%20ppm%20in%20Switzerland%2C%20and%20648%20ppm%20in%20Tanzania.%20The%20annual%20risk%20of%20infection%20for%20Mtb%20was%2022.1%25%20%28interquartile%20range%20%5BIQR%5D%202.7%25-89.5%25%29%20in%20South%20Africa%2C%200.7%25%20%28IQR%200.1%25-6.4%25%29%20in%20Switzerland%2C%20and%200.5%25%20%28IQR%200.0%25-3.9%25%29%20in%20Tanzania.%20For%20SARS-CoV-2%2C%20the%20monthly%20risk%20of%20infection%20was%206.8%25%20%28IQR%200.8%25-43.8%25%29%20in%20South%20Africa%2C%201.2%25%20%28IQR%200.1%25-8.8%25%29%20in%20Switzerland%2C%20and%200.9%25%20%28IQR%200.1%25-6.6%25%29%20in%20Tanzania.%20The%20differences%20in%20transmission%20risks%20primarily%20reflect%20a%20higher%20incidence%20of%20SARS-CoV-2%20and%20particularly%20prevalence%20of%20TB%20in%20South%20Africa%2C%20but%20also%20higher%20air%20change%20rates%20due%20to%20better%20natural%20ventilation%20of%20the%20classrooms%20in%20Tanzania.%20Global%20comparisons%20of%20the%20modeled%20risk%20of%20infectious%20disease%20transmission%20in%20classrooms%20can%20provide%20high-level%20information%20for%20policy-making%20regarding%20appropriate%20infection%20control%20strategies.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0002800%22%2C%22ISSN%22%3A%222767-3375%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A49%3A05Z%22%7D%7D%5D%7D
Ruffieux, Yann; Mwansa-Kambafwile, Judith; Metekoua, Carole; Tombe-Nyahuma, Tinashe; Bohlius, Julia et al. (2024). HIV-1 Viremia and Cancer Risk in 2.8 Million People: the South African HIV Cancer Match Study.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, S. ciae652.
http://doi.org/10.1093/cid/ciae652.
Siedentop, Berit; Kachalov, Viacheslav N.; Witzany, Christopher; Egger, Matthias; Kouyos, Roger D. et al. (2024). The effect of combining antibiotics on resistance: A systematic review and meta-analysis.
eLife,
13, S. RP93740.
http://doi.org/10.7554/eLife.93740.
Carlucci, James G.; Huntington, Thomas; Technau, Karl-Gunter; Yotebieng, Marcel; Leroy, Valeriane et al. (2024). High Prevalence of Unconfirmed Positive HIV Polymerase Chain Reaction Test Results Among African Infants With HIV Exposure in the International Epidemiology Databases to Evaluate AIDS Consortium.
Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America,
79 (6), S. 1475–1478.
http://doi.org/10.1093/cid/ciae251.
Phillips, Tamsin K.; Gomba, Yolanda; Mogoba, Pheposadi; Phelanyane, Florence; Anderson, Kim et al. (2024). Routine Electronic Mother-Infant Data (REMInD): a proof-of-concept Data to Care study to support retention in maternal HIV treatment and infant HIV testing in Cape Town, South Africa.
Research Square, S. rs.3.rs-5626699.
http://doi.org/10.21203/rs.3.rs-5626699/v1.
Brenner, Isaac Ravi; Flanagan, Clare F.; Penazzato, Martina; Webb, Karen A.; Horsfall, Stephanie B. et al. (2024). Cost-effectiveness of viral load testing for transitioning antiretroviral therapy-experienced children to dolutegravir in South Africa: a modelling analysis.
The Lancet. Global Health,
12 (12), S. e2068–e2079.
http://doi.org/10.1016/S2214-109X(24)00381-4.
Musonda, Taonga; Wallace, Michael S.; Patel, Hailey; Martin, Owen P.; Oetheimer, Christopher et al. (2024). New Window Into Hepatitis B in Africa: Liver Sampling Combined With Single-Cell Omics Enables Deep and Longitudinal Assessment of Intrahepatic Immunity in Zambia.
The Journal of Infectious Diseases,
230 (5), S. e1171–e1175.
http://doi.org/10.1093/infdis/jiae054.
de Waal, Reneé; Wools-Kaloustian, Kara; Brazier, Ellen; Althoff, Keri N.; Jaquet, Antoine et al. (2024). Global trends in CD4 count measurement and distribution at first antiretroviral treatment initiation.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, S. ciae548.
http://doi.org/10.1093/cid/ciae548.
Yotebieng, Marcel; Zotova, Natalia; Bernard, Charlotte; Goodrich, Suzanne; Awoh, Ajeh Rogers et al. (2024). Accuracy of nine-item Patient Health Questionnaire against psychiatric diagnosis for depression among people with HIV.
AIDS (London, England),
38 (12), S. 1765–1773.
http://doi.org/10.1097/QAD.0000000000003963.
Anderson, Kim; van Zyl, Gert; Hsiao, Nei-Yuan; Claassen, Mathilda; Mudaly, Vanessa et al. (2024). HIV Drug Resistance in Newly Diagnosed Young Children in the Western Cape, South Africa.
The Pediatric Infectious Disease Journal,
43 (10), S. 970–976.
http://doi.org/10.1097/INF.0000000000004482.
Parcesepe, Angela M.; Stockton, Melissa; Bernard, Charlotte; Kanguya, Tukiya; Kwobah, Edith Kamaru et al. (2024). Prevalence and co-occurrence of symptoms of mental and substance use disorders among people with HIV age 40 and older in low- and middle-income countries: a cross-sectional study.
Journal of the International AIDS Society,
27 (10), S. e26359.
http://doi.org/10.1002/jia2.26359.
Schwab, Tiana Carina; Perrig, Lisa; Goller, Pauline Carlotta; Guebely De la Hoz, Freddy Fernando; Lahousse, Adrien Philippe et al. (2024). Targeted next-generation sequencing to diagnose drug-resistant tuberculosis: a systematic review and meta-analysis.
The Lancet. Infectious Diseases,
24 (10), S. 1162–1176.
http://doi.org/10.1016/S1473-3099(24)00263-9.
Technau, Karl-Günter; Maskew, Mhairi; Nattey, Cornelius; Hwang, Candice; van Dongen, Nicola et al. (2024). Cohort profile: Rahima Moosa Mother and Child Hospital maternal HIV cohort, Johannesburg, South Africa.
BMJ Open,
14 (9), S. e085082.
http://doi.org/10.1136/bmjopen-2024-085082.
Kuniholm, Mark H.; Murenzi, Gad; Shumbusho, Fabienne; Brazier, Ellen; Plaisy, Marie K. et al. (2024). Association of cardiovascular disease risk with liver steatosis and fibrosis in people living with hiv in low- and middle-income countries.
AIDS (London, England).
http://doi.org/10.1097/QAD.0000000000004012.
Zaniewski, Elizabeth; Skrivankova, Veronika Whitesell; Brazier, Ellen; Avihingsanon, Anchalee; Cardoso, Sandra Wagner et al. (2024). Transition to dolutegravir-based ART in 35 low- and middle-income countries: a global survey of HIV care clinics.
AIDS (London, England).
http://doi.org/10.1097/QAD.0000000000004007.
Ruffieux, Yann; Folb, Naomi; Grimsrud, Anna; Hislop, Michael; Dunn, Liezl et al. (2024). Courier delivery of antiretroviral therapy: a cohort study of a South African private-sector HIV programme.
Journal of the International AIDS Society,
27 (9), S. e26360.
http://doi.org/10.1002/jia2.26360.
Egger, Matthias; Sauermann, Mamatha; Loosli, Tom; Hossmann, Stefanie; Riedo, Selma et al. (2024). HIV-1 subtype-specific drug resistance on dolutegravir-based antiretroviral therapy: protocol for a multicentre study (DTG RESIST).
BMJ Open,
14 (8), S. e085819.
http://doi.org/10.1136/bmjopen-2024-085819.
Ruffieux, Yann; Fernandez Villalobos, Nathalie V.; Didden, Christiane; Haas, Andreas D.; Chinogurei, Chido et al. (2024). Prostate Cancer Diagnosis Rates among Insured Men with and without HIV in South Africa: A Cohort Study.
Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology,
33 (8), S. 1057–1064.
http://doi.org/10.1158/1055-9965.EPI-24-0137.
Kalk, Emma; Heekes, Alexa; Lavies, Diane; Jacobs, Lizel; Spencer, Careni et al. (2024). Population-based prevalence of congenital defects in a routine sentinel site-based surveillance system in the Western Cape, South Africa.
Birth Defects Research,
116 (8), S. e2388.
http://doi.org/10.1002/bdr2.2388.
Nyakato, Patience; Schomaker, Michael; Boulle, Andrew; Euvrard, Jonathan; Wood, Robin et al. (2024). Correcting mortality estimates among children and youth on antiretroviral therapy in southern Africa: A comparative analysis between a multi-country tracing study and linkage to a health information exchange.
Tropical Medicine & International Health: TM & IH,
29 (8), S. 739–751.
http://doi.org/10.1111/tmi.14030.
de Beer, Shani T.; Davies, Mary-Ann; Phelanyane, Florence; Jones, Hayley E.; Ingle, Suzanne M. et al. (2024). The Retrospective Implementation of Standardized In Utero HIV Exposure Definitions Using Routinely Collected Public Sector Data Across the Western Cape Province, South Africa.
The Pediatric Infectious Disease Journal.
http://doi.org/10.1097/INF.0000000000004486.
Moolla, Haroon; Davies, Mary-Ann; Davies, Claire; Euvrard, Jonathan; Prozesky, Hans W. et al. (2024). The effect of care interruptions on mortality in adults resuming antiretroviral therapy.
AIDS (London, England),
38 (8), S. 1198–1205.
http://doi.org/10.1097/QAD.0000000000003859.
Asangbeh-Kerman, Serra Lem; Davidović, Maša; Taghavi, Katayoun; Dhokotera, Tafadzwa; Manasyan, Albert et al. (2024). Cervical cancer prevention and care in HIV clinics across sub-Saharan Africa: results of a facility-based survey.
Journal of the International AIDS Society,
27 (7), S. e26303.
http://doi.org/10.1002/jia2.26303.
Jacobs, T.; Morden, E.; Smith, M.; von Delft, A.; Kassanjee, R. et al. (2024). Severe outcomes among adults with TB during COVID-19.
IJTLD Open,
1 (7), S. 292–298.
http://doi.org/10.5588/ijtldopen.24.0220.
Siedentop, Berit; Kachalov, Viacheslav N.; Witzany, Christopher; Egger, Matthias; Kouyos, Roger D. et al. (2024). The effect of combining antibiotics on resistance: A systematic review and meta-analysis.
medRxiv: The Preprint Server for Health Sciences, S. 2023.07.10.23292374.
http://doi.org/10.1101/2023.07.10.23292374.
Shafi, Jenine; Virk, Maneet K.; Kalk, Emma; Carlucci, James G.; Chepkemoi, Audrey et al. (2024). Pharmacovigilance in Pregnancy Studies, Exposures and Outcomes Ascertainment, and Findings from Low- and Middle-Income Countries: A Scoping Review.
Drug Safety.
http://doi.org/10.1007/s40264-024-01445-1.
Rossouw, Laura; Ngcobo, Nkosinathi; Clouse, Kate; Nattey, Cornelius; Technau, Karl-Günter et al. (2024). Augmenting maternal clinical cohort data with administrative laboratory dataset linkages: a validation study.
medRxiv: The Preprint Server for Health Sciences, S. 2024.06.19.24309149.
http://doi.org/10.1101/2024.06.19.24309149.
Vinikoor, Michael J.; Hamusonde, Kalongo; Muula, Guy; Asombang, Mah; Riebensahm, Carlotta et al. (2024). Long-term Hepatitis B and Liver Outcomes Among Adults Taking Tenofovir-Containing Antiretroviral Therapy for HBV/HIV Coinfection in Zambia.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America,
78 (6), S. 1583–1590.
http://doi.org/10.1093/cid/ciad654.
Skrivankova, Veronika Whitesell; Huwa, Jacqueline; Muula, Guy; Chiwaya, Geldert D.; Banda, Esau et al. (2024). Virologic Failure and Drug Resistance After Programmatic Switching to Dolutegravir-based First-line Antiretroviral Therapy in Malawi and Zambia.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, S. ciae261.
http://doi.org/10.1093/cid/ciae261.
Kassanjee, Reshma; Davies, Mary-Ann; Heekes, Alexa; Mahomed, Hassan; Hawkridge, Anthony J. et al. (2024). COVID-19 Vaccine Uptake and Effectiveness by Time since Vaccination in the Western Cape Province, South Africa: An Observational Cohort Study during 2020-2022.
Vaccines,
12 (6), S. 628.
http://doi.org/10.3390/vaccines12060628.
Nyakato, Patience; Boulle, Andrew; Wood, Robin; Eley, Brian; Rabie, Helena et al. (2024). Self-transfers, Hospital Admissions and Mortality Among Children and Adolescents Lost to Follow-up From Antiretroviral Therapy Programs in the Western Cape, South Africa Between 2004 and 2019: Linkage to Provincial Records.
The Pediatric Infectious Disease Journal,
43 (5), S. 430–436.
http://doi.org/10.1097/INF.0000000000004281.
Kebede, Samuel; Brazier, Ellen; Freeman, Aimee M.; Muwonge, Timothy R.; Choi, Jun Yong et al. (2024). Preexposure prophylaxis availability among health facilities participating in the global International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.
AIDS (London, England),
38 (5), S. 751–756.
http://doi.org/10.1097/QAD.0000000000003824.
Plaisy, Marie Kerbie; Minga, Albert K.; Wandeler, Gilles; Murenzi, Gad; Samala, Niharika et al. (2024). Metabolic causes of liver disease among adults living with HIV from low- and middle-income countries: a cross-sectional study.
Journal of the International AIDS Society,
27 (4), S. e26238.
http://doi.org/10.1002/jia2.26238.
Phillips, Tamsin Kate; Kassanjee, Reshma; Maxwell, Nicola; Anderson, Kim; Johnson, Leigh et al. (2024). ART history prior to conception: trends and association with postpartum disengagement from HIV care in Khayelitsha, South Africa (2013-2019): a retrospective cohort study.
Journal of the International AIDS Society,
27 (4), S. e26236.
http://doi.org/10.1002/jia2.26236.
Anderson, Kim; Kalk, Emma; Heekes, Alexa; Phelanyane, Florence; Jacob, Nisha et al. (2024). Factors associated with vertical transmission of HIV in the Western Cape, South Africa: a retrospective cohort analysis.
Journal of the International AIDS Society,
27 (3), S. e26235.
http://doi.org/10.1002/jia2.26235.
Brazier, Ellen; Tymejczyk, Olga; Wools-Kaloustian, Kara; Jiamsakul, Awachana; Torres, Marco Tulio Luque et al. (2024). Long-term HIV care outcomes under universal HIV treatment guidelines: A retrospective cohort study in 25 countries.
PLoS Medicine,
21 (3), S. e1004367.
http://doi.org/10.1371/journal.pmed.1004367.
Mesa-Vieira, Cristina; Didden, Christiane; Schomaker, Michael; Mouton, Johannes P.; Folb, Naomi et al. (2024). Post-traumatic stress disorder as a risk factor for major adverse cardiovascular events: a cohort study of a South African medical insurance scheme.
Epidemiology and Psychiatric Sciences,
33, S. e5.
http://doi.org/10.1017/S2045796024000052.
Davidović, Maša; Asangbeh, Serra Lem; Taghavi, Katayoun; Dhokotera, Tafadzwa; Jaquet, Antoine et al. (2024). Facility-Based Indicators to Manage and Scale Up Cervical Cancer Prevention and Care Services for Women Living With HIV in Sub-Saharan Africa: a Three-Round Online Delphi Consensus Method.
Journal of Acquired Immune Deficiency Syndromes (1999),
95 (2), S. 170–178.
http://doi.org/10.1097/QAI.0000000000003343.
Lancaster, Kathryn E.; Stockton, Melissa; Remch, Molly; Wester, C. William; Nash, Denis et al. (2024). Availability of substance use screening and treatment within HIV clinical sites across seven geographic regions within the IeDEA consortium.
The International Journal on Drug Policy,
124, S. 104309.
http://doi.org/10.1016/j.drugpo.2023.104309.
Shamu, Tinei; Egger, Matthias; Mudzviti, Tinashe; Chimbetete, Cleophas; Manasa, Justen et al. (2024). Body weight and blood pressure changes on dolutegravir-, efavirenz- or atazanavir-based antiretroviral therapy in Zimbabwe: a longitudinal study.
Journal of the International AIDS Society,
27 (2), S. e26216.
http://doi.org/10.1002/jia2.26216.
Kassanjee, Reshma; Davies, Mary-Ann; Heekes, Alexa; Mahomed, Hassan; Hawkridge, Anthony J. et al. (2024). COVID-19 vaccine uptake and effectiveness by time since vaccination in the Western Cape province, South Africa: An observational cohort study during 2020-2022.
medRxiv: The Preprint Server for Health Sciences, S. 2024.01.24.24301721.
http://doi.org/10.1101/2024.01.24.24301721.
Dhokotera, Tafadzwa G.; Muchengeti, Mazvita; Davidović, Maša; Rohner, Eliane; Olago, Victor et al. (2024). Gynaecologic and breast cancers in women living with HIV in South Africa: A record linkage study.
International Journal of Cancer,
154 (2), S. 284–296.
http://doi.org/10.1002/ijc.34712.
Fernández Villalobos, Nathalie Verónica; Ruffieux, Yann; Haas, Andreas D.; Chinogurei, Chido; Cornell, Morna et al. (2024). Cervical precancer and cancer incidence among insured women with and without HIV in South Africa.
International Journal of Cancer,
154 (2), S. 273–283.
http://doi.org/10.1002/ijc.34707.
Enane, Leslie A.; Duda, Stephany N.; Chanyachukul, Thida; Bolton-Moore, Carolyn; Navuluri, Neelima et al. (2024). The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America.
BMJ Open,
14 (1), S. e079138.
http://doi.org/10.1136/bmjopen-2023-079138.
Olago, Victor; Nimako, Gideon; Bartels, Lina; Bohlius, Julia; Dhokotera, Tafadzwa et al. (2024). Cancer diagnostic service use in people living with HIV in South Africa: A cross-sectional study.
PloS One,
19 (6), S. e0291897.
http://doi.org/10.1371/journal.pone.0291897.
Taghavi, Katayoun; Moono, Misinzo; Mwanahamuntu, Mulindi; Roumet, Marie; Limacher, Andreas et al. (2024). Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia.
BMJ Oncology,
3 (1), S. e000111.
http://doi.org/10.1136/bmjonc-2023-000111.
Atkinson, Andrew; Kraus, David; Banholzer, Nicolas; Miro, Jose M.; Reiss, Peter et al. (2024). HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983-2015.
PloS One,
19 (10), S. e0312035.
http://doi.org/10.1371/journal.pone.0312035.
Davidovic, Masa;
Dhokotera, Tafadzwa;
Dos-Santos-Silva, Isabel;
Bohlius, Julia &
Sengayi-Muchengeti, Mazvita (2024). Breast cancer in women by HIV status: A report from the South African National Cancer Registry.
PloS One,
19 (6), S. e0305274.
http://doi.org/10.1371/journal.pone.0305274.
Sharma, Anjali; Mwamba, Chanda; St Clair-Sullivan, Natalie; Chihota, Belinda V.; Pry, Jake M. et al. (2024). The Social Construction of Aging Among a Clinic-Based Population and Their Healthcare Workers in Zambia.
International Journal of Public Health,
69, S. 1606607.
http://doi.org/10.3389/ijph.2024.1606607.
Tsondai, Priscilla R.; Davies, Mary-Ann; Singtoroj, Thida; Maxwell, Nicola; Technau, Karl-Günter et al. (2024). Creating a data collection and management platform to support measurement of adolescent HIV care transition processes within low- and middle-income countries: The GRADUATE project.
PLOS Global Public Health,
4 (8), S. e0002705.
http://doi.org/10.1371/journal.pgph.0002705.
Banholzer, Nicolas; Schmutz, Remo; Middelkoop, Keren; Hella, Jerry; Egger, Matthias et al. (2024). Airborne transmission risks of tuberculosis and COVID-19 in schools in South Africa, Switzerland, and Tanzania: Modeling of environmental data.
PLOS Global Public Health,
4 (1), S. e0002800.
http://doi.org/10.1371/journal.pgph.0002800.
2775998
TCMBXKKM
2023
1
padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe
50
date
desc
year
254
https://www.iedea.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229LM6AC8B%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-30%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJent%2C%20Philipp%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBittel%2C%20Pascal%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZ%26%23xFC%3Brcher%2C%20Kathrin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFurrer%2C%20Lavinia%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Air%20cleaners%20and%20respiratory%20infections%20in%20schools%3A%20A%20modeling%20study%20using%20epidemiological%2C%20environmental%2C%20and%20molecular%20data.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.12.29.23300635.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.12.29.23300635%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.12.29.23300635%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Air%20cleaners%20and%20respiratory%20infections%20in%20schools%3A%20A%20modeling%20study%20using%20epidemiological%2C%20environmental%2C%20and%20molecular%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Jent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Bittel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Z%5Cu00fcrcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lavinia%22%2C%22lastName%22%3A%22Furrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Bertschinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ernest%22%2C%22lastName%22%3A%22Weingartner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Ramette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tina%22%2C%22lastName%22%3A%22Hascher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Using%20a%20multiple-measurement%20approach%2C%20we%20examined%20the%20real-world%20effectiveness%20of%20portable%20HEPA-air%20filtration%20devices%20%28air%20cleaners%29%20in%20a%20school%20setting.%5CnMETHODS%3A%20We%20collected%20environmental%20%28CO2%2C%20particle%20concentrations%29%2C%20epidemiological%20%28absences%20related%20to%20respiratory%20infections%29%2C%20audio%20%28coughing%29%2C%20and%20molecular%20data%20%28bioaerosol%20and%20saliva%20samples%29%20over%20seven%20weeks%20during%20winter%202022%5C%2F2023%20in%20two%20Swiss%20secondary%20school%20classes.%20Using%20a%20cross-over%20study%20design%2C%20we%20compared%20particle%20concentrations%2C%20coughing%2C%20and%20the%20risk%20of%20infection%20with%20vs%20without%20air%20cleaners.%5CnRESULTS%3A%20All%2038%20students%20%28age%2013-15%20years%29%20participated.%20With%20air%20cleaners%2C%20mean%20particle%20concentration%20decreased%20by%2077%25%20%2895%25%20credible%20interval%2063%25-86%25%29.%20There%20were%20no%20differences%20in%20CO2%20levels.%20Absences%20related%20to%20respiratory%20infections%20were%2022%20without%20vs%2013%20with%20air%20cleaners.%20Bayesian%20modeling%20suggested%20a%20reduced%20risk%20of%20infection%2C%20with%20a%20posterior%20probability%20of%2091%25%20and%20a%20relative%20risk%20of%200.73%20%2895%25%20credible%20interval%200.44-1.18%29.%20Coughing%20also%20tended%20to%20be%20less%20frequent%20%28posterior%20probability%2093%25%29.%20Molecular%20analysis%20detected%20mainly%20non-SARS-CoV-2%20viruses%20in%20saliva%20%2850%5C%2F448%20positive%29%2C%20but%20not%20in%20bioaerosols%20%282%5C%2F105%20positive%29%20or%20HEPA-filters%20%284%5C%2F160%29.%20The%20detection%20rate%20was%20similar%20with%20vs%20without%20air%20cleaners.%20Spatiotemporal%20analysis%20of%20positive%20saliva%20samples%20identified%20several%20likely%20transmissions.%5CnCONCLUSIONS%3A%20Air%20cleaners%20improved%20air%20quality%2C%20showed%20a%20potential%20benefit%20in%20reducing%20respiratory%20infections%2C%20and%20were%20associated%20with%20less%20coughing.%20Airborne%20detection%20of%20non-SARS-CoV-2%20viruses%20was%20rare%2C%20suggesting%20that%20these%20viruses%20may%20be%20more%20difficult%20to%20detect%20in%20the%20air.%20Future%20studies%20should%20examine%20the%20importance%20of%20close%20contact%20and%20long-range%20transmission%2C%20and%20the%20cost-effectiveness%20of%20using%20air%20cleaners.%22%2C%22date%22%3A%222023-12-30%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.12.29.23300635%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A50%3A02Z%22%7D%7D%2C%7B%22key%22%3A%222HTNPKKX%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Trickey%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTrickey%2C%20Adam%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJohnson%2C%20Leigh%20F.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFung%2C%20Fai%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBonifacio%2C%20Rogerio%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIwuji%2C%20Collins%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Associations%20of%20inter-annual%20rainfall%20decreases%20with%20subsequent%20HIV%20outcomes%20for%20persons%20with%20HIV%20on%20antiretroviral%20therapy%20in%20Southern%20Africa%3A%20a%20collaborative%20analysis%20of%20cohort%20studies.%20%26lt%3Bi%26gt%3BBMC%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B23%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20889.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-023-08902-9%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-023-08902-9%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Associations%20of%20inter-annual%20rainfall%20decreases%20with%20subsequent%20HIV%20outcomes%20for%20persons%20with%20HIV%20on%20antiretroviral%20therapy%20in%20Southern%20Africa%3A%20a%20collaborative%20analysis%20of%20cohort%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%22%2C%22lastName%22%3A%22Trickey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fai%22%2C%22lastName%22%3A%22Fung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogerio%22%2C%22lastName%22%3A%22Bonifacio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Collins%22%2C%22lastName%22%3A%22Iwuji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Biraro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Chirimuta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20P.%22%2C%22lastName%22%3A%22Fox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22Von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joe%22%2C%22lastName%22%3A%22Gumulira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Howard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauren%22%2C%22lastName%22%3A%22Jennings%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnes%22%2C%22lastName%22%3A%22Kiragga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Tanser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thorsten%22%2C%22lastName%22%3A%22Wagener%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Vickerman%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Periods%20of%20droughts%20can%20lead%20to%20decreased%20food%20security%2C%20and%20altered%20behaviours%2C%20potentially%20affecting%20outcomes%20on%20antiretroviral%20therapy%20%28ART%29%20among%20persons%20with%20HIV%20%28PWH%29.%20We%20investigated%20whether%20decreased%20rainfall%20is%20associated%20with%20adverse%20outcomes%20among%20PWH%20on%20ART%20in%20Southern%20Africa.%5CnMETHODS%3A%20Data%20were%20combined%20from%2011%20clinical%20cohorts%20of%20PWH%20in%20Lesotho%2C%20Malawi%2C%20Mozambique%2C%20South%20Africa%2C%20Zambia%2C%20and%20Zimbabwe%2C%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20Southern%20Africa%20%28IeDEA-SA%29%20collaboration.%20Adult%20PWH%20who%20had%20started%20ART%20prior%20to%2001%5C%2F06%5C%2F2016%20and%20were%20in%20follow-up%20in%20the%20year%20prior%20to%2001%5C%2F06%5C%2F2016%20were%20included.%20Two-year%20rainfall%20from%20June%202014%20to%20May%202016%20at%20the%20location%20of%20each%20HIV%20centre%20was%20summed%20and%20ranked%20against%20historical%202-year%20rainfall%20amounts%20%281981-2016%29%20to%20give%20an%20empirical%20relative%20percentile%20rainfall%20estimate.%20The%20IeDEA-SA%20and%20rainfall%20data%20were%20combined%20using%20each%20HIV%20centre%26%23039%3Bs%20latitude%5C%2Flongitude.%20In%20individual-level%20analyses%2C%20multivariable%20Cox%20or%20generalized%20estimating%20equation%20regression%20models%20%28GEEs%29%20assessed%20associations%20between%20decreased%20rainfall%20versus%20historical%20levels%20and%20four%20separate%20outcomes%20%28mortality%2C%20CD4%20counts%5Cu2009%26lt%3B%5Cu2009200%20cells%5C%2Fmm3%2C%20viral%20loads%5Cu2009%26gt%3B%5Cu2009400%20copies%5C%2FmL%2C%20and%5Cu2009%26gt%3B%5Cu200912-month%20gaps%20in%20follow-up%29%20in%20the%20two%20years%20following%20the%20rainfall%20period.%20GEEs%20were%20used%20to%20investigate%20the%20association%20between%20relative%20rainfall%20and%20monthly%20numbers%20of%20unique%20visitors%20per%20HIV%20centre.%5CnRESULTS%3A%20Among%20270%2C708%20PWH%20across%20386%20HIV%20centres%20%2867%25%20female%2C%20median%20age%2039%20%5BIQR%3A%2032-46%5D%29%2C%20lower%20rainfall%20than%20usual%20was%20associated%20with%20higher%20mortality%20%28adjusted%20Hazard%20Ratio%3A%201.18%20%5B95%25CI%3A%201.07-1.32%5D%20per%2010%20percentile%20rainfall%20rank%20decrease%29%20and%20unsuppressed%20viral%20loads%20%28adjusted%20Odds%20Ratio%3A%201.05%20%5B1.01-1.09%5D%29.%20Levels%20of%20rainfall%20were%20not%20strongly%20associated%20with%20CD4%20counts%5Cu2009%26lt%3B%5Cu2009200%20cell%5C%2Fmm3%20or%5Cu2009%26gt%3B%5Cu200912-month%20gaps%20in%20care.%20HIV%20centres%20in%20areas%20with%20less%20rainfall%20than%20usual%20had%20lower%20numbers%20of%20PWH%20visiting%20them%20%28adjusted%20Rate%20Ratio%3A%200.80%20%5B0.66-0.98%5D%20per%2010%20percentile%20rainfall%20rank%20decrease%29.%5CnCONCLUSIONS%3A%20Decreased%20rainfall%20could%20negatively%20impact%20on%20HIV%20treatment%20behaviours%20and%20outcomes.%20Further%20research%20is%20needed%20to%20explore%20the%20reasons%20for%20these%20effects.%20Interventions%20to%20mitigate%20the%20health%20impact%20of%20severe%20weather%20events%20are%20required.%22%2C%22date%22%3A%222023-12-19%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12879-023-08902-9%22%2C%22ISSN%22%3A%221471-2334%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-01-12T13%3A20%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22I5QF6ZNX%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Skrivankova%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSkrivankova%2C%20Veronika%20W.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20Morna%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBallif%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDupont%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Authorship%20inequalities%20in%20global%20health%20research%3A%20the%20IeDEA%20Southern%20Africa%20collaboration.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B8%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%20e013316.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2023-013316%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2023-013316%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Authorship%20inequalities%20in%20global%20health%20research%3A%20the%20IeDEA%20Southern%20Africa%20collaboration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronika%20W.%22%2C%22lastName%22%3A%22Skrivankova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Dupont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstantinos%22%2C%22lastName%22%3A%22Seintaridis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thokozani%22%2C%22lastName%22%3A%22Kalua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Gunter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20conducts%20research%20in%20several%20regions%2C%20including%20in%20Southern%20Africa.%20We%20assessed%20authorship%20inequalities%20for%20the%20Southern%20African%20region%2C%20which%20is%20led%20by%20South%20African%20and%20Swiss%20investigators.%5CnMETHODS%3A%20We%20analysed%20authorships%20of%20publications%20from%202007%20to%202020%20by%20gender%2C%20country%20income%20group%2C%20time%20and%20citation%20impact.%20We%20used%202020%20World%20Bank%20categories%20to%20define%20income%20groups%20and%20the%20relative%20citation%20ratio%20%28RCR%29%20to%20assess%20citation%20impact.%20Authorship%20parasitism%20was%20defined%20as%20articles%20without%20authors%20from%20the%20countries%20where%20the%20study%20was%20conducted.%20A%20regression%20model%20examined%20the%20probability%20of%20different%20authorship%20positions.%5CnRESULTS%3A%20We%20included%20313%20articles.%20Of%20the%201064%20contributing%20authors%2C%20547%20%2851.4%25%29%20were%20women%2C%20and%20223%20%2821.0%25%29%20were%20from%2032%20low-income%5C%2Flower%20middle-income%20countries%20%28LLMICs%29%2C%20269%20%2825.3%25%29%20were%20from%2013%20upper%20middle-income%20countries%20and%20572%20%2853.8%25%29%20were%20from%2025%20high-income%20countries%20%28HICs%29.%20Most%20articles%20%28150%5C%2F157%2C%2095.5%25%29%20reporting%20data%20from%20Southern%20Africa%20included%20authors%20from%20all%20participating%20countries.%20Women%20were%20more%20likely%20to%20be%20the%20first%20author%20than%20men%20%28OR%201.74%3B%2095%25%5Cu2009CI%201.06%20to%202.83%29%20but%20less%20likely%20to%20be%20last%20authors%20%28OR%200.63%3B%2095%25%5Cu2009CI%200.40%20to%200.99%29.%20Compared%20with%20HIC%2C%20LLMIC%20authors%20were%20less%20likely%20to%20publish%20as%20first%20%28OR%200.21%3B%2095%25%5Cu2009CI%200.11%20to%200.41%29%20or%20last%20author%20%28OR%200.20%3B%2095%25%5Cu2009CI%200.09%20to%200.42%29.%20The%20proportion%20of%20women%20and%20LLMIC%20first%20and%20last%20authors%20increased%20over%20time.%20The%20RCR%20tended%20to%20be%20higher%2C%20indicating%20greater%20impact%2C%20if%20first%20or%20last%20authors%20were%20from%20HIC%20%28p%3D0.06%29.%5CnCONCLUSIONS%3A%20This%20analysis%20of%20a%20global%20health%20collaboration%20co-led%20by%20South%20African%20and%20Swiss%20investigators%20showed%20little%20evidence%20of%20authorship%20parasitism.%20There%20were%20stark%20inequalities%20in%20authorship%20position%2C%20with%20women%20occupying%20more%20first%20and%20men%20more%20last%20author%20positions%20and%20researchers%20from%20LLMIC%20being%20%26%23039%3Bstuck%20in%20the%20middle%26%23039%3B%20on%20the%20byline.%20Global%20health%20research%20collaborations%20should%20monitor%2C%20analyse%20and%20address%20authorship%20inequalities.%22%2C%22date%22%3A%222023-12-16%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2023-013316%22%2C%22ISSN%22%3A%222059-7908%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-01-12T13%3A22%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22MGI477IL%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWettstein%2C%20Anja%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMesa-Vieira%2C%20Cristina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Life%20years%20lost%20associated%20with%20mental%20illness%3A%20A%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme.%20%26lt%3Bi%26gt%3BJournal%20of%20Affective%20Disorders%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B340%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20204%26%23x2013%3B212.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jad.2023.08.013%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jad.2023.08.013%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Life%20years%20lost%20associated%20with%20mental%20illness%3A%20A%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Wettstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Mesa-Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chanwyn%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Schomaker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20People%20with%20mental%20illness%20have%20a%20reduced%20life%20expectancy%2C%20but%20the%20extent%20of%20the%20mortality%20gap%20and%20the%20contribution%20of%20natural%20and%20unnatural%20causes%20to%20excess%20mortality%20among%20people%20with%20mental%20illness%20in%20South%20Africa%20are%20unknown.%5CnMETHODS%3A%20We%20analysed%20reimbursement%20claims%20from%20South%20African%20medical%20insurance%20scheme%20beneficiaries%20aged%2015-85%5Cu00a0years.%20We%20estimated%20excess%20life%20years%20lost%20%28LYL%29%20associated%20with%20organic%2C%20substance%20use%2C%20psychotic%2C%20mood%2C%20anxiety%2C%20eating%2C%20personality%2C%20developmental%20or%20any%20mental%20disorders.%5CnRESULTS%3A%20We%20followed%201%2C070%2C183%20beneficiaries%20for%20a%20median%20of%20three%20years%2C%20of%20whom%20282%2C926%20%2826.4%5Cu00a0%25%29%20received%20mental%20health%20diagnoses.%20Men%20with%20a%20mental%20health%20diagnosis%20lost%203.83%20life%20years%20%2895%5Cu00a0%25%20CI%203.58-4.10%29%20compared%20to%20men%20without.%20Women%20with%20a%20mental%20health%20diagnosis%20lost%202.19%20life%20years%20%281.97-2.41%29%20compared%20to%20women%20without.%20Excess%20mortality%20varied%20by%20sex%20and%20diagnosis%2C%20from%2011.50%20LYL%20%2895%5Cu00a0%25%20CI%209.79-13.07%29%20among%20men%20with%20alcohol%20use%20disorder%20to%200.87%20LYL%20%280.40-1.43%29%20among%20women%20with%20generalised%20anxiety%20disorder.%20Most%20LYL%20were%20attributable%20to%20natural%20causes%20%28men%3A%203.42%2C%20women%3A%201.94%29.%20A%20considerable%20number%20of%20LYL%20were%20attributable%20to%20unnatural%20causes%20among%20men%20with%20bipolar%20%281.52%29%20or%20substance%20use%20%282.45%29%20disorder.%5CnLIMITATIONS%3A%20Mental%20diagnoses%20are%20based%20on%20reimbursement%20claims.%5CnCONCLUSIONS%3A%20Premature%20mortality%20among%20South%20African%20individuals%20with%20mental%20disorders%20is%20high.%20Our%20findings%20support%20interventions%20for%20the%20prevention%2C%20early%20detection%2C%20and%20treatment%20of%20physical%20comorbidities%20in%20this%20population.%20Targeted%20programs%20for%20suicide%20prevention%20and%20substance%20use%20treatment%2C%20particularly%20among%20men%2C%20can%20help%20reduce%20excess%20mortality%20from%20unnatural%20causes.%22%2C%22date%22%3A%222023-11-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jad.2023.08.013%22%2C%22ISSN%22%3A%221573-2517%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A08%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22MYPZC62H%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Muula%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBosomprah%2C%20Samuel%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSinkala%2C%20Edford%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNsokolo%2C%20Bright%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusonda%2C%20Taonga%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Hepatitis%20B%20viral%20replication%20markers%20and%20hepatic%20fibrosis%20in%20untreated%20chronic%20hepatitis%20B%20virus%20infection%20with%20and%20without%20HIV%20coinfection%20in%20Zambia.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%2813%29%2C%20S.%202015%26%23x2013%3B2020.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003659%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003659%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hepatitis%20B%20viral%20replication%20markers%20and%20hepatic%20fibrosis%20in%20untreated%20chronic%20hepatitis%20B%20virus%20infection%20with%20and%20without%20HIV%20coinfection%20in%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%20K.%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edford%22%2C%22lastName%22%3A%22Sinkala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bright%22%2C%22lastName%22%3A%22Nsokolo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taonga%22%2C%22lastName%22%3A%22Musonda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kalongo%22%2C%22lastName%22%3A%22Hamusonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debika%22%2C%22lastName%22%3A%22Bhattacharya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georg%22%2C%22lastName%22%3A%22Lauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%20T.%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lloyd%20B.%22%2C%22lastName%22%3A%22Mulenga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Vinikoor%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20To%20inform%20novel%20therapies%2C%20a%20more%20nuanced%20understanding%20of%20HIV%26%23039%3Bs%20impact%20on%20hepatitis%20B%20virus%20%28HBV%29%20natural%20history%20is%20needed%2C%20particularly%20in%20high%20burden%20countries.%5CnMETHODS%3A%20In%20Lusaka%2C%20Zambia%2C%20we%20compared%20prospectively%20recruited%20adults%20%2818%2B%20years%29%20with%20chronic%20HBV%20infection%2C%20with%20and%20without%20HIV.%20We%20excluded%20those%20with%20prior%20antiviral%20treatment%20experience%20or%20HBV%20diagnosis%20due%20to%20clinical%20suspicion%20%28rather%20than%20routine%20testing%29.%20We%20assessed%20HBV%20DNA%20levels%2C%20hepatitis%20B%20e%20antigen%20%28HBeAg%29%2C%20CD4%20%2B%20%28if%20HIV%20coinfection%29%2C%20and%20liver%20disease%20%28transient%20elastography%2C%20serum%20alanine%20aminotransferase%29.%20In%20multivariable%20analyses%2C%20we%20evaluated%20the%20association%20of%20HIV%20overall%20and%20by%20level%20of%20CD4%20%2B%20count%20on%20these%20markers.%5CnRESULTS%3A%20Among%20713%20adults%20analyzed%2C%20median%20age%20was%2033%5Cu200ayears%2C%2063%25%20were%20male%2C%20and%20433%20had%20HBV%5C%2FHIV%20coinfection.%20Median%20CD4%20%2B%20count%20was%20200%5Cu200acells%5C%2F%5Cu03bcl.%20HBV%20DNA%20was%20greater%20than%202000%5Cu200aIU%5C%2Fml%20for%20311%20%2851.0%25%29%20and%20227%20%2832.5%25%29%20were%20HBeAg-positive.%2015.5%25%20had%20advanced%20fibrosis%20or%20cirrhosis.%20HIV%20coinfection%20was%20associated%20with%20five-fold%20increased%20HBV%20DNA%20levels%20%5Badjusted%20geometric%20mean%20ratio%2C%205.78%3B%2095%25%20confidence%20interval%20%28CI%29%2C%202.29-14.62%5D%20and%20two%20times%20the%20odds%20of%20HBeAg-positivity%20%28adjusted%20odds%20ratio%2C%202.54%3B%2095%25%20CI%2C%201.59-4.08%29.%20These%20associations%20were%20significant%20only%20at%20CD4%20%2B%20counts%20100-350%20and%20%26lt%3B100%5Cu200acells%5C%2F%5Cu03bcl.%20HIV%20was%20not%20associated%20with%20markers%20of%20fibrosis%20or%20ALT.%5CnDISCUSSION%3A%20HIV%26%23039%3Bs%20impact%20on%20HBV%20natural%20history%20likely%20depends%20on%20the%20degree%20and%20duration%20of%20immune%20suppression.%20There%20is%20strong%20rationale%20to%20monitor%20HBV%20DNA%20in%20people%20with%20HBV%5C%2FHIV%20coinfection%20and%20immune%20suppression.%20A%20better%20understanding%20is%20needed%20of%20mechanisms%20of%20increased%20liver-related%20mortality%20in%20people%20with%20HBV%5C%2FHIV%20coinfection.%22%2C%22date%22%3A%222023-11-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003659%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-11-08T09%3A56%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22RSD8GVHK%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Loosli%20et%20al.%22%2C%22parsedDate%22%3A%222023-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLoosli%2C%20Tom%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOkhai%2C%20Hajra%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKusejko%2C%20Katharina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20HIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20a%20collaborative%20cohort%20analysis.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20HIV%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%20%2811%29%2C%20S.%20e733%26%23x2013%3Be741.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2352-3018%2823%2900228-X%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2352-3018%2823%2900228-X%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20a%20collaborative%20cohort%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Loosli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajra%22%2C%22lastName%22%3A%22Okhai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Kusejko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Mouton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pantxika%22%2C%22lastName%22%3A%22Bellecave%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ard%22%2C%22lastName%22%3A%22van%20Sighem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Stecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonella%22%2C%22lastName%22%3A%22d%27Arminio%20Monforte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20John%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%20A.%22%2C%22lastName%22%3A%22Sabin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huldrych%20F.%22%2C%22lastName%22%3A%22G%5Cu00fcnthard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20A.%20C.%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Lessells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20D.%22%2C%22lastName%22%3A%22Kouyos%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20widespread%20use%20of%20the%20integrase%20strand%20transfer%20inhibitor%20%28INSTI%29%20dolutegravir%20in%20first-line%20and%20second-line%20antiretroviral%20therapy%20%28ART%29%20might%20facilitate%20emerging%20resistance.%20The%20DTG%20RESIST%20study%20combined%20data%20from%20HIV%20cohorts%20to%20examine%20patterns%20of%20drug%20resistance%20mutations%20%28DRMs%29%20and%20identify%20risk%20factors%20for%20dolutegravir%20resistance.%5CnMETHODS%3A%20We%20included%20cohorts%20with%20INSTI%20resistance%20data%20from%20two%20collaborations%20%28ART%20Cohort%20Collaboration%2C%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20in%20Southern%20Africa%29%2C%20and%20the%20UK%20Collaborative%20HIV%20Cohort.%20Eight%20cohorts%20from%20Canada%2C%20France%2C%20Germany%2C%20Italy%2C%20the%20Netherlands%2C%20Switzerland%2C%20South%20Africa%2C%20and%20the%20UK%20contributed%20data%20on%20individuals%20who%20were%20viraemic%20on%20dolutegravir-based%20ART%20and%20underwent%20genotypic%20resistance%20testing.%20Individuals%20with%20unknown%20dolutegravir%20initiation%20date%20were%20excluded.%20Resistance%20levels%20were%20categorised%20using%20the%20Stanford%20algorithm.%20We%20identified%20risk%20factors%20for%20resistance%20using%20mixed-effects%20ordinal%20logistic%20regression%20models.%5CnFINDINGS%3A%20We%20included%20599%20people%20with%20genotypic%20resistance%20testing%20on%20dolutegravir-based%20ART%20between%20May%2022%2C%202013%2C%20and%20Dec%2020%2C%202021.%20Most%20had%20HIV-1%20subtype%20B%20%28n%3D351%2C%2059%25%29%2C%20a%20third%20had%20been%20exposed%20to%20first-generation%20INSTIs%20%28n%3D193%2C%2032%25%29%2C%2070%20%2812%25%29%20were%20on%20dolutegravir%20dual%20therapy%2C%20and%2018%20%283%25%29%20were%20on%20dolutegravir%20monotherapy.%20INSTI%20DRMs%20were%20detected%20in%2086%20%2814%25%29%20individuals%3B%2020%20%283%25%29%20had%20more%20than%20one%20mutation.%20Most%20%28n%3D563%2C%2094%25%29%20were%20susceptible%20to%20dolutegravir%2C%20seven%20%281%25%29%20had%20potential%20low%2C%20six%20%281%25%29%20low%2C%2017%20%283%25%29%20intermediate%2C%20and%20six%20%281%25%29%20high-level%20dolutegravir%20resistance.%20The%20risk%20of%20dolutegravir%20resistance%20was%20higher%20on%20dolutegravir%20monotherapy%20%28adjusted%20odds%20ratio%20%5BaOR%5D%2034%5Cu00b71%2C%2095%25%20CI%209%5Cu00b793-117%29%20and%20dolutegravir%20plus%20lamivudine%20dual%20therapy%20%28aOR%209%5Cu00b721%2C%202%5Cu00b720-38%5Cu00b76%29%20compared%20with%20combination%20ART%2C%20and%20in%20the%20presence%20of%20potential%20low%20or%20low%20%28aOR%205%5Cu00b723%2C%201%5Cu00b732-20%5Cu00b77%29%20or%20intermediate%20or%20high-level%20%28aOR%2013%5Cu00b74%2C%204%5Cu00b755-39%5Cu00b77%29%20nucleoside%20reverse%20transcriptase%20inhibitor%20%28NRTI%29%20resistance.%5CnINTERPRETATION%3A%20Among%20people%20with%20viraemia%20on%20dolutegravir-based%20ART%2C%20INSTI%20DRMs%20and%20dolutegravir%20resistance%20were%20rare.%20NRTI%20resistance%20substantially%20increased%20the%20risk%20of%20dolutegravir%20resistance%2C%20which%20is%20of%20concern%2C%20notably%20in%20resource-limited%20settings.%20Monitoring%20is%20important%20to%20prevent%20resistance%20at%20the%20individual%20and%20population%20level%20and%20ensure%20the%20long-term%20sustainability%20of%20ART.%5CnFUNDING%3A%20US%20National%20Institutes%20of%20Health%2C%20Swiss%20National%20Science%20Foundation.%22%2C%22date%22%3A%222023-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2FS2352-3018%2823%2900228-X%22%2C%22ISSN%22%3A%222352-3018%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-07-26T10%3A08%3A18Z%22%7D%7D%2C%7B%22key%22%3A%228JN7GFW9%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Metekoua%20et%20al.%22%2C%22parsedDate%22%3A%222023-10-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMetekoua%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20Victor%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Decreasing%20incidence%20of%20conjunctival%20squamous%20cell%20carcinoma%20in%20people%20with%20HIV%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20National%20Cancer%20Institute%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B115%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%201213%26%23x2013%3B1219.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjnci%5C%2Fdjad119%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjnci%5C%2Fdjad119%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Decreasing%20incidence%20of%20conjunctival%20squamous%20cell%20carcinoma%20in%20people%20with%20HIV%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Metekoua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Muchengeti%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20main%20risk%20factors%20for%20squamous%20cell%20carcinoma%20of%20the%20conjunctiva%20%28SCCC%29%20are%20immunodeficiency%20and%20exposure%20to%20ultraviolet%20radiation.%20Little%20is%20known%20about%20SCCC%20epidemiology%20among%20people%20with%20HIV%20%28PWH%29%20in%20South%20Africa.%5CnMETHODS%3A%20We%20used%20data%20from%20the%20South%20African%20HIV%20Cancer%20Match%20study%2C%20a%20nation-wide%20cohort%20of%20PWH%20in%20South%20Africa%2C%20created%20through%20a%20privacy-preserving%20probabilistic%20record%20linkage%20of%20HIV-related%20laboratory%20records%20from%20the%20National%20Health%20Laboratory%20Service%20and%20cancer%20records%20from%20the%20National%20Cancer%20Registry%20from%202004%20to%202014.%20We%20calculated%20crude%20incidence%20rates%2C%20analyzed%20trends%20using%20joinpoint%20models%2C%20and%20estimated%20hazard%20ratios%20for%20different%20risk%20factors%20using%20Royston-Parmar%20flexible%20parametric%20survival%20models.%5CnRESULTS%3A%20Among%205%5Cu200a247%5Cu200a968%20PWH%2C%201059%20cases%20of%20incident%20SCCC%20were%20diagnosed%2C%20for%20a%20crude%20overall%20SCCC%20incidence%20rate%20of%206.8%20per%20100%5Cu200a000%20person-years.%20The%20SCCC%20incidence%20rate%20decreased%20between%202004%20and%202014%2C%20with%20an%20annual%20percentage%20change%20of%20%5Cu201210.9%25%20%2895%25%20confidence%20interval%3A%20%5Cu201213.3%20to%20%5Cu20128.3%29.%20PWH%20residing%20within%20latitudes%2030%5Cu00b0S%20to%2034%5Cu00b0S%20had%20a%2049%25%20lower%20SCCC%20risk%20than%20those%20residing%20at%20less%20than%2025%5Cu00b0S%20latitude%20%28adjusted%20hazard%20ratio%5Cu2009%3D%5Cu20090.67%3B%2095%25%20confidence%20interval%3A%200.55%20to%200.82%29.%20Other%20risk%20factors%20for%20SCCC%20were%20lower%20CD4%20counts%20and%20middle%20age.%20There%20was%20no%20evidence%20for%20an%20association%20of%20sex%20or%20settlement%20type%20with%20SCCC%20risk.%5CnCONCLUSIONS%3A%20An%20increased%20risk%20of%20developing%20SCCC%20was%20associated%20with%20lower%20CD4%20counts%20and%20residence%20closer%20to%20the%20equator%2C%20indicative%20of%20higher%20ultraviolet%20radiation%20exposure.%20Clinicians%20and%20PWH%20should%20be%20educated%20on%20known%20SCCC%20preventive%20measures%2C%20such%20as%20maintaining%20high%20CD4%20counts%20and%20protection%20from%20ultraviolet%20radiation%20through%20sunglasses%20and%20sunhats%20when%20outdoors.%22%2C%22date%22%3A%222023-10-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fjnci%5C%2Fdjad119%22%2C%22ISSN%22%3A%221460-2105%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-11-08T10%3A00%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22TUIRIF5D%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Beer%20et%20al.%22%2C%22parsedDate%22%3A%222023-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Beer%2C%20Shani%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSlogrove%2C%20Amy%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJones%2C%20Hayley%20E.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Change%20in%20HIV-related%20characteristics%20of%20children%20hospitalised%20with%20infectious%20diseases%20in%20Western%20Cape%2C%20South%20Africa%2C%202008-2021%3A%20a%20time%20trend%20analysis.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%20Suppl%204%26lt%3B%5C%2Fi%26gt%3B%20%28Suppl%204%29%2C%20S.%20e26151.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26151%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26151%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Change%20in%20HIV-related%20characteristics%20of%20children%20hospitalised%20with%20infectious%20diseases%20in%20Western%20Cape%2C%20South%20Africa%2C%202008-2021%3A%20a%20time%20trend%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shani%20T.%22%2C%22lastName%22%3A%22de%20Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20L.%22%2C%22lastName%22%3A%22Slogrove%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hayley%20E.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20With%20the%20scaling%20up%20of%20vertical%20HIV%20transmission%20prevention%20programmes%2C%20the%20HIV-related%20population%20profile%20of%20children%20in%20South%20Africa%20has%20shifted.%20We%20described%20temporal%20changes%20in%20HIV-related%20characteristics%20of%20children%2C%20aged%20%5Cu22643%20years%20%28up%20to%20the%20third%20birthday%29%2C%20with%20infectious%20disease%20hospitalisations%20across%20the%20Western%20Cape%20province.%5CnMETHODS%3A%20We%20used%20routinely%20collected%20electronic%20data%20to%20identify%20children%20born%20in%20the%20Western%20Cape%20with%20infectious%20disease%20hospital%20records%20for%20lower%20respiratory%20tract%20infections%2C%20diarrhoea%2C%20meningitis%20and%20tuberculous%20meningitis%2C%20from%202008%20to%202021.%20Linked%20maternal%20and%20child%20unique%20identifiers%20were%20used%20to%20extract%20pregnancy%2C%20HIV-related%2C%20laboratory%2C%20pharmacy%20and%20hospitalisation%20data.%20We%20described%20temporal%20changes%20in%20child%20HIV%20exposure%20and%20acquisition%20status%2C%20timing%20of%20maternal%20HIV%20diagnosis%20and%20antiretroviral%20therapy%20%28ART%29%20start%2C%20infant%20exposure%20to%20maternal%20ART%20and%20timing%20thereof%2C%20and%20maternal%20CD4%20and%20HIV%20viral%20load%20closest%20to%20delivery.%20We%20used%20logistic%20and%20multinomial%20regression%20to%20assess%20changes%20in%20characteristics%20between%20the%20Pre-Option%20B%2B%20%282008-2013%29%2C%20Option%20B%2B%20%282013-2016%29%20and%20Universal%20ART%20periods%20%282016-2021%29.%5CnRESULTS%3A%20Among%2052%2C811%20children%20aged%20%5Cu22643%20years%20with%20hospitalisations%2C%20the%20proportion%20living%20with%20HIV%20dreased%20from%207.0%25%20%282008%29%20to%201.1%25%20%282021%29%2C%20while%20those%20exposed%20to%20HIV%20and%20uninfected%20increased%20from%2014.0%25%20%282008%29%20to%2016.1%25%20%282021%29%20with%20a%20peak%20of%2018.3%25%20in%202017.%20Among%20mothers%20with%20HIV%20%28n%20%3D%209873%29%2C%20the%20proportion%20diagnosed%20with%20HIV%20and%20starting%20ART%20before%20pregnancy%20increased%20from%2020.2%25%20to%2069.2%25%20and%205.8%25%20to%2059.0%25%2C%20respectively%2C%20between%202008%20and%202021.%20Children%20hospitalised%20during%20the%20Universal%20ART%20period%20had%20eight%20times%20higher%20odds%20%28Odds%20Ratio%3A%208.41%3B%2095%25%20CI%3A%207.36-9.61%29%20of%20exposure%20to%20maternal%20ART%20versus%20children%20admitted%20Pre-Option%20B%2B.%20Among%20mothers%20of%20children%20exposed%20to%20HIV%20and%20uninfected%20with%20CD4%20records%20%28n%20%3D%207523%29%2C%20the%20proportion%20with%20CD4%20%26lt%3B350%20cells%5C%2F%5Cu03bcl%20decreased%20from%2090.6%25%20%282008%29%20to%2027.8%25%20%282021%29.%5CnCONCLUSIONS%3A%20In%20recent%20years%2C%20among%20children%20hospitalised%20with%20infectious%20diseases%2C%20there%20were%20fewer%20children%20with%20perinatally%20acquired%20HIV%2C%20while%20an%20increased%20proportion%20of%20those%20without%20HIV%20acquisition%20are%20exposed%20to%20maternal%20HIV%20and%20ART.%20There%20is%20a%20need%20to%20look%20beyond%20paediatric%20HIV%20prevalence%20and%20consider%20child%20exposure%20to%20HIV%20and%20ART%20among%20children%20without%20HIV%2C%20when%20assessing%20the%20HIV%20epidemic%26%23039%3Bs%20impact%20on%20child%20health%20services.%22%2C%22date%22%3A%222023-10%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26151%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T09%3A56%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22L9URNVGG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Slogrove%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSlogrove%2C%20Amy%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBovu%2C%20Andisiwe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Beer%2C%20Shani%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhelanyane%2C%20Florence%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWilliams%2C%20Paige%20L.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Maternal%20and%20birth%20outcomes%20in%20pregnant%20people%20with%20and%20without%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20population-based%20cohort%20study.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003728%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003728%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Maternal%20and%20birth%20outcomes%20in%20pregnant%20people%20with%20and%20without%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20population-based%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20L.%22%2C%22lastName%22%3A%22Slogrove%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andisiwe%22%2C%22lastName%22%3A%22Bovu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shani%22%2C%22lastName%22%3A%22de%20Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paige%20L.%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ushma%22%2C%22lastName%22%3A%22Mehta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%22%2C%22lastName%22%3A%22Theron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elaine%20J.%22%2C%22lastName%22%3A%22Abrams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20F.%22%2C%22lastName%22%3A%22Cotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Landon%22%2C%22lastName%22%3A%22Myer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20We%20evaluated%20associations%20of%20HIV%20and%20antiretroviral%20therapy%20%28ART%29%20with%20birth%20and%20maternal%20outcomes%20at%20a%20province-wide-level%20in%20the%20Western%20Cape%2C%20South%20Africa%2C%20in%20a%20recent%20cohort%20before%20dolutegravir-based%20first-line%20ART%20implementation.%5CnMETHODS%3A%20This%20retrospective%20cohort%20study%20included%20pregnant%20people%20delivering%20in%202018-2019%20with%20data%20in%20the%20Western%20Cape%20Provincial%20Health%20Data%20Centre%20which%20integrates%20individual-level%20data%20on%20all%20public%20sector%20patients%20from%20multiple%20electronic%20platforms%20using%20unique%20identifiers.%20Adverse%20birth%20outcomes%20%28stillbirth%2C%20low%20birth%20weight%20%28LBW%29%2C%20very%20LBW%20%28VLBW%29%29%20and%20maternal%20outcomes%20%28early%20and%20late%20pregnancy-related%20deaths%2C%20early%20and%20late%20hospitalizations%29%20were%20compared%20by%20HIV%5C%2FART%20status%20and%20adjusted%20prevalence%20ratios%20%28aPRs%29%20calculated%20using%20log-binomial%20regression.%5CnRESULTS%3A%20Overall%20171%2C960%20pregnant%20people%20and%20their%20singleton%20newborns%20were%20included%2C%2019%25%20%28N%5Cu200a%3D%5Cu200a32%2C015%29%20identified%20with%20HIV.%20Amongst%20pregnant%20people%20with%20HIV%20%28PPHIV%29%2C%2060%25%20%28N%5Cu200a%3D%5Cu200a19%2C157%29%20were%20on%20ART%20preconception%2C%2029%25%20%28N%5Cu200a%3D%5Cu200a9%2C276%29%20initiated%20ART%20during%20pregnancy%20and%2011%25%20%28N%5Cu200a%3D%5Cu200a3%2C582%29%20had%20no%20ART.%20Adjusted%20for%20maternal%20age%2C%20multiparity%2C%20hypertensive%20disorders%20and%20residential%20district%2C%20stillbirths%20were%20higher%20only%20for%20PPHIV%20not%20on%20ART%20%28aPR%201.31%20%5B95%25CI%201.04-1.66%5D%29%20compared%20to%20those%20without%20HIV.%20However%2C%20LBW%20and%20VLBW%20were%20higher%20among%20all%20PPHIV%2C%20with%20aPRs%20of%201.11-1.22%20for%20LBW%20and%201.14-1.54%20for%20VLBW.%20Pregnancy-initiated%20ART%20was%20associated%20with%20early%20pregnancy-related%20death%20%28aPR%203.21%3B%2095%25CI%201.55-6.65%29%2C%20and%20HIV%20with%20or%20without%20ART%20was%20associated%20with%20late%20pregnancy-related%20death%20%28aPRs%207.89-9.01%29.%5CnCONCLUSIONS%3A%20Even%20in%20the%20universal%20ART%20era%2C%20PPHIV%20experienced%20higher%20rates%20of%20LBW%20and%20VLBW%20newborns%2C%20and%20higher%20late%20pregnancy-related%20death%20regardless%20of%20ART%20status%20than%20pregnant%20people%20without%20HIV.%22%2C%22date%22%3A%222023-09-15%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003728%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A09%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22J88A92VI%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hansford%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHansford%2C%20Harrison%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCashin%2C%20Aidan%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJones%2C%20Matthew%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSwanson%2C%20Sonja%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIslam%2C%20Nazrul%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Development%20of%20the%20TrAnsparent%20ReportinG%20of%20observational%20studies%20Emulating%20a%20Target%20trial%20%28TARGET%29%20guideline.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20e074626.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2023-074626%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2023-074626%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20of%20the%20TrAnsparent%20ReportinG%20of%20observational%20studies%20Emulating%20a%20Target%20trial%20%28TARGET%29%20guideline%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harrison%20J.%22%2C%22lastName%22%3A%22Hansford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aidan%20G.%22%2C%22lastName%22%3A%22Cashin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20D.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%20A.%22%2C%22lastName%22%3A%22Swanson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazrul%22%2C%22lastName%22%3A%22Islam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Issa%20J.%22%2C%22lastName%22%3A%22Dahabreh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbra%20A.%22%2C%22lastName%22%3A%22Dickerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Garcia-Albeniz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20M.%22%2C%22lastName%22%3A%22Golub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Lodi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margarita%22%2C%22lastName%22%3A%22Moreno-Betancur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sallie-Anne%22%2C%22lastName%22%3A%22Pearson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Schneeweiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%20K.%22%2C%22lastName%22%3A%22Sharp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20A.%22%2C%22lastName%22%3A%22Stuart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%20A.%22%2C%22lastName%22%3A%22Hernan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hopin%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20H.%22%2C%22lastName%22%3A%22McAuley%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Observational%20studies%20are%20increasingly%20used%20to%20inform%20health%20decision-making%20when%20randomised%20trials%20are%20not%20feasible%2C%20ethical%20or%20timely.%20The%20target%20trial%20approach%20provides%20a%20framework%20to%20help%20minimise%20common%20biases%20in%20observational%20studies%20that%20aim%20to%20estimate%20the%20causal%20effect%20of%20interventions.%20Incomplete%20reporting%20of%20studies%20using%20the%20target%20trial%20framework%20limits%20the%20ability%20for%20clinicians%2C%20researchers%2C%20patients%20and%20other%20decision-makers%20to%20appraise%2C%20synthesise%20and%20interpret%20findings%20to%20inform%20clinical%20and%20public%20health%20practice%20and%20policy.%20This%20paper%20describes%20the%20methods%20that%20we%20will%20use%20to%20develop%20the%20TrAnsparent%20ReportinG%20of%20observational%20studies%20Emulating%20a%20Target%20trial%20%28TARGET%29%20reporting%20guideline.%5CnMETHODS%5C%2FDESIGN%3A%20The%20TARGET%20reporting%20guideline%20will%20be%20developed%20in%20five%20stages%20following%20recommended%20guidance.%20The%20first%20stage%20will%20identify%20target%20trial%20reporting%20practices%20by%20systematically%20reviewing%20published%20studies%20that%20explicitly%20emulated%20a%20target%20trial.%20The%20second%20stage%20will%20identify%20and%20refine%20items%20to%20be%20considered%20for%20inclusion%20in%20the%20TARGET%20guideline%20by%20consulting%20content%20experts%20using%20sequential%20online%20surveys.%20The%20third%20stage%20will%20prioritise%20and%20consolidate%20key%20items%20to%20be%20included%20in%20the%20TARGET%20guideline%20at%20an%20in-person%20consensus%20meeting%20of%20TARGET%20investigators.%20The%20fourth%20stage%20will%20produce%20and%20pilot-test%20both%20the%20TARGET%20guideline%20and%20explanation%20and%20elaboration%20document%20with%20relevant%20stakeholders.%20The%20fifth%20stage%20will%20disseminate%20the%20TARGET%20guideline%20and%20resources%20via%20journals%2C%20conferences%20and%20courses.%5CnETHICS%20AND%20DISSEMINATION%3A%20Ethical%20approval%20for%20the%20survey%20has%20been%20attained%20%28HC220536%29.%20The%20TARGET%20guideline%20will%20be%20disseminated%20widely%20in%20partnership%20with%20stakeholders%20to%20maximise%20adoption%20and%20improve%20reporting%20of%20these%20studies.%22%2C%22date%22%3A%222023-09-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2023-074626%22%2C%22ISSN%22%3A%222044-6055%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T11%3A17%3A53Z%22%7D%7D%2C%7B%22key%22%3A%2297TK8ITG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Olago%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20Victor%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNimako%2C%20Gideon%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBartels%2C%20Lina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBohlius%2C%20Julia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Cancer%20diagnostic%20service%20use%20in%20people%20with%20HIV%20in%20South%20Africa%3A%20a%20cross-sectional%20study.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.09.10.23295338.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.09.10.23295338%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.09.10.23295338%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cancer%20diagnostic%20service%20use%20in%20people%20with%20HIV%20in%20South%20Africa%3A%20a%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gideon%22%2C%22lastName%22%3A%22Nimako%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Bartels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvira%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Sengayi-Muchengeti%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20The%20objective%20of%20this%20study%20was%20to%20map%20place%20of%20cancer%20diagnosis%20in%20relation%20to%20Human%20Immunodeficiency%20Virus%20%28HIV%29%20care%20centre%20among%20people%20with%20HIV%20%28PWH%29%20within%20South%20Africa%20%28SA%29%20using%20national%20laboratory%20database.%5CnDESIGN%3A%20We%20linked%20HIV%20and%20cancer%20laboratory%20data%20from%202004-2014%20using%20supervised%20machine-learning%20algorithms.%20We%20performed%20a%20cross-sectional%20analysis%20comparing%20province%20where%20individuals%20accessed%20their%20HIV%20care%20versus%20where%20they%20had%20their%20cancer%20diagnosis.%5CnSETTING%3A%20We%20used%20laboratory%20test%20records%20related%20to%20HIV%20diagnostics%20and%20care%2C%20such%20as%20CD4%20cell%20counts%20and%20percentages%2C%20rapid%20tests%2C%20qualitative%20Polymerase%20Chain%20Reaction%20%28PCR%29%2C%20antibody%20and%20antigen%20tests%20for%20HIV%20data%20that%20was%20documented%20as%20HIV%20positive%20and%20laboratory%20diagnosed%20cancer%20records%20from%20SA.%5CnSTUDY%20POPULATION%3A%20Our%20study%20population%20consisted%20of%20HIV%20records%20from%20the%20National%20Health%20Laboratory%20Service%20%28NHLS%29%20that%20linked%20to%20cancer%20record%20at%20the%20National%20Cancer%20Registry%20%28NCR%29%20between%202004-2014.%5CnPRIMARY%20AND%20SECONDARY%20OUTCOMES%3A%20We%20linked%20HIV%20records%20from%20NHLS%20to%20cancer%20records%20at%20NCR%20in%20order%20to%20study%20the%20inherent%20characteristics%20of%20the%20population%20with%20both%20HIV%20and%20cancer.%5CnRESULTS%3A%20The%20study%20population%20was%2068%2C284%20individuals%20with%20cancer%20and%20documented%20HIV%20related%20laboratory%20test.%20The%20median%20age%20at%20cancer%20diagnosis%20was%2040%20%5BIQR%2C%2033-48%5D%20years%20for%20the%20study%20population%20with%20most%20cancers%20in%20PWH%20diagnosed%20in%20females%2070.9%25%20%5Bn%3D46%2C313%5D.%20Of%20all%20the%20PWH%20and%20cancer%2C%2025%25%20%28n%3D16%2C364%20p%20%26lt%3B%200.001%29%20sought%20treatment%20outside%20their%20province%20of%20residence%20with%2060.7%25%20%28n%3D10%2C235%29%20travelling%20to%20Gauteng.%20KZN%20had%2046.6%25%20%28n%3D4%2C107%29%20of%20its%20PWH%20getting%20cancer%20diagnosis%20in%20Gauteng.%20Western%20Cape%20had%2095%25%20%28n%3D6%2C200%29%20of%20PWH%20getting%20cancer%20diagnosis%20within%20the%20province.%5CnCONCLUSIONS%3A%20Our%20results%20showed%20health%20systems%20inequalities%20across%20provinces%20in%20South%20Africa%20with%20respect%20to%20cancer%20diagnosis.%20KZN%20for%20example%20had%20nearly%20half%20of%20the%20PWH%20getting%20cancer%20diagnosis%20outside%20the%20province%20while%20Western%20Cape%20is%20able%20to%20offer%20cancer%20diagnostic%20services%20to%20most%20of%20the%20PWH%20in%20the%20province.%20Gauteng%20is%20getting%20over%20burdened%20with%20referral%20for%20cancer%20diagnosis%20from%20other%20provinces.%20More%20effort%20is%20required%20to%20ensure%20equitable%20access%20to%20cancer%20diagnostic%20services%20within%20the%20country.%5CnARTICLE%20SUMMARY%3A%20Strengths%20and%20limitations%20of%20this%20study%3A%20We%20mapped%20the%20facilities%20of%20cancer%20diagnosis%20versus%20HIV%20care%20facilities%20for%20the%20PWH%20seeking%20cancer%20diagnosis%20in%20South%20Africa.We%20compared%20PWH%20who%20sought%20treatment%20in%20their%20province%20of%20residence%20versus%20those%20who%20sought%20treatment%20outside%20their%20province%20of%20residence.We%20used%20HIV%20care%20facility%26%23039%3Bs%20addresses%20as%20a%20proxy%20for%20place%20of%20residence%20for%20PWH.We%20did%20not%20account%20for%20movement%20due%20to%20other%20reasons%20such%20as%20migration%20for%20better%20jobs%20and%20education.%22%2C%22date%22%3A%222023-09-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.09.10.23295338%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-10-10T12%3A04%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22DRBQK4QM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hansford%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHansford%2C%20Harrison%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCashin%2C%20Aidan%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJones%2C%20Matthew%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSwanson%2C%20Sonja%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIslam%2C%20Nazrul%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Reporting%20of%20Observational%20Studies%20Explicitly%20Aiming%20to%20Emulate%20Randomized%20Trials%3A%20A%20Systematic%20Review.%20%26lt%3Bi%26gt%3BJAMA%20Network%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B6%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20e2336023.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.36023%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.36023%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reporting%20of%20Observational%20Studies%20Explicitly%20Aiming%20to%20Emulate%20Randomized%20Trials%3A%20A%20Systematic%20Review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harrison%20J.%22%2C%22lastName%22%3A%22Hansford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aidan%20G.%22%2C%22lastName%22%3A%22Cashin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20D.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%20A.%22%2C%22lastName%22%3A%22Swanson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazrul%22%2C%22lastName%22%3A%22Islam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%20R.%20G.%22%2C%22lastName%22%3A%22Douglas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodrigo%20R.%20N.%22%2C%22lastName%22%3A%22Rizzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jack%20J.%22%2C%22lastName%22%3A%22Devonshire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sam%20A.%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Issa%20J.%22%2C%22lastName%22%3A%22Dahabreh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbra%20A.%22%2C%22lastName%22%3A%22Dickerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xabier%22%2C%22lastName%22%3A%22Garcia-Albeniz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20M.%22%2C%22lastName%22%3A%22Golub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Lodi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margarita%22%2C%22lastName%22%3A%22Moreno-Betancur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sallie-Anne%22%2C%22lastName%22%3A%22Pearson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Schneeweiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20A.%20C.%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%20K.%22%2C%22lastName%22%3A%22Sharp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20A.%22%2C%22lastName%22%3A%22Stuart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%20A.%22%2C%22lastName%22%3A%22Hern%5Cu00e1n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hopin%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20H.%22%2C%22lastName%22%3A%22McAuley%22%7D%5D%2C%22abstractNote%22%3A%22IMPORTANCE%3A%20Observational%20%28nonexperimental%29%20studies%20that%20aim%20to%20emulate%20a%20randomized%20trial%20%28ie%2C%20the%20target%20trial%29%20are%20increasingly%20informing%20medical%20and%20policy%20decision-making%2C%20but%20it%20is%20unclear%20how%20these%20studies%20are%20reported%20in%20the%20literature.%20Consistent%20reporting%20is%20essential%20for%20quality%20appraisal%2C%20evidence%20synthesis%2C%20and%20translation%20of%20evidence%20to%20policy%20and%20practice.%5CnOBJECTIVE%3A%20To%20assess%20the%20reporting%20of%20observational%20studies%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial.%5CnEVIDENCE%20REVIEW%3A%20We%20searched%20Medline%2C%20Embase%2C%20PsycINFO%2C%20and%20Web%20of%20Science%20for%20observational%20studies%20published%20between%20March%202012%20and%20October%202022%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial%20of%20a%20health%20or%20medical%20intervention.%20Two%20reviewers%20double-screened%20and%20-extracted%20data%20on%20study%20characteristics%2C%20key%20predefined%20components%20of%20the%20target%20trial%20protocol%20and%20its%20emulation%20%28eligibility%20criteria%2C%20treatment%20strategies%2C%20treatment%20assignment%2C%20outcome%5Bs%5D%2C%20follow-up%2C%20causal%20contrast%5Bs%5D%2C%20and%20analysis%20plan%29%2C%20and%20other%20items%20related%20to%20the%20target%20trial%20emulation.%5CnFINDINGS%3A%20A%20total%20of%20200%20studies%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial%20were%20included.%20These%20studies%20included%2026%20subfields%20of%20medicine%2C%20and%20168%20%2884%25%29%20were%20published%20from%20January%202020%20to%20October%202022.%20The%20aim%20to%20emulate%20a%20target%20trial%20was%20explicit%20in%2070%20study%20titles%20%2835%25%29.%20Forty-three%20studies%20%2822%25%29%20reported%20use%20of%20a%20published%20reporting%20guideline%20%28eg%2C%20Strengthening%20the%20Reporting%20of%20Observational%20Studies%20in%20Epidemiology%29.%20Eighty-five%20studies%20%2843%25%29%20did%20not%20describe%20all%20key%20items%20of%20how%20the%20target%20trial%20was%20emulated%20and%20113%20%2857%25%29%20did%20not%20describe%20the%20protocol%20of%20the%20target%20trial%20and%20its%20emulation.%5CnCONCLUSION%20AND%20RELEVANCE%3A%20In%20this%20systematic%20review%20of%20200%20studies%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial%2C%20reporting%20of%20how%20the%20target%20trial%20was%20emulated%20was%20inconsistent.%20A%20reporting%20guideline%20for%20studies%20explicitly%20aiming%20to%20emulate%20a%20target%20trial%20may%20improve%20the%20reporting%20of%20the%20target%20trial%20protocols%20and%20other%20aspects%20of%20these%20emulation%20attempts.%22%2C%22date%22%3A%222023-09-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1001%5C%2Fjamanetworkopen.2023.36023%22%2C%22ISSN%22%3A%222574-3805%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A26%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22K2ZRBLPD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Z%5Cu00fcrcher%20et%20al.%22%2C%22parsedDate%22%3A%222023-08-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZ%26%23xFC%3Brcher%2C%20Kathrin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAbela%2C%20Irene%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStange%2C%20Madlen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDupont%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMugglin%2C%20Catrina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Alpha%20Variant%20Coronavirus%20Outbreak%20in%20a%20Nursing%20Home%20Despite%20High%20Vaccination%20Coverage%3A%20Molecular%2C%20Epidemiological%2C%20and%20Immunological%20Studies.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B77%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20537%26%23x2013%3B546.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciab1005%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciab1005%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Alpha%20Variant%20Coronavirus%20Outbreak%20in%20a%20Nursing%20Home%20Despite%20High%20Vaccination%20Coverage%3A%20Molecular%2C%20Epidemiological%2C%20and%20Immunological%20Studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Z%5Cu00fcrcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%20A.%22%2C%22lastName%22%3A%22Abela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madlen%22%2C%22lastName%22%3A%22Stange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Dupont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catrina%22%2C%22lastName%22%3A%22Mugglin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrian%22%2C%22lastName%22%3A%22Egli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Trkola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Vaccination%20may%20control%20the%20coronavirus%20disease%202019%20%28COVID-19%29%20pandemic%2C%20including%20in%20nursing%20homes%20where%20many%20high-risk%20people%20live.%20We%20conducted%20extensive%20outbreak%20investigations.%5CnMETHODS%3A%20We%20studied%20an%20outbreak%20at%20a%20nursing%20home%20in%20Switzerland%2C%20where%20the%20uptake%20of%20messenger%20RNA%20vaccines%20against%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-CoV-2%29%20was%2082%25%20among%20residents%20as%20of%2021%20January%202021.%20After%20diagnosis%20of%20COVID-19%20in%20a%20vaccinated%20symptomatic%20healthcare%20worker%20%28HCW%29%20on%2022%20February%2C%20we%20performed%20outbreak%20investigations%20in%20house%20A%20%2847%20residents%3B%2037%20HCWs%29%2C%20using%20SARS-CoV-2-specific%20polymerase%20chain%20reaction%20testing%20of%20nasopharyngeal%20swab%20samples.%20We%20performed%20whole-genome%20sequencing%20of%20SARS-CoV-2%20and%20serological%20analyses.%5CnRESULTS%3A%20We%20identified%2017%20individuals%20with%20positive%20polymerase%20chain%20reaction%20results%2C%2010%20residents%20%285%20vaccinated%29%20and%207%20HCWs%20%283%20vaccinated%29.%20The%20median%20age%20%28interquartile%20range%29%20was%2086%20%2870-90%29%20years%20among%20residents%20and%2049%20%2829-59%29%20years%20among%20HCWs.%20Of%20the%205%20vaccinated%20residents%2C%203%20had%20mild%20disease%20and%202%20had%20no%20symptoms%2C%20whereas%20all%205%20unvaccinated%20residents%20had%20mild%20to%20severe%20disease%2C%20and%202%20died.%20Vaccine%20effectiveness%20for%20the%20prevention%20of%20infection%20among%20residents%20was%2073.0%25%20%2895%25%20confidence%20interval%2C%2024.7%25-90.1%25%29.%20The%2012%20available%20genomes%20were%20all%20alpha%20variants.%20Neutralizing%20titers%20were%20significantly%20higher%20in%20vaccinated%20individuals%20on%20reexposure%20%28%26gt%3B1%20week%20after%20diagnosis%29%20than%20in%20vaccinated%2C%20unexposed%20HCWs%20%28P%5Cu2005%3D%5Cu2005.01%29.%20Transmission%20networks%20indicated%204%20likely%20or%20possible%20transmissions%20from%20vaccinated%20to%20other%20individuals%20and%2012%20transmission%20events%20from%20unvaccinated%20individuals.%5CnCONCLUSIONS%3A%20COVID-19%20outbreaks%20can%20occur%20in%20nursing%20homes%2C%20including%20transmission%20from%20vaccinated%20persons%20to%20others.%20Outbreaks%20might%20occur%20silently%2C%20underlining%20the%20need%20for%20continued%20testing%20and%20basic%20infection%20control%20measures%20in%20these%20high-risk%20settings.%22%2C%22date%22%3A%222023-08-22%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciab1005%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-11-08T10%3A07%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22RZU3UQMM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderegg%20et%20al.%22%2C%22parsedDate%22%3A%222023-08-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderegg%2C%20Nanina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchwab%2C%20Tiana%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBorcard%2C%20Lo%26%23xEF%3Bc%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMugglin%2C%20Catrina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKeune-D%26%23xFC%3Bbi%2C%20Bettina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Population-Based%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20Whole-Genome%20Sequencing%20and%20Contact%20Tracing%20During%20the%20Coronavirus%20Disease%202019%20Pandemic%20in%20Switzerland.%20%26lt%3Bi%26gt%3BThe%20Journal%20of%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B228%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20251%26%23x2013%3B260.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiad074%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiad074%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Population-Based%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20Whole-Genome%20Sequencing%20and%20Contact%20Tracing%20During%20the%20Coronavirus%20Disease%202019%20Pandemic%20in%20Switzerland%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiana%22%2C%22lastName%22%3A%22Schwab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lo%5Cu00efc%22%2C%22lastName%22%3A%22Borcard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catrina%22%2C%22lastName%22%3A%22Mugglin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bettina%22%2C%22lastName%22%3A%22Keune-D%5Cu00fcbi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Ramette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Testing%20and%20contact%20tracing%20%28CT%29%20can%20interrupt%20transmission%20chains%20of%20SARS-CoV-2.%20Whole-genome%20sequencing%20%28WGS%29%20can%20potentially%20strengthen%20these%20investigations%20and%20provide%20insights%20on%20transmission.%5CnMETHODS%3A%20We%20included%20all%20laboratory-confirmed%20COVID-19%20cases%20diagnosed%20between%204%20June%20and%2026%20July%202021%2C%20in%20a%20Swiss%20canton.%20We%20defined%20CT%20clusters%20based%20on%20epidemiological%20links%20reported%20in%20the%20CT%20data%20and%20genomic%20clusters%20as%20sequences%20with%20no%20single-nucleotide%20polymorphism%20%28SNP%29%20differences%20between%20any%202%20pairs%20of%20sequences%20being%20compared.%20We%20assessed%20the%20agreement%20between%20CT%20clusters%20and%20genomic%20clusters.%5CnRESULTS%3A%20Of%20359%20COVID-19%20cases%2C%20213%20were%20sequenced.%20Overall%2C%20agreement%20between%20CT%20and%20genomic%20clusters%20was%20low%20%28Cohen%26%23039%3Bs%20%5Cu03ba%20%3D%200.13%29.%20Of%2024%20CT%20clusters%20with%20%5Cu22652%20sequenced%20samples%2C%209%20%2837.5%25%29%20were%20also%20linked%20based%20on%20genomic%20sequencing%20but%20in%204%20of%20these%2C%20WGS%20found%20additional%20cases%20in%20other%20CT%20clusters.%20Household%20was%20most%20often%20reported%20source%20of%20infection%20%28n%20%3D%20101%20%5B28.1%25%5D%29%20and%20home%20addresses%20coincided%20well%20with%20CT%20clusters%3A%20In%2044%20of%2054%20CT%20clusters%20containing%20%5Cu22652%20cases%20%2881.5%25%29%2C%20all%20cases%20in%20the%20cluster%20had%20the%20same%20reported%20home%20address.%20However%2C%20only%20a%20quarter%20of%20household%20transmission%20was%20confirmed%20by%20WGS%20%286%20of%2026%20genomic%20clusters%20%5B23.1%25%5D%29.%20A%20sensitivity%20analysis%20using%20%5Cu22641-SNP%20differences%20to%20define%20genomic%20clusters%20resulted%20in%20similar%20results.%5CnCONCLUSIONS%3A%20WGS%20data%20supplemented%20epidemiological%20CT%20data%2C%20supported%20the%20detection%20of%20potential%20additional%20clusters%20missed%20by%20CT%2C%20and%20identified%20misclassified%20transmissions%20and%20sources%20of%20infection.%20Household%20transmission%20was%20overestimated%20by%20CT.%22%2C%22date%22%3A%222023-08-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Finfdis%5C%2Fjiad074%22%2C%22ISSN%22%3A%221537-6613%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-09-07T03%3A39%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22EQBKRS4L%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22parsedDate%22%3A%222023-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGlobal%20variations%20in%20pubertal%20growth%20spurts%20in%20adolescents%20living%20with%20perinatal%20HIV%20%282023%29.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%201603%26%23x2013%3B1615.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003602%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003602%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20variations%20in%20pubertal%20growth%20spurts%20in%20adolescents%20living%20with%20perinatal%20HIV%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20describe%20pubertal%20growth%20spurts%20among%20adolescents%20living%20with%20perinatally%20acquired%20HIV%20%28ALWPHIV%29%20on%20antiretroviral%20therapy%20%28ART%29.%5CnDESIGN%3A%20Observational%20data%20collected%20from%201994%20to%202015%20in%20the%20CIPHER%20global%20cohort%20collaboration.%5CnMETHODS%3A%20ALWPHIV%20who%20initiated%20ART%20age%20less%20than%2010%5Cu200ayears%20with%20at%20least%20four%20height%20measurements%20age%20at%20least%208%20years%20were%20included.%20Super%20Imposition%20by%20Translation%20And%20Rotation%20%28SITAR%29%20models%2C%20with%20parameters%20representing%20timing%20and%20intensity%20of%20the%20growth%20spurt%2C%20were%20used%20to%20describe%20growth%2C%20separately%20by%20sex.%20Associations%20between%20region%2C%20ART%20regimen%2C%20age%2C%20height-for-age%20%28HAZ%29%2C%20and%20BMI-for-age%20z%20-scores%20%28BMIz%29%20at%20ART%20initiation%20%28baseline%29%20and%20age%2010%5Cu200ayears%2C%20and%20SITAR%20parameters%20were%20explored.%5CnRESULTS%3A%20Four%20thousand%20seven%20hundred%20and%20twenty-three%20ALWPHIV%20were%20included%3A%2051%25%20from%20East%20and%20Southern%20Africa%20%28excluding%20Botswana%20and%20South%20Africa%29%2C%2017%25%20Botswana%20and%20South%20Africa%2C%206%25%20West%20and%20Central%20Africa%2C%2011%25%20Europe%20and%20North%20America%2C%2011%25%20Asia-Pacific%2C%20and%204%25%20Central%2C%20South%20America%2C%20and%20Caribbean.%20Growth%20spurts%20were%20later%20and%20least%20intense%20in%20sub-Saharan%20regions.%20In%20females%2C%20older%20baseline%20age%20and%20lower%20BMIz%20at%20baseline%20were%20associated%20with%20later%20and%20more%20intense%20growth%20spurts%3B%20lower%20HAZ%20was%20associated%20with%20later%20growth%20spurts.%20In%20males%2C%20older%20baseline%20age%20and%20lower%20HAZ%20were%20associated%20with%20later%20and%20less%20intense%20growth%20spurts%3B%20however%2C%20associations%20between%20baseline%20HAZ%20and%20timing%20varied%20by%20age.%20Lower%20HAZ%20and%20BMIz%20at%2010%5Cu200ayears%20were%20associated%20with%20later%20and%20less%20intense%20growth%20spurts%20in%20both%20sexes.%5CnCONCLUSION%3A%20ALWPHIV%20who%20started%20ART%20at%20older%20ages%20or%20already%20stunted%20were%20more%20likely%20to%20have%20delayed%20pubertal%20growth%20spurts.%20Longer-term%20follow-up%20is%20important%20to%20understand%20the%20impact%20of%20delayed%20growth.%22%2C%22date%22%3A%222023-08-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003602%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T15%3A53%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22K22SKTEE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Parcesepe%20et%20al.%22%2C%22parsedDate%22%3A%222023-08%22%2C%22numChildren%22%3A10%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BParcesepe%2C%20Angela%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStockton%2C%20Melissa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRemch%2C%20Molly%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWester%2C%20C.%20William%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBernard%2C%20Charlotte%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Availability%20of%20screening%20and%20treatment%20for%20common%20mental%20disorders%20in%20HIV%20clinic%20settings%3A%20data%20from%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Consortium%2C%202016-2017%20and%202020.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e26147.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26147%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26147%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Availability%20of%20screening%20and%20treatment%20for%20common%20mental%20disorders%20in%20HIV%20clinic%20settings%3A%20data%20from%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Consortium%2C%202016-2017%20and%202020%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Stockton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Molly%22%2C%22lastName%22%3A%22Remch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20William%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogers%22%2C%22lastName%22%3A%22Ajeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22Pape%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%22%2C%22lastName%22%3A%22Kwobah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junko%22%2C%22lastName%22%3A%22Tanuma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Consortium%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Common%20mental%20disorders%20%28CMDs%29%20are%20highly%20prevalent%20among%20people%20with%20HIV.%20Integrating%20mental%20healthcare%20into%20HIV%20care%20may%20improve%20mental%20health%20and%20HIV%20treatment%20outcomes.%20We%20describe%20the%20reported%20availability%20of%20screening%20and%20treatment%20for%20depression%2C%20anxiety%20and%20post-traumatic%20stress%20disorder%20%28PTSD%29%20at%20global%20HIV%20treatment%20centres%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Consortium%20in%202020%20and%20changes%20in%20availability%20at%20sites%20in%20low-%20or%20middle-income%20countries%20%28LMICs%29%20between%202016%5C%2F2017%20and%202020.%5CnMETHODS%3A%20In%202020%2C%20238%20sites%20contributing%20individual-level%20data%20to%20the%20IeDEA%20Consortium%20and%20in%202016%5C%2F2017%20a%20stratified%20random%20sample%20of%20IeDEA%20sites%20in%20LMICs%20were%20eligible%20to%20participate%20in%20site%20surveys%20on%20the%20availability%20of%20screening%20and%20treatment%20for%20CMDs.%20We%20assessed%20trends%20over%20time%20for%2068%20sites%20across%2027%20LMICs%20that%20participated%20in%20both%20surveys.%5CnRESULTS%3A%20Among%20the%20238%20sites%20eligible%20to%20participate%20in%20the%202020%20site%20survey%2C%20227%20%2895%25%29%20participated%2C%20and%20mental%20health%20screening%20and%20treatment%20data%20were%20available%20for%20223%20%2898%25%29%20sites%20across%2041%20countries.%20A%20total%20of%2095%20sites%20across%2029%20LMICs%20completed%20the%202016%5C%2F2017%20survey.%20In%202020%2C%2068%25%20of%20sites%20were%20in%20urban%20settings%2C%20and%2077%25%20were%20in%20LMICs.%20Overall%2C%2050%25%2C%2014%25%20and%2012%25%20of%20sites%20reported%20screening%20with%20a%20validated%20instrument%20for%20depression%2C%20anxiety%20and%20PTSD%2C%20respectively.%20Screening%20plus%20treatment%20in%20the%20form%20of%20counselling%20was%20available%20for%20depression%2C%20anxiety%20and%20PTSD%20at%2046%25%2C%2013%25%20and%2011%25%20of%20sites%2C%20respectively.%20Screening%20plus%20treatment%20in%20the%20form%20of%20medication%20was%20available%20for%20depression%2C%20anxiety%20and%20PTSD%20at%2036%25%2C%2011%25%20and%208%25%20of%20sites%2C%20respectively.%20Among%20sites%20that%20participated%20in%20both%20surveys%2C%20screening%20for%20depression%20was%20more%20commonly%20available%20in%202020%20than%202016%5C%2F2017%20%2875%25%20vs.%2059%25%2C%20respectively%2C%20p%20%3D%200.048%29.%5CnCONCLUSIONS%3A%20Reported%20availability%20of%20screening%20for%20depression%20increased%20among%20this%20group%20of%20IeDEA%20sites%20in%20LMICs%20between%202016%5C%2F2017%20and%202020.%20However%2C%20substantial%20gaps%20persist%20in%20the%20availability%20of%20mental%20healthcare%20at%20HIV%20treatment%20sites%20across%20global%20settings%2C%20particularly%20in%20resource-constrained%20settings.%20Implementation%20of%20sustainable%20strategies%20to%20integrate%20mental%20health%20services%20into%20HIV%20care%20is%20needed.%22%2C%22date%22%3A%222023-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26147%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222024-01-12T13%3A25%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22QZJ4MTKF%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222023-07-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKunzekwenyika%2C%20Cordelia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BManzero%2C%20Josphat%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLimacher%2C%20Andreas%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Effect%20of%20the%20Friendship%20Bench%20Intervention%20on%20Antiretroviral%20Therapy%20Outcomes%20and%20Mental%20Health%20Symptoms%20in%20Rural%20Zimbabwe%3A%20A%20Cluster%20Randomized%20Trial.%20%26lt%3Bi%26gt%3BJAMA%20Network%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B6%26lt%3B%5C%2Fi%26gt%3B%20%287%29%2C%20S.%20e2323205.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.23205%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.23205%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20the%20Friendship%20Bench%20Intervention%20on%20Antiretroviral%20Therapy%20Outcomes%20and%20Mental%20Health%20Symptoms%20in%20Rural%20Zimbabwe%3A%20A%20Cluster%20Randomized%20Trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josphat%22%2C%22lastName%22%3A%22Manzero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Limacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janneke%20H.%22%2C%22lastName%22%3A%22van%20Dijk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%22%2C%22lastName%22%3A%22Manhibi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Hobbins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruth%22%2C%22lastName%22%3A%22Verhey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Friendship%20Bench%20ART%20trial%20group%22%7D%5D%2C%22abstractNote%22%3A%22IMPORTANCE%3A%20Common%20mental%20disorders%20%28CMD%29%2C%20which%20include%20depression%20and%20anxiety%2C%20are%20prevalent%20among%20people%20living%20with%20HIV%20and%20are%20associated%20with%20suboptimal%20antiretroviral%20therapy%20%28ART%29%20adherence.%5CnOBJECTIVE%3A%20To%20assess%20the%20effect%20of%20a%20lay%20health%20worker-led%20psychological%20intervention%20on%20ART%20adherence%2C%20virologic%20suppression%2C%20and%20mental%20health%20symptoms.%5CnDESIGN%2C%20SETTING%2C%20AND%20PARTICIPANTS%3A%20Open-label%20pragmatic%20cluster%20trial%20with%201%3A1%20block%20randomization%20of%2016%20health%20facilities%20in%20rural%20Bikita%2C%20Zimbabwe.%20Recruitment%20occurred%20from%20October%202018%20to%20December%202019%2C%20and%20participants%20were%20followed%20up%20for%2012%20months%2C%20ending%20in%20December%202020.%20Participants%20were%20adults%20aged%2018%20years%20and%20older%2C%20who%20spoke%20English%20or%20Shona%2C%20screened%20positive%20for%20CMD%20%28Shona%20Symptoms%20Questionnaire%20%5BSSQ%5D-14%20score%20%5Cu22659%29%2C%20received%20first-line%20ART%20for%206%20or%20more%20months%2C%20had%20no%20World%20Health%20Organization%20stage%204%20disease%2C%20no%20psychosis%2C%20were%20not%20pregnant%2C%20and%20provided%20informed%20consent.%20Data%20were%20analyzed%20from%20March%202021%20to%20February%202022.%5CnINTERVENTION%3A%20The%20Friendship%20Bench%2C%20consisting%20of%206%20lay%20health%20worker-led%20weekly%20problem-solving%20therapy%20sessions%20and%20optional%20peer-led%20group%20support.%5CnMAIN%20OUTCOMES%20AND%20MEASURES%3A%20The%20primary%20outcome%20was%20mean%20adherence%20during%202%20to%206%20months%20of%20follow-up%2C%20and%20the%20secondary%20outcomes%20were%20mean%20adherence%20during%201%20to%2012%20months%20of%20follow-up%2C%20change%20in%20SSQ-14%20and%20Patient%20Health%20Questionnaire%20%28PHQ-9%29%20scores%20%283%2C%206%2C%209%2C%20and%2012%20months%29%2C%20and%20viral%20load%20suppression%20%286%20and%2012%20months%29.%5CnRESULTS%3A%20A%20total%20of%20516%20participants%20were%20recruited%20%28244%20in%20Friendship%20Bench%20and%20272%20in%20enhanced%20standard%20care%20facilities%29%3B%20438%20%2884.9%25%29%20were%20female%20and%20the%20mean%20%28SD%29%20age%20was%2045.6%20%2810.9%29%20years.%20Mean%20%28SD%29%20adherence%20between%202%20to%206%20months%20was%2089.9%25%20%2818.4%25%29%20in%20the%20Friendship%20Bench%20group%20and%2087.2%25%20%2820.1%25%29%20in%20the%20control%20group.%20The%20intervention%20had%20no%20statistically%20significant%20effect%20on%20adherence%20between%202%20to%206%20months%20%28unadjusted%20mean%20difference%2C%201.93%20percentage%20points%3B%2095%25%20CI%2C%20-1.20%20to%205.06%20percentage%20points%3B%20P%5Cu2009%3D%5Cu2009.23%29%2C%20between%20months%201%20to%2012%20%28mean%20difference%200.79%20percentage%20points%3B%2095%25%20CI%2C%20-2.14%20to%203.71%20percentage%20points%3B%20P%5Cu2009%3D%5Cu2009.60%29%2C%20or%20viral%20suppression.%20Declines%20in%20SSQ-14%20scores%20from%20baseline%20to%203%20months%20%28difference%2C%20-1.65%3B%2095%25%20CI%2C%20-3.07%20to%20-0.24%29%2C%206%20months%20%28difference%2C%20-1.57%3B%2095%25%20CI%2C%20-2.98%20to%20-0.15%29%2C%20and%209%20months%20%28difference%2C%20-1.63%3B%2095%25%20CI%2C%20-3.05%20to%20-0.22%29%20were%20greater%20in%20the%20Friendship%20Bench%20than%20the%20standard%20care%20group%20%28P%5Cu2009%26lt%3B%5Cu2009.05%29.%20There%20were%20no%20differences%20in%20the%20decline%20in%20the%20SSQ-14%20scores%20from%20baseline%20to%2012%20months%20and%20in%20declines%20in%20PHQ-9%20scores%20from%20baseline%20to%203%2C%206%2C%209%2C%20and%2012%20months.%5CnCONCLUSIONS%20AND%20RELEVANCE%3A%20In%20this%20randomized%20trial%20of%20HIV-positive%20participants%20with%20CMD%2C%20the%20Friendship%20Bench%20intervention%20had%20no%20effect%20on%20adherence%20and%20viral%20suppression%2C%20possibly%20due%20to%20the%20absence%20of%20skill-based%20adherence%20training%20and%20a%20ceiling%20effect.%5CnTRIAL%20REGISTRATION%3A%20ClinicalTrials.gov%20Identifier%3A%20NCT03704805.%22%2C%22date%22%3A%222023-07-03%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1001%5C%2Fjamanetworkopen.2023.23205%22%2C%22ISSN%22%3A%222574-3805%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-01-24T16%3A08%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22RHAAX2AX%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Person%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-16%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPerson%2C%20Anna%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCrabtree-Ramirez%2C%20Brenda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKim%2C%20Ahra%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVeloso%2C%20Valdil%26%23xE9%3Ba%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaruri%2C%20Fernanda%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Cryptococcal%20Meningitis%20and%20Clinical%20Outcomes%20in%20Persons%20With%20Human%20Immunodeficiency%20Virus%3A%20A%20Global%20View.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B76%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%202116%26%23x2013%3B2125.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciad076%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciad076%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cryptococcal%20Meningitis%20and%20Clinical%20Outcomes%20in%20Persons%20With%20Human%20Immunodeficiency%20Virus%3A%20A%20Global%20View%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20K.%22%2C%22lastName%22%3A%22Person%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brenda%22%2C%22lastName%22%3A%22Crabtree-Ramirez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahra%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valdil%5Cu00e9a%22%2C%22lastName%22%3A%22Veloso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Fox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22John%20Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Darma%22%2C%22lastName%22%3A%22Imran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kinh%22%2C%22lastName%22%3A%22Van%20Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Nalitya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winnie%22%2C%22lastName%22%3A%22Muyindike%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bryan%20E.%22%2C%22lastName%22%3A%22Shepherd%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%20C.%22%2C%22lastName%22%3A%22McGowan%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Cryptococcal%20meningitis%20%28CM%29%20is%20a%20major%20cause%20of%20morbidity%20and%20mortality%20in%20persons%20with%20human%20immunodeficiency%20virus%20%28HIV%3B%20PWH%29.%20Little%20is%20known%20about%20CM%20outcomes%20and%20availability%20of%20diagnostic%20and%20treatment%20modalities%20globally.%5CnMETHODS%3A%20In%20this%20retrospective%20cohort%20study%2C%20we%20investigated%20CM%20incidence%20and%20all-cause%20mortality%20in%20PWH%20in%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20cohort%20from%201996%20to%202017.%20We%20estimated%20incidence%20using%20quasi-Poisson%20models%20adjusted%20for%20sex%2C%20age%2C%20calendar%20year%2C%20CD4%20cell%20count%20%28CD4%29%2C%20and%20antiretroviral%20therapy%20%28ART%29%20status.%20Mortality%20after%20CM%20diagnosis%20was%20examined%20using%20multivariable%20Cox%20models.%20A%20site%20survey%20from%202017%20assessed%20availability%20of%20CM%20diagnostic%20and%20treatment%20modalities.%5CnRESULTS%3A%20Among%20518%20852%20PWH%2C%20there%20were%203857%20cases%20of%20CM%20with%20an%20estimated%20incidence%20of%201.54%20per%201000%20person-years.%20Mortality%20over%20a%20median%20of%202.6%20years%20of%20post-CM%20diagnosis%20follow-up%20was%2031.6%25%2C%20with%2029%25%20lost%20to%20follow-up.%20In%20total%2C%202478%20%2864%25%29%20were%20diagnosed%20with%20CM%20after%20ART%20start%20with%20a%20median%20of%20253%20days%20from%20ART%20start%20to%20CM%20diagnosis.%20Older%20age%20%28hazard%20%5BHR%5D%2C%201.31%20for%2050%20vs%2035%20years%29%2C%20lower%20CD4%20%28HR%2C%201.15%20for%20200%20vs%20350%20cells%5C%2Fmm3%29%2C%20and%20earlier%20year%20of%20CM%20diagnosis%20%28HR%2C%200.51%20for%202015%20vs%202000%29%20were%20associated%20with%20higher%20mortality.%20Of%2089%20sites%2C%2034%25%20reported%20access%20to%20amphotericin%20B%3B%2012%25%20had%20access%20to%20flucytosine.%5CnCONCLUSIONS%3A%20Mortality%20after%20CM%20diagnosis%20was%20high.%20A%20substantial%20portion%20of%20CM%20cases%20occurred%20after%20ART%20start%2C%20though%20incidence%20and%20mortality%20may%20be%20higher%20than%20reported%20due%20to%20ascertainment%20bias.%20Many%20sites%20lacked%20access%20to%20recommended%20CM%20treatment.%22%2C%22date%22%3A%222023-06-16%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciad076%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22A3X487HE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kubjane%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-10%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKubjane%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOsman%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoulle%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20%26amp%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJohnson%2C%20L.%20F.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Drivers%20of%20sex%20differences%20in%20the%20South%20African%20adult%20tuberculosis%20incidence%20and%20mortality%20trends%2C%201990-2019.%20%26lt%3Bi%26gt%3BSci%20Rep%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%209487.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-36432-6%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-36432-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Drivers%20of%20sex%20differences%20in%20the%20South%20African%20adult%20tuberculosis%20incidence%20and%20mortality%20trends%2C%201990-2019%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Kubjane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Osman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%5D%2C%22abstractNote%22%3A%22Males%20have%20higher%20tuberculosis%20incidence%20and%20mortality%20rates%20than%20females.%20This%20study%20aimed%20to%20assess%20how%20sex%20differences%20in%20tuberculosis%20incidence%20and%20mortality%20could%20be%20explained%20by%20sex%20differences%20in%20HIV%2C%20antiretroviral%20treatment%20%28ART%29%20uptake%2C%20smoking%2C%20alcohol%20abuse%2C%20undernutrition%2C%20diabetes%2C%20social%20contact%20rates%2C%20health-seeking%20patterns%2C%20and%20treatment%20discontinuation.%20We%20developed%20an%20age-sex-stratified%20dynamic%20tuberculosis%20transmission%20model%20and%20calibrated%20it%20to%20South%20African%20data.%20We%20estimated%20male-to-female%20%28M%3AF%29%20tuberculosis%20incidence%20and%20mortality%20ratios%2C%20the%20effect%20of%20the%20abovementioned%20factors%20on%20the%20M%3AF%20ratios%20and%20PAFs%20for%20the%20tuberculosis%20risk%20factors.%20Over%20the%20period%201990-2019%2C%20the%20M%3AF%20ratios%20for%20tuberculosis%20incidence%20and%20mortality%20rates%20persisted%20above%201.0%2C%20and%20the%20figures%20reached%201.70%20and%201.65%2C%20respectively%2C%20by%20the%20end%20of%202019.%20In%202019%2C%20HIV%20contributed%20greater%20increases%20in%20tuberculosis%20incidence%20among%20females%20than%20males%20%2854.5%25%20vs.%2045.6%25%29%3B%20however%2C%20females%20experienced%20more%20reductions%20due%20to%20ART%20than%20males%20%2838.3%25%20vs.%2017.5%25%29.%20PAFs%20for%20tuberculosis%20incidence%20due%20to%20alcohol%20abuse%2C%20smoking%2C%20and%20undernutrition%2C%20in%20men%20were%2051.4%25%2C%2029.5%25%2C%20and%2016.1%25%2C%20respectively%2C%20higher%20than%20females%20%2830.1%25%2C%2015.4%25%2C%20and%2010.7%25%2C%20respectively%29%3B%20the%20PAF%20due%20to%20diabetes%20was%20higher%20in%20females%20than%20males%20%2822.9%25%20vs.%2017.5%25%29.%20Lower%20health-seeking%20rates%20in%20males%20accounted%20for%20a%207%25%20higher%20mortality%20rate%20in%20men.%20The%20higher%20burden%20of%20tuberculosis%20in%20men%20highlights%20the%20need%20to%20improve%20men%26%23039%3Bs%20access%20to%20routine%20screening%20and%20ensure%20earlier%20diagnosis.%20Sustained%20efforts%20in%20providing%20ART%20remain%20critical%20in%20reducing%20HIV-associated%20tuberculosis.%20Additional%20interventions%20to%20reduce%20alcohol%20abuse%20and%20tobacco%20smoking%20are%20also%20needed.%22%2C%22date%22%3A%22Jun%2010%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-023-36432-6%22%2C%22ISSN%22%3A%222045-2322%20%28Electronic%29%202045-2322%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A14%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22KFNK273W%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Taghavi%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20Katayoun%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMoono%2C%20Misinzo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMwanahamuntu%2C%20Mulindi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoumet%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLimacher%2C%20Andreas%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Accuracy%20of%20screening%20tests%20for%20cervical%20pre-cancer%20in%20women%20living%20with%20HIV%20in%20low-resource%20settings%3A%20a%20paired%20prospective%20study%20in%20Lusaka%2C%20Zambia.%20%26lt%3Bi%26gt%3BmedRxiv%26%23x202F%3B%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.05.31.23290779.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.05.31.23290779%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.05.31.23290779%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Accuracy%20of%20screening%20tests%20for%20cervical%20pre-cancer%20in%20women%20living%20with%20HIV%20in%20low-resource%20settings%3A%20a%20paired%20prospective%20study%20in%20Lusaka%2C%20Zambia.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katayoun%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Misinzo%22%2C%22lastName%22%3A%22Moono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mulindi%22%2C%22lastName%22%3A%22Mwanahamuntu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Roumet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Limacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herbert%22%2C%22lastName%22%3A%22Kapesa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thamsanqa%22%2C%22lastName%22%3A%22Madliwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Rutjes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Partha%22%2C%22lastName%22%3A%22Basu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Manasyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%3A%20To%20provide%20evidence%20to%20improve%20cervical%20screening%20for%20women%20living%20with%20HIV%20%28WLHIV%29%2C%20we%20assessed%20the%20accuracy%20of%20screening%20tests%20that%20can%20be%20used%20in%20low-resource%20settings%20and%20give%20results%20at%20the%20same%20visit.%20Methods%3A%20We%20conducted%20a%20paired%2C%20prospective%20study%20among%20consecutive%20eligible%20WLHIV%2C%20aged%2018-65%20years%2C%20receiving%20cervical%20cancer%20screening%20at%20one%20hospital%20in%20Lusaka%2C%20Zambia.%20The%20histopathological%20reference%20standard%20was%20multiple%20biopsies%20taken%20at%20two%20time%20points.%20The%20target%20condition%20was%20high-grade%20cervical%20intraepithelial%20neoplasia%20%28CIN2%2B%29.%20The%20index%20tests%20were%20high-risk%20human%20papillomavirus%20detection%20%28hrHPV%2C%20Xpert%20HPV%2C%20Cepheid%29%2C%20portable%20colposcopy%20%28Gynocular%2C%20Gynius%29%2C%20and%20visual%20inspection%20with%20acetic%20acid%20%28VIA%29.%20Accuracy%20of%20stand-alone%20and%20test%20combinations%20were%20calculated%20as%20the%20point%20estimate%20with%2095%25%20confidence%20intervals.%20A%20sensitivity%20analysis%20considered%20disease%20when%20only%20visible%20lesions%20were%20biopsied.%20Results%3A%20Among%20371%20participants%20with%20histopathological%20results%2C%2027%25%20%28101%5C%2F371%29%20women%20had%20CIN2%2B%20and%2023%25%20%2823%5C%2F101%29%20was%20not%20detected%20by%20any%20index%20test.%20Sensitivity%20and%20specificity%20for%20stand-alone%20tests%20were%3A%20hrHPV%2C%2067.3%25%20%2895%25%20CI%3A%2057.7-75.7%29%20and%2065.3%25%20%2859.4-70.7%29%3B%20Gynocular%2051.5%25%20%2841.9-61.0%29%20and%2080.0%25%20%2874.8-84.3%29%3B%20and%20VIA%2022.8%25%20%2815.7-31.9%29%20and%2092.6%25%20%2888.8-95.2%29%2C%20respectively.%20The%20combination%20of%20hrHPV%20testing%20followed%20by%20Gynocular%20had%20the%20best%20balance%20of%20sensitivity%20%2842.6%25%20%5B33.4-52.3%5D%29%20and%20specificity%20%2889.6%25%20%5B85.3-92.7%5D%29.%20All%20test%20accuracies%20improved%20in%20sensitivity%20analysis.%20Conclusion%3A%20The%20low%20accuracy%20of%20screening%20tests%20assessed%20might%20be%20explained%20by%20our%20reference%20standard%2C%20which%20reduced%20verification%20and%20misclassification%20biases.%20Better%20screening%20strategies%20for%20WLHIV%20in%20low-resource%20settings%20are%20urgently%20needed.%20Registration%20number%3A%20The%20trial%20was%20registered%20prospectively%20at%20ClinicalTrials.gov%20%28ref%3A%20NCT03931083%20%29.%20The%20study%20protocol%20has%20been%20previously%20published%2C%20and%20the%20statistical%20analysis%20plan%20can%20be%20accessed%20on%20ClinicalTrials.gov%20.%20Key%20messages%3A%20What%20is%20already%20known%20on%20this%20topic%3A%20The%202021%20World%20Health%20Organization%20guidelines%20recommend%20that%20women%20living%20with%20HIV%20%28WLHIV%29%20receive%20screening%20for%20high%20risk%20human%20papillomavirus%20high-risk%20human%20papillomavirus%20%28hrHPV%29%20genotypes%20at%20three-%20to%20five-year%20intervals%2C%20followed%20by%20a%20triage%20test%20to%20determine%20whether%20treatment%20is%20needed%20but%20this%20is%20based%20on%20low%20and%20moderate%20certainty%20evidence.What%20this%20study%20adds%3A%20This%20study%20among%20WLHIV%20in%20Lusaka%2C%20Zambia%20evaluated%20three%20screening%20tests%20that%20allow%20same-day%20treatment%3B%20hrHPV%20test%2C%20portable%20colposcopy%20%28Gynocular%29%2C%20and%20visual%20inspection%20with%20acetic%20acid%20%28VIA%29%2C%20using%20strict%20methods%20to%20reduce%20verification%20and%20misclassification%20biases.%20The%20test%20accuracy%20of%20the%20different%20screening%20was%20poor%2C%20with%20sensitivities%20and%20specificity%20for%20stand-alone%20tests%3A%20hrHPV%2C%2067.3%25%20and%2065.3%25%3B%20Gynocular%2051.5%25%20and%2080.0%25%3B%20and%20VIA%2022.8%25%20and%2092.6%25%3B%20respectively.How%20this%20study%20might%20affect%20research%2C%20practice%20or%20policy%3A%20Our%20findings%20have%20implications%20for%20research%20and%20cervical%20cancer%20screening%20policies%20among%20WLHIV%20if%20test-%20accuracy%20in%20this%20high-risk%20population%20has%20been%20overestimated%20from%20a%20majority%20of%20exsisting%20studies%20that%20are%20affected%20by%20verification%20and%20misclassification%20biases.%20Methodologically%20robust%20studies%20are%20crucial%20to%20inform%20cervical%20cancer%20screening%20practices%20and%20policies%20for%20the%20successful%20implementation%20of%20a%20cervical%20cancer%20elimination%20plan%20in%20sub-%20Saharan%20Africa%2C%20where%2085%25%20of%20women%20with%20cervical%20cancer%20and%20HIV%20live.%22%2C%22date%22%3A%222023%20Jun%201%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.05.31.23290779%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%222JTBM5VT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dovel%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDovel%2C%20K.%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHariprasad%2C%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHubbard%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhiri%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Strategies%20to%20improve%20antiretroviral%20therapy%20%28ART%29%20initiation%20and%20early%20engagement%20among%20men%20in%20sub-Saharan%20Africa%3A%20A%20scoping%20review%20of%20interventions%20in%20the%20era%20of%20universal%20treatment.%20%26lt%3Bi%26gt%3BTrop%20Med%20Int%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20454%26%23x2013%3B465.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ftmi.13880%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ftmi.13880%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Strategies%20to%20improve%20antiretroviral%20therapy%20%28ART%29%20initiation%20and%20early%20engagement%20among%20men%20in%20sub-Saharan%20Africa%3A%20A%20scoping%20review%20of%20interventions%20in%20the%20era%20of%20universal%20treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20L.%22%2C%22lastName%22%3A%22Dovel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Hariprasad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Hubbard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Phiri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Choko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Abbott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Nichols%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Gupta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Long%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20Men%20in%20sub-Saharan%20Africa%20%28SSA%29%20have%20lower%20rates%20of%20antiretroviral%20therapy%20%28ART%29%20initiation%20and%20higher%20rates%20of%20early%20default%20than%20women.%20Little%20is%20known%20about%20effective%20interventions%20to%20improve%20men%26%23039%3Bs%20outcomes.%20We%20conducted%20a%20scoping%20review%20of%20interventions%20aimed%20to%20increase%20ART%20initiation%20and%5C%2For%20early%20retention%20among%20men%20in%20SSA%20since%20universal%20treatment%20policies%20were%20implemented.%20METHODS%3A%20Three%20databases%2C%20HIV%20conference%20databases%20and%20grey%20literature%20were%20searched%20for%20studies%20published%20between%20January%202016%20to%20May%202021%20that%20reported%20on%20initiation%20and%5C%2For%20early%20retention%20among%20men.%20Eligibility%20criteria%20included%3A%20participants%20in%20SSA%2C%20data%20collected%20after%20universal%20treatment%20policies%20were%20implemented%20%282016-2021%29%2C%20quantitative%20data%20on%20ART%20initiation%20and%5C%2For%20early%20retention%20for%20males%2C%20general%20male%20population%20%28not%20exclusively%20focused%20on%20key%20populations%29%2C%20intervention%20study%20%28report%20outcomes%20for%20at%20least%20one%20non-standard%20service%20delivery%20strategy%29%2C%20and%20written%20in%20English.%20RESULTS%3A%20Of%20the%204351%20sources%20retrieved%2C%2015%20%28reporting%20on%2016%20interventions%29%20met%20inclusion%20criteria.%20Of%20the%2016%20interventions%2C%20only%20two%20%282%5C%2F16%2C%2013%25%29%20exclusively%20focused%20on%20men.%20Five%20%285%5C%2F16%2C%2031%25%29%20were%20randomised%20control%20trials%20%28RCT%29%2C%20one%20%281%5C%2F16%2C%206%25%29%20was%20a%20retrospective%20cohort%20study%2C%20and%2010%20%2810%5C%2F16%2C%2063%25%29%20did%20not%20have%20comparison%20groups.%20Thirteen%20%2813%5C%2F16%2C%2081%25%29%20interventions%20measured%20ART%20initiation%20and%20six%20%286%5C%2F16%2C%2037%25%29%20measured%20early%20retention.%20Outcome%20definitions%20and%20time%20frames%20varied%20greatly%2C%20with%20seven%20%287%5C%2F16%2C%2044%25%29%20not%20specifying%20time%20frames%20at%20all.%20Five%20types%20of%20interventions%20were%20represented%3A%20optimising%20ART%20services%20at%20health%20facilities%2C%20community-based%20ART%20services%2C%20outreach%20support%20%28such%20as%20reminders%20and%20facility%20escort%29%2C%20counselling%20and%5C%2For%20peer%20support%2C%20and%20conditional%20incentives.%20Across%20all%20intervention%20types%2C%20ART%20initiation%20rates%20ranged%20from%2027%25%20to%2097%25%20and%20early%20retention%20from%2047%25%20to%2095%25.%20CONCLUSIONS%3A%20Despite%20years%20of%20data%20of%20men%26%23039%3Bs%20suboptimal%20ART%20outcomes%2C%20there%20is%20little%20high-quality%20evidence%20on%20interventions%20to%20increase%20men%26%23039%3Bs%20ART%20initiation%20or%20early%20retention%20in%20SSA.%20Additional%20randomised%20or%20quasi-experimental%20studies%20are%20urgently%20needed.%22%2C%22date%22%3A%22Jun%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Ftmi.13880%22%2C%22ISSN%22%3A%221365-3156%20%28Electronic%29%201360-2276%20%28Print%29%201360-2276%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A18%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22JMM5FY67%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20A.%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLienhard%2C%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDidden%2C%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Mental%20Health%2C%20ART%20Adherence%2C%20and%20Viral%20Suppression%20Among%20Adolescents%20and%20Adults%20Living%20with%20HIV%20in%20South%20Africa%3A%20A%20Cohort%20Study.%20%26lt%3Bi%26gt%3BAIDS%20Behav%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%201849%26%23x2013%3B1861.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-022-03916-x%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-022-03916-x%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mental%20Health%2C%20ART%20Adherence%2C%20and%20Viral%20Suppression%20Among%20Adolescents%20and%20Adults%20Living%20with%20HIV%20in%20South%20Africa%3A%20A%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Lienhard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%20M.%20G.%22%2C%22lastName%22%3A%22Boshomane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Salazar-Vizcaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Nyakato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20E.%22%2C%22lastName%22%3A%22Wettstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Wainberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%5D%2C%22abstractNote%22%3A%22We%20followed%20adolescents%20and%20adults%20living%20with%20HIV%20aged%20older%20than%2015%20years%20who%20enrolled%20in%20a%20South%20African%20private-sector%20HIV%20programme%20to%20examine%20adherence%20and%20viral%20non-suppression%20%28viral%20load%20%26gt%3B%20400%20copies%5C%2FmL%29%20of%20participants%20with%20%2820%2C743%2C%2038%25%29%20and%20without%20%2833%2C635%2C%2062%25%29%20mental%20health%20diagnoses.%20Mental%20health%20diagnoses%20were%20associated%20with%20unfavourable%20adherence%20patterns.%20The%20risk%20of%20viral%20non-suppression%20was%20higher%20among%20patients%20with%20organic%20mental%20disorders%20%5Badjusted%20risk%20ratio%20%28aRR%29%201.55%2C%2095%25%20confidence%20interval%20%28CI%29%201.22-1.96%5D%2C%20substance%20use%20disorders%20%28aRR%201.53%2C%2095%25%20CI%201.19-1.97%29%2C%20serious%20mental%20disorders%20%28aRR%201.30%2C%2095%25%20CI%201.09-1.54%29%2C%20and%20depression%20%28aRR%201.19%2C%2095%25%20CI%201.10-1.28%29%20when%20compared%20with%20patients%20without%20mental%20health%20diagnoses.%20The%20risk%20of%20viral%20non-suppression%20was%20also%20higher%20among%20males%2C%20adolescents%20%2815-19%20years%29%2C%20and%20young%20adults%20%2820-24%20years%29.%20Our%20study%20highlights%20the%20need%20for%20psychosocial%20interventions%20to%20improve%20HIV%20treatment%20outcomes-particularly%20of%20adolescents%20and%20young%20adults-and%20supports%20strengthening%20mental%20health%20services%20in%20HIV%20treatment%20programmes.%22%2C%22date%22%3A%22Jun%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10461-022-03916-x%22%2C%22ISSN%22%3A%221573-3254%20%28Electronic%29%201090-7165%20%28Print%29%201090-7165%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A17%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22ZHPVL3IM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kassanjee%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20M.%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNgwenya%2C%20O.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOsei-Yeboah%2C%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJacobs%2C%20T.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20COVID-19%20among%20adults%20living%20with%20HIV%3A%20correlates%20of%20mortality%20among%20public%20sector%20healthcare%20users%20in%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BJ%20Int%20AIDS%20Soc%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20e26104.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26104%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26104%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22COVID-19%20among%20adults%20living%20with%20HIV%3A%20correlates%20of%20mortality%20among%20public%20sector%20healthcare%20users%20in%20Western%20Cape%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%22%2C%22lastName%22%3A%22Ngwenya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Osei-Yeboah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Morden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Timmerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Britz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Mendelson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Taljaard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Riou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Tiffin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Zinyakatira%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20While%20a%20large%20proportion%20of%20people%20with%20HIV%20%28PWH%29%20have%20experienced%20SARS-CoV-2%20infections%2C%20there%20is%20uncertainty%20about%20the%20role%20of%20HIV%20disease%20severity%20on%20COVID-19%20outcomes%2C%20especially%20in%20lower-income%20settings.%20We%20studied%20the%20association%20of%20mortality%20with%20characteristics%20of%20HIV%20severity%20and%20management%2C%20and%20vaccination%2C%20among%20adult%20PWH.%20METHODS%3A%20We%20analysed%20observational%20cohort%20data%20on%20all%20PWH%20aged%20%26gt%3B%5C%2F%3D15%20years%20experiencing%20a%20diagnosed%20SARS-CoV-2%20infection%20%28until%20March%202022%29%2C%20who%20accessed%20public%20sector%20healthcare%20in%20the%20Western%20Cape%20province%20of%20South%20Africa.%20Logistic%20regression%20was%20used%20to%20study%20the%20association%20of%20mortality%20with%20evidence%20of%20antiretroviral%20therapy%20%28ART%29%20collection%2C%20time%20since%20first%20HIV%20evidence%2C%20CD4%20cell%20count%2C%20viral%20load%20%28among%20those%20with%20evidence%20of%20ART%20collection%29%20and%20COVID-19%20vaccination%2C%20adjusting%20for%20demographic%20characteristics%2C%20comorbidities%2C%20admission%20pressure%2C%20location%20and%20time%20period.%20RESULTS%3A%20Mortality%20occurred%20in%205.7%25%20%2895%25%20CI%3A%205.3%2C6.0%29%20of%2017%2C831%20first-diagnosed%20infections.%20Higher%20mortality%20was%20associated%20with%20lower%20recent%20CD4%2C%20no%20evidence%20of%20ART%20collection%2C%20high%20or%20unknown%20recent%20viral%20load%20and%20recent%20first%20HIV%20evidence%2C%20differentially%20by%20age.%20Vaccination%20was%20protective.%20The%20burden%20of%20comorbidities%20was%20high%2C%20and%20tuberculosis%20%28especially%20more%20recent%20episodes%20of%20tuberculosis%29%2C%20chronic%20kidney%20disease%2C%20diabetes%20and%20hypertension%20were%20associated%20with%20higher%20mortality%2C%20more%20strongly%20in%20younger%20adults.%20CONCLUSIONS%3A%20Mortality%20was%20strongly%20associated%20with%20suboptimal%20HIV%20control%2C%20and%20the%20prevalence%20of%20these%20risk%20factors%20increased%20in%20later%20COVID-19%20waves.%20It%20remains%20a%20public%20health%20priority%20to%20ensure%20PWH%20are%20on%20suppressive%20ART%20and%20vaccinated%2C%20and%20manage%20any%20disruptions%20in%20care%20that%20occurred%20during%20the%20pandemic.%20The%20diagnosis%20and%20management%20of%20comorbidities%2C%20including%20for%20tuberculosis%2C%20should%20be%20optimized.%22%2C%22date%22%3A%22Jun%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26104%22%2C%22ISSN%22%3A%221758-2652%20%28Electronic%29%201758-2652%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A14%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22662YB787%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cipriani%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCipriani%2C%20Andrea%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSeedat%2C%20Soraya%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMilligan%2C%20Lea%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSalanti%2C%20Georgia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMacleod%2C%20Malcolm%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20New%20living%20evidence%20resource%20of%20human%20and%20non-human%20studies%20for%20early%20intervention%20and%20research%20prioritisation%20in%20anxiety%2C%20depression%20and%20psychosis.%20%26lt%3Bi%26gt%3BBMJ%20Mental%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20e300759.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjment-2023-300759%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjment-2023-300759%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22New%20living%20evidence%20resource%20of%20human%20and%20non-human%20studies%20for%20early%20intervention%20and%20research%20prioritisation%20in%20anxiety%2C%20depression%20and%20psychosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Cipriani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soraya%22%2C%22lastName%22%3A%22Seedat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Milligan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georgia%22%2C%22lastName%22%3A%22Salanti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malcolm%22%2C%22lastName%22%3A%22Macleod%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janna%22%2C%22lastName%22%3A%22Hastings%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Thomas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Michie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Toshi%20A.%22%2C%22lastName%22%3A%22Furukawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Gilbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karla%22%2C%22lastName%22%3A%22Soares-Weiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Moreno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Leucht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Parisa%22%2C%22lastName%22%3A%22Mansoori%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20M.%22%2C%22lastName%22%3A%22Barker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Spyridon%22%2C%22lastName%22%3A%22Siafis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edoardo%20Giuseppe%22%2C%22lastName%22%3A%22Ostinelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22McCutcheon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simonne%22%2C%22lastName%22%3A%22Wright%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matilda%22%2C%22lastName%22%3A%22Simpson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olufisayo%22%2C%22lastName%22%3A%22Elugbadebo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginia%22%2C%22lastName%22%3A%22Chiocchia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomy%22%2C%22lastName%22%3A%22Tonia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rania%22%2C%22lastName%22%3A%22Elgarf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayse%22%2C%22lastName%22%3A%22Kurtulmus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%22%2C%22lastName%22%3A%22Sena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ouma%22%2C%22lastName%22%3A%22Simple%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niall%22%2C%22lastName%22%3A%22Boyce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anjuli%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Wolpert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Potts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%20H.%22%2C%22lastName%22%3A%22Elliott%22%7D%5D%2C%22abstractNote%22%3A%22In%20anxiety%2C%20depression%20and%20psychosis%2C%20there%20has%20been%20frustratingly%20slow%20progress%20in%20developing%20novel%20therapies%20that%20make%20a%20substantial%20difference%20in%20practice%2C%20as%20well%20as%20in%20predicting%20which%20treatments%20will%20work%20for%20whom%20and%20in%20what%20contexts.%20To%20intervene%20early%20in%20the%20process%20and%20deliver%20optimal%20care%20to%20patients%2C%20we%20need%20to%20understand%20the%20underlying%20mechanisms%20of%20mental%20health%20conditions%2C%20develop%20safe%20and%20effective%20interventions%20that%20target%20these%20mechanisms%2C%20and%20improve%20our%20capabilities%20in%20timely%20diagnosis%20and%20reliable%20prediction%20of%20symptom%20trajectories.%20Better%20synthesis%20of%20existing%20evidence%20is%20one%20way%20to%20reduce%20waste%20and%20improve%20efficiency%20in%20research%20towards%20these%20ends.%20Living%20systematic%20reviews%20produce%20rigorous%2C%20up-to-date%20and%20informative%20evidence%20summaries%20that%20are%20particularly%20important%20where%20research%20is%20emerging%20rapidly%2C%20current%20evidence%20is%20uncertain%20and%20new%20findings%20might%20change%20policy%20or%20practice.%20Global%20Alliance%20for%20Living%20Evidence%20on%20aNxiety%2C%20depressiOn%20and%20pSychosis%20%28GALENOS%29%20aims%20to%20tackle%20the%20challenges%20of%20mental%20health%20science%20research%20by%20cataloguing%20and%20evaluating%20the%20full%20spectrum%20of%20relevant%20scientific%20research%20including%20both%20human%20and%20preclinical%20studies.%20GALENOS%20will%20also%20allow%20the%20mental%20health%20community-including%20patients%2C%20carers%2C%20clinicians%2C%20researchers%20and%20funders-to%20better%20identify%20the%20research%20questions%20that%20most%20urgently%20need%20to%20be%20answered.%20By%20creating%20open-access%20datasets%20and%20outputs%20in%20a%20state-of-the-art%20online%20resource%2C%20GALENOS%20will%20help%20identify%20promising%20signals%20early%20in%20the%20research%20process.%20This%20will%20accelerate%20translation%20from%20discovery%20science%20into%20effective%20new%20interventions%20for%20anxiety%2C%20depression%20and%20psychosis%2C%20ready%20to%20be%20translated%20in%20clinical%20practice%20across%20the%20world.%22%2C%22date%22%3A%222023-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjment-2023-300759%22%2C%22ISSN%22%3A%222755-9734%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A15%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22KN2YW9HN%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pretsch%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPretsch%2C%20Peyton%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSpees%2C%20Lisa%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrewer%2C%20Noel%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHudgens%2C%20Michael%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSanusi%2C%20Busola%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Effect%20of%20HPV%20self-collection%20kits%20on%20cervical%20cancer%20screening%20uptake%20among%20under-screened%20women%20from%20low-income%20US%20backgrounds%20%28MBMT-3%29%3A%20a%20phase%203%2C%20open-label%2C%20randomised%20controlled%20trial.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B8%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20e411%26%23x2013%3Be421.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2468-2667%2823%2900076-2%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2468-2667%2823%2900076-2%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20HPV%20self-collection%20kits%20on%20cervical%20cancer%20screening%20uptake%20among%20under-screened%20women%20from%20low-income%20US%20backgrounds%20%28MBMT-3%29%3A%20a%20phase%203%2C%20open-label%2C%20randomised%20controlled%20trial.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peyton%20K.%22%2C%22lastName%22%3A%22Pretsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%20P.%22%2C%22lastName%22%3A%22Spees%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noel%20T.%22%2C%22lastName%22%3A%22Brewer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20G.%22%2C%22lastName%22%3A%22Hudgens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Busola%22%2C%22lastName%22%3A%22Sanusi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elyse%22%2C%22lastName%22%3A%22Miller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20L.%22%2C%22lastName%22%3A%22Jackson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lynn%22%2C%22lastName%22%3A%22Barclay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicia%22%2C%22lastName%22%3A%22Carter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20B.%22%2C%22lastName%22%3A%22Wheeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%20S.%22%2C%22lastName%22%3A%22Smith%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Most%20cervical%20cancer%20in%20the%20USA%20occurs%20in%20under-screened%20women.%20The%20My%20Body%2C%20My%20Test-3%20%28MBMT-3%29%20trial%20sought%20to%20assess%20the%20efficacy%20of%20mailed%20human%20papillomavirus%20%28HPV%29%20self-collection%20kits%20with%20appointment-scheduling%20assistance%20to%20increase%20uptake%20of%20cervical%20cancer%20screening%20among%20under-screened%20women%20from%20low-income%20backgrounds%20compared%20with%20scheduling%20assistance%20alone.%20METHODS%3A%20MBMT-3%20is%20a%20phase%203%2C%20open-%20label%2C%20two-arm%2C%20randomised%20controlled%20trial.%20Participants%20were%20recruited%20from%2022%20counties%20in%20North%20Carolina%20state%2C%20USA%2C%20and%20we%20partnered%20with%2021%20clinics%20across%20these%20counties.%20Participants%20were%20eligible%20for%20inclusion%20if%20they%20were%20aged%2025-64%20years%2C%20had%20an%20intact%20cervix%2C%20were%20uninsured%20or%20enrolled%20in%20Medicaid%20or%20Medicare%2C%20had%20an%20income%20of%20250%25%20or%20less%20of%20the%20US%20Federal%20Poverty%20Level%2C%20were%20living%20within%20the%20catchment%20area%20of%20a%20trial-%20associated%20clinic%2C%20and%20were%20overdue%20for%20screening%20%28ie%2C%20Papanicolaou%20test%20%26gt%3B%5C%2F%3D4%20years%20ago%20or%20high-risk%20HPV%20test%20%26gt%3B%5C%2F%3D6%20years%20ago%29.%20Participants%20were%20randomly%20assigned%20%282%3A1%29%20to%20receive%20a%20mailed%20HPV%20self-collection%20kit%20and%20assistance%20for%20scheduling%20a%20free%20screening%20appointment%20%28intervention%20group%29%20or%20to%20receive%20scheduling%20assistance%20alone%20%28control%20group%29.%20Randomisation%20was%20conducted%20by%20county%20using%20permuted%20blocks%20of%20nine%20patients%20and%20assignment%20to%20group%20was%20not%20masked.%20Participants%20in%20the%20intervention%20group%20were%20mailed%20HPV%20self-collection%20kits%20to%20collect%20a%20cervical-vaginal%20sample%20and%20return%20it%20by%20mail%20for%20testing.%20Samples%20were%20tested%20with%20the%20Aptima%20HPV%20assay%20%28Hologic%2C%20San%20Diego%2C%20CA%2C%20USA%29%2C%20and%20participants%20were%20informed%20of%20high-risk%20HPV%20results%20by%20telephone%20call.%20Trial%20staff%20made%20up%20to%20three%20telephone%20call%20attempts%20to%20provide%20scheduling%20assistance%20for%20in-clinic%20screening%20for%20all%20participants.%20The%20primary%20outcome%20was%20cervical%20cancer%20screening%20uptake%20%28ie%2C%20attending%20an%20in-clinic%20screening%20appointment%20or%20testing%20negative%20for%20high-risk%20HPV%20with%20a%20returned%20self-collected%20sample%29%20within%206%20months%20of%20enrolment%20in%20the%20intention-to-treat%20population.%20This%20trial%20is%20registered%20with%20ClinicalTrials.gov%2C%20NCT02651883%2C%20and%20has%20been%20completed.%20FINDINGS%3A%20Recruitment%20occurred%20between%20April%2011%2C%202016%2C%20and%20Dec%2016%2C%202019.%204256%20women%20contacted%20the%20trial%20to%20participate%2C%20of%20whom%20899%20%2821%25%29%20were%20eligible%20for%20inclusion%20and%20697%20%2878%25%29%20returned%20consent%20forms.%20Of%20those%20who%20consented%2C%20461%20%2866%25%29%20women%20were%20randomly%20assigned%20to%20the%20intervention%20group%20and%20236%20%2834%25%29%20women%20were%20randomly%20assigned%20to%20the%20control%20group.%20We%20excluded%2032%20ineligible%20women%20post-randomisation%2C%20leaving%20665%20for%20primary%20analysis.%20Screening%20uptake%20was%20higher%20in%20the%20intervention%20group%20%28317%20%5B72%25%5D%20of%20438%29%20than%20control%20group%20%2885%20%5B37%25%5D%20of%20227%3B%20risk%20ratio%201.93%2C%2095%25%20CI%201.62-2.31%29.%20Among%20intervention%20participants%2C%20341%20%2878%25%29%20of%20438%20returned%20a%20self-%20collection%20kit.%20Three%20participants%20reported%20hurt%20or%20injury%20when%20using%20the%20self-collection%20kit%3B%20no%20participants%20withdrew%20due%20to%20adverse%20effects.%20INTERPRETATION%3A%20Among%20under-screened%20women%20from%20low-income%20backgrounds%2C%20mailed%20HPV%20self-collection%20kits%20with%20scheduling%20assistance%20led%20to%20greater%20uptake%20of%20cervical%20cancer%20screening%20than%20scheduling%20assistance%20alone.%20At-%20home%20HPV%20self-collection%20testing%20has%20the%20potential%20to%20increase%20screening%20uptake%20among%20under-screened%20women.%20FUNDING%3A%20National%20Cancer%20Institute.%22%2C%22date%22%3A%222023%20Jun%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2FS2468-2667%2823%2900076-2%22%2C%22ISSN%22%3A%222468-2667%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22TTF9I5PE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222023-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZurcher%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJent%2C%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBittel%2C%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFurrer%2C%20L.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20SARS-CoV-2%20transmission%20with%20and%20without%20mask%20wearing%20or%20air%20cleaners%20in%20schools%20in%20Switzerland%3A%20A%20modeling%20study%20of%20epidemiological%2C%20environmental%2C%20and%20molecular%20data.%20%26lt%3Bi%26gt%3BPLoS%20Med%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B20%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20e1004226.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004226%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004226%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22SARS-CoV-2%20transmission%20with%20and%20without%20mask%20wearing%20or%20air%20cleaners%20in%20schools%20in%20Switzerland%3A%20A%20modeling%20study%20of%20epidemiological%2C%20environmental%2C%20and%20molecular%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Zurcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Jent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Bittel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Furrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Hascher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Growing%20evidence%20suggests%20an%20important%20contribution%20of%20airborne%20transmission%20to%20the%20overall%20spread%20of%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20%28SARS-CoV-2%29%2C%20in%20particular%20via%20smaller%20particles%20called%20aerosols.%20However%2C%20the%20contribution%20of%20school%20children%20to%20SARS-CoV-2%20transmission%20remains%20uncertain.%20The%20aim%20of%20this%20study%20was%20to%20assess%20transmission%20of%20airborne%20respiratory%20infections%20and%20the%20association%20with%20infection%20control%20measures%20in%20schools%20using%20a%20multiple-measurement%20approach.%20METHODS%20AND%20FINDINGS%3A%20We%20collected%20epidemiological%20%28cases%20of%20Coronavirus%20Disease%202019%20%28COVID-19%29%29%2C%20environmental%20%28CO2%2C%20aerosol%20and%20particle%20concentrations%29%2C%20and%20molecular%20data%20%28bioaerosol%20and%20saliva%20samples%29%20over%207%20weeks%20from%20January%20to%20March%202022%20%28Omicron%20wave%29%20in%202%20secondary%20schools%20%28n%20%3D%2090%2C%20average%2018%20students%5C%2Fclassroom%29%20in%20Switzerland.%20We%20analyzed%20changes%20in%20environmental%20and%20molecular%20characteristics%20between%20different%20study%20conditions%20%28no%20intervention%2C%20mask%20wearing%2C%20air%20cleaners%29.%20Analyses%20of%20environmental%20changes%20were%20adjusted%20for%20different%20ventilation%2C%20the%20number%20of%20students%20in%20class%2C%20school%20and%20weekday%20effects.%20We%20modeled%20disease%20transmission%20using%20a%20semi-mechanistic%20Bayesian%20hierarchical%20model%2C%20adjusting%20for%20absent%20students%20and%20community%20transmission.%20Molecular%20analysis%20of%20saliva%20%2821%5C%2F262%20positive%29%20and%20airborne%20samples%20%2810%5C%2F130%29%20detected%20SARS-CoV-2%20throughout%20the%20study%20%28weekly%20average%20viral%20concentration%200.6%20copies%5C%2FL%29%20and%20occasionally%20other%20respiratory%20viruses.%20Overall%20daily%20average%20CO2%20levels%20were%201%2C064%20%2B%5C%2F-%20232%20ppm%20%28%2B%5C%2F-%20standard%20deviation%29.%20Daily%20average%20aerosol%20number%20concentrations%20without%20interventions%20were%20177%20%2B%5C%2F-%20109%201%5C%2Fcm3%20and%20decreased%20by%2069%25%20%2895%25%20CrI%2042%25%20to%2086%25%29%20with%20mask%20mandates%20and%2039%25%20%2895%25%20CrI%204%25%20to%2069%25%29%20with%20air%20cleaners.%20Compared%20to%20no%20intervention%2C%20the%20transmission%20risk%20was%20lower%20with%20mask%20mandates%20%28adjusted%20odds%20ratio%200.19%2C%2095%25%20CrI%200.09%20to%200.38%29%20and%20comparable%20with%20air%20cleaners%20%281.00%2C%2095%25%20CrI%200.15%20to%206.51%29.%20Study%20limitations%20include%20possible%20confounding%20by%20period%20as%20the%20number%20of%20susceptible%20students%20declined%20over%20time.%20Furthermore%2C%20airborne%20detection%20of%20pathogens%20document%20exposure%20but%20not%20necessarily%20transmission.%20CONCLUSIONS%3A%20Molecular%20detection%20of%20airborne%20and%20human%20SARS-CoV-2%20indicated%20sustained%20transmission%20in%20schools.%20Mask%20mandates%20were%20associated%20with%20greater%20reductions%20in%20aerosol%20concentrations%20than%20air%20cleaners%20and%20with%20lower%20transmission.%20Our%20multiple-measurement%20approach%20could%20be%20used%20to%20continuously%20monitor%20transmission%20risk%20of%20respiratory%20infections%20and%20the%20effectiveness%20of%20infection%20control%20measures%20in%20schools%20and%20other%20congregate%20settings.%22%2C%22date%22%3A%22May%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pmed.1004226%22%2C%22ISSN%22%3A%221549-1676%20%28Electronic%29%201549-1277%20%28Print%29%201549-1277%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T14%3A20%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22CKQ753WT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-17%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Y.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuchengeti%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBohlius%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Age%20and%20Cancer%20Incidence%20in%205.2%20Million%20People%20With%20Human%20Immunodeficiency%20Virus%20%28HIV%29%3A%20The%20South%20African%20HIV%20Cancer%20Match%20Study.%20%26lt%3Bi%26gt%3BClin%20Infect%20Dis%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B76%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%201440%26%23x2013%3B1448.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac925%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac925%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Age%20and%20Cancer%20Incidence%20in%205.2%20Million%20People%20With%20Human%20Immunodeficiency%20Virus%20%28HIV%29%3A%20The%20South%20African%20HIV%20Cancer%20Match%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Muchengeti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Old%20age%20is%20an%20important%20risk%20factor%20for%20developing%20cancer%2C%20but%20few%20data%20exist%20on%20this%20association%20in%20people%20with%20human%20immunodeficiency%20virus%20%28HIV%2C%20PWH%29%20in%20sub-Saharan%20Africa.%20METHODS%3A%20The%20South%20African%20HIV%20Cancer%20Match%20study%20is%20a%20nationwide%20cohort%20of%20PWH%20based%20on%20a%20linkage%20between%20HIV-related%20laboratory%20records%20from%20the%20National%20Health%20Laboratory%20Service%20and%20cancer%20diagnoses%20from%20the%20National%20Cancer%20Registry%20for%202004-2014.%20We%20included%20PWH%20who%20had%20HIV-related%20tests%20on%20separate%20days.%20Using%20natural%20splines%2C%20we%20modeled%20cancer%20incidence%20rates%20as%20a%20function%20of%20age.%20RESULTS%3A%20We%20included%205%20222%20827%20PWH%20with%2029%20580%20incident%20cancer%20diagnoses-most%20commonly%20cervical%20cancer%20%28n%20%3D%207418%29%2C%20Kaposi%20sarcoma%20%28n%20%3D%206380%29%2C%20and%20breast%20cancer%20%28n%20%3D%202748%29.%20In%20young%20PWH%2C%20the%20incidence%20rates%20for%20infection-related%20cancers%20were%20substantially%20higher%20than%20for%20infection-unrelated%20cancers.%20At%20age%2040%20years%2C%20the%20most%20frequent%20cancer%20was%20cervical%20cancer%20in%20female%20and%20Kaposi%20sarcoma%20in%20male%20PWH.%20Thereafter%2C%20the%20rates%20of%20infection-unrelated%20cancers%20increased%20steeply%2C%20particularly%20among%20male%20PWH%2C%20where%20prostate%20cancer%20became%20the%20most%20frequent%20cancer%20type%20at%20older%20age.%20Whereas%20Kaposi%20sarcoma%20rates%20peaked%20at%2034%20years%20%28101%5C%2F100%20000%20person-years%29%20in%20male%20PWH%2C%20cervical%20cancer%20remained%20the%20most%20frequent%20cancer%20among%20older%20female%20PWH.%20CONCLUSIONS%3A%20Infection-related%20cancers%20are%20common%20in%20PWH%20in%20South%20Africa%2C%20but%20rates%20of%20infection-unrelated%20cancers%20overtook%20those%20of%20infection-related%20cancers%20after%20age%2054%20years%20in%20the%20overall%20study%20population.%20As%20PWH%20in%20South%20Africa%20live%20longer%2C%20prevention%20and%20early%20detection%20of%20infection-unrelated%20cancers%20becomes%20increasingly%20important.%20Meanwhile%2C%20control%20strategies%20for%20infection-related%20cancers%2C%20especially%20cervical%20cancer%2C%20remain%20essential.%22%2C%22date%22%3A%22Apr%2017%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciac925%22%2C%22ISSN%22%3A%221537-6591%20%28Electronic%29%201058-4838%20%28Print%29%201058-4838%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A10%3A31Z%22%7D%7D%2C%7B%22key%22%3A%223QZXXMYY%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Loosli%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLoosli%2C%20Tom%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOkhai%2C%20Hajra%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKusejko%2C%20Katharina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20sHIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20ART%3A%20Collaborative%20analysis%20of%20cohort%20studies.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.04.05.23288183.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.04.05.23288183%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.04.05.23288183%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22sHIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20ART%3A%20Collaborative%20analysis%20of%20cohort%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Loosli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajra%22%2C%22lastName%22%3A%22Okhai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Kusejko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Mouton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pantxika%22%2C%22lastName%22%3A%22Bellecave%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ard%22%2C%22lastName%22%3A%22van%20Sighem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Stecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonella%22%2C%22lastName%22%3A%22d%27Arminio%20Monforte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20John%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%20A.%22%2C%22lastName%22%3A%22Sabin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huldrych%20F.%22%2C%22lastName%22%3A%22G%5Cu00fcnthard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20A.%20C.%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Lessells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%22%2C%22lastName%22%3A%22Kouyos%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20widespread%20use%20of%20the%20integrase%20strand%20transfer%20inhibitor%20%28INSTI%29%20dolutegravir%20%28DTG%29%20in%20first-%20and%20second-line%20antiretroviral%20therapy%20%28ART%29%20may%20facilitate%20emerging%20resistance.%20We%20combined%20data%20from%20HIV%20cohorts%20to%20examine%20patterns%20of%20drug%20resistance%20mutations%20%28DRMs%29%20and%20identify%20risk%20factors%20for%20DTG%20resistance.%5CnMETHODS%3A%20Eight%20cohorts%20from%20Canada%2C%20Europe%2C%20and%20South%20Africa%20contributed%20data%20on%20individuals%20with%20genotypic%20resistance%20testing%20on%20DTG-based%20ART.%20Resistance%20levels%20were%20categorised%20using%20the%20Stanford%20algorithm.%20We%20identified%20risk%20factors%20for%20resistance%20using%20mixed-effects%20ordinal%20logistic%20regression%20models.%5CnRESULTS%3A%20We%20included%20750%20people%20with%20genotypic%20resistance%20testing%20on%20DTG-based%20ART%20between%202013%20and%202022.%20Most%20had%20HIV%20subtype%20B%20%28N%3D444%2C%2059%5Cu00b72%25%29%20and%20were%20treatment-experienced%3B%20134%20%2817.9%25%29%20were%20on%20DTG%20dual%20and%2019%20%282.5%25%29%20on%20DTG%20monotherapy.%20INSTI%20DRMs%20were%20detected%20in%20100%20%2813%5Cu00b73%25%29%20individuals%3B%2021%20%282%5Cu00b78%25%29%20had%20more%20than%20one%20mutation.%20Most%20%28N%3D713%2C%2095%5Cu00b71%25%29%20were%20susceptible%20to%20DTG%2C%208%20%281%5Cu00b71%25%29%20had%20potential-low%2C%205%20%280%5Cu00b77%25%29%20low%2C%2018%20%282%5Cu00b74%25%29%20intermediate%20and%206%20%280%5Cu00b78%25%29%20high-level%20DTG%20resistance.%20The%20risk%20of%20DTG%20resistance%20was%20higher%20on%20DTG%20monotherapy%20%28adjusted%20odds%20ratio%20%28aOR%29%2037%5Cu00b725%2C%2095%25%20CI%2011%5Cu00b717%20to%20124%5Cu00b72%29%20and%20DTG%20lamivudine%20dual%20therapy%20%28aOR%206%5Cu00b759%2C%2095%25%20CI%201%5Cu00b770%20to%2025%5Cu00b755%29%20compared%20to%20combination%20ART%2C%20and%20higher%20in%20the%20presence%20of%20potential-low%5C%2Flow%20%28aOR%204.62%2C%2095%25%20CI%201.24%20to%2017.2%29%20or%20intermediate%5C%2Fhigh-level%20%28aOR%207%5Cu00b701%2C%2095%25%20CI%202%5Cu00b752%20to%2019%5Cu00b748%29%20nucleoside%20reverse%20transcriptase%20inhibitors%20%28NRTI%29%20resistance.%20Viral%20load%20on%20DTG%20showed%20a%20trend%20towards%20increased%20DTG%20resistance%20%28aOR%201%5Cu00b742%2C%2095%25%20CI%200%5Cu00b792%20to%202%5Cu00b719%20per%20standard%20deviation%20of%20log10%20area%20under%20the%20viral%20load%20curve%29.%5CnINTERPRETATION%3A%20Among%20people%20experiencing%20virological%20failure%20on%20DTG-based%20ART%2C%20INSTI%20DRMs%20were%20uncommon%2C%20and%20DTG%20resistance%20was%20rare.%20DTG%20monotherapy%20and%20NRTI%20resistance%20substantially%20increased%20the%20risk%20for%20DTG%20resistance%2C%20which%20is%20of%20concern%2C%20notably%20in%20resource-limited%20settings.%22%2C%22date%22%3A%222023-04-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.04.05.23288183%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A29%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22MC2VDBK4%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSipambo%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20K.%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEuvrard%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFord%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Ongoing%20High%20Prevalence%20of%20Severe%20Immune%20Suppression%20Among%20Children%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BJ%20Acquir%20Immune%20Defic%20Syndr%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B92%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20273%26%23x2013%3B280.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003137%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003137%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ongoing%20High%20Prevalence%20of%20Severe%20Immune%20Suppression%20Among%20Children%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20G.%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Among%20children%20in%20Southern%20Africa%20severe%20immune%20suppression%20%28SIS%29%20has%20declined%2C%20but%20most%20continue%20to%20initiate%20antiretroviral%20therapy%20%28ART%29%20with%20SIS.%20SETTING%3A%20Using%20data%20from%20South%20Africa%2C%20we%20describe%20SIS%20at%20ART%20start%20and%20on%20ART%20between%202007%20and%202020%2C%20among%20children%20%26lt%3B5%20years%20with%20a%20CD4%25%5C%2Fcell%20count%20at%20ART%20start%20and%20%26gt%3B%5C%2F%3D1%20subsequent%20measure.%20METHODS%3A%20Gap%20in%20care%20was%20defined%20as%20%26gt%3B9%20months%20without%20a%20recorded%20visit.%20We%20defined%20SIS%20according%20to%20age%20and%20CD4%25%5C%2Fcell%20count.%20A%20multistate%20model%20was%20used%20to%20estimate%20transition%20probabilities%20between%205%20states%3A%20SIS%20on%20ART%3B%20Stable%2C%20not%20SIS%3B%20Early%20Gap%2C%20commencing%20%26lt%3B9%20months%20from%20ART%20start%3B%20Late%20Gap%2C%20commencing%20%26gt%3B%5C%2F%3D9%20months%20on%20ART%3B%20and%20Death.%20RESULTS%3A%20Among%202536%20children%2C%2070%25%20had%20SIS%20at%20ART%20start%2C%20and%2036%25%20experienced%20SIS%20on%20ART.%20An%20increasing%20proportion%20were%20age%20%26lt%3B1%20year%20at%20ART%20initiation%20%282007-2009%3A%2043%25%20to%202013-2020%3A%2055%25%29.%20Increasingly%2C%20SIS%20on%20ART%20occurred%20after%20a%20gap%2C%20in%20those%20with%20SIS%20on%20ART%20for%20%26gt%3B1%20year%2C%20and%20after%20a%20period%20of%20unknown%20immune%20status.%20Later%20year%20of%20ART%20initiation%20was%20associated%20with%20reduced%20transition%20from%20SIS%20on%20ART%20to%20Stable.%20Infants%20and%20those%20initiating%20ART%20with%20SIS%20were%20more%20likely%20to%20transition%20from%20Stable%20to%20SIS.%20Viremia%20strongly%20predicted%20death%20from%20both%20the%20on%20ART%20states.%20CONCLUSIONS%3A%20Increasingly%20SIS%20occurred%20among%20ART-experienced%20children.%20Those%20starting%20ART%20with%20SIS%20and%20during%20infancy%20remained%20especially%20vulnerable%20to%20SIS%20once%20on%20treatment.%20Managing%20ART%20in%20these%20children%20may%20be%20more%20complex%20and%20further%20reducing%20AIDS-related%20mortality%20is%20likely%20to%20remain%20challenging.%22%2C%22date%22%3A%22Apr%201%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003137%22%2C%22ISSN%22%3A%221944-7884%20%28Electronic%29%201525-4135%20%28Print%29%201525-4135%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A11%3A32Z%22%7D%7D%2C%7B%22key%22%3A%2235XYKA8G%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zwyer%20et%20al.%22%2C%22parsedDate%22%3A%222023-04%22%2C%22numChildren%22%3A8%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZwyer%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRutaihwa%2C%20L.%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWindels%2C%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHella%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMenardo%2C%20F.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Back-to-Africa%20introductions%20of%20Mycobacterium%20tuberculosis%20as%20the%20main%20cause%20of%20tuberculosis%20in%20Dar%20es%20Salaam%2C%20Tanzania.%20%26lt%3Bi%26gt%3BPLoS%20Pathog%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e1010893.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.ppat.1010893%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.ppat.1010893%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Back-to-Africa%20introductions%20of%20Mycobacterium%20tuberculosis%20as%20the%20main%20cause%20of%20tuberculosis%20in%20Dar%20es%20Salaam%2C%20Tanzania%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Zwyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20K.%22%2C%22lastName%22%3A%22Rutaihwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Windels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Hella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Menardo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Sasamalo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Sommer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Schmulling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Borrell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Reinhard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Dotsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Hiza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Stritt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Sikalengo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20C.%22%2C%22lastName%22%3A%22De%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Kato-Maeda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Jugheli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20D.%22%2C%22lastName%22%3A%22Ernst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Jeljeli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Rakotosamimanana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Yeboah-Manu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Asare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Malla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%20Y.%22%2C%22lastName%22%3A%22Dou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Zetola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20J.%22%2C%22lastName%22%3A%22Wilkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20J.%22%2C%22lastName%22%3A%22Carter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Gnokoro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Gotuzzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Abimiku%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Avihingsanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Z.%20M.%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Fellay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Portevin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Reither%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Stadler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Gagneux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Brites%22%7D%5D%2C%22abstractNote%22%3A%22In%20settings%20with%20high%20tuberculosis%20%28TB%29%20endemicity%2C%20distinct%20genotypes%20of%20the%20Mycobacterium%20tuberculosis%20complex%20%28MTBC%29%20often%20differ%20in%20prevalence.%20However%2C%20the%20factors%20leading%20to%20these%20differences%20remain%20poorly%20understood.%20Here%20we%20studied%20the%20MTBC%20population%20in%20Dar%20es%20Salaam%2C%20Tanzania%20over%20a%20six-year%20period%2C%20using%201%2C082%20unique%20patient-derived%20MTBC%20whole-genome%20sequences%20%28WGS%29%20and%20associated%20clinical%20data.%20We%20show%20that%20the%20TB%20epidemic%20in%20Dar%20es%20Salaam%20is%20dominated%20by%20multiple%20MTBC%20genotypes%20introduced%20to%20Tanzania%20from%20different%20parts%20of%20the%20world%20during%20the%20last%20300%20years.%20The%20most%20common%20MTBC%20genotypes%20deriving%20from%20these%20introductions%20exhibited%20differences%20in%20transmission%20rates%20and%20in%20the%20duration%20of%20the%20infectious%20period%2C%20but%20little%20differences%20in%20overall%20fitness%2C%20as%20measured%20by%20the%20effective%20reproductive%20number.%20Moreover%2C%20measures%20of%20disease%20severity%20and%20bacterial%20load%20indicated%20no%20differences%20in%20virulence%20between%20these%20genotypes%20during%20active%20TB.%20Instead%2C%20the%20combination%20of%20an%20early%20introduction%20and%20a%20high%20transmission%20rate%20accounted%20for%20the%20high%20prevalence%20of%20L3.1.1%2C%20the%20most%20dominant%20MTBC%20genotype%20in%20this%20setting.%20Yet%2C%20a%20longer%20co-existence%20with%20the%20host%20population%20did%20not%20always%20result%20in%20a%20higher%20transmission%20rate%2C%20suggesting%20that%20distinct%20life-history%20traits%20have%20evolved%20in%20the%20different%20MTBC%20genotypes.%20Taken%20together%2C%20our%20results%20point%20to%20bacterial%20factors%20as%20important%20determinants%20of%20the%20TB%20epidemic%20in%20Dar%20es%20Salaam.%22%2C%22date%22%3A%22Apr%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.ppat.1010893%22%2C%22ISSN%22%3A%221553-7374%20%28Electronic%29%201553-7366%20%28Print%29%201553-7366%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A06%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22SF5ZU36U%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vreeman%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-13%22%2C%22numChildren%22%3A14%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVreeman%2C%20R.%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYiannoutsos%2C%20C.%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYusoff%2C%20N.%20K.%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWester%2C%20C.%20W.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEdmonds%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Global%20HIV%20prevention%2C%20care%20and%20treatment%20services%20for%20children%3A%20a%20cross-sectional%20survey%20from%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e069399.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2022-069399%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2022-069399%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20HIV%20prevention%2C%20care%20and%20treatment%20services%20for%20children%3A%20a%20cross-sectional%20survey%20from%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20C.%22%2C%22lastName%22%3A%22Vreeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20K.%20N.%22%2C%22lastName%22%3A%22Yusoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20W.%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Edmonds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Ofner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Lumbiganon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20C.%22%2C%22lastName%22%3A%22de%20Menezes%20Succi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Brown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Bolton-Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%20E.%22%2C%22lastName%22%3A%22Takassi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Scanlon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%22%2C%22lastName%22%3A%22IeDea%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20To%20assess%20access%20children%20with%20HIV%20have%20to%20comprehensive%20HIV%20care%20services%2C%20to%20longitudinally%20evaluate%20the%20implementation%20and%20scale-up%20of%20services%2C%20and%20to%20use%20site%20services%20and%20clinical%20cohort%20data%20to%20explore%20whether%20access%20to%20these%20services%20influences%20retention%20in%20care.%20METHODS%3A%20A%20cross-sectional%20standardised%20survey%20was%20completed%20in%202014-2015%20by%20sites%20providing%20paediatric%20HIV%20care%20across%20regions%20of%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20We%20developed%20a%20comprehensiveness%20score%20based%20on%20the%20WHO%26%23039%3Bs%20nine%20categories%20of%20essential%20services%20to%20categorise%20sites%20as%20%26%23039%3Blow%26%23039%3B%20%280-5%29%2C%20%26%23039%3Bmedium%26%23039%3B%2C%20%286-7%29%20or%20%26%23039%3Bhigh%26%23039%3B%20%288-9%29.%20When%20available%2C%20comprehensiveness%20scores%20were%20compared%20with%20scores%20from%20a%202009%20survey.%20We%20used%20patient-level%20data%20with%20site%20services%20to%20investigate%20the%20relationship%20between%20the%20comprehensiveness%20of%20services%20and%20retention.%20RESULTS%3A%20Survey%20data%20from%20174%20IeDEA%20sites%20in%2032%20countries%20were%20analysed.%20Of%20the%20WHO%20essential%20services%2C%20sites%20were%20most%20likely%20to%20offer%20antiretroviral%20therapy%20%28ART%29%20provision%20and%20counselling%20%28n%3D173%3B%2099%25%29%2C%20co-trimoxazole%20prophylaxis%20%28168%3B%2097%25%29%2C%20prevention%20of%20perinatal%20transmission%20services%20%28167%3B%2096%25%29%2C%20outreach%20for%20patient%20engagement%20and%20follow-up%20%28166%3B%2095%25%29%2C%20CD4%20cell%20count%20testing%20%28126%3B%2088%25%29%2C%20tuberculosis%20screening%20%28151%3B%2087%25%29%20and%20select%20immunisation%20services%20%28126%3B%2072%25%29.%20Sites%20were%20less%20likely%20to%20offer%20nutrition%5C%2Ffood%20support%20%2897%3B%2056%25%29%2C%20viral%20load%20testing%20%2899%3B%2069%25%29%20and%20HIV%20counselling%20and%20testing%20%2869%3B%2040%25%29.%2010%25%20of%20sites%20rated%20%26%23039%3Blow%26%23039%3B%2C%2059%25%20%26%23039%3Bmedium%26%23039%3B%20and%2031%25%20%26%23039%3Bhigh%26%23039%3B%20in%20the%20comprehensiveness%20score.%20The%20mean%20comprehensiveness%20of%20services%20score%20increased%20significantly%20from%205.6%20in%202009%20to%207.3%20in%202014%20%28p%26lt%3B0.001%3B%20n%3D30%29.%20Patient-level%20analysis%20of%20lost%20to%20follow-up%20after%20ART%20initiation%20estimated%20the%20hazard%20was%20highest%20in%20sites%20rated%20%26%23039%3Blow%26%23039%3B%20and%20lowest%20in%20sites%20rated%20%26%23039%3Bhigh%26%23039%3B.%20CONCLUSION%3A%20This%20global%20assessment%20suggests%20the%20potential%20care%20impact%20of%20scaling-up%20and%20sustaining%20comprehensive%20paediatric%20HIV%20services.%20Meeting%20recommendations%20for%20comprehensive%20HIV%20services%20should%20remain%20a%20global%20priority.%22%2C%22date%22%3A%22Mar%2013%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2022-069399%22%2C%22ISSN%22%3A%222044-6055%20%28Electronic%29%202044-6055%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A07%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22RDYHKG64%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIyun%2C%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20B.%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20H.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFerreira%2C%20T.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Hospitalization%20among%20infants%20who%20initiate%20antiretroviral%20therapy%20before%203%20months%20of%20age.%20%26lt%3Bi%26gt%3BAIDS%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20435%26%23x2013%3B445.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003422%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003422%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hospitalization%20among%20infants%20who%20initiate%20antiretroviral%20therapy%20before%203%20months%20of%20age%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Iyun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Ferreira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dea%20Sa%22%2C%22lastName%22%3A%22Ie%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Studies%20examining%20hospitalization%20among%20infants%20with%20HIV%20in%20resource-limited%20settings%2C%20in%20the%20context%20of%20early%20infant%20diagnosis%20and%20early%20antiretroviral%20therapy%20%28ART%29%20initiation%2C%20are%20limited.%20METHODS%3A%20We%20used%20routinely%20collected%20data%20on%20infants%20who%20initiated%20ART%20aged%20%26lt%3B3%20months%20%28Western%20Cape%20province%2C%20South%20Africa%3B%202013-2017%29%20to%20describe%20hospitalization%20from%20birth%20until%2012%20months%20post-ART%20initiation.%20Record%20reviews%20were%20additionally%20performed%20at%20three%20tertiary-level%20facilities.%20We%20used%20mixed-effects%20Poisson%20regression%20to%20examine%20factors%20associated%20with%20hospitalization.%20RESULTS%3A%20Among%20840%20infants%2C%20579%20%2869%25%29%20were%20hospitalized%3B%2036%25%20had%20%26gt%3B1%20hospitalization.%20Median%20age%20at%20ART%20initiation%20decreased%20from%2057%20days%20%28interquartile%20range%20%5BIQR%5D%2022-74%3B%202013-2015%29%20to%2019%20days%20%28IQR%205-54%3B%202016-2017%29.%20Early%20neonatal%20hospitalization%20%28age%20%26lt%3B7%20days%29%20occurred%20in%20271%20infants%20%2832%25%29%20and%20represented%2024%25%20of%20hospitalizations%20%28272%5C%2F1131%29.%20Overall%2C%20443%20infants%20%2853%25%29%20were%20hospitalized%20at%20age%20%26gt%3B%5C%2F%3D7%20days%2C%20including%2013%25%20with%20hospitalizations%20pre-ART%20initiation%2C%2015%25%20pre%20and%20post-ART%20initiation%20and%2025%25%20post-ART%20initiation.%20Excluding%20early%20neonatal%20hospitalizations%2C%20initiating%20ART%20at%20older%20age%20vs.%20age%20%26lt%3B1%20week%20was%20associated%20with%20higher%20hospitalization%20rates%3A%20adjusted%20incidence%20rate%20ratios%20%2895%25%20confidence%20interval%29%20were%201.86%20%281.31-2.64%29%3B%202.31%20%281.62-3.29%29%20and%202.47%20%281.76-3.46%29%20if%20ART%20initiation%20age%20was%201-4%20weeks%3B%205-8%20weeks%20and%209-12%20weeks%20respectively.%20Among%20infants%20whose%20hospital%20records%20were%20reviewed%2C%20reasons%20for%20early%20neonatal%20hospitalizations%20mostly%20related%20to%20prematurity%20or%20low%20birthweight%20%28n%20%3D%2046%5C%2F60%3B%2077%25%29%20whereas%20hospitalizations%20at%20age%20%26gt%3B%5C%2F%3D7%20days%20were%20mostly%20due%20to%20infections%20%28n%20%3D%20206%5C%2F243%3B%2085%25%29.%20CONCLUSIONS%3A%20Earlier%20ART%20initiation%20is%20associated%20with%20lower%20hospitalization%20rates.%20High%20hospitalization%20rates%2C%20despite%20initiation%20age%20%26lt%3B3%20months%2C%20is%20concerning.%22%2C%22date%22%3A%22Mar%201%202023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003422%22%2C%22ISSN%22%3A%221473-5571%20%28Electronic%29%200269-9370%20%28Print%29%200269-9370%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T14%3A20%3A55Z%22%7D%7D%2C%7B%22key%22%3A%2279FNT5LD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20G.%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEuvrard%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderegg%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoulle%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BArendse%2C%20K.%20D.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Advanced%20HIV%20disease%20and%20engagement%20in%20care%20among%20patients%20on%20antiretroviral%20therapy%20in%20South%20Africa%3A%20results%20from%20a%20multi-state%20model.%20%26lt%3Bi%26gt%3BAIDS%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20513%26%23x2013%3B522.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003442%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003442%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Advanced%20HIV%20disease%20and%20engagement%20in%20care%20among%20patients%20on%20antiretroviral%20therapy%20in%20South%20Africa%3A%20results%20from%20a%20multi-state%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20E.%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20D.%22%2C%22lastName%22%3A%22Arendse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22von%20der%20Heyden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Despite%20improved%20access%20to%20antiretroviral%20therapy%20%28ART%29%20for%20people%20with%20HIV%20%28PWH%29%2C%20HIV%20continues%20to%20contribute%20considerably%20to%20morbidity%20and%20mortality.%20Increasingly%2C%20advanced%20HIV%20disease%20%28AHD%29%20is%20found%20among%20PWH%20who%20are%20ART-experienced.%20DESIGN%3A%20Using%20a%20multi-state%20model%20we%20examined%20associations%20between%20engagement%20with%20care%20and%20AHD%20on%20ART%20in%20South%20Africa.%20METHODS%3A%20Using%20data%20from%20IeDEA%20Southern%20Africa%2C%20we%20included%20PWH%20from%20South%20Africa%2C%20initiating%20ART%20from%202004%20to%202017%20aged%20more%20than%205%20years%20with%20a%20CD4%2B%20cell%20count%20at%20ART%20start%20and%20at%20least%20one%20subsequent%20measure.%20We%20defined%20a%20gap%20as%20no%20visit%20for%20at%20least%2018%20months.%20Five%20states%20were%20defined%3A%20%26%23039%3BAHD%20on%20ART%26%23039%3B%20%28CD4%2B%20cell%20count%20%26lt%3B200%20cells%5C%2Fmul%29%2C%20%26%23039%3BClinically%20Stable%20on%20ART%26%23039%3B%20%28CD4%2B%20cell%20count%20%26gt%3B%5C%2F%3D200%20or%20if%20no%20CD4%2B%20cell%20count%2C%20viral%20load%20%26lt%3B1000%20copies%5C%2Fml%29%2C%20%26%23039%3BEarly%20Gap%26%23039%3B%20%28commencing%20%26lt%3B%5C%2F%3D18%20months%20from%20ART%20start%29%2C%20%26%23039%3BLate%20Gap%26%23039%3B%20%28commencing%20%26gt%3B18%20months%20from%20ART%20start%29%20and%20%26%23039%3BDeath%26%23039%3B.%20RESULTS%3A%20Among%2032%20452%20PWH%2C%20men%20and%20those%20aged%2015-25%20years%20were%20more%20likely%20to%20progress%20to%20unfavourable%20states.%20Later%20years%20of%20ART%20start%20were%20associated%20with%20a%20lower%20probability%20of%20transitioning%20from%20AHD%20to%20clinically%20stable%2C%20increasing%20the%20risk%20of%20death%20following%20AHD.%20In%20stratified%20analyses%2C%20those%20starting%20ART%20with%20AHD%20in%20later%20years%20were%20more%20likely%20to%20re-engage%20in%20care%20with%20AHD%20following%20a%20gap%20and%20to%20die%20following%20AHD%20on%20ART.%20CONCLUSION%3A%20In%20more%20recent%20years%2C%20those%20with%20AHD%20on%20ART%20were%20more%20likely%20to%20die%2C%20and%20AHD%20at%20re-engagement%20in%20care%20increased.%20To%20further%20reduce%20HIV-related%20mortality%2C%20efforts%20to%20address%20the%20challenges%20facing%20these%20more%20vulnerable%20patients%20are%20needed.%22%2C%22date%22%3A%22Mar%201%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003442%22%2C%22ISSN%22%3A%221473-5571%20%28Electronic%29%200269-9370%20%28Print%29%200269-9370%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A11%3A51Z%22%7D%7D%2C%7B%22key%22%3A%222DGQGUPD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWettstein%2C%20Anja%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVieira%2C%20Cristina%20Mesa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Life-years%20lost%20associated%20with%20mental%20illness%3A%20a%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme.%20%26lt%3Bi%26gt%3BmedRxiv%26%23x202F%3B%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.01.19.23284778.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.19.23284778%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.19.23284778%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Life-years%20lost%20associated%20with%20mental%20illness%3A%20a%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Wettstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%20Mesa%22%2C%22lastName%22%3A%22Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chanwyn%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Schomaker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22Importance%3A%20People%20with%20mental%20illness%20have%20a%20reduced%20life%20expectancy%2C%20but%20the%20extent%20of%20the%20mortality%20gap%20and%20the%20contribution%20of%20natural%20and%20unnatural%20causes%20to%20excess%20mortality%20among%20people%20with%20mental%20illness%20in%20South%20Africa%20are%20unknown.%20Objective%3A%20To%20quantify%20excess%20mortality%20due%20to%20natural%20and%20unnatural%20causes%20associated%20with%20mental%20illness.%20Design%20setting%20and%20participants%3A%20Cohort%20study%20using%20reimbursement%20claims%20and%20vital%20registration%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme%2C%20aged%2015-84%20years%20and%20covered%20by%20medical%20insurance%20at%20any%20point%20between%20January%201%2C%202011%2C%20and%20June%2030%2C%202020.%20Exposures%3A%20ICD-10%20diagnoses%20of%20mental%20disorders%20including%20organic%2C%20substance%20use%2C%20psychotic%2C%20mood%2C%20anxiety%2C%20eating%2C%20personality%2C%20and%20developmental%20disorders.%20Outcomes%3A%20Mortality%20from%20natural%2C%20unnatural%2C%20unknown%20and%20all%20causes%2C%20as%20measured%20by%20the%20life-years%20lost%20%28LYL%29%20metric.%20Results%3A%20We%20followed%201%20070%20183%20beneficiaries%20%2851.7%25%20female%2C%20median%20age%2036.1%20years%20for%20a%20median%20duration%20of%203.0%20years%2C%20of%20whom%20282%20926%20%2826.4%25%29%20received%20mental%20health%20diagnoses%20and%2027%20640%20%282.6%25%29%20died.%20Life%20expectancy%20of%20people%20with%20mental%20health%20diagnoses%20was%203.83%20years%20%2895%25%20CI%203.58-4.10%29%20shorter%20for%20men%20and%202.19%20years%20%281.97-2.41%29%20shorter%20for%20women.%20Excess%20mortality%20varied%20by%20sex%20and%20diagnosis%2C%20ranging%20from%2011.50%20LYL%20%2895%25%20CI%209.79-13.07%29%20among%20men%20with%20alcohol%20use%20disorder%20to%200.87%20LYL%20%280.40-1.43%29%20among%20women%20with%20generalised%20anxiety%20disorder.%20Most%20LYL%20were%20attributable%20to%20natural%20causes%20%283.42%20among%20men%20and%201.94%20among%20women%29.%20A%20considerable%20number%20of%20LYL%20were%20attributable%20to%20unnatural%20causes%20among%20men%20with%20bipolar%20%281.52%29%20or%20substance%20use%20%282.45%29%20disorder.%20Conclusions%20and%20Relevance%3A%20The%20burden%20of%20premature%20mortality%20among%20persons%20with%20mental%20disorders%20in%20South%20Africa%20is%20high.%20Our%20findings%20support%20implementing%20interventions%20for%20prevention%2C%20early%20detection%2C%20and%20treatment%20of%20physical%20comorbidities%20among%20people%20with%20mental%20disorders.%20Suicide%20prevention%20and%20substance%20use%20treatment%20programmes%20are%20needed%20to%20reduce%20excess%20mortality%20from%20unnatural%20causes%2C%20especially%20among%20men.%20Key%20points%3A%20Question%3A%20How%20much%20shorter%20is%20the%20life%20expectancy%20of%20people%20with%20mental%20illness%20compared%20to%20the%20general%20population%20and%20how%20many%20life%20years%20are%20lost%20due%20to%20natural%20and%20unnatural%20causes%20of%20death%3FFindings%3A%20The%20life%20expectancy%20of%20people%20with%20mental%20health%20diagnoses%20was%203.83%20years%20shorter%20for%20men%20and%202.19%20years%20shorter%20for%20women.%20Most%20excess%20life%20years%20lost%20were%20attributable%20to%20natural%20causes%20%283.42%20among%20men%20and%201.94%20among%20women%29.%20However%2C%20bipolar%20and%20substance%20use%20disorders%20were%20associated%20with%20considerable%20premature%20mortality%20from%20unnatural%20causes.Meaning%3A%20Our%20findings%20support%20the%20implementation%20of%20interventions%20for%20improving%20the%20physical%20health%20of%20people%20with%20mental%20illness%20and%20targeted%20suicide%20prevention%20and%20substance%20use%20treatment%20programmes.%22%2C%22date%22%3A%222023%20Feb%202%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.01.19.23284778%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22K663J73M%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Waal%20et%20al.%22%2C%22parsedDate%22%3A%222023-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Waal%2C%20Renee%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-Gunter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSipambo%2C%20Nosisa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Abacavir%20safety%20and%20effectiveness%20in%20young%20infants%20with%20HIV%20in%20South%20African%20observational%20cohorts.%20%26lt%3Bi%26gt%3BAntiviral%20Therapy%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%2013596535231168480.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F13596535231168480%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F13596535231168480%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Abacavir%20safety%20and%20effectiveness%20in%20young%20infants%20with%20HIV%20in%20South%20African%20observational%20cohorts.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Renee%22%2C%22lastName%22%3A%22de%20Waal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Gunter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nosisa%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Cotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Tanser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20WHO%20guidelines%20recommend%20abacavir%20in%20first-line%20antiretroviral%20treatment%20for%20children%20and%20neonates.%20However%2C%20there%20is%20no%20approved%20dose%20%26lt%3B3%20months%20of%20age%2C%20and%20data%20in%20neonates%20are%20limited.%20METHODS%3A%20We%20included%20infants%20who%20initiated%20ART%20aged%20%26lt%3B3%20months%2C%20between%202006%20and%202019%2C%20in%20nine%20South%20African%20cohorts.%20In%20those%20who%20received%20abacavir%20or%20zidovudine%2C%20we%20described%20antiretroviral%20discontinuation%20rates%3B%20and%206-%20and%2012-month%20viral%20suppression%20%28%26lt%3B400%20copies%5C%2FmL%29.%20We%20compared%20infants%20aged%20%26lt%3B28%20and%20%26gt%3B%5C%2F%3D28%20days%2C%20those%20weighing%20%26lt%3B3%20and%20%26gt%3B%5C%2F%3D3%20kg.%20RESULTS%3A%20Overall%20837%5C%2F1643%20infants%20%2851%25%29%20received%20abacavir%20and%20443%20%2827%25%29%20received%20zidovudine.%20Median%20%28interquartile%20range%2C%20IQR%29%20age%20was%2052%20days%20%2823-71%29%2C%20CD4%20percentage%20was%2027.9%20%2819.2-38.0%29%2C%20and%20weight%20was%204.0%20kg%20%283.0-4.7%29%20at%20ART%20initiation.%20In%20those%20with%20%26gt%3B%5C%2F%3D1%20month%26%23039%3Bs%20follow-up%2C%20100%5C%2F718%20%2814%25%29%20infants%20discontinued%20abacavir%2C%20at%20a%20median%20of%2017.5%20months%20%28IQR%206.5-39.5%29.%20Abacavir%20discontinuations%20did%20not%20differ%20by%20age%20or%20weight%20category%20%28p%20%3D%200.4%20and%200.2%2C%20respectively%29%3B%20and%20were%20less%20frequent%20than%20zidovudine%20discontinuations%20%28adjusted%20hazard%20ratio%200.14%2C%2095%25%20confidence%20interval%200.10-0.20%29.%20Viral%20suppression%20at%2012%20months%20occurred%20in%2043%5C%2F79%20%2854%25%29%20and%20130%5C%2F250%20%2852%25%29%20of%20those%20who%20started%20abacavir%20aged%20%26lt%3B28%20and%20%26gt%3B%5C%2F%3D28%20days%2C%20respectively%20%28p%20%3D%200.8%29%3B%2011%5C%2F19%20%2858%25%29%20and%2031%5C%2F60%20%2852%25%29%20in%20those%20who%20weighed%20%26lt%3B3%20and%20%26gt%3B%5C%2F%3D3%20kg%2C%20respectively%20%28p%20%3D%200.6%29%3B%20and%20174%5C%2F329%20%2853%25%29%20in%20those%20on%20abacavir%20versus%2077%5C%2F138%20%2856%25%29%20in%20those%20on%20zidovudine%20%28adjusted%20odds%20ratio%201.8%2C%2095%25%20confidence%20interval%201.0-3.2%29.%20CONCLUSION%3A%20Our%20data%20suggest%20that%20abacavir%20may%20be%20used%20safely%20in%20infants%20%26lt%3B28%20days%20old%20or%20who%20weigh%20%26lt%3B3%20kg.%22%2C%22date%22%3A%222023%20Feb%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1177%5C%2F13596535231168480%22%2C%22ISSN%22%3A%222040-2058%201359-6535%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%223JXGHVXS%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKunzekwenyika%2C%20Cordelia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BManzero%2C%20Josphat%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLimacher%2C%20Andreas%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Effect%20of%20the%20Friendship%20Bench%20intervention%20on%20antiretroviral%20therapy%20outcomes%20and%20mental%20health%20symptoms%20in%20rural%20Zimbabwe%3A%20A%20cluster%20randomized%20trial.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.01.21.23284784.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.21.23284784%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.21.23284784%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20the%20Friendship%20Bench%20intervention%20on%20antiretroviral%20therapy%20outcomes%20and%20mental%20health%20symptoms%20in%20rural%20Zimbabwe%3A%20A%20cluster%20randomized%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josphat%22%2C%22lastName%22%3A%22Manzero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Limacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janneke%20H.%22%2C%22lastName%22%3A%22van%20Dijk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%22%2C%22lastName%22%3A%22Manhibi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Hobbins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruth%22%2C%22lastName%22%3A%22Verhey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Friendship%20Bench%20ART%20trial%20group%22%7D%5D%2C%22abstractNote%22%3A%22IMPORTANCE%3A%20Common%20mental%20disorders%20%28CMD%29%20are%20prevalent%20in%20people%20living%20with%20HIV%20and%20associated%20with%20suboptimal%20antiretroviral%20therapy%20%28ART%29%20adherence.%5CnOBJECTIVE%3A%20To%20assess%20the%20effect%20of%20a%20lay%20health%20worker-led%20psychological%20intervention%20on%20adherence%20to%20ART%2C%20virologic%20suppression%20and%20mental%20health%20symptoms.%5CnDESIGN%3A%20Pragmatic%20cluster%20trial%20with%20block%20randomization%20of%20health%20facilities.%20Treatment%20assignment%20was%20known%20to%20participants%2C%20providers%2C%20evaluators%2C%20and%20data%20analysts.%20Recruitment%20started%20in%20October%202018%20and%20the%20last%20follow-up%20visit%20was%20done%20in%20December%202020.%20Participants%20were%20followed%20up%20for%2012%20months.%5CnSETTING%3A%20Sixteen%20public%20health%20care%20facilities%20in%20Bikita%2C%20a%20rural%20district%20in%20Masvingo%20Province%2C%20about%20300%20km%20south%20of%20Harare.%5CnPARTICIPANTS%3A%20Men%20and%20non-pregnant%20women%20aged%2018%20years%20or%20older%20who%20spoke%20English%20or%20Shona%2C%20screened%20positive%20for%20CMD%20%28Shona%20Symptoms%20Questionnaire%20%5BSSQ%5D-14%20score%20%5Cu00e2%5Cu2030%5Cu00a59%29%2C%20had%20received%20first-line%20ART%20for%20at%20least%20six%20months%2C%20had%20no%20WHO%20clinical%20stage%204%20disease%2C%20no%20psychotic%20symptoms%2C%20and%20gave%20informed%20consent.%5CnINTERVENTION%3A%20The%20Friendship%20Bench%2C%20a%20lay%20health%20worker-led%20intervention%20consisting%20of%20six%20weekly%20individual%20counselling%20sessions%20of%20problem-solving%20therapy%20and%20optional%20peer-led%20group%20support.%5CnMAIN%20OUTCOMES%20AND%20MEASURES%3A%20The%20primary%20outcome%20was%20Medication%20Event%20Monitoring%20System%20%28MEMS%29%20mean%20adherence%20between%202-6%20months%20of%20follow-up.%20Secondary%20outcomes%20included%20mean%20adherence%20between%201-12%20months%2C%20change%20from%20baseline%20SSQ-14%20and%20Patient%20Health%20Questionnaire%20%28PHQ-9%29%20score%20at%203%2C%206%2C%209%2C%20and%2012%20months%20and%20change%20in%20viral%20load%20suppression%20%28viral%20load%20%26lt%3B1000%20copies%20per%20mL%29%20at%20months%206%20and%2012.%5CnRESULTS%3A%20We%20recruited%20516%20participants%2C%20244%20in%20Friendship%20bench%20and%20272%20in%20standard%20care%20facilities.%20The%20mean%20age%20was%2045.6%20years%20%28SD%2010.9%29%2C%20and%20most%20participants%20were%20women%20%2884.9%25%29.%20In%20the%20Friendship%20Bench%20group%2C%2088.1%25%20of%20participants%20attended%20all%20six%20individual%20counselling%20sessions.%20Rates%20of%20adherence%20%28%26gt%3B85%25%29%20and%20virologic%20suppression%20%28%26gt%3B90%25%29%20were%20high%20in%20both%20groups.%20The%20intervention%20had%20no%20statistically%20significant%20effect%20on%20adherence%20or%20viral%20suppression.%20Declines%20in%20SSQ-14%20scores%20from%20baseline%20to%203%20months%20%28-1.65%2C%2095%25%20CI%20-3.07%20to%20-0.24%29%2C%206%20months%20%28-1.57%2C%2095%25%20CI%20-2.98%20to%20-0.15%29%2C%20and%209%20months%20%28-1.63%2C%2095%25%20CI%20-3.05%20to%20-0.22%29%20were%20greater%20in%20the%20Friendship%20Bench%20than%20the%20standard%20care%20group%20%28p%26lt%3B0.05%29.%20There%20were%20no%20differences%20in%20the%20decline%20in%20the%20SSQ-14%20scores%20from%20baseline%20to%2012%20months%20and%20in%20declines%20in%20PHQ-9%20scores%20from%20baseline%20to%203%2C%206%2C%209%2C%20and%2012%20months.%5CnCONCLUSIONS%20AND%20RELEVANCE%3A%20The%20Friendship%20Bench%20intervention%20is%20a%20feasible%20and%20acceptable%20approach%20to%20closing%20the%20treatment%20gap%20in%20mental%20health%20care%20in%20rural%20Zimbabwe.%20The%20intervention%20improved%20CMD%20symptoms%20but%20the%20intervention%20effect%20was%20smaller%20than%20previously%20shown%20in%20an%20urban%20setting.%20The%20intervention%20had%20no%20effect%20on%20adherence%20and%20viral%20suppression%2C%20possibly%20due%20to%20the%20absence%20of%20skill-based%20adherence%20training%20and%20ceiling%20effect.%5CnTRIAL%20REGISTRATION%3A%20ClinicalTrials.gov%20Identifier%3A%20NCT03704805.%5CnKEY%20POINTS%3A%20Question%3A%20Does%20the%20Friendship%20Bench%20intervention%20improve%20antiretroviral%20therapy%20%28ART%29%20adherence%2C%20viral%20suppression%20and%20mental%20health%20symptoms%20in%20people%20living%20with%20HIV%20in%20rural%20Zimbabwe%3FFindings%3A%20In%20this%20cluster-randomized%20trial%2C%20participants%20in%20the%20intervention%20group%20had%20a%20significantly%20greater%20decrease%20in%20symptoms%20of%20common%20mental%20disorders%20than%20those%20in%20the%20control%20group%2C%20but%20the%20intervention%20showed%20no%20significant%20effect%20on%20antiretroviral%20therapy%20%28ART%29%20adherence%20or%20viral%20suppression.Meaning%3A%20The%20intervention%20did%20not%20affect%20adherence%20and%20viral%20suppression%20and%20the%20effect%20of%20the%20intervention%20on%20mental%20health%20symptoms%20was%20smaller%20than%20previously%20shown.%22%2C%22date%22%3A%222023-01-22%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.01.21.23284784%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T15%3A45%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22DQZY2PUS%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ross%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-06%22%2C%22numChildren%22%3A16%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoss%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFatti%2C%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJaquet%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTanon%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Same-Day%20Antiretroviral%20Therapy%20Initiation%20as%20a%20Predictor%20of%20Loss%20to%20Follow-up%20and%20Viral%20Suppression%20Among%20People%20With%20Human%20Immunodeficiency%20Virus%20in%20Sub-Saharan%20Africa.%20%26lt%3Bi%26gt%3BClin%20Infect%20Dis%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B76%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%2039%26%23x2013%3B47.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac759%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac759%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Same-Day%20Antiretroviral%20Therapy%20Initiation%20as%20a%20Predictor%20of%20Loss%20to%20Follow-up%20and%20Viral%20Suppression%20Among%20People%20With%20Human%20Immunodeficiency%20Virus%20in%20Sub-Saharan%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Tanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Castelnuovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20M.%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Yotebieng%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Treat-All%20guidelines%20recommend%20initiation%20of%20antiretroviral%20therapy%20%28ART%29%20for%20all%20people%20with%20HIV%20%28PWH%29%20on%20the%20day%20of%20diagnosis%20when%20possible%2C%20yet%20uncertainty%20exists%20about%20the%20impact%20of%20same-day%20ART%20initiation%20on%20subsequent%20care%20engagement.%20We%20examined%20the%20association%20of%20same-day%20ART%20initiation%20with%20loss%20to%20follow-up%20and%20viral%20suppression%20among%20patients%20in%2011%20sub-Saharan%20African%20countries.%20METHODS%3A%20We%20included%20ART-naive%20adult%20PWH%20from%20sites%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%20who%20enrolled%20in%20care%20after%20Treat-All%20implementation%20and%20prior%20to%20January%202019.%20We%20used%20multivariable%20Cox%20regression%20to%20estimate%20the%20association%20between%20same-day%20ART%20initiation%20and%20loss%20to%20follow-up%20and%20Poisson%20regression%20to%20estimate%20the%20association%20between%20same-day%20ART%20initiation%20and%206-month%20viral%20suppression.%20RESULTS%3A%20Among%2029%20017%20patients%20from%2063%20sites%2C%2018%20584%20%2864.0%25%29%20initiated%20ART%20on%20the%20day%20of%20enrollment.%20Same-day%20ART%20initiation%20was%20less%20likely%20among%20those%20with%20advanced%20HIV%20disease%20versus%20early-stage%20disease.%20Loss%20to%20follow-up%20was%20significantly%20lower%20among%20those%20initiating%20ART%20%26gt%3B%5C%2F%3D1%20day%20of%20enrollment%2C%20compared%20with%20same-day%20ART%20initiators%20%2820.6%25%20vs%2027.7%25%3B%20adjusted%20hazard%20ratio%3A%20.66%3B%2095%25%20CI%20.57-.76%29.%20No%20difference%20in%20viral%20suppression%20was%20observed%20by%20time%20to%20ART%20initiation%20%28adjusted%20rate%20ratio%3A%201.00%3B%2095%25%20CI%3A%20.98-1.02%29.%20CONCLUSIONS%3A%20Patients%20initiating%20ART%20on%20the%20day%20of%20enrollment%20were%20more%20frequently%20lost%20to%20follow-up%20than%20those%20initiating%20later%20but%20were%20equally%20likely%20to%20be%20virally%20suppressed.%20Our%20findings%20support%20recent%20World%20Health%20Organization%20recommendations%20for%20providing%20tailored%20counseling%20and%20support%20to%20patients%20who%20accept%20an%20offer%20of%20same-day%20ART.%22%2C%22date%22%3A%22Jan%206%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciac759%22%2C%22ISSN%22%3A%221537-6591%20%28Electronic%29%201058-4838%20%28Print%29%201058-4838%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A10%3A50Z%22%7D%7D%2C%7B%22key%22%3A%226YLLHW7Q%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A16%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaruri%2C%20F.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWester%2C%20C.%20W.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusick%2C%20B.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFreeman%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Design%20and%20implementation%20of%20a%20global%20site%20assessment%20survey%20among%20HIV%20clinics%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20research%20consortium.%20%26lt%3Bi%26gt%3BPLoS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B18%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e0268167.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0268167%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0268167%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Design%20and%20implementation%20of%20a%20global%20site%20assessment%20survey%20among%20HIV%20clinics%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20research%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20W.%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Christ%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Kimmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Humphrey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20E.%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20E.%22%2C%22lastName%22%3A%22Golub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aids%20consortium%22%2C%22lastName%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Timely%20descriptions%20of%20HIV%20service%20characteristics%20and%20their%20evolution%20over%20time%20across%20diverse%20settings%20are%20important%20for%20monitoring%20the%20scale-up%20of%20evidence-based%20program%20strategies%2C%20understanding%20the%20implementation%20landscape%2C%20and%20examining%20service%20delivery%20factors%20that%20influence%20HIV%20care%20outcomes.%20METHODS%3A%20The%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%20undertakes%20periodic%20cross-sectional%20surveys%20on%20service%20availability%20and%20care%20at%20participating%20HIV%20treatment%20sites%20to%20characterize%20trends%20and%20inform%20the%20scientific%20agenda%20for%20HIV%20care%20and%20implementation%20science%20communities.%20IeDEA%26%23039%3Bs%202020%20general%20site%20assessment%20survey%20was%20developed%20through%20a%20consultative%2C%2018-month%20process%20that%20engaged%20diverse%20researchers%20in%20identifying%20content%20from%20previous%20surveys%20that%20should%20be%20retained%20for%20longitudinal%20analyses%20and%20in%20developing%20expanded%20and%20new%20content%20to%20address%20gaps%20in%20the%20literature.%20An%20iterative%20review%20process%20was%20undertaken%20to%20standardize%20the%20format%20of%20new%20survey%20questions%20and%20align%20them%20with%20best%20practices%20in%20survey%20design%20and%20measurement%20and%20lessons%20learned%20through%20prior%20IeDEA%20site%20assessment%20surveys.%20RESULTS%3A%20The%20survey%20questionnaire%20developed%20through%20this%20process%20included%20eight%20content%20domains%20covered%20in%20prior%20surveys%20%28patient%20population%2C%20staffing%20and%20community%20linkages%2C%20HIV%20testing%20and%20diagnosis%2C%20new%20patient%20care%2C%20treatment%20monitoring%20and%20retention%2C%20routine%20HIV%20care%20and%20screening%2C%20pharmacy%2C%20record-keeping%20and%20patient%20tracing%29%2C%20along%20with%20expanded%20content%20related%20to%20antiretroviral%20therapy%20%28differentiated%20service%20delivery%20and%20roll-out%20of%20dolutegravir-based%20regimens%29%3B%20mental%20health%20and%20substance%20use%20disorders%3B%20care%20for%20pregnant%5C%2Fpostpartum%20women%20and%20HIV-exposed%20infants%3B%20tuberculosis%20preventive%20therapy%3B%20and%20pediatric%5C%2Fadolescent%20tuberculosis%20care%3B%20and%20new%20content%20related%20to%20Kaposi%26%23039%3Bs%20sarcoma%20diagnostics%2C%20the%20impact%20of%20COVID-19%20on%20service%20delivery%2C%20and%20structural%20barriers%20to%20HIV%20care.%20The%20survey%20was%20distributed%20to%20238%20HIV%20treatment%20sites%20in%20late%202020%2C%20with%20a%2095%25%20response%20rate.%20CONCLUSION%3A%20IeDEA%26%23039%3Bs%20approach%20for%20site%20survey%20development%20has%20broad%20relevance%20for%20HIV%20research%20networks%20and%20other%20priority%20health%20conditions.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0268167%22%2C%22ISSN%22%3A%221932-6203%20%28Electronic%29%201932-6203%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A19%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22URS9BIA7%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Humphrey%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHumphrey%2C%20John%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNagel%2C%20Elizabeth%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCarlucci%2C%20James%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEdmonds%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKinikar%2C%20Aarti%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Integration%20of%20HIV%20care%20into%20maternal%20and%20child%20health%20services%20in%20the%20global%20IeDEA%20consortium.%20%26lt%3Bi%26gt%3BFrontiers%20in%20Global%20Women%26%23x2019%3Bs%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%201066297.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffgwh.2023.1066297%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffgwh.2023.1066297%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Integration%20of%20HIV%20care%20into%20maternal%20and%20child%20health%20services%20in%20the%20global%20IeDEA%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Humphrey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Nagel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20G.%22%2C%22lastName%22%3A%22Carlucci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Edmonds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aarti%22%2C%22lastName%22%3A%22Kinikar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dwight%20E.%22%2C%22lastName%22%3A%22Yin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Tulio%20Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Safari%22%2C%22lastName%22%3A%22Mbewe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tulathip%22%2C%22lastName%22%3A%22Suwanlerk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Athanase%22%2C%22lastName%22%3A%22Munyaneza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rena%20C.%22%2C%22lastName%22%3A%22Patel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beverly%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Abuogi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%5D%2C%22abstractNote%22%3A%22The%20WHO%20recommends%20the%20integration%20of%20routine%20HIV%20services%20within%20maternal%20and%20child%20health%20%28MCH%29%20services%20to%20reduce%20the%20fragmentation%20of%20and%20to%20promote%20retention%20in%20care%20for%20pregnant%20and%20postpartum%20women%20living%20with%20HIV%20%28WWH%29%20and%20their%20infants%20and%20children%20exposed%20to%20HIV%20%28ICEH%29.%20During%202020-2021%2C%20we%20surveyed%20202%20HIV%20treatment%20sites%20across%2040%20low-%20and%20middle-income%20countries%20within%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20We%20determined%20the%20proportion%20of%20sites%20providing%20HIV%20services%20integrated%20within%20MCH%20clinics%2C%20defined%20as%20full%20%5BHIV%20care%20and%20antiretroviral%20treatment%20%28ART%29%20initiation%20in%20MCH%20clinic%5D%2C%20partial%20%28HIV%20care%20or%20ART%20initiation%20in%20MCH%20clinic%29%2C%20or%20no%20integration.%20Among%20sites%20serving%20pregnant%20WWH%2C%2054%25%20were%20fully%20and%2021%25%20partially%20integrated%2C%20with%20the%20highest%20proportions%20of%20fully%20integrated%20sites%20in%20Southern%20Africa%20%2880%25%29%20and%20East%20Africa%20%2876%25%29%20compared%20to%2014%25-40%25%20in%20other%20regions%20%28i.e.%2C%20Asia-Pacific%3B%20the%20Caribbean%2C%20Central%20and%20South%20America%20Network%20for%20HIV%20Epidemiology%3B%20Central%20Africa%3B%20West%20Africa%29.%20Among%20sites%20serving%20postpartum%20WWH%2C%2051%25%20were%20fully%20and%2010%25%20partially%20integrated%2C%20with%20a%20similar%20regional%20integration%20pattern%20to%20sites%20serving%20pregnant%20WWH.%20Among%20sites%20serving%20ICEH%2C%2056%25%20were%20fully%20and%209%25%20were%20partially%20integrated%2C%20with%20the%20highest%20proportions%20of%20fully%20integrated%20sites%20in%20East%20Africa%20%2876%25%29%2C%20West%20Africa%20%2858%25%29%20and%20Southern%20Africa%20%2854%25%29%20compared%20to%20%5Cu226433%25%20in%20the%20other%20regions.%20Integration%20was%20heterogenous%20across%20IeDEA%20regions%20and%20most%20prevalent%20in%20East%20and%20Southern%20Africa.%20More%20research%20is%20needed%20to%20understand%20this%20heterogeneity%20and%20the%20impacts%20of%20integration%20on%20MCH%20outcomes%20globally.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3389%5C%2Ffgwh.2023.1066297%22%2C%22ISSN%22%3A%222673-5059%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222023-12-01T11%3A00%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22KJCNL3QA%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Matzopoulos%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMatzopoulos%2C%20Richard%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPrinsloo%2C%20Megan%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMhlongo%2C%20Shibe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMarineau%2C%20Lea%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20Morna%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20South%20Africa%26%23x2019%3Bs%20male%20homicide%20epidemic%20hiding%20in%20plain%20sight%3A%20Exploring%20sex%20differences%20and%20patterns%20in%20homicide%20risk%20in%20a%20retrospective%20descriptive%20study%20of%20postmortem%20investigations.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%20%2811%29%2C%20S.%20e0002595.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002595%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002595%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22South%20Africa%27s%20male%20homicide%20epidemic%20hiding%20in%20plain%20sight%3A%20Exploring%20sex%20differences%20and%20patterns%20in%20homicide%20risk%20in%20a%20retrospective%20descriptive%20study%20of%20postmortem%20investigations%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Matzopoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megan%20R.%22%2C%22lastName%22%3A%22Prinsloo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shibe%22%2C%22lastName%22%3A%22Mhlongo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Marineau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brett%22%2C%22lastName%22%3A%22Bowman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thakadu%20A.%22%2C%22lastName%22%3A%22Mamashela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nomonde%22%2C%22lastName%22%3A%22Gwebushe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Asiphe%22%2C%22lastName%22%3A%22Ketelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorna%20J.%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%22%2C%22lastName%22%3A%22Dekel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carl%22%2C%22lastName%22%3A%22Lombard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Jewkes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naeemah%22%2C%22lastName%22%3A%22Abrahams%22%7D%5D%2C%22abstractNote%22%3A%22South%20Africa%20has%20an%20overall%20homicide%20rate%20six%20times%20the%20global%20average.%20Males%20are%20predominantly%20the%20victims%20and%20perpetrators%2C%20but%20little%20is%20known%20about%20the%20male%20victims.%20For%20the%20country%26%23039%3Bs%20first%20ever%20study%20on%20male%20homicide%20we%20compared%202017%20male%20and%20female%20victim%20profiles%20for%20selected%20covariates%2C%20against%20global%20average%20and%20previous%20estimates%20for%202009.%20We%20conducted%20a%20retrospective%20descriptive%20study%20of%20routine%20data%20collected%20through%20postmortem%20investigations%2C%20calculating%20age-standardised%20mortality%20rates%20for%20manner%20of%20death%20by%20age%2C%20sex%20and%20province%20and%20male-to-female%20incidence%20rate%20ratios%20with%2095%25%20confidence%20intervals.%20We%20then%20used%20generalised%20linear%20models%20and%20linear%20regression%20models%20to%20assess%20the%20association%20between%20sex%20and%20victim%20characteristics%20including%20age%20and%20mechanism%20of%20injury%20%28guns%2C%20sharp%20and%20blunt%20force%29%20within%20and%20between%20years.%2087%25%20of%2019%2C477%20homicides%20in%202017%20were%20males%2C%20equating%20to%20seven%20male%20deaths%20for%20every%20female%2C%20with%20sharp%20force%20and%20firearm%20discharge%20being%20the%20most%20common%20cause%20of%20death.%20Rates%20were%20higher%20among%20males%20than%20females%20at%20all%20ages%2C%20and%20up%20to%20eight%20times%20higher%20for%20the%20age%20group%2015-44%20years.%20Provincial%20rates%20varied%20overall%20and%20by%20sex%2C%20with%20the%20highest%20comparative%20risk%20for%20men%20vs.%20women%20in%20the%20Western%20Cape%20Province%20%2811.4%20males%20for%20every%201%20female%29.%20Male%20homicides%20peaked%20during%20December%20and%20were%20highest%20during%20weekends%2C%20underscoring%20the%20prominent%20role%20of%20alcohol%20as%20a%20risk%20factor.%20There%20is%20a%20massive%2C%20disproportionate%20and%20enduring%20homicide%20risk%20among%20South%20African%20men%20which%20highlights%20their%20relative%20neglect%20in%20the%20country%26%23039%3Bs%20prevention%20and%20policy%20responses.%20Only%20through%20challenging%20the%20normative%20perception%20of%20male%20invulnerability%20do%20we%20begin%20to%20address%20the%20enormous%20burden%20of%20violence%20impacting%20men.%20There%20is%20an%20urgent%20need%20to%20address%20the%20insidious%20effect%20of%20such%20societal%20norms%20alongside%20implementing%20structural%20interventions%20to%20overcome%20the%20root%20causes%20of%20poverty%2C%20inequality%20and%20better%20control%20alcohol%20and%20firearms.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0002595%22%2C%22ISSN%22%3A%222767-3375%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-12-01T10%3A51%3A04Z%22%7D%7D%2C%7B%22key%22%3A%225M799P4L%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dovel%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDovel%2C%20Kathryn%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPaneno%2C%20Rose%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBalakasi%2C%20Kelvin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHubbard%2C%20Julie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaga%26%23xE7%3Bo%2C%20Am%26%23xED%3Blcar%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Health%20care%20workers%26%23x2019%3B%20perceptions%20and%20bias%20toward%20men%20as%20HIV%20clients%20in%20Malawi%20and%20Mozambique%3A%20A%20qualitative%20study.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%20e0001356.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0001356%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0001356%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Health%20care%20workers%27%20perceptions%20and%20bias%20toward%20men%20as%20HIV%20clients%20in%20Malawi%20and%20Mozambique%3A%20A%20qualitative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Dovel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rose%22%2C%22lastName%22%3A%22Paneno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelvin%22%2C%22lastName%22%3A%22Balakasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Hubbard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00edlcar%22%2C%22lastName%22%3A%22Maga%5Cu00e7o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khumbo%22%2C%22lastName%22%3A%22Phiri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Coates%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%5D%2C%22abstractNote%22%3A%22Men%20are%20underrepresented%20in%20HIV%20services%20throughout%20sub-Saharan%20Africa.%20Little%20is%20known%20about%20health%20care%20worker%20%28HCW%29%20perceptions%20of%20men%20as%20clients%2C%20which%20may%20directly%20affect%20the%20quality%20of%20care%20provided%2C%20and%20HCWs%26%23039%3B%20buy-in%20for%20male-specific%20interventions.%20Focus%20group%20discussions%20%28FGDs%29%20were%20conducted%20in%202016%20with%20HCWs%20from%2015%20facilities%20across%20Malawi%20and%20Mozambique%20and%20were%20originally%20conducted%20to%20evaluate%20barriers%20to%20universal%20treatment%20%28not%20HCW%20bias%29.%20FGDs%20were%20conducted%20in%20local%20languages%2C%20recorded%2C%20translated%20to%20English%2C%20and%20transcribed.%20For%20this%20study%2C%20we%20focused%20on%20HCW%20perceptions%20of%20men%20as%20HIV%20clients%20and%20any%20explicit%20bias%20against%20men%2C%20using%20inductive%20and%20deductive%20coding%20in%20Atlas.ti%20v.8%2C%20and%20analyzed%20using%20constant%20comparison%20methods.%2020%20FGDs%20with%20154%20HCWs%20working%20in%20HIV%20treatment%20clinics%20were%20included.%20Median%20age%20was%2030%20years%2C%2059%25%20were%20female%2C%20and%2043%25%20were%20providers%20versus%20support%20staff.%20HCWs%20held%20strong%20explicit%20bias%20against%20men%20as%20clients.%20Most%20HCWs%20believed%20men%20could%20easily%20navigate%20HIV%20services%20due%20to%20their%20elevated%20position%20within%20society%2C%20regardless%20of%20facility-level%20barriers%20faced.%20Men%20were%20described%20in%20pejorative%20terms%20as%20ill-informed%20and%20difficult%20clients%20who%20were%20absent%20from%20health%20systems.%20Men%20were%20largely%20seen%20as%20%26quot%3Bbad%20clients%26quot%3B%20due%20to%20assumptions%20about%20men%26%23039%3Bs%20%26%23039%3Bselfish%26%23039%3B%20and%20%26%23039%3Bprideful%26%23039%3B%20nature%2C%20resulting%20in%20little%20HCW%20sympathy%20for%20men%26%23039%3Bs%20poor%20use%20of%20care.%20Our%20study%20highlights%20a%20strong%20explicit%20bias%20against%20men%20as%20HIV%20clients%2C%20even%20when%20gender%20and%20bias%20were%20not%20the%20focus%20of%20data%20collection.%20As%20a%20result%2C%20HCWs%20may%20have%20little%20motivation%20to%20implement%20male-specific%20interventions%20or%20improve%20provider-patient%20interactions%20with%20men.%20Framing%20men%20as%20problematic%20places%20undue%20responsibility%20on%20individual%20men%20while%20minimizing%20institutional%20barriers%20that%20uniquely%20affect%20them.%20Bias%20in%20local%2C%20national%2C%20and%20global%20discourses%20about%20men%20must%20be%20immediately%20addressed.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0001356%22%2C%22ISSN%22%3A%222767-3375%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A53%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22VXJDKC43%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hermans%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHermans%2C%20Lucas%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBooysen%2C%20Petro%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoloko%2C%20Linda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAdriaanse%2C%20Marguerite%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Wet%2C%20Timothy%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Changing%20character%20and%20waning%20impact%20of%20COVID-19%20at%20a%20tertiary%20centre%20in%20Cape%20Town%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BSouthern%20African%20Journal%20of%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20550.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4102%5C%2Fsajid.v38i1.550%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4102%5C%2Fsajid.v38i1.550%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Changing%20character%20and%20waning%20impact%20of%20COVID-19%20at%20a%20tertiary%20centre%20in%20Cape%20Town%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucas%20E.%22%2C%22lastName%22%3A%22Hermans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petro%22%2C%22lastName%22%3A%22Booysen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Boloko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marguerite%22%2C%22lastName%22%3A%22Adriaanse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20J.%22%2C%22lastName%22%3A%22de%20Wet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%20R.%22%2C%22lastName%22%3A%22Lifson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naweed%22%2C%22lastName%22%3A%22Wadee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nectarios%22%2C%22lastName%22%3A%22Papavarnavas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gert%22%2C%22lastName%22%3A%22Marais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nei-Yuan%22%2C%22lastName%22%3A%22Hsiao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael-Jon%22%2C%22lastName%22%3A%22Rosslee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%22%2C%22lastName%22%3A%22Symons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20L.%22%2C%22lastName%22%3A%22Calligaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arash%22%2C%22lastName%22%3A%22Iranzadeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20J.%22%2C%22lastName%22%3A%22Wilkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ntobeko%20A.%20B.%22%2C%22lastName%22%3A%22Ntusi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Williamson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Graeme%22%2C%22lastName%22%3A%22Meintjes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Wasserman%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20emergence%20of%20genetic%20variants%20of%20SARS-CoV-2%20was%20associated%20with%20changing%20epidemiological%20characteristics%20throughout%20coronavirus%20disease%202019%20%28COVID-19%29%20pandemic%20in%20population-based%20studies.%20Individual-level%20data%20on%20the%20clinical%20characteristics%20of%20infection%20with%20different%20SARS-CoV-2%20variants%20in%20African%20countries%20is%20less%20well%20documented.%5CnOBJECTIVES%3A%20To%20describe%20the%20evolving%20clinical%20differences%20observed%20with%20the%20various%20SARS-CoV-2%20variants%20of%20concern%20and%20compare%20the%20Omicron-driven%20wave%20in%20infections%20to%20the%20previous%20Delta-driven%20wave.%5CnMETHOD%3A%20We%20performed%20a%20retrospective%20observational%20cohort%20study%20among%20patients%20admitted%20to%20a%20South%20African%20referral%20hospital%20with%20COVID-19%20pneumonia.%20Patients%20were%20stratified%20by%20epidemiological%20wave%20period%2C%20and%20in%20a%20subset%2C%20the%20variants%20associated%20with%20each%20wave%20were%20confirmed%20by%20genomic%20sequencing.%20Outcomes%20were%20analysed%20by%20Cox%20proportional%20hazard%20models.%5CnRESULTS%3A%20We%20included%201689%20patients%20were%20included%2C%20representing%20infection%20waves%20driven%20predominantly%20by%20ancestral%2C%20Beta%2C%20Delta%20and%20Omicron%20BA1%5C%2FBA2%20%26amp%3B%20BA4%5C%2FBA5%20variants.%20Crude%2028-day%20mortality%20was%2025.8%25%20%2834%5C%2F133%29%20in%20the%20Omicron%20wave%20period%20versus%2037.1%25%20%28138%5C%2F374%29%20in%20the%20Delta%20wave%20period%20%28hazard%20ratio%20%5BHR%5D%200.68%20%5B95%25%20CI%200.47-1.00%5D%20p%20%3D%200.049%29%3B%20this%20effect%20persisted%20after%20adjustment%20for%20age%2C%20gender%2C%20HIV%20status%20and%20presence%20of%20cardiovascular%20disease%20%28adjusted%20HR%20%5BaHR%5D%200.43%20%5B95%25%20CI%200.28-0.67%5D%20p%20%26lt%3B%200.001%29.%20Hospital-wide%20SARS-CoV-2%20admissions%20and%20deaths%20were%20highest%20during%20the%20Delta%20wave%20period%2C%20with%20a%20decoupling%20of%20SARS-CoV-2%20deaths%20and%20overall%20deaths%20thereafter.%5CnCONCLUSION%3A%20There%20was%20lower%20in-hospital%20mortality%20during%20Omicron-driven%20waves%20compared%20with%20the%20prior%20Delta%20wave%2C%20despite%20patients%20admitted%20during%20the%20Omicron%20wave%20being%20at%20higher%20risk.%5CnCONTRIBUTION%3A%20This%20study%20summarises%20clinical%20characteristics%20associated%20with%20SARS-CoV-2%20variants%20during%20the%20COVID-19%20pandemic%20at%20a%20South%20African%20tertiary%20hospital%2C%20demonstrating%20a%20waning%20impact%20of%20COVID-19%20on%20healthcare%20services%20over%20time%20despite%20epidemic%20waves%20driven%20by%20new%20variants.%20Findings%20suggest%20the%20absence%20of%20increasing%20virulence%20from%20later%20variants%20and%20protection%20from%20population%20and%20individual-level%20immunity.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.4102%5C%2Fsajid.v38i1.550%22%2C%22ISSN%22%3A%222313-1810%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A51%3A39Z%22%7D%7D%5D%7D
Banholzer, Nicolas; Jent, Philipp; Bittel, Pascal; Zürcher, Kathrin; Furrer, Lavinia et al. (2023). Air cleaners and respiratory infections in schools: A modeling study using epidemiological, environmental, and molecular data.
medRxiv: The Preprint Server for Health Sciences, S. 2023.12.29.23300635.
http://doi.org/10.1101/2023.12.29.23300635.
Trickey, Adam; Johnson, Leigh F.; Fung, Fai; Bonifacio, Rogerio; Iwuji, Collins et al. (2023). Associations of inter-annual rainfall decreases with subsequent HIV outcomes for persons with HIV on antiretroviral therapy in Southern Africa: a collaborative analysis of cohort studies.
BMC Infectious Diseases,
23 (1), S. 889.
http://doi.org/10.1186/s12879-023-08902-9.
Skrivankova, Veronika W.; Hossmann, Stefanie; Cornell, Morna; Ballif, Marie; Dupont, Carole et al. (2023). Authorship inequalities in global health research: the IeDEA Southern Africa collaboration.
BMJ Global Health,
8 (12), S. e013316.
http://doi.org/10.1136/bmjgh-2023-013316.
Ruffieux, Yann; Wettstein, Anja; Maartens, Gary; Folb, Naomi; Mesa-Vieira, Cristina et al. (2023). Life years lost associated with mental illness: A cohort study of beneficiaries of a South African medical insurance scheme.
Journal of Affective Disorders,
340, S. 204–212.
http://doi.org/10.1016/j.jad.2023.08.013.
Muula, Guy K.; Bosomprah, Samuel; Sinkala, Edford; Nsokolo, Bright; Musonda, Taonga et al. (2023). Hepatitis B viral replication markers and hepatic fibrosis in untreated chronic hepatitis B virus infection with and without HIV coinfection in Zambia.
AIDS (London, England),
37 (13), S. 2015–2020.
http://doi.org/10.1097/QAD.0000000000003659.
Loosli, Tom; Hossmann, Stefanie; Ingle, Suzanne M.; Okhai, Hajra; Kusejko, Katharina et al. (2023). HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis.
The Lancet. HIV,
10 (11), S. e733–e741.
http://doi.org/10.1016/S2352-3018(23)00228-X.
Metekoua, Carole; Ruffieux, Yann; Olago, Victor; Dhokotera, Tafadzwa; Egger, Matthias et al. (2023). Decreasing incidence of conjunctival squamous cell carcinoma in people with HIV in South Africa.
Journal of the National Cancer Institute,
115 (10), S. 1213–1219.
http://doi.org/10.1093/jnci/djad119.
de Beer, Shani T.; Slogrove, Amy L.; Eley, Brian; Ingle, Suzanne M.; Jones, Hayley E. et al. (2023). Change in HIV-related characteristics of children hospitalised with infectious diseases in Western Cape, South Africa, 2008-2021: a time trend analysis.
Journal of the International AIDS Society,
26 Suppl 4 (Suppl 4), S. e26151.
http://doi.org/10.1002/jia2.26151.
Slogrove, Amy L.; Bovu, Andisiwe; de Beer, Shani; Phelanyane, Florence; Williams, Paige L. et al. (2023). Maternal and birth outcomes in pregnant people with and without HIV in the Western Cape, South Africa: population-based cohort study.
AIDS (London, England).
http://doi.org/10.1097/QAD.0000000000003728.
Hansford, Harrison J.; Cashin, Aidan G.; Jones, Matthew D.; Swanson, Sonja A.; Islam, Nazrul et al. (2023). Development of the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline.
BMJ Open,
13 (9), S. e074626.
http://doi.org/10.1136/bmjopen-2023-074626.
Olago, Victor; Nimako, Gideon; Bartels, Lina; Bohlius, Julia; Dhokotera, Tafadzwa et al. (2023). Cancer diagnostic service use in people with HIV in South Africa: a cross-sectional study.
medRxiv: The Preprint Server for Health Sciences, S. 2023.09.10.23295338.
http://doi.org/10.1101/2023.09.10.23295338.
Hansford, Harrison J.; Cashin, Aidan G.; Jones, Matthew D.; Swanson, Sonja A.; Islam, Nazrul et al. (2023). Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.
JAMA Network Open,
6 (9), S. e2336023.
http://doi.org/10.1001/jamanetworkopen.2023.36023.
Zürcher, Kathrin; Abela, Irene A.; Stange, Madlen; Dupont, Carole; Mugglin, Catrina et al. (2023). Alpha Variant Coronavirus Outbreak in a Nursing Home Despite High Vaccination Coverage: Molecular, Epidemiological, and Immunological Studies.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America,
77 (4), S. 537–546.
http://doi.org/10.1093/cid/ciab1005.
Anderegg, Nanina; Schwab, Tiana; Borcard, Loïc; Mugglin, Catrina; Keune-Dübi, Bettina et al. (2023). Population-Based Severe Acute Respiratory Syndrome Coronavirus 2 Whole-Genome Sequencing and Contact Tracing During the Coronavirus Disease 2019 Pandemic in Switzerland.
The Journal of Infectious Diseases,
228 (3), S. 251–260.
http://doi.org/10.1093/infdis/jiad074.
Global variations in pubertal growth spurts in adolescents living with perinatal HIV (2023).
AIDS (London, England),
37 (10), S. 1603–1615.
http://doi.org/10.1097/QAD.0000000000003602.
Parcesepe, Angela M.; Stockton, Melissa; Remch, Molly; Wester, C. William; Bernard, Charlotte et al. (2023). Availability of screening and treatment for common mental disorders in HIV clinic settings: data from the global International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium, 2016-2017 and 2020.
Journal of the International AIDS Society,
26 (8), S. e26147.
http://doi.org/10.1002/jia2.26147.
Haas, Andreas D.; Kunzekwenyika, Cordelia; Manzero, Josphat; Hossmann, Stefanie; Limacher, Andreas et al. (2023). Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial.
JAMA Network Open,
6 (7), S. e2323205.
http://doi.org/10.1001/jamanetworkopen.2023.23205.
Person, Anna K.; Crabtree-Ramirez, Brenda; Kim, Ahra; Veloso, Valdiléa; Maruri, Fernanda et al. (2023). Cryptococcal Meningitis and Clinical Outcomes in Persons With Human Immunodeficiency Virus: A Global View.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America,
76 (12), S. 2116–2125.
http://doi.org/10.1093/cid/ciad076.
Kubjane, M.;
Cornell, M.;
Osman, M.;
Boulle, A. &
Johnson, L. F. (2023). Drivers of sex differences in the South African adult tuberculosis incidence and mortality trends, 1990-2019.
Sci Rep,
13 (1), S. 9487.
http://doi.org/10.1038/s41598-023-36432-6.
Taghavi, Katayoun; Moono, Misinzo; Mwanahamuntu, Mulindi; Roumet, Marie; Limacher, Andreas et al. (2023). Accuracy of screening tests for cervical pre-cancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia.
medRxiv : The Preprint Server for Health Sciences, S. 2023.05.31.23290779.
http://doi.org/10.1101/2023.05.31.23290779.
Dovel, K. L.; Hariprasad, S.; Hubbard, J.; Cornell, M.; Phiri, K. et al. (2023). Strategies to improve antiretroviral therapy (ART) initiation and early engagement among men in sub-Saharan Africa: A scoping review of interventions in the era of universal treatment.
Trop Med Int Health,
28 (6), S. 454–465.
http://doi.org/10.1111/tmi.13880.
Haas, A. D.; Lienhard, R.; Didden, C.; Cornell, M.; Folb, N. et al. (2023). Mental Health, ART Adherence, and Viral Suppression Among Adolescents and Adults Living with HIV in South Africa: A Cohort Study.
AIDS Behav,
27 (6), S. 1849–1861.
http://doi.org/10.1007/s10461-022-03916-x.
Kassanjee, R.; Davies, M. A.; Ngwenya, O.; Osei-Yeboah, R.; Jacobs, T. et al. (2023). COVID-19 among adults living with HIV: correlates of mortality among public sector healthcare users in Western Cape, South Africa.
J Int AIDS Soc,
26 (6), S. e26104.
http://doi.org/10.1002/jia2.26104.
Cipriani, Andrea; Seedat, Soraya; Milligan, Lea; Salanti, Georgia; Macleod, Malcolm et al. (2023). New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis.
BMJ Mental Health,
26 (1), S. e300759.
http://doi.org/10.1136/bmjment-2023-300759.
Pretsch, Peyton K.; Spees, Lisa P.; Brewer, Noel T.; Hudgens, Michael G.; Sanusi, Busola et al. (2023). Effect of HPV self-collection kits on cervical cancer screening uptake among under-screened women from low-income US backgrounds (MBMT-3): a phase 3, open-label, randomised controlled trial.
The Lancet. Public Health,
8 (6), S. e411–e421.
http://doi.org/10.1016/S2468-2667(23)00076-2.
Banholzer, N.; Zurcher, K.; Jent, P.; Bittel, P.; Furrer, L. et al. (2023). SARS-CoV-2 transmission with and without mask wearing or air cleaners in schools in Switzerland: A modeling study of epidemiological, environmental, and molecular data.
PLoS Med,
20 (5), S. e1004226.
http://doi.org/10.1371/journal.pmed.1004226.
Ruffieux, Y.; Muchengeti, M.; Olago, V.; Dhokotera, T.; Bohlius, J. et al. (2023). Age and Cancer Incidence in 5.2 Million People With Human Immunodeficiency Virus (HIV): The South African HIV Cancer Match Study.
Clin Infect Dis,
76 (8), S. 1440–1448.
http://doi.org/10.1093/cid/ciac925.
Loosli, Tom; Hossmann, Stefanie; Ingle, Suzanne M.; Okhai, Hajra; Kusejko, Katharina et al. (2023). sHIV-1 drug resistance in people on dolutegravir-based ART: Collaborative analysis of cohort studies.
medRxiv: The Preprint Server for Health Sciences, S. 2023.04.05.23288183.
http://doi.org/10.1101/2023.04.05.23288183.
Patten, G.; Sipambo, N.; Technau, K. G.; Euvrard, J.; Ford, N. et al. (2023). Ongoing High Prevalence of Severe Immune Suppression Among Children in South Africa.
J Acquir Immune Defic Syndr,
92 (4), S. 273–280.
http://doi.org/10.1097/QAI.0000000000003137.
Zwyer, M.; Rutaihwa, L. K.; Windels, E.; Hella, J.; Menardo, F. et al. (2023). Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.
PLoS Pathog,
19 (4), S. e1010893.
http://doi.org/10.1371/journal.ppat.1010893.
Vreeman, R. C.; Yiannoutsos, C. T.; Yusoff, N. K. N.; Wester, C. W.; Edmonds, A. et al. (2023). Global HIV prevention, care and treatment services for children: a cross-sectional survey from the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium.
BMJ Open,
13 (3), S. e069399.
http://doi.org/10.1136/bmjopen-2022-069399.
Anderson, K.; Iyun, V.; Eley, B. S.; Rabie, H.; Ferreira, T. et al. (2023). Hospitalization among infants who initiate antiretroviral therapy before 3 months of age.
AIDS,
37 (3), S. 435–445.
http://doi.org/10.1097/QAD.0000000000003422.
Patten, G. E.; Euvrard, J.; Anderegg, N.; Boulle, A.; Arendse, K. D. et al. (2023). Advanced HIV disease and engagement in care among patients on antiretroviral therapy in South Africa: results from a multi-state model.
AIDS,
37 (3), S. 513–522.
http://doi.org/10.1097/QAD.0000000000003442.
Ruffieux, Yann; Wettstein, Anja; Maartens, Gary; Folb, Naomi; Vieira, Cristina Mesa et al. (2023). Life-years lost associated with mental illness: a cohort study of beneficiaries of a South African medical insurance scheme.
medRxiv : The Preprint Server for Health Sciences, S. 2023.01.19.23284778.
http://doi.org/10.1101/2023.01.19.23284778.
de Waal, Renee; Rabie, Helena; Technau, Karl-Gunter; Eley, Brian; Sipambo, Nosisa et al. (2023). Abacavir safety and effectiveness in young infants with HIV in South African observational cohorts.
Antiviral Therapy,
28 (2), S. 13596535231168480.
http://doi.org/10.1177/13596535231168480.
Haas, Andreas D.; Kunzekwenyika, Cordelia; Manzero, Josphat; Hossmann, Stefanie; Limacher, Andreas et al. (2023). Effect of the Friendship Bench intervention on antiretroviral therapy outcomes and mental health symptoms in rural Zimbabwe: A cluster randomized trial.
medRxiv: The Preprint Server for Health Sciences, S. 2023.01.21.23284784.
http://doi.org/10.1101/2023.01.21.23284784.
Ross, J.; Brazier, E.; Fatti, G.; Jaquet, A.; Tanon, A. et al. (2023). Same-Day Antiretroviral Therapy Initiation as a Predictor of Loss to Follow-up and Viral Suppression Among People With Human Immunodeficiency Virus in Sub-Saharan Africa.
Clin Infect Dis,
76 (1), S. 39–47.
http://doi.org/10.1093/cid/ciac759.
Brazier, E.; Maruri, F.; Wester, C. W.; Musick, B.; Freeman, A. et al. (2023). Design and implementation of a global site assessment survey among HIV clinics participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium.
PLoS One,
18 (3), S. e0268167.
http://doi.org/10.1371/journal.pone.0268167.
Humphrey, John; Nagel, Elizabeth; Carlucci, James G.; Edmonds, Andrew; Kinikar, Aarti et al. (2023). Integration of HIV care into maternal and child health services in the global IeDEA consortium.
Frontiers in Global Women’s Health,
4, S. 1066297.
http://doi.org/10.3389/fgwh.2023.1066297.
Matzopoulos, Richard; Prinsloo, Megan R.; Mhlongo, Shibe; Marineau, Lea; Cornell, Morna et al. (2023). South Africa’s male homicide epidemic hiding in plain sight: Exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations.
PLOS Global Public Health,
3 (11), S. e0002595.
http://doi.org/10.1371/journal.pgph.0002595.
Dovel, Kathryn; Paneno, Rose; Balakasi, Kelvin; Hubbard, Julie; Magaço, Amílcar et al. (2023). Health care workers’ perceptions and bias toward men as HIV clients in Malawi and Mozambique: A qualitative study.
PLOS Global Public Health,
3 (10), S. e0001356.
http://doi.org/10.1371/journal.pgph.0001356.
Hermans, Lucas E.; Booysen, Petro; Boloko, Linda; Adriaanse, Marguerite; de Wet, Timothy J. et al. (2023). Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa.
Southern African Journal of Infectious Diseases,
38 (1), S. 550.
http://doi.org/10.4102/sajid.v38i1.550.
2022
Nyemba, D. C.; Kalk, E.; Vinikoor, M. J.; Madlala, H. P.; Mubiana-Mbewe, M. et al. (2022). Growth patterns of infants with in- utero HIV and ARV exposure in Cape Town, South Africa and Lusaka, Zambia. BMC Public Health, 22 (1), S. 55. http://doi.org/10.1186/s12889-021-12476-z.
Davies, M. A.; Kassanjee, R.; Rosseau, P.; Morden, E.; Johnson, L. et al. (2022). Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa. MedRxiv, S. 2022.01.12.22269148. http://doi.org/10.1101/2022.01.12.22269148.
Dhokotera, T.; Asangbeh, S.; Bohlius, J.; Singh, E.; Egger, M. et al. (2022). Cervical cancer in women living in South Africa: a record linkage study of the National Health Laboratory Service and the National Cancer Registry. Ecancermedicalscience, 16, S. 1348. http://doi.org/10.3332/ecancer.2022.1348.
Cassidy, T.; Cornell, M.; Runeyi, P.; Dutyulwa, T.; Kilani, C. et al. (2022). Attrition from HIV care among youth initiating ART in youth-only clinics compared with general primary healthcare clinics in Khayelitsha, South Africa: a matched propensity score analysis. J Int AIDS Soc, 25 (1), S. e25854. http://doi.org/10.1002/jia2.25854.
Nyakato, P.; Schomaker, M.; Fatti, G.; Tanser, F.; Euvrard, J. et al. (2022). Virologic non-suppression and early loss to follow up among pregnant and non-pregnant adolescents aged 15-19 years initiating antiretroviral therapy in South Africa: a retrospective cohort study. J Int AIDS Soc, 25 (1), S. e25870. http://doi.org/10.1002/jia2.25870.
Romo, M. L.; Patel, R. C.; Edwards, J. K.; Humphrey, J. M.; Musick, B. S. et al. (2022). Disparities in Dolutegravir Uptake Affecting Females of Reproductive Age With HIV in Low- and Middle-Income Countries After Initial Concerns About Teratogenicity : An Observational Study. Ann Intern Med, 175 (1), S. 84–94. http://doi.org/10.7326/M21-3037.
Taghavi, K.; Mandiriri, A.; Shamu, T.; Rohner, E.; Butikofer, L. et al. (2022). Cervical Cancer Screening Cascade for women living with HIV: a cohort study from Zimbabwe. PLOS Glob Public Health, 2 (2), S. e0000156. http://doi.org/10.1371/journal.pgph.0000156.
Collaborative Initiative for Paediatric, H. I. V. Education; Research Global Cohort, Collaboration; Jesson, J.; Crichton, S.; Quartagno, M. et al. (2022). Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis. J Int AIDS Soc, 25 (3), S. e25871. http://doi.org/10.1002/jia2.25871.
Riebensahm, C.; Chitundu, H.; Muula, G.; Chihota, B.; Sinkala, E. et al. (2022). Screening for hepatocellular carcinoma among adults with HIV/HBV co-infection in Zambia: a pilot study. Int J Infect Dis, 116, S. 391–396. http://doi.org/10.1016/j.ijid.2021.12.338.
Davies, C.; Johnson, L.; Sawry, S.; Chimbetete, C.; Eley, B. et al. (2022). Effect of antiretroviral therapy care interruptions on mortality in children living with HIV. AIDS, 36 (5), S. 729–737. http://doi.org/10.1097/QAD.0000000000003194.
Muchengeti, M.; Bartels, L.; Olago, V.; Dhokotera, T.; Chen, W. C. et al. (2022). Cohort profile: the South African HIV Cancer Match (SAM) Study, a national population-based cohort. BMJ Open, 12 (4), S. e053460. http://doi.org/10.1136/bmjopen-2021-053460.
Antimycobacterial Susceptibility Testing, Group (2022). Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment. Eur Respir J, 59 (4), S. 2200166. http://doi.org/10.1183/13993003.00166-2022.
Justice, A. C.; Goetz, M. B.; Stewart, C. N.; Hogan, B. C.; Humes, E. et al. (2022). Delayed presentation of HIV among older individuals: a growing problem. Lancet HIV, 9 (4), S. e269–e280. http://doi.org/10.1016/S2352-3018(22)00003-0.
Staub, K.; Panczak, R.; Matthes, K. L.; Floris, J.; Berlin, C. et al. (2022). Historically High Excess Mortality During the COVID-19 Pandemic in Switzerland, Sweden, and Spain. Ann Intern Med, 175 (4), S. 523–532. http://doi.org/10.7326/M21-3824.
Zurcher, K.; Riou, J.; Morrow, C.; Ballif, M.; Koch, A. et al. (2022). Estimating Tuberculosis Transmission Risks in a Primary Care Clinic in South Africa: Modeling of Environmental and Clinical Data. J Infect Dis, 225 (9), S. 1642–1652. http://doi.org/10.1093/infdis/jiab534.
Hussey, H.; Davies, M. A.; Heekes, A.; Williamson, C.; Valley-Omar, Z. et al. (2022). Assessing the clinical severity of the Omicron variant in the Western Cape Province, South Africa, using the diagnostic PCR proxy marker of RdRp target delay to distinguish between Omicron and Delta infections – a survival analysis. Int J Infect Dis, 118, S. 150–154. http://doi.org/10.1016/j.ijid.2022.02.051.
van der Hoven, J.; Allen, E.; Cois, A.; de Waal, R.; Maartens, G. et al. (2022). Determining antenatal medicine exposures in South African women: a comparison of three methods of ascertainment. BMC Pregnancy Childbirth, 22 (1), S. 466. http://doi.org/10.1186/s12884-022-04765-1.
Wettstein, A.; Tlali, M.; Joska, J. A.; Cornell, M.; Skrivankova, V. W. et al. (2022). The effect of the COVID-19 lockdown on mental health care use in South Africa: an interrupted time-series analysis. Epidemiol Psychiatr Sci, 31, S. e43. http://doi.org/10.1017/S2045796022000270.
Kalk, E.; Heekes, A.; Slogrove, A. L.; Phelanyane, F.; Davies, M. A. et al. (2022). Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER). BMJ Open, 12 (6), S. e060205. http://doi.org/10.1136/bmjopen-2021-060205.
Chihota, B. V.; Riebensahm, C.; Muula, G.; Sinkala, E.; Chilengi, R. et al. (2022). Liver steatosis and metabolic dysfunction-associated fatty liver disease among HIV-positive and negative adults in urban Zambia. BMJ Open Gastroenterol, 9 (1), S. e000945. http://doi.org/10.1136/bmjgast-2022-000945.
Lewis, J. T.; Stephens, J.; Musick, B.; Brown, S.; Malateste, K. et al. (2022). The IeDEA harmonist data toolkit: A data quality and data sharing solution for a global HIV research consortium. J Biomed Inform, 131, S. 104110. http://doi.org/10.1016/j.jbi.2022.104110.
Romo, M. L.; Brazier, E.; Mahambou-Nsonde, D.; De Waal, R.; Sekaggya-Wiltshire, C. et al. (2022). Real-world use and outcomes of dolutegravir-containing antiretroviral therapy in HIV and tuberculosis co-infection: a site survey and cohort study in sub-Saharan Africa. J Int AIDS Soc, 25 (7), S. e25961. http://doi.org/10.1002/jia2.25961.
Asangbeh-Kerman, S. L.; Davidovic, M.; Taghavi, K.; Kachingwe, J.; Rammipi, K. M. et al. (2022). Cervical cancer prevention in countries with the highest HIV prevalence: a review of policies. BMC Public Health, 22 (1), S. 1530. http://doi.org/10.1186/s12889-022-13827-0.
Christ, B.; van Dijk, J. H.; Nyandoro, T. Y.; Reichmuth, M. L.; Kunzekwenyika, C. et al. (2022). Availability and experiences of differentiated antiretroviral therapy delivery at HIV care facilities in rural Zimbabwe: a mixed-method study. J Int AIDS Soc, 25 (8), S. e25944. http://doi.org/10.1002/jia2.25944.
Hauser, A.; Goldstein, F.; Reichmuth, M. L.; Kouyos, R. D.; Wandeler, G. et al. (2022). Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis. J Clin Epidemiol, 148, S. 135–145. http://doi.org/10.1016/j.jclinepi.2022.02.005.
Edmonds, A.; Brazier, E.; Musick, B. S.; Yotebieng, M.; Humphrey, J. et al. (2022). Clinical and programmatic outcomes of HIV-exposed infants enrolled in care at geographically diverse clinics, 1997-2021: A cohort study. PLoS Med, 19 (9), S. e1004089. http://doi.org/10.1371/journal.pmed.1004089.
Kubjane, M.; Osman, M.; Boulle, A. & Johnson, L. F. (2022). The impact of HIV and tuberculosis interventions on South African adult tuberculosis trends, 1990-2019: a mathematical modeling analysis. Int J Infect Dis, 122, S. 811–819. http://doi.org/10.1016/j.ijid.2022.07.047.
Wada, P. Y.; Kim, A.; Jayathilake, K.; Duda, S. N.; Abo, Y. et al. (2022). Site-Level Comprehensiveness of Care Is Associated with Individual Clinical Retention Among Adults Living with HIV in International Epidemiology Databases to Evaluate AIDS, a Global HIV Cohort Collaboration, 2000-2016. AIDS Patient Care STDS, 36 (9), S. 343–355. http://doi.org/10.1089/apc.2022.0042.
Kalua, T.; Egger, M.; Jahn, A.; Chimpandule, T.; Kolola, R. et al. (2022). HIV suppression was maintained during the COVID-19 pandemic in Malawi: a program-level cohort study. J Clin Epidemiol, 150, S. 116–125. http://doi.org/10.1016/j.jclinepi.2022.06.019.
Marti, M.; Zurcher, K.; Enane, L. A.; Diero, L.; Marcy, O. et al. (2022). Impact of the COVID-19 pandemic on TB services at ART programmes in low- and middle-income countries: a multi-cohort survey. J Int AIDS Soc, 25 (10), S. e26018. http://doi.org/10.1002/jia2.26018.
Shamu, T.; Rohner, E.; Chokunonga, E.; Spoerri, A.; Mandiriri, A. et al. (2022). Cancer incidence among people living with HIV in Zimbabwe: A record linkage study. Cancer Rep (Hoboken), 5 (10), S. e1597. http://doi.org/10.1002/cnr2.1597.
Turdo, Y. Q.; Ruffieux, Y.; Boshomane, T. M. G.; Mouton, H.; Taghavi, K. et al. (2022). Cancer treatment and survival among cervical cancer patients living with or without HIV in South Africa. Gynecol Oncol Rep, 43, S. 101069. http://doi.org/10.1016/j.gore.2022.101069.
Iskandar, R.; Taghavi, K.; Low, N.; Bramer, W. M.; Egger, M. et al. (2022). Mathematical Models for Evaluating Effectiveness and Cost-Effectiveness of Cervical Cancer Control Policies in Populations Including Women Living With Human Immunodeficiency Virus: A Scoping Review. Value Health Reg Issues, 32, S. 39–46. http://doi.org/10.1016/j.vhri.2022.07.001.
Tlali, M.; Scheibe, A.; Ruffieux, Y.; Cornell, M.; Wettstein, A. E. et al. (2022). Diagnosis and treatment of opioid-related disorders in a South African private sector medical insurance scheme: A cohort study. Int J Drug Policy, 109, S. 103853. http://doi.org/10.1016/j.drugpo.2022.103853.
Nyakato, P.; Christ, B.; Anderegg, N.; Muhairwe, J.; Jefferys, L. et al. (2022). High Unreported Mortality in Children and Youth (<25 Years) Living With HIV Who Were Lost to Care From Antiretroviral Therapy Programs in Southern Africa: Results From a Multicountry Tracing Study. J Acquir Immune Defic Syndr, 91 (5), S. 429–433. http://doi.org/10.1097/QAI.0000000000003090.
Brazier, E.; Ajeh, R.; Maruri, F.; Musick, B.; Freeman, A. et al. (2022). Service delivery challenges in HIV care during the first year of the COVID-19 pandemic: results from a site assessment survey across the global IeDEA consortium. J Int AIDS Soc, 25 (12), S. e26036. http://doi.org/10.1002/jia2.26036.
Chihota, B. V.; Mandiriri, A.; Shamu, T.; Muula, G.; Nyamutowa, H. et al. (2022). Metabolic syndrome among treatment-naive people living with and without HIV in Zambia and Zimbabwe: a cross-sectional analysis. J Int AIDS Soc, 25 (12), S. e26047. http://doi.org/10.1002/jia2.26047.
McCann, N. C.; Stanic, T.; Penazzato, M.; Flanagan, C. F.; Abrams, E. J. et al. (2022). Prevalence of undiagnosed HIV among children in South Africa, Cote d’Ivoire and Zimbabwe: a model-based analysis to inform paediatric HIV screening programmes. J Int AIDS Soc, 25 (12), S. e26045. http://doi.org/10.1002/jia2.26045.
Zurcher, K.; Cox, S. R.; Ballif, M.; Enane, L. A.; Marcy, O. et al. (2022). Integrating services for HIV and multidrug-resistant tuberculosis: A global cross-sectional survey among ART clinics in low- and middle-income countries. PLOS Glob Public Health, 2 (3), S. e0000180. http://doi.org/10.1371/journal.pgph.0000180.
2021
Anderson, K.; Mutemaringa, T.; Technau, K. G.; Johnson, L. F.; Braithwaite, K. et al. (2021). The next generation: Pregnancy in adolescents and women living with perinatally acquired HIV in South Africa. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 111 (3), S. 260–264. http://doi.org/10.7196/SAMJ.2021.v111i3.14987.
Brazier, Ellen; Tymejczyk, Olga; Zaniewski, Elizabeth; Egger, Matthias; Wools-Kaloustian, Kara et al. (2021). Effects of national adoption of Treat-All guidelines on pre-ART CD4 testing and viral load monitoring after ART initiation: A regression discontinuity analysis. Clinical Infectious Diseases, S. ciab222. http://doi.org/10.1093/cid/ciab222.
Nyemba, Dorothy C.; Kalk, Emma; Madlala, Hlengiwe P.; Malaba, Thokozile R.; Slogrove, Amy L. et al. (2021). Lower birth weight-for-age and length-for-age z-scores in infants with in-utero HIV and ART exposure: a prospective study in Cape Town, South Africa. BMC Pregnancy and Childbirth, 21 (1), S. 354. http://doi.org/10.1186/s12884-021-03836-z.
Timire, Collins; Ngwenya, Mkhokheli; Chirenda, Joconiah; Metcalfe, John Z.; Kranzer, Katharina et al. (2021). Catastrophic costs among tuberculosis-affected households in Zimbabwe: a national health facility-based survey. Tropical Medicine & International Health: TM & IH. http://doi.org/10.1111/tmi.13647.
Haas, Andreas D.; Kunzekwenyika, Cordelia; Hossmann, Stefanie; Manzero, Josphat; van Dijk, Janneke et al. (2021). Symptoms of common mental disorders and adherence to antiretroviral therapy among adults living with HIV in rural Zimbabwe: a cross-sectional study. BMJ Open, 11 (7), S. e049824. http://doi.org/10.1136/bmjopen-2021-049824.
Zaniewski, Elizabeth; Brazier, Ellen; Ostinelli, Cam Ha Dao; Wood, Robin; Osler, Meg et al. (2021). Regression discontinuity analysis demonstrated varied effect of Treat-All on CD4 testing among Southern African countries. Journal of Clinical Epidemiology, S. S0895- 4356(21)00281- X. http://doi.org/10.1016/j.jclinepi.2021.09.001.
Jaquet, Antoine; Muula, Guy; Ekouevi, Didier K. & Wandeler, Gilles (2021). Elimination of Viral Hepatitis in Low and Middle-Income Countries: Epidemiological Research Gaps. Current Epidemiology Reports, 8 (3), S. 89–96. http://doi.org/10.1007/s40471-021-00273-6.
Johnson, Leigh F.; Kariminia, Azar; Trickey, Adam; Yiannoutsos, Constantin T.; Ekouevi, Didier K. et al. (2021). Achieving consistency in measures of HIV-1 viral suppression across countries: derivation of an adjustment based on international antiretroviral treatment cohort data. Journal of the International AIDS Society, 24 Suppl 5, S. e25776. http://doi.org/10.1002/jia2.25776.
Stover, John; Glaubius, Robert; Kassanjee, Reshma & Dugdale, Caitlin M. (2021). Updates to the Spectrum/AIM model for the UNAIDS 2020 HIV estimates. Journal of the International AIDS Society, 24 Suppl 5, S. e25778. http://doi.org/10.1002/jia2.25778.
Riou, Julien; Dupont, Carole; Bertagnolio, Silvia; Gupta, Ravindra K.; Kouyos, Roger D. et al. (2021). Drivers of HIV-1 drug resistance to non-nucleoside reverse-transcriptase inhibitors (NNRTIs) in nine southern African countries: a modelling study. BMC Infectious Diseases, 21 (1), S. 1042. http://doi.org/10.1186/s12879-021-06757-6.
Dhokotera, Tafadzwa; Bohlius, Julia; Egger, Matthias; Spoerri, Adrian; Ncayiyana, Jabulani Ronnie et al. (2021). Cancer in HIV-positive and HIV-negative adolescents and young adults in South Africa: a cross-sectional study. BMJ Open, 11 (10), S. e043941. http://doi.org/10.1136/bmjopen-2020-043941.
Shamu, Tinei; Rohner, Eliane; Chokunonga, Eric; Spoerri, Adrian; Mandiriri, Ardele et al. (2021). Cancer incidence among people living with HIV in Zimbabwe: A record linkage study. Cancer Reports (Hoboken, N.J.), S. e1597. http://doi.org/10.1002/cnr2.1597.
Ballif, Marie; Christ, Benedikt; Anderegg, Nanina; Chammartin, Frédérique & Muhairwe, Josephine (2021). Tracing people living with HIV who are lost to follow-up at ART programs in Southern Africa: A sampling-based cohort study in six countries. http://doi.org/10.1093/cid/ciab428.
Cornell, Morna; Majola, Mandla; Johnson, Leigh F. & Dubula-Majola, Vuyiseka (2021). HIV services in sub-Saharan Africa: the greatest gap is men. The Lancet. http://doi.org/10.1016/S0140-6736(21)01163-6.
Haas, Andreas D.; Kunzekwenyika, Cordelia; Hossmann, Stefanie; Manzero, Josphat; Dijk et al. (2021). Symptoms of common mental disorders and adherence to antiretroviral therapy among adults living with HIV in rural Zimbabwe: a cross-sectional study. BMJ Open, 11 (7), S. 049824. http://doi.org/10.1136/bmjopen-2021-049824.
Han, Win Min; Law, Matthew G.; Egger, Matthias; Wools-Kaloustian, Kara; Moore, Richard et al. (2021). Global estimates of viral suppression in children and adolescents and adults on antiretroviral therapy adjusted for missing viral load measurements: a multiregional, retrospective cohort study in 31 countries. The Lancet HIV, 8 (12), S. e766–e775. http://doi.org/10.1016/S2352-3018(21)00265-4.
Hussey, Hannah; Zinyakatira, Nesbert; Morden, Erna; Ismail, Muzzammil; Paleker, Masudah et al. (2021). Higher COVID-19 mortality in low-income communities in the City of Cape Town – a descriptive ecological study. Gates Open Research, 5, S. 90. http://doi.org/10.12688/gatesopenres.13288.1.
Iyun, Victoria; Technau, Karl-Gunter; Vinikoor, Michael; Yotebieng, Marcel & Vreeman, Rachel (2021). Variations in the characteristics and outcomes of children living with HIV following universal ART in sub-Saharan Africa (2006-17): a retrospective cohort study. The Lancet. HIV. http://doi.org/10.1016/S2352-3018(21)00004-7.
Kassanjee, Reshma; Johnson, Leigh F.; Zaniewski, Elizabeth; Ballif, Marie; Christ, Benedikt et al. (2021). Global HIV mortality trends among children on antiretroviral treatment corrected for under‐reported deaths: an updated analysis of the International epidemiology Databases to Evaluate AIDS collaboration. Journal of the International AIDS Society, 24 (S5). http://doi.org/10.1002/jia2.25780.
McMahon, Devon E.; Semeere, Aggrey; Laker-Oketta, Miriam; Byakwaga, Helen & Mugglin, Catrina (2021). Global disparities in skin cancer services at HIV treatment centers across 29 countries. The Journal of Investigative Dermatology. http://doi.org/10.1016/j.jid.2021.02.758.
Muchengeti, Mazvita; Bohlius, Julia & Dhokotera, Tafadzwa G. (2021). Conjunctival cancer in people living with HIV. Current Opinion in Infectious Diseases, 34 (1), S. 1–7. http://doi.org/10.1097/QCO.0000000000000705.
Mugglin, Catrina; Kläger, Delia; Gueler, Aysel; Vanobberghen, Fiona & Rice, Brian (2021). The HIV care cascade in sub‐Saharan Africa: systematic review of published criteria and definitions. Journal of the International AIDS Society, 24 (7). http://doi.org/10.1002/jia2.25761.
Nyakato, Patience; Schomaker, Michael; Sipambo, Nosisa; Technau, Karl-Günter & Fatti, Geoffrey (2021). Virologic response of adolescents living with perinatally acquired HIV receiving antiretroviral therapy in the period of early adolescence (10-14 years) in South Africa In AIDS. London, England. http://doi.org/10.1097/QAD.0000000000002818.
Osman, Muhammad; Meehan, Sue-Ann; Delft; Arne, Du Preez; Karen, Dunbar et al. (2021). Early mortality in tuberculosis patients initially lost to follow up following diagnosis in provincial hospitals and primary health care facilities in Western Cape, South Africa. PloS One, 16 (6), S. 0252084. http://doi.org/10.1371/journal.pone.0252084.
Riebensahm, C.; Chitundu, H.; Muula, G.; Chihota, B.; Sinkala, E. et al. (2021). Screening for Hepatocellular Carcinoma among adults with HIV/Hepatitis B coinfection in Zambia: A Pilot Study. International Journal of Infectious Diseases, S. S1201971221012388. http://doi.org/10.1016/j.ijid.2021.12.338.
Ruffieux, Yann; Dhokotera, Tafadzwa; Muchengeti, Mazvita; Bartels, Lina & Olago, Victor (2021). Cancer risk in adolescents and young adults living with HIV in South Africa: a nationwide cohort study. The Lancet HIV. http://doi.org/10.1016/S2352-3018(21)00158-2.
Ruffieux, Y.; Muchengeti, M.; Egger, M.; Efthimiou, O. & Bartels, L. (2021). Immunodeficiency and Cancer in 3.5 Million People Living with Human Immunodeficiency Virus: the South African HIV Cancer Match Study. Clinical Infectious Diseases. http://doi.org/10.1093/cid/ciab087.
Ruffieux, Y.; Efthimiou, O.; Heuvel, L. L.; Joska, J. A. & Cornell, M. (2021). The treatment gap for mental disorders in adults enrolled in HIV treatment programmes in South Africa: a cohort study using linked electronic health records. Epidemiology and Psychiatric Sciences, 30, S. 37. http://doi.org/10.1017/S2045796021000196.
Tafadzwa, Dhokotera; Julien, Riou; Lina, Bartels; Eliane, Rohner & Frederique, Chammartin (2021). Spatiotemporal modelling and mapping of cervical cancer incidence among HIV positive women in South Africa: a nationwide study. International Journal of Health Geographics, 20 (1), S. 30. http://doi.org/10.1186/s12942-021-00283-z.
Tsondai, Priscilla Ruvimbo; Davies, Mary-Ann; Singtoroj, Thida; Maxwell, Nicola & McGowan, Catherine C. (2021). Improving Methods to Classify Perinatal versus Nonperinatal HIV Acquisition in Young Adolescents 10-14 Years of Age. The Pediatric Infectious Disease Journal. http://doi.org/10.1097/INF.0000000000003059.
Ujeneza, Eva Liliane; Ndifon, Wilfred; Sawry, Shobna; Fatti, Geoffrey & Riou, Julien (2021). A mechanistic model for long-term immunological outcomes in South African HIV-infected children and adults receiving ART. ELife, 10. http://doi.org/10.7554/eLife.42390.
Zürcher, Kathrin; Reichmuth, Martina L.; Ballif, Marie; Loiseau, Chloé; Borrell, Sonia et al. (2021). Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study. The Lancet Microbe, 2 (7), S. e320–e330. http://doi.org/10.1016/S2666-5247(21)00044-6.
2020
Boulle, Andrew; Davies, Mary-Ann; Hussey, Hannah; Ismail, Muzzammil; Morden, Erna et al. (2020). Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa. Clinical Infectious Diseases. http://doi.org/10.1093/cid/ciaa1198.
Desmonde, Sophie; Ciaranello, Andrea L.; Malateste, Karen; Musick, Beverly; Patten, Gabriela et al. (2020). Age-specific mortality rate ratios in adolescents and youth aged 10–24 years living with perinatally versus non-perinatally-acquired HIV. AIDS, Publish Ahead of Print. http://doi.org/10.1097/QAD.0000000000002765.
Anderegg, Nanina; Hector, Jonas; Jefferys, Laura F.; Burgos-Soto, Juan & Hobbins, Michael A. (2020). Loss to follow-up correction increased mortality estimates in HIV–positive people on antiretroviral therapy in Mozambique. Journal of Clinical Epidemiology, 128, S. 83–92. http://doi.org/10.1016/j.jclinepi.2020.08.012.
Beer; Shani, Kalk; Emma, Kroon; Max, Boulle; Andrew, Osler et al. (2020). A longitudinal analysis of the completeness of maternal HIV testing, including repeat testing in Cape Town, South Africa. Journal of the International AIDS Society, 23 (1). http://doi.org/10.1002/jia2.25441.
Bell-Gorrod, Helen; Fox, Matthew P.; Boulle, Andrew; Prozesky, Hans & Wood, Robin (2020). The Impact of Delayed Switch to Second-Line Antiretroviral Therapy on Mortality, Depending on Failure Time Definition and CD4 Count at Failure. American Journal of Epidemiology. http://doi.org/10.1093/aje/kwaa049.
Boulle, Andrew; Davies, Mary-Ann; Hussey, Hannah; Ismail, Muzzammil & Morden, Erna (2020). Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa. Clinical Infectious Diseases. http://doi.org/10.1093/cid/ciaa1198.
Chammartin, Frédérique; Ostinelli, Dao; Ha, Cam; Anastos, Kathryn; Jaquet, Antoine et al. (2020). International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019. BMJ Open, 10 (5). http://doi.org/10.1136/bmjopen-2019-035246.
Chimbetete, Cleophas; Shamu, Tinei & Keiser, Olivia (2020). Zimbabwe’s national third-line antiretroviral therapy program: Cohort description and treatment outcomes. PloS One, 15 (3), S. 0228601. http://doi.org/10.1371/journal.pone.0228601.
Desmonde, Sophie; Neilan, Anne M.; Musick, Beverly; Patten, Gabriela & Chokephaibulkit, Kulkanya (2020). Time-varying age- and CD4-stratified rates of mortality and WHO stage 3 and stage 4 events in children, adolescents and youth 0 to 24 years living with perinatally acquired HIV, before and after antiretroviral therapy initiation in the paediatric IeDEA Gl. Journal of the International AIDS Society, 23 (10), S. 25617– 25617. http://doi.org/10.1002/jia2.25617.
Dovel, Kathryn; Dworkin, Shari L.; Cornell, Morna; Coates, Thomas J. & Yeatman, Sara (2020). Gendered health institutions: examining the organization of health services and men’s use of HIV testing in Malawi. Journal of the International AIDS Society, 23 (S2). http://doi.org/10.1002/jia2.25517.
Gorrod, Bell; Helen, Court; Richard, Schomaker; Michael, Maartens; Gary et al. (2020). Increased Mortality With Delayed and Missed Switch to Second-Line Antiretroviral Therapy in South Africa. Journal of Acquired Immune Deficiency Syndromes, 84 (1), S. 107–113. http://doi.org/10.1097/QAI.0000000000002313.
Haas, Andreas D.; Ruffieux, Yann; Heuvel; Luella, Leigh; Lund, Crick et al. (2020). Excess mortality associated with mental illness in people living with HIV in Cape Town, South Africa: a cohort study using linked electronic health records. The Lancet Global Health, 8 (10), S. 1326– 1334. http://doi.org/10.1016/S2214-109X(20)30279-5.
Haas, Andreas D.; Technau, Karl‐Günter; Pahad, Shenaaz; Braithwaite, Kate & Madzivhandila, Mampho (2020). Mental health, substance use and viral suppression in adolescents receiving ART at a paediatric HIV clinic in South Africa. Journal of the International AIDS Society, 23 (12). http://doi.org/10.1002/jia2.25644.
Harezlak, Jaroslaw; Sarwat, Samiha; Wools-Kaloustian, Kara; Schomaker, Michael & Balestre, Eric (2020). PS-SiZer map to investigate significant features of body-weight profile changes in HIV infected patients in the IeDEA Collaboration. PLoS ONE, 15, S. 5. http://doi.org/10.1371/journal.pone.0220165.
Hauser, Anthony; Kusejko, Katharina; Johnson, Leigh F.; Günthard, Huldrych F. & Riou, Julien (2020). Impact of scaling up dolutegravir on antiretroviral resistance in South Africa: A modeling study. PLOS Medicine, 17 (12), S. 1003397– 1003397. http://doi.org/10.1371/journal.pmed.1003397.
IeDEA & EuroCoord Cohort Collaboration, C. O. H. E. R. E. (2020). All-cause mortality after antiretroviral therapy initiation in HIV-positive women from Europe, Sub-Saharan Africa and the Americas. AIDS, 34 (2), S. 277–289. http://doi.org/10.1097/QAD.0000000000002399.
Jacob, Nisha; Rice, Brian; Kalk, Emma; Heekes, Alexa & Morgan, Jennie (2020). Utility of digitising point of care HIV test results to accurately measure, and improve performance towards, the UNAIDS 90-90-90 targets. PloS One, 15 (6), S. 0235471– 0235471. http://doi.org/10.1371/journal.pone.0235471.
Jacob, Nisha; Rice, Brian; Kalk, Emma; Heekes, Alexa & Morgan, Jennie (2020). Consolidating strategic information to monitor progress against the UNAIDS 90-90-90 targets: evaluating the operational feasibility of an electronic HIV testing register in Cape Town, South Africa. BMC Health Services Research, 20 (1), S. 720–720. http://doi.org/10.1186/s12913-020-05517-7.
Jesson, Julie; Desmonde, Sophie; Yiannoutsos, Constantin T.; Patten, Gabriela & Malateste, Karen (2020). Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium. BMC Research Notes, 13 (1), S. 249–249. http://doi.org/10.1186/s13104-020-05081-7.
Johnson, Leigh F.; Mutemaringa, Themba; Mutemaringa, Themba; Heekes, Alexa & Heekes, Alexa (2020). Effect of HIV Infection and Antiretroviral Treatment on Pregnancy Rates in the Western Cape Province of South Africa. Journal of Infectious Diseases, 221 (12), S. 1953–1962. http://doi.org/10.1093/infdis/jiz362.
Johnson, Leigh F.; Patrick, Mark; Stephen, Cindy; Patten, Gabriela & Dorrington, Rob E. (2020). Steep Declines in Pediatric AIDS Mortality in South Africa, Despite Poor Progress Toward Pediatric Diagnosis and Treatment Targets. Pediatric Infectious Disease Journal, 39 (9), S. 843–848. http://doi.org/10.1097/inf.0000000000002680.
Kalk, Emma; Heekes, Alexa; Mehta, Ushma; Waal; Renee, Jacob et al. (2020). Safety and Effectiveness of Isoniazid Preventive Therapy in HIV-Positive Pregnant Women on Art: An Observational Study using Linked Population Data. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. http://doi.org/10.1093/cid/ciz1224.
Kehoe, Kathleen; Boulle, Andrew; Tsondai, Priscilla R.; Euvrard, Jonathan & Davies, Mary Ann (2020). Long‐term virologic responses to antiretroviral therapy among HIV‐positive patients entering adherence clubs in Khayelitsha, Cape Town, South Africa: a longitudinal analysis. Journal of the International AIDS Society, 23 (5). http://doi.org/10.1002/jia2.25476.
Loiseau, Chloé; Brites, Daniela; Reinhard, Miriam; Zürcher, Kathrin & Borrell, Sonia (2020). HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. http://doi.org/10.1128/AAC.00782-20.
Lurie, Mark N.; Kirwa, Kipruto; Callaway, Julia; Cornell, Morna & Boulle, Andrew (2020). Quantifying the HIV treatment cascade in a South African health sub-district by gender: retrospective cohort study. Tropical Medicine and International Health, 25 (2), S. 186–192. http://doi.org/10.1111/tmi.13334.
Makusha, Tawanda; Rooyen; Heidi & Cornell, Morna (2020). Reframing the approach to heterosexual men in the HIV epidemic in sub-Saharan Africa. Journal of the International AIDS Society, 2 (S2), S. 25510– 25510. http://doi.org/10.1002/jia2.25510.
Nyakato, Patience; Davies, Mary Ann; Technau, Karl Gunter; Fatti, Geoffrey & Rabie, Helena (2020). Virologic response to efavirenz-based firstline antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. PLoS ONE, 15, S. 5. http://doi.org/10.1371/journal.pone.0233693.
Osler, Meg; Cornell, Morna; Ford, Nathan; Hilderbrand, Katherine & Goemaere, Eric (2020). Population-wide differentials in HIV service access and outcomes in the Western Cape for men as compared to women, South Africa: 2008 to 2018: a cohort analysis. Journal of the International AIDS Society, 2 (S2), S. 25530– 25530. http://doi.org/10.1002/jia2.25530.
Parcesepe, Angela M.; Lancaster, Kathryn; Edelman, E. Jennifer; DeBoni, Raquel & Ross, Jeremy (2020). Substance use service availability in HIV treatment programs: Data from the global IeDEA consortium, 2014-2015 and 2017. PLoS ONE, 15, S. 0237772– 0237772. http://doi.org/10.1371/journal.pone.0237772.
Patel, Kunjal; Smith, Colette; Collins, Intira Jeannie; Goodall, Ruth & Abrams, Elaine J. (2020). Outcomes of second-line antiretroviral therapy among children living with HIV: a global cohort analysis. Journal of the International AIDS Society, 23 (4). http://doi.org/10.1002/jia2.25477.
Patten, Gabriela; Puthanakit, Thanyawee; McGowan, Catherine C.; Wools-Kaloustian, Kara & Hazra, Rohan (2020). Raltegravir use and outcomes among children and adolescents living with HIV in the IeDEA global consortium. Journal of the International AIDS Society, 23 (7). http://doi.org/10.1002/jia2.25580.
Pillay, Tameryn; Cornell, Morna; Fox, Matthew P.; Euvrard, Jonathan; Fatti, Geoffrey et al. (2020). Recording of HIV viral loads and viral suppression in South African patients receiving antiretroviral treatment: a multicentre cohort study. Antiviral Therapy. https://doi.org/10.3851/IMP3371.
Reichmuth, Martina L.; Hömke, Rico; Zürcher, Kathrin; Sander, Peter & Avihingsanon, Anchalee (2020). Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients. Antimicrobial Agents and Chemotherapy, 64 (11). http://doi.org/10.1128/AAC.00513-20.
Rohner, Eliane; Bütikofer, Lukas; Schmidlin, Kurt; Sengayi, Mazvita & Maskew, Mhairi (2020). Cervical cancer risk in women living with HIV across four continents: A multicohort study. International Journal of Cancer, 146 (3), S. 601–609. http://doi.org/10.1002/ijc.32260.
Taghavi, Katayoun; Moono, Misinzo; Mwanahamuntu, Mulindi; Basu, Partha & Limacher, Andreas (2020). Screening test accuracy to improve detection of precancerous lesions of the cervix in women living with HIV: a study protocol. BMJ Open, 10 (12), S. 037955. http://doi.org/10.1136/bmjopen-2020-037955.
Taghavi, Katayoun; Rohner, Eliane; Basu, Partha; Low, Nicola & Rutjes, Anne (2020). Screening test accuracy of portable devices that can be used to perform colposcopy for detecting CIN2+ in low- and middle-income countries: a systematic review and meta-analysis. BMC Women’s Health, 20 (1). http://doi.org/10.1186/s12905-020-01121-3.
Tsondai, Priscilla R.; Sohn, Annette H.; Phiri, Sam; Sikombe, Kombatende & Sawry, Shobna (2020). Characterizing the double-sided cascade of care for adolescents living with HIV transitioning to adulthood across Southern Africa. Journal of the International AIDS Society, 23 (1). http://doi.org/10.1002/jia2.25447.
Tsondai, Priscilla R.; Braithwaite, Kate; Fatti, Geoffrey; Moore, Bolton; Carolyn, Chimbetete et al. (2020). Characteristics and outcomes of adolescents living with perinatally acquired HIV within Southern Africa. AIDS (London, England, 34 (15), S. 2275–2284. http://doi.org/10.1097/QAD.0000000000002683.
Zaniewski, Elizabeth; Ostinelli, Dao; H., Cam; Chammartin, Frédérique; Maxwell, Nicola et al. (2020). Trends in CD4 and viral load testing 2005 to 2018: multi-cohort study of people living with HIV in Southern Africa. Journal of the International AIDS Society, 23 (7), S. 25546– 25546. http://doi.org/10.1002/jia2.25546.
Zürcher, Kathrin; Morrow, Carl; Riou, Julien; Ballif, Marie & Koch, Anastasia Sideris (2020). Novel approach to estimate tuberculosis transmission in primary care clinics in sub-Saharan Africa: protocol of a prospective study. BMJ Open, 10 (8), S. 036214– 036214. http://doi.org/10.1136/bmjopen-2019-036214.
2019
Yotebieng, Marcel; Brazier, Ellen; Addison, Diane; Kimmel, April D.; Cornell, Morna et al. (2019). Research priorities to inform “Treat All” policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA). Journal of the International AIDS Society, 22 (1), S. e25218–e25218. http://doi.org/10.1002/jia2.25218.
Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration, Intira J.; Wools-Kaloustian, Kara; Goodall, Ruth; Smith, Colette; Abrams, Elaine J. et al. (2019). Incidence of switching to second-line antiretroviral therapy and associated factors in children with HIV: an international cohort collaboration. The Lancet. HIV, 6 (2), S. e105–e115. http://doi.org/10.1016/S2352-3018(18)30319-9.
Hermans, Sabine; Cornell, Morna; Middelkoop, Keren & Wood, Robin (2019). The differential impact of HIV and antiretroviral therapy on gender-specific tuberculosis rates. Tropical Medicine & International Health. http://doi.org/10.1111/tmi.13209.
Cohen, Karen; Stewart, Annemie; Kengne, Andre P.; Leisegang, Rory; Coetsee, Marla et al. (2019). A Clinical Prediction Rule for Protease Inhibitor Resistance in Patients Failing Second-Line Antiretroviral Therapy. Journal of Acquired Immune Deficiency Syndromes (1999), 80 (3), S. 325–329. http://doi.org/10.1097/QAI.0000000000001923.
Msukwa, Malango T.; Keiser, Olivia; Jahn, Andreas; Van Oosterhout, Joep J.; Edmonds, Andrew et al. (2019). Timing of combination antiretroviral therapy ( cART ) initiation is not associated with stillbirth among HIV ‐infected pregnant women in Malawi. Tropical Medicine & International Health, S. tmi.13233-tmi.13233. http://doi.org/10.1111/tmi.13233.
Zürcher, Kathrin; Ballif, Marie; Fenner, Lukas; Borrell, Sonia; Keller, Peter M. et al. (2019). Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study. The Lancet Infectious Diseases, 19 (3), S. 298–307. http://doi.org/10.1016/S1473-3099(18)30673-X.
Gygli, Sebastian M.; Keller, Peter M.; Ballif, Marie; Blöchliger, Nicolas; Hömke, Rico et al. (2019). Whole-Genome Sequencing for Drug Resistance Profile Prediction in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 63 (4). http://doi.org/10.1128/AAC.02175-18.
Vreeman, Rachel C.; Scanlon, Michael L.; Tu, Wanzhu; Slaven, James E.; McAteer, Carole I. et al. (2019). Validation of a self-report adherence measurement tool among a multinational cohort of children living with HIV in Kenya, South Africa and Thailand. Journal of the International AIDS Society, 22 (5), S. e25304–e25304. http://doi.org/10.1002/jia2.25304.
Hauser, Anthony; Kusejko, Katharina; Johnson, Leigh F.; Wandeler, Gilles; Riou, Julien et al. (2019). Bridging the gap between HIV epidemiology and antiretroviral resistance evolution: Modelling the spread of resistance in South Africa. PLOS Computational Biology, 15 (6), S. e1007083–e1007083. http://doi.org/10.1371/journal.pcbi.1007083.
Joseph Davey, Dvora L.; Bekker, Linda-Gail; Gomba, Yolanda; Coates, Thomas; Myer, Landon et al. (2019). Modelling the potential impact of providing preexposure prophylaxis in pregnant and breastfeeding women in South Africa. AIDS (London, England), 33 (8), S. 1391–1395. http://doi.org/10.1097/QAD.0000000000002221.
Brazier, Ellen; Maruri, Fernanda; Duda, Stephany N.; Tymejczyk, Olga; Wester, C. William et al. (2019). Implementation of “Treat-all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey. Journal of the International AIDS Society, 22 (7), S. e25331–e25331. http://doi.org/10.1002/jia2.25331.
Slogrove, Amy L.; Johnson, Leigh F. & Powis, Kathleen M. (2019). Population-level Mortality Associated with HIV Exposure in HIV-uninfected Infants in Botswana and South Africa: A Model-based Evaluation. Journal of Tropical Pediatrics, 65 (4), S. 373–379. http://doi.org/10.1093/tropej/fmy064.
Haas, Andreas D.; Johnson, Leigh F.; Grimsrud, Anna; Ford, Nathan; Mugglin, Catarina et al. (2019). Extending Visit Intervals for Clinically Stable Patients on Antiretroviral Therapy: Multicohort Analysis of HIV Programs in Southern Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 81 (4), S. 439–447. http://doi.org/10.1097/QAI.0000000000002060.
Schomaker, M.; Luque-Fernandez, M. A.; Leroy, V. & Davies, M. A. (2019). Using longitudinal targeted maximum likelihood estimation in complex settings with dynamic interventions. Statistics in Medicine, S. sim.8340-sim.8340. http://doi.org/10.1002/sim.8340.
Boettiger, David C.; Law, Matthew G.; Sohn, Annette H.; Davies, Mary Ann; Wools-Kaloustian, Kara et al. (2019). Temporal Trends in Co-trimoxazole Use Among Children on Antiretroviral Therapy and the Impact of Co-trimoxazole on Mortality Rates in Children Without Severe Immunodeficiency. Journal of the Pediatric Infectious Diseases Society, 8 (5), S. 450–460. http://doi.org/10.1093/jpids/piy087.
Zürcher, Kathrin; Ballif, Marie; Kiertiburanakul, Sasisopin; Chenal, Henri; Yotebieng, Marcel et al. (2019). Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low- and middle-income countries: a multicohort study. Journal of the International AIDS Society, 22 (9), S. e25392–e25392. http://doi.org/10.1002/jia2.25392.
Chihota, Belinda V.; Wandeler, Gilles; Chilengi, Roma; Mulenga, Lloyd; Chung, Raymond T. et al. (2019). High Rates of Hepatitis B Virus (HBV) Functional Cure Among Human Immunodeficiency Virus-HBV Coinfected Patients on Antiretroviral Therapy in Zambia. The Journal of Infectious Diseases. http://doi.org/10.1093/infdis/jiz450.
Boulle, A.; Heekes, A.; Tiffin, N.; Smith, M.; Mutemaringa, T. et al. (2019). Data Centre Profile: The Provincial Health Data Centre of the Western Cape Province, South Africa. International Journal of Population Data Science, 4 (2), S. 1143–1143. http://doi.org/10.23889/ijpds.v4i2.1143.
Iyun, Victoria; Technau, Karl-Gunter; Eley, Brian; Rabie, Helena; Boulle, Andrew et al. (2019). Earlier Antiretroviral Therapy Initiation and Decreasing Mortality Among HIV-infected Infants Initiating Antiretroviral Therapy Within 3 Months of Age in South Africa, 2006-2017. The Pediatric Infectious Disease Journal, S. 1–1. http://doi.org/10.1097/INF.0000000000002516.
Jesson, Julie; Schomaker, Michael; Malasteste, Karen; Wati, Dewi K.; Kariminia, Azar et al. (2019). Stunting and growth velocity of adolescents with perinatally acquired HIV: differential evolution for males and females. A multiregional analysis from the IeDEA global paediatric collaboration. Journal of the International AIDS Society, 22 (11), S. e25412–e25412. http://doi.org/10.1002/jia2.25412.
Mugglin, Catrina; Haas, Andreas D.; van Oosterhout, Joep J.; Msukwa, Malango; Tenthani, Lyson et al. (2019). Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study. PloS One, 14 (11), S. e0224837–e0224837. http://doi.org/10.1371/journal.pone.0224837.
Tymejczyk, Olga; Brazier, Ellen; Wools-Kaloustian, Kara; Davies, Mary-Ann; DiLorenzo, Madeline et al. (2019). Impact of universal antiretroviral treatment eligibility on rapid treatment initiation among young adolescents with HIV in sub-Saharan Africa. The Journal of Infectious Diseases. http://doi.org/10.1093/infdis/jiz547.
Dhokotera, Tafadzwa; Bohlius, Julia; Spoerri, Adrian; Egger, Matthias; Ncayiyana, Jabulani et al. (2019). The burden of cancers associated with HIV in the South African public health sector, 2004-2014: a record linkage study. Infectious Agents and Cancer, 14 (1), S. 12–12. http://doi.org/10.1186/s13027-019-0228-7.
Johnson, Leigh F.; Anderegg, Nanina; Zaniewski, Elizabeth; Eaton, Jeffrey W.; Rebeiro, Peter F. et al. (2019). Global variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration. AIDS (London, England), 33 Suppl 3, S. S283–S294. http://doi.org/10.1097/QAD.0000000000002358.
Pettit, April C.; Jenkins, Cathy A.; Blevins Peratikos, Meridith; Yotebieng, Marcel; Diero, Lameck et al. (2019). Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries. Journal of the International AIDS Society, 22 (12), S. e25423–e25423. http://doi.org/10.1002/jia2.25423.
Stover, John; Glaubius, Robert; Mofenson, Lynne; Dugdale, Caitlin M.; Davies, Mary Ann et al. (2019). Updates to the Spectrum/AIM model for estimating key HIV indicators at national and subnational levels. AIDS, 33, S. S227–S234. http://doi.org/10.1097/QAD.0000000000002357.
Patten, Gabriela; Schomaker, Michael; Davies, Mary-Ann; Rabie, Helena; van Zyl, Gert et al. (2019). What Should we do When HIV-Positive Children Fail First-Line Combination Antiretroviral Therapy? A Comparison of 4 ART Management Strategies. The Pediatric Infectious Disease Journal, 38 (4). http://doi.org/10.1097/INF.0000000000002156.
Tymejczyk, Olga; Brazier, Ellen; Yiannoutsos, Constantin T.; Vinikoor, Michael; van Lettow, Monique et al. (2019). Changes in rapid HIV treatment initiation after national “treat all” policy adoption in 6 sub-Saharan African countries: Regression discontinuity analysis. PLoS Medicine, 16 (6), S. e1002822–e1002822. http://doi.org/10.1371/journal.pmed.1002822.
2018
Ballif, Marie; Zürcher, Kathrin; Reid, Stewart E.; Boulle, Andrew; Fox, Matthew P. et al. (2018). Seasonal variations in tuberculosis diagnosis among HIV-positive individuals in Southern Africa: analysis of cohort studies at antiretroviral treatment programmes. BMJ Open, 8 (1), S. e017405–e017405. http://doi.org/10.1136/bmjopen-2017-017405.
IeDEA and COHERE Cohort Collaborations (2018). Global Trends in CD4 Cell Count at the Start of Antiretroviral Therapy: Collaborative Study of Treatment Programs. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. http://doi.org/10.1093/cid/cix915.
Vinikoor, Michael J.; Zyambo, Zude; Muyoyeta, Monde; Chander, Geetanjali; Saag, Michael S. et al. (2018). Point-of-Care Urine Ethyl Glucuronide Testing to Detect Alcohol Use Among HIV-Hepatitis B Virus Coinfected Adults in Zambia. AIDS and Behavior. http://doi.org/10.1007/s10461-018-2030-8.
Bohlius, Julia; Foster, Caroline; Naidu, Gita; Sengayi, Mazvita & Turkova, Anna (2018). Cancer in adolescents and young adults living with HIV. Current Opinion in HIV and AIDS, S. 1–1. http://doi.org/10.1097/COH.0000000000000460.
Chimbetete, Cleophas; Katzenstein, David; Shamu, Tinei; Spoerri, Adrian; Estill, Janne et al. (2018). HIV-1 Drug Resistance and Third-Line Therapy Outcomes in Patients Failing Second-Line Therapy in Zimbabwe. Open Forum Infectious Diseases, 5 (2), S. ofy005–ofy005. http://doi.org/10.1093/ofid/ofy005.
CIPHER Global Cohort Collaboration (2018). Inequality in outcomes for adolescents living with perinatally acquired HIV in sub-Saharan Africa: a Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Cohort Collaboration analysis. Journal of the International AIDS Society, 21 Suppl 1, S. e25044–e25044. http://doi.org/10.1002/jia2.25044.
Haas, Andreas D.; Zaniewski, Elizabeth; Anderegg, Nanina; Ford, Nathan; Fox, Matthew P. et al. (2018). Retention and mortality on antiretroviral therapy in sub-Saharan Africa: collaborative analyses of HIV treatment programmes. Journal of the International AIDS Society, 21 (2), S. e25084–e25084. http://doi.org/10.1002/jia2.25084.
Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration, CIPHER; Slogrove, Amy L.; Schomaker, Michael; Davies, Mary-Ann; Williams, Paige et al. (2018). The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. PLoS Medicine, 15 (3), S. e1002514–e1002514. http://doi.org/10.1371/journal.pmed.1002514.
Parcesepe, Angela M.; Mugglin, Catrina; Nalugoda, Fred; Bernard, Charlotte; Yunihastuti, Evy et al. (2018). Screening and management of mental health and substance use disorders in HIV treatment settings in low- and middle-income countries within the global IeDEA consortium. Journal of the International AIDS Society, 21 (3), S. e25101–e25101. http://doi.org/10.1002/jia2.25101.
Tymejczyk, Olga; Brazier, Ellen; Yiannoutsos, Constantin; Wools-Kaloustian, Kara; Althoff, Keri et al. (2018). HIV treatment eligibility expansion and timely antiretroviral treatment initiation following enrollment in HIV care: A metaregression analysis of programmatic data from 22 countries. PLoS Medicine, 15 (3), S. e1002534–e1002534. http://doi.org/10.1371/journal.pmed.1002534.
Wandeler, Gilles; Coffie, Patrick A.; Kuniholm, Mark H.; Ocama, Ponsiano & Egger, Matthias (2018). Issues with measuring hepatitis prevalence in resource-limited settings. Lancet (London, England), 391 (10123), S. 835–836. http://doi.org/10.1016/S0140-6736(18)30463-X.
Wools-Kaloustian, Kara; Marete, Irene; Ayaya, Samuel; Sohn, Annette H.; Van Nguyen, Lam et al. (2018). Time to First-Line ART Failure and Time to Second-Line ART Switch in the IeDEA Pediatric Cohort. JAIDS Journal of Acquired Immune Deficiency Syndromes, S. 1–1. http://doi.org/10.1097/QAI.0000000000001667.
Hector, Jonas; Vinikoor, Michael; Chilengi, Roma; Ehmer, Jochen; Egger, Matthias et al. (2018). No Impact of Hepatitis B Virus Infection on Early Mortality among HIV-infected Patients in Southern Africa. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. http://doi.org/10.1093/cid/ciy304.
Rohr, Julia K.; Ive, Prudence; Horsburgh, Charles Robert; Berhanu, Rebecca; Hoffmann, Christopher J. et al. (2018). Brief Report: Assessing the Association Between Changing NRTIs When Initiating Second-Line ART and Treatment Outcomes. Journal of Acquired Immune Deficiency Syndromes (1999), 77 (4), S. 413–416. http://doi.org/10.1097/QAI.0000000000001611.
Cornell, Morna & Dovel, Kathryn (2018). Reaching key adolescent populations. Current Opinion in HIV and AIDS, 13 (3), S. 274–280. http://doi.org/10.1097/COH.0000000000000457.
Desmonde, Sophie; Tanser, Franck; Vreeman, Rachel; Takassi, Elom; Edmonds, Andrew et al. (2018). Access to antiretroviral therapy in HIV-infected children aged 0-19 years in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Global Cohort Consortium, 2004-2015: A prospective cohort study. PLoS Medicine, 15 (5), S. e1002565–e1002565. http://doi.org/10.1371/journal.pmed.1002565.
Judd, Ali & Davies, Mary-Ann (2018). Adolescent transition among young people with perinatal HIV in high-income and low-income settings. Current Opinion in HIV and AIDS, 13 (3), S. 236–248. http://doi.org/10.1097/COH.0000000000000448.
Giles, Michelle L.; Achhra, Amit C.; Abraham, Alison G.; Haas, Andreas D.; Gill, Michael John et al. (2018). Sex-based differences in antiretroviral therapy initiation, switching and treatment interruptions: global overview from the International Epidemiologic Databases to Evaluate AIDS (IeDEA). Journal of the International AIDS Society, 21 (6), S. e25149–e25149. http://doi.org/10.1002/jia2.25149.
Phiri, Nozgechi; Haas, Andreas D.; Msukwa, Malango T.; Tenthani, Lyson; Keiser, Olivia et al. (2018). “I found that I was well and strong”: Women’s motivations for remaining on ART under Option B+ in Malawi. PloS One, 13 (6), S. e0197854–e0197854. http://doi.org/10.1371/journal.pone.0197854.
Schomaker, Michael & Heumann, Christian (2018). Bootstrap inference when using multiple imputation. Statistics in Medicine, 37 (14), S. 2252–2266. http://doi.org/10.1002/sim.7654.
Arrivé, Elise; Ayaya, Samuel; Davies, Mary-Ann; Chimbetete, Cleophas; Edmonds, Andrew et al. (2018). Models of support for disclosure of HIV status to HIV-infected children and adolescents in resource-limited settings. Journal of the International AIDS Society, 21 (7), S. e25157–e25157. http://doi.org/10.1002/jia2.25157.
Gehringer, Christian; Rode, Heinz & Schomaker, Michael (2018). The effect of electrical load shedding on pediatric hospital admissions in South Africa. Epidemiology (Cambridge, Mass.), S. 1–1. http://doi.org/10.1097/EDE.0000000000000905.
Msukwa, Malango T.; Estill, Janne; Haas, Andreas D.; van Oosterhout, Joep J.; Tenthani, Lyson et al. (2018). Weight gain of HIV-exposed, uninfected children born before and after introduction of the “Option B+” programme in Malawi. AIDS (London, England), S. 1–1. http://doi.org/10.1097/QAD.0000000000001942.
Sohn, Annette H.; Judd, Ali; Mofenson, Lynne; Vicari, Marisa; Jerene, Degu et al. (2018). Using Observational Data to Inform HIV Policy Change for Children and Youth. Journal of Acquired Immune Deficiency Syndromes (1999), 78 Suppl 1, S. S22–S26. http://doi.org/10.1097/QAI.0000000000001745.
Solanki, Geetesh; Cornell, Morna & Lalloo, Ratilal (2018). Uptake and cost of influenza vaccines in a private health insured South African population. Southern African Journal of Infectious Diseases, S. 1–4. http://doi.org/10.1080/23120053.2018.1504532.
van der Heijden, Y. F.; Karim, F.; Chinappa, T.; Mufamadi, G.; Zako, L. et al. (2018). Older age at first tuberculosis diagnosis is associated with tuberculosis recurrence in HIV-negative persons. The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 22 (8), S. 871–877. http://doi.org/10.5588/ijtld.17.0766.
Brennan, Alana T.; Bor, Jacob; Davies, Mary-Ann; Wandeler, Gilles; Prozesky, Hans et al. (2018). Medication Side Effects and Retention in HIV Treatment: A Regression Discontinuity Study of Tenofovir Implementation in South Africa and Zambia. American Journal of Epidemiology, 187 (9), S. 1990–2001. http://doi.org/10.1093/aje/kwy093.
Rohner, Eliane & AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018). Non-Hodgkin lymphoma risk in adults living with HIV across five continents: a multicohort study. AIDS (London, England). http://doi.org/10.1097/QAD.0000000000002003.
Vinikoor, Michael J.; Sinkala, Edford; Kanunga, Annie; Muchimba, Mutinta; Nsokolo, Bright et al. (2018). Chronic hepatitis B virus monoinfection at a university hospital in Zambia. World Journal of Hepatology, 10 (9), S. 622–628. http://doi.org/10.4254/wjh.v10.i9.622.
Patten, Gabriela; Bernheimer, Jonathan; Fairlie, Lee; Rabie, Helena; Sawry, Shobna et al. (2018). Lamivudine monotherapy as a holding regimen for HIV-positive children. PloS One, 13 (10), S. e0205455–e0205455. http://doi.org/10.1371/journal.pone.0205455.
Chammartin, Frédérique; Zürcher, Kathrin; Keiser, Olivia; Weigel, Ralf; Chu, Kathryn et al. (2018). Outcomes of Patients Lost to Follow-up in African Antiretroviral Therapy Programs: Individual Patient Data Meta-analysis. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 67 (11), S. 1643–1652. http://doi.org/10.1093/cid/ciy347.
de Waal, Reneé; Lessells, Richard; Hauser, Anthony; Kouyos, Roger; Davies, Mary-Ann et al. (2018). HIV drug resistance in sub-Saharan Africa: public health questions and the potential role of real-world data and mathematical modelling. Journal of Virus Eradication, 4 (Suppl 2), S. 55–58. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/30515315
Horner, Marie-Josèphe; Chasimpha, Steady; Spoerri, Adrian; Edwards, Jessie; Bohlius, Julia et al. (2018). High Cancer Burden Among Antiretroviral Therapy Users in Malawi: a Record Linkage Study of Observational HIV Cohorts and Cancer Registry Data. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. http://doi.org/10.1093/cid/ciy960.
Panayidou, Klea; Davies, Mary-Ann; Anderegg, Nanina; Egger, Matthias & IeDEA, COHERE, PHACS and IMPAACT 219C Collaborations Writing Group (2018). Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation. Journal of the International AIDS Society, 21 (11), S. e25200–e25200. http://doi.org/10.1002/jia2.25200.
Parcesepe, Angela M.; Bernard, Charlotte; Agler, Robert; Ross, Jeremy; Yotebieng, Marcel et al. (2018). Mental health and HIV: research priorities related to the implementation and scale up of “treat all” in sub-Saharan Africa. Journal of Virus Eradication, 4 (Suppl 2), S. 16–25. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/30515310
Zaniewski, Elizabeth; Tymejczyk, Olga; Kariminia, Azar; Desmonde, Sophie; Leroy, Valériane et al. (2018). IeDEA-WHO Research-Policy Collaboration: contributing real-world evidence to HIV progress reporting and guideline development. Journal of Virus Eradication, 4 (Suppl 2), S. 9–15. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/30515309
Kariminia, Azar; Law, Matthew; Davies, Mary‐Ann; Vinikoor, Michael; Wools‐Kaloustian, Kara et al. (2018). Mortality and losses to follow‐up among adolescents living with HIV in the Ie DEA global cohort collaboration. Journal of the International AIDS Society, 21 (12), S. e25215–e25215. http://doi.org/10.1002/jia2.25215.
Nouaman, Marcellin N.; Vinikoor, Michael; Seydi, Moussa; Ekouevi, Didier K.; Coffie, Patrick A. et al. (2018). High prevalence of binge drinking among people living with HIV in four African countries. Journal of the International AIDS Society, 21 (12), S. e25202–e25202. http://doi.org/10.1002/jia2.25202.
Ford, Nathan; Penazzato, Martina; Vitoria, Marco; Doherty, Meg; Davies, Mary Ann et al. (2018). The contribution of observational studies in supporting the WHO “treat all” recommendation for HIV/AIDS. Journal of Virus Eradication, 4 (Suppl 2), S. 5–8. http://doi.org/10.1016/S2055-6640(20)30346-0.
2017
Brennan, Alana T.; Davies, Mary-Ann; Bor, Jacob; Wandeler, Gilles; Stinson, Kathryn et al. (2017). Has the phasing out of stavudine in accordance with changes in WHO guidelines led to a decrease in single-drug substitutions in first-line antiretroviral therapy for HIV in sub-Saharan Africa? AIDS (London, England), 31 (1), S. 147–157. http://doi.org/10.1097/QAD.0000000000001307.
Fritz, Cristin Q.; Blevins, Meridith; Lindegren, Mary Lou; Wools-Kaloutsian, Kara; Musick, Beverly S. et al. (2017). Comprehensiveness of HIV care provided at global HIV treatment sites in the IeDEA consortium: 2009 and 2014. Journal of the International AIDS Society, 20 (1), S. 1–14. http://doi.org/10.7448/IAS.20.1.20933.
Singh, Elvira; Naidu, Gita; Davies, Mary-Ann & Bohlius, Julia (2017). HIV-associated malignancies in children. Current Opinion in HIV and AIDS, 12 (1), S. 77–83. http://doi.org/10.1097/COH.0000000000000331.
Fortuin-de Smidt, Melony; de Waal, Reneé; Cohen, Karen; Technau, Karl-Günter; Stinson, Kathryn et al. (2017). First-line antiretroviral drug discontinuations in children. PloS One, 12 (2), S. e0169762–e0169762. http://doi.org/10.1371/journal.pone.0169762.
Bohlius, Julia; Rohner, Eliane & Egger, Matthias (2017). Reply to El-Mallawany et al. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 64 (6), S. 819–820. http://doi.org/10.1093/cid/ciw880.
Manson, Abigail L.; Cohen, Keira A.; Abeel, Thomas; Desjardins, Christopher A.; Armstrong, Derek T. et al. (2017). Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance. Nature Genetics, 49 (3), S. 395–402. http://doi.org/10.1038/ng.3767.
Anderegg, Nanina; Johnson, Leigh F.; Zaniewski, Elizabeth; Althoff, Keri N.; Balestre, Eric et al. (2017). All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS (London, England), 31 Suppl 1, S. S31–S40. http://doi.org/10.1097/QAD.0000000000001321.
Schomaker, Michael; Leroy, Valeriane; Wolfs, Tom; Technau, Karl-Günter; Renner, Lorna et al. (2017). Optimal timing of antiretroviral treatment initiation in HIV-positive children and adolescents: a multiregional analysis from Southern Africa, West Africa and Europe. International Journal of Epidemiology, 46 (2), S. 453–465. http://doi.org/10.1093/ije/dyw097.
Zürcher, Kathrin; Mooser, Anne; Anderegg, Nanina; Tymejczyk, Olga; Couvillon, Margaret J. et al. (2017). Outcomes of HIV-positive patients lost to follow-up in African treatment programmes. Tropical Medicine & International Health : TM & IH, 22 (4), S. 375–387. http://doi.org/10.1111/tmi.12843.
Slogrove, Amy L.; Mahy, Mary; Armstrong, Alice & Davies, Mary-Ann (2017). Living and dying to be counted: What we know about the epidemiology of the global adolescent HIV epidemic. Journal of the International AIDS Society, 20 (Suppl 3), S. 21520. http://doi.org/10.7448/IAS.20.4.21520.
Dahourou, Désiré Lucien; Gautier-Lafaye, Chloé; Teasdale, Chloe A.; Renner, Lorna; Yotebieng, Marcel et al. (2017). Transition from paediatric to adult care of adolescents living with HIV in sub-Saharan Africa: challenges, youth-friendly models, and outcomes. Journal of the International AIDS Society, 20 (Suppl 3), S. 34–49. http://doi.org/10.7448/IAS.20.4.21528.
Davies, Mary-Ann; Tsondai, Priscilla; Tiffin, Nicki; Eley, Brian; Rabie, Helena et al. (2017). Where do HIV-infected adolescents go after transfer? – Tracking transition/transfer of HIV-infected adolescents using linkage of cohort data to a health information system platform. Journal of the International AIDS Society, 20 (Suppl 3), S. 16–24. http://doi.org/10.7448/IAS.20.4.21668.
Vinikoor, Michael J.; Sinkala, Edford; Chilengi, Roma; Mulenga, Lloyd B.; Chi, Benjamin H. et al. (2017). Impact of Antiretroviral Therapy on Liver Fibrosis Among Human Immunodeficiency Virus-Infected Adults With and Without HBV Coinfection in Zambia. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 64 (10), S. 1343–1349. http://doi.org/10.1093/cid/cix122.
Barlow-Mosha, Linda; Musiime, Victor; Davies, Mary-Ann; Prendergast, Andrew J.; Musoke, Philippa et al. (2017). Universal antiretroviral therapy for HIV-infected children: a review of the benefits and risks to consider during implementation. Journal of the International AIDS Society, 20 (1), S. 21552. http://doi.org/10.7448/IAS.20.1.21552.
Carlucci, James G.; Blevins Peratikos, Meridith; Kipp, Aaron M.; Lindegren, Mary L.; Du, Quy T. et al. (2017). Tuberculosis Treatment Outcomes Among HIV/TB-Coinfected Children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Network. Journal of Acquired Immune Deficiency Syndromes (1999), 75 (2), S. 156–163. http://doi.org/10.1097/QAI.0000000000001335.
Fenner, Lukas; Atkinson, Andrew; Boulle, Andrew; Fox, Matthew P.; Prozesky, Hans et al. (2017). HIV viral load as an independent risk factor for tuberculosis in South Africa: collaborative analysis of cohort studies. Journal of the International AIDS Society, 20 (1), S. 1–7. http://doi.org/10.7448/IAS.20.1.21327.
IeDEA Pediatric Working Group (2017). Taking a critical look at the UNAIDS global estimates on paediatric and adolescent HIV survival and death. Journal of the International AIDS Society, 20 (1), S. 1–2. http://doi.org/10.7448/IAS.20.1.21952.
van der Heijden, Y. F.; Karim, F.; Mufamadi, G.; Zako, L.; Chinappa, T. et al. (2017). Isoniazid-monoresistant tuberculosis is associated with poor treatment outcomes in Durban, South Africa. The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 21 (6), S. 670–676. http://doi.org/10.5588/ijtld.16.0843.
Chimbetete, Cleophas; Mugglin, Catrina; Shamu, Tinei; Kalesan, Bindu; Bertisch, Barbara et al. (2017). New-onset type 2 diabetes mellitus among patients receiving HIV care at Newlands Clinic, Harare, Zimbabwe: retrospective cohort analysis. Tropical Medicine & International Health : TM & IH, 22 (7), S. 839–845. http://doi.org/10.1111/tmi.12896.
Jiamsakul, Awachana; Kariminia, Azar; Althoff, Keri N.; Cesar, Carina; Cortes, Claudia P. et al. (2017). HIV viral load suppression in adults and children receiving antiretroviral therapy – results from the IeDEA collaboration. Journal of Acquired Immune Deficiency Syndromes (1999), S. 1–1. http://doi.org/10.1097/QAI.0000000000001499.
Koch, Anastasia S.; Brites, Daniela; Stucki, David; Evans, Joanna C.; Seldon, Ronnett et al. (2017). The Influence of HIV on the Evolution of Mycobacterium tuberculosis. Molecular Biology and Evolution, 34 (7), S. 1654–1668. http://doi.org/10.1093/molbev/msx107.
Rohner, Eliane; Sengayi, Mazvita; Goeieman, Bridgette; Michelow, Pamela; Firnhaber, Cynthia et al. (2017). Cervical cancer risk and impact of Pap-based screening in HIV-positive women on antiretroviral therapy in Johannesburg, South Africa. International Journal of Cancer, 141 (3), S. 488–496. http://doi.org/10.1002/ijc.30749.
Brown, Steven A.; Abbas, Salma; Davies, Mary-Ann; Bunupuradah, Torsak; Sohn, Annette H. et al. (2017). Brief Report: Pediatric Cancer Burden and Treatment Resources Within the Pediatric IeDEA Consortium. JAIDS Journal of Acquired Immune Deficiency Syndromes, 76 (1), S. 60–64. http://doi.org/10.1097/QAI.0000000000001453.
Sengayi, M. M.; Kielkowski, D.; Egger, M.; Dreosti, L. & Bohlius, J. (2017). Survival of patients with Kaposi’s sarcoma in the South African antiretroviral treatment era: A retrospective cohort study. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 107 (10), S. 871–876. http://doi.org/10.7196/SAMJ.2017.v107i10.12362.
Haas, Andreas D.; van Oosterhout, Joep J.; Tenthani, Lyson; Jahn, Andreas; Zwahlen, Marcel et al. (2017). HIV transmission and retention in care among HIV-exposed children enrolled in Malawi’s prevention of mother-to-child transmission programme. Journal of the International AIDS Society, 20 (1), S. 1–10. http://doi.org/10.7448/IAS.20.1.21947.
Semeere, Aggrey; Freeman, Esther; Wenger, Megan; Glidden, David; Bwana, Mwebesa et al. (2017). Updating vital status by tracking in the community among patients with epidemic Kaposi sarcoma who are lost to follow-up in sub-Saharan Africa. BMC Cancer, 17 (1), S. 611–611. http://doi.org/10.1186/s12885-017-3549-1.
AIDS-defining Cancer Project Working Group for IeDEA and COHERE in EuroCoord & AIDS-defining Cancer Project Working Group for IeDEA and COHERE in EuroCoord (2017). Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 65 (8), S. 1316–1326. http://doi.org/10.1093/cid/cix480.
Chisenga, Caroline C.; Musukuma, Kalo; Chilengi, Roma; Zürcher, Samuel; Munamunungu, Virginia et al. (2017). Field performance of the Determine HBsAg point-of-care test for diagnosis of hepatitis B virus co-infection among HIV patients in Zambia. Journal of Clinical Virology : The Official Publication of the Pan American Society for Clinical Virology, 98, S. 5–7. http://doi.org/10.1016/j.jcv.2017.11.005.
Coffie, Patrick A.; Egger, Matthias; Vinikoor, Michael J.; Zannou, Marcel; Diero, Lameck et al. (2017). Trends in hepatitis B virus testing practices and management in HIV clinics across sub-Saharan Africa. BMC Infectious Diseases, 17 (Suppl 1), S. 706. http://doi.org/10.1186/s12879-017-2768-z.
Johnson, Leigh F.; May, Margaret T.; Dorrington, Rob E.; Cornell, Morna; Boulle, Andrew et al. (2017). Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study. PLoS Medicine, 14 (12), S. e1002468–e1002468. http://doi.org/10.1371/journal.pmed.1002468.
Bauer, Sophie; Wa Mwanza, Mwanza; Chilengi, Roma; Holmes, Charles B.; Zyambo, Zude et al. (2017). Awareness and management of elevated blood pressure among human immunodeficiency virus-infected adults receiving antiretroviral therapy in urban Zambia: a call to action. Global Health Action, 10 (1), S. 1359923. http://doi.org/10.1080/16549716.2017.1359923.
Cornell, Morna; Johnson, Leigh F.; Wood, Robin; Tanser, Frank; Fox, Matthew P. et al. (2017). Twelve-year mortality in adults initiating antiretroviral therapy in South Africa. Journal of the International AIDS Society, 20 (1), S. 21902–21902. http://doi.org/10.7448/IAS.20.1.21902.
Rohner, Eliane; Kasaro, Margaret; Msadabwe-Chikuni, Susan Citonje; Stinson, Kathryn; Mohamed, Zainab et al. (2017). Treatment and outcome of AIDS-related Kaposi sarcoma in South Africa, Malawi and Zambia: an international comparison. The Pan African Medical Journal, 28, S. 261–261. http://doi.org/10.11604/pamj.2017.28.261.11300.
2016
Hofer, Cristina Barroso; Keiser, Olivia; Zwahlen, Marcel; Lustosa, Carla Sepulveda; Frota, Ana Cristina Cisne et al. (2016). In Utero Exposure to Antiretroviral Drugs: Effect on Birth Weight and Growth Among HIV-exposed Uninfected Children in Brazil. The Pediatric Infectious Disease Journal, 35 (1), S. 71–77. http://doi.org/10.1097/INF.0000000000000926.
Rohner, Eliane; Wyss, Natascha; Heg, Zina; Faralli, Zully; Mbulaiteye, Sam M. et al. (2016). HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. International Journal of Cancer, 138 (1), S. 45–54. http://doi.org/10.1002/ijc.29687.
Freeman, Esther; Semeere, Aggrey; Wenger, Megan; Bwana, Mwebesa; Asirwa, F. Chite et al. (2016). Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa. BMC Cancer, 16 (1), S. 65–65. http://doi.org/10.1186/s12885-016-2080-0.
Blaser, Nello; Zahnd, Cindy; Hermans, Sabine; Salazar-Vizcaya, Luisa; Estill, Janne et al. (2016). Tuberculosis in Cape Town: An age-structured transmission model. Epidemics, 14, S. 54–61. http://doi.org/10.1016/j.epidem.2015.10.001.
Estill, Janne; Ford, Nathan; Salazar-Vizcaya, Luisa; Haas, Andreas D.; Blaser, Nello et al. (2016). The need for second-line antiretroviral therapy in adults in sub-Saharan Africa up to 2030: a mathematical modelling study. The Lancet. HIV, 3 (3), S. e132-9. http://doi.org/10.1016/S2352-3018(16)00016-3.
Schomaker, Michael; Davies, Mary-Ann; Malateste, Karen; Renner, Lorna; Sawry, Shobna et al. (2016). Growth and Mortality Outcomes for Different Antiretroviral Therapy Initiation Criteria in Children Ages 1-5 Years: A Causal Modeling Analysis. Epidemiology (Cambridge, Mass.), 27 (2), S. 237–46. http://doi.org/10.1097/EDE.0000000000000412.
Tweya, Hannock; Feldacker, Caryl; Gadabu, Oliver Jintha; Ng’ambi, Wingston; Mumba, Soyapi L. et al. (2016). Developing a point-of-care electronic medical record system for TB/HIV co-infected patients: experiences from Lighthouse Trust, Lilongwe, Malawi. BMC Research Notes, 9 (1), S. 146–146. http://doi.org/10.1186/s13104-016-1943-4.
Tweya, Hannock; Keiser, Olivia; Haas, Andreas D.; Tenthani, Lyson; Phiri, Sam et al. (2016). Comparative cost-effectiveness of Option B+ for prevention of mother-to-child transmission of HIV in Malawi. AIDS (London, England), 30 (6), S. 953–962. http://doi.org/10.1097/QAD.0000000000001009.
Wandeler, Gilles; Mulenga, Lloyd; Hobbins, Michael; Joao, Candido; Sinkala, Edford et al. (2016). Absence of Active Hepatitis C Virus Infection in Human Immunodeficiency Virus Clinics in Zambia and Mozambique. Open Forum Infectious Diseases, 3 (2), S. ofw049–ofw049. http://doi.org/10.1093/ofid/ofw049.
Wandeler, Gilles; Musukuma, Kalo; Zürcher, Samuel; Vinikoor, Michael J.; Llenas-García, Jara et al. (2016). Hepatitis B Infection, Viral Load and Resistance in HIV-Infected Patients in Mozambique and Zambia. PloS One, 11 (3), S. e0152043. http://doi.org/10.1371/journal.pone.0152043.
Charles, M. Katherine; Lindegren, Mary Lou; Wester, C. William; Blevins, Meridith; Sterling, Timothy R. et al. (2016). Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control (“Three I’s”) and HIV-Tuberculosis Service Integration in Lower Income Countries. PloS One, 11 (4), S. e0153243–e0153243. http://doi.org/10.1371/journal.pone.0153243.
Haas, Andreas D.; Tenthani, Lyson; Msukwa, Malango T.; Tal, Kali; Jahn, Andreas et al. (2016). Retention in care during the first 3 years of antiretroviral therapy for women in Malawi’s option B+ programme: an observational cohort study. The Lancet. HIV, 3 (4), S. e175-82. http://doi.org/10.1016/S2352-3018(16)00008-4.
Morden, Erna; Technau, Karl-Günter; Giddy, Janet; Maxwell, Nicola; Keiser, Olivia et al. (2016). Growth of HIV-Exposed Uninfected Infants in the First 6 Months of Life in South Africa: The IeDEA-SA Collaboration. PloS One, 11 (4), S. e0151762–e0151762. http://doi.org/10.1371/journal.pone.0151762.
Desjardins, Christopher A.; Cohen, Keira A.; Munsamy, Vanisha; Abeel, Thomas; Maharaj, Kashmeel et al. (2016). Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance. Nature Genetics, 48 (5), S. 544–551. http://doi.org/10.1038/ng.3548.
Azevedo, Tiago Castro Lopes; Zwahlen, Marcel; Rauch, Andri; Egger, Matthias & Wandeler, Gilles (2016). Hepatitis C in HIV-infected individuals: a systematic review and meta-analysis of estimated prevalence in Africa. Journal of the International AIDS Society, 19 (1). http://doi.org/10.7448/IAS.19.1.20711.
Bohlius, Julia; Maxwell, Nicola; Spoerri, Adrian; Wainwright, Rosalind; Sawry, Shobna et al. (2016). Incidence of AIDS-defining and Other Cancers in HIV-positive Children in South Africa: Record Linkage Study. The Pediatric Infectious Disease Journal, 35 (6), S. e164–70. http://doi.org/10.1097/INF.0000000000001117.
Grimsrud, Anna; Cornell, Morna; Schomaker, Michael; Fox, Matthew P.; Orrell, Catherine et al. (2016). CD4 count at antiretroviral therapy initiation and the risk of loss to follow-up: results from a multicentre cohort study. Journal of Epidemiology and Community Health, 70 (6), S. 549–555. http://doi.org/10.1136/jech-2015-206629.
Begré, Lorin; Rohner, Eliane; Mbulaiteye, Sam M.; Egger, Matthias & Bohlius, Julia (2016). Is human herpesvirus 8 infection more common in men than in women? Systematic review and meta-analysis. International Journal of Cancer, 139 (4), S. 776–783. http://doi.org/10.1002/ijc.30129.
Davies, Mary-Ann; Gibb, Diana & Turkova, Anna (2016). Survival of HIV-1 vertically infected children. Current Opinion in HIV and AIDS, 11 (5), S. 455–464. http://doi.org/10.1097/COH.0000000000000303.
Sengayi, Mazvita; Spoerri, Adrian; Egger, Matthias; Kielkowski, Danuta; Crankshaw, Tamaryn et al. (2016). Record linkage to correct under-ascertainment of cancers in HIV cohorts: The Sinikithemba HIV clinic linkage project. International Journal of Cancer, 139 (6), S. 1209–1216. http://doi.org/10.1002/ijc.30154.
Wandeler, Gilles; Johnson, Leigh F. & Egger, Matthias (2016). Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: comparisons with general population. Current Opinion in HIV and AIDS, 11 (5), S. 492–500. http://doi.org/10.1097/COH.0000000000000298.
Johnson, Leigh F.; Keiser, Olivia; Fox, Matthew P.; Tanser, Frank; Cornell, Morna et al. (2016). Life expectancy trends in adults on antiretroviral treatment in South Africa. AIDS (London, England), 30 (16), S. 2545–2550. http://doi.org/10.1097/QAD.0000000000001197.
Rachlis, Beth; Karwa, Rakhi; Chema, Celia; Pastakia, Sonak; Olsson, Sten et al. (2016). Targeted Spontaneous Reporting: Assessing Opportunities to Conduct Routine Pharmacovigilance for Antiretroviral Treatment on an International Scale. Drug Safety, 39 (10), S. 959–976. http://doi.org/10.1007/s40264-016-0434-9.
Wandeler, Gilles; Mulenga, Lloyd; Vinikoor, Michael J.; Kovari, Helen; Battegay, Manuel et al. (2016). Liver fibrosis in treatment-naïve HIV-infected and HIV/HBV co-infected patients: Zambia and Switzerland compared. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 51, S. 97–102. http://doi.org/10.1016/j.ijid.2016.08.028.
Haas, Andreas D.; Msukwa, Malango T.; Egger, Matthias; Tenthani, Lyson; Tweya, Hannock et al. (2016). Adherence to Antiretroviral Therapy During and After Pregnancy: Cohort Study on Women Receiving Care in Malawi’s Option B+ Program. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 63 (9), S. 1227–1235. http://doi.org/10.1093/cid/ciw500.
Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa, TApHOD, and COHERE in EuroCoord (2016). Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 63 (9), S. 1245–1253. http://doi.org/10.1093/cid/ciw519.
Vinikoor, Michael J.; Mulenga, Lloyd; Siyunda, Alice; Musukuma, Kalo; Chilengi, Roma et al. (2016). Association between hepatitis B co-infection and elevated liver stiffness among HIV-infected adults in Lusaka, Zambia. Tropical Medicine & International Health : TM & IH, 21 (11), S. 1435–1441. http://doi.org/10.1111/tmi.12764.
2015
Koller, Manuel; Althoff, Keri N.; Davies, Mary-Ann & Egger, Matthias (2015). Authors’ reply: immunodeficiency at the start of combination antiretroviral therapy: steady improvement or step changes? Journal of Acquired Immune Deficiency Syndromes (1999), 68 (1), S. e16-7. http://doi.org/10.1097/QAI.0000000000000399.
Koller, Manuel; Patel, Kunjal; Chi, Benjamin H.; Wools-Kaloustian, Kara; Dicko, Fatoumata et al. (2015). Immunodeficiency in children starting antiretroviral therapy in low-, middle-, and high-income countries. Journal of Acquired Immune Deficiency Syndromes (1999), 68 (1), S. 62–72. http://doi.org/10.1097/QAI.0000000000000380.
Yotebieng, Marcel; Meyers, Tammy; Behets, Frieda; Davies, Mary-Ann; Keiser, Olivia et al. (2015). Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries. AIDS (London, England), 29 (1), S. 101–109. http://doi.org/10.1097/QAD.0000000000000506.
Geng, Elvin H.; Neilands, Torsten B.; Thièbaut, Rodolphe; Bwana, Mwebesa Bosco; Nash, Denis et al. (2015). CD41 T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa. International Journal of Epidemiology, 44 (1), S. 251–263. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/25859596
Ballif, Marie; Renner, Lorna; Dusingize, Jean Claude; Leroy, Valeriane; Ayaya, Samuel et al. (2015). Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices. Journal of the Pediatric Infectious Diseases Society, 4 (1), S. 30–38. http://doi.org/10.1093/jpids/piu020.
Blaser, Nello; Vizcaya, Luisa Salazar; Estill, Janne; Zahnd, Cindy; Kalesan, Bindu et al. (2015). gems: An R Package for Simulating from Disease Progression Models. Journal of Statistical Software, 64 (10), S. 1–22. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/26064082
Bohlius, Julia; Maskew, Mhairi; Davies, Mary-Ann & Egger, Matthias (2015). HHV-8 seroprevalence in HIV-positive and HIV-negative populations. International Journal of Cancer, 136 (5), S. 1243–1243. http://doi.org/10.1002/ijc.29183.
Egger, Matthias & Johnson, Leigh F. (2015). Estimating trends in life expectancy in HIV-positive individuals. The Lancet. Global Health, 3 (3), S. e122-3. http://doi.org/10.1016/S2214-109X(14)70383-3.
Estill, Janne; Salazar-Vizcaya, Luisa; Blaser, Nello; Egger, Matthias & Keiser, Olivia (2015). The cost-effectiveness of monitoring strategies for antiretroviral therapy of HIV infected patients in resource-limited settings: software tool. PloS One, 10 (3), S. e0119299–e0119299. http://doi.org/10.1371/journal.pone.0119299.
Sengayi, Mazvita; Babb, Chantal; Egger, Matthias & Urban, Margaret I. (2015). HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study. BMC Cancer, 15 (1), S. 144–144. http://doi.org/10.1186/s12885-015-1171-7.
Stucki, David; Ballif, Marie; Bodmer, Thomas; Coscolla, Mireia; Maurer, Anne-Marie et al. (2015). Tracking a tuberculosis outbreak over 21 years: strain-specific single-nucleotide polymorphism typing combined with targeted whole-genome sequencing. The Journal of Infectious Diseases, 211 (8), S. 1306–1316. http://doi.org/10.1093/infdis/jiu601.
Haas, Andreas D.; Keiser, Olivia; Balestre, Eric; Brown, Steve; Bissagnene, Emmanuel et al. (2015). Monitoring and switching of first-line antiretroviral therapy in adult treatment cohorts in sub-Saharan Africa: collaborative analysis. The Lancet. HIV, 2 (7), S. e271-8. http://doi.org/10.1016/S2352-3018(15)00087-9.
Hermans, Sabine; Horsburgh, C. Robert & Wood, Robin (2015). A Century of Tuberculosis Epidemiology in the Northern and Southern Hemisphere: The Differential Impact of Control Interventions. PloS One, 10 (8), S. e0135179–e0135179. http://doi.org/10.1371/journal.pone.0135179.
Porter, Mireille; Davies, Mary-Ann; Mapani, Muntanga K.; Rabie, Helena; Phiri, Sam et al. (2015). Outcomes of Infants Starting Antiretroviral Therapy in Southern Africa, 2004-2012. JAIDS Journal of Acquired Immune Deficiency Syndromes, 69 (5), S. 593–601. http://doi.org/10.1097/QAI.0000000000000683.
Tenthani, Lyson; Haas, Andreas D.; Egger, Matthias; Van Oosterhout, Joep J.; Jahn, Andreas et al. (2015). Brief Report: HIV Testing Among Pregnant Women Who Attend Antenatal Care in Malawi. Journal of Acquired Immune Deficiency Syndromes (1999), 69 (5), S. 610–614. http://doi.org/10.1097/QAI.0000000000000669.
Cornell, Morna; Johnson, Leigh F.; Schomaker, Michael; Tanser, Frank; Maskew, Mhairi et al. (2015). Age in antiretroviral therapy programmes in South Africa: a retrospective, multicentre, observational cohort study. The Lancet. HIV, 2 (9), S. e368-75. http://doi.org/10.1016/S2352-3018(15)00113-7.
Hermans, Sabine; Boulle, Andrew; Caldwell, Judy; Pienaar, David & Wood, Robin (2015). Temporal trends in TB notification rates during ART scale-up in Cape Town: an ecological analysis. Journal of the International AIDS Society, 18 (1). http://doi.org/10.7448/IAS.18.1.20240.
Schomaker, Michael; Hogger, Sara; Johnson, Leigh F.; Hoffmann, Christopher J.; Bärnighausen, Till et al. (2015). Simultaneous Treatment of Missing Data and Measurement Error in HIV Research Using Multiple Overimputation. Epidemiology (Cambridge, Mass.), 26 (5), S. 628–636. http://doi.org/10.1097/EDE.0000000000000334.
Huisin ʼt Veld, Diana; Balestre, Eric; Buyze, Jozefien; Menten, Joris; Jaquet, Antoine et al. (2015). Determinants of Weight Evolution Among HIV-Positive Patients Initiating Antiretroviral Treatment in Low-Resource Settings. Journal of Acquired Immune Deficiency Syndromes (1999), 70 (2), S. 146–154. http://doi.org/10.1097/QAI.0000000000000691.
Keiser, Olivia; Blaser, Nello; Davies, Mary-Ann; Wessa, Patrick; Eley, Brian et al. (2015). Growth in Virologically Suppressed HIV-Positive Children on Antiretroviral Therapy: Individual and Population-level References. The Pediatric Infectious Disease Journal, 34 (10), S. e254-9. http://doi.org/10.1097/INF.0000000000000801.
Koller, Manuel; Patel, Kunjal; Chi, Benjamin H.; Wools-Kaloustian, Kara; Dicko, Fatoumata et al. (2015). Authors’ Reply: Early Initiation of Antiretroviral Therapy Among Young Children: A Long Way to Go. Journal of Acquired Immune Deficiency Syndromes (1999), 70 (2), S. e71-2. http://doi.org/10.1097/QAI.0000000000000773.
Brown, Daniel M.; Petersen, Maya; Costello, Sadie; Noth, Elizabeth M.; Hammond, Katherine et al. (2015). Occupational Exposure to PM2.5 and Incidence of Ischemic Heart Disease: Longitudinal Targeted Minimum Loss-based Estimation. Epidemiology (Cambridge, Mass.), 26 (6), S. 806–814. http://doi.org/10.1097/EDE.0000000000000329.
Koller, Manuel; Fatti, Geoffrey; Chi, Benjamin H.; Keiser, Olivia; Hoffmann, Christopher J. et al. (2015). Implementation and Operational Research: Risk Charts to Guide Targeted HIV-1 Viral Load Monitoring of ART: Development and Validation in Patients From Resource-Limited Settings. Journal of Acquired Immune Deficiency Syndromes (1999), 70 (3), S. e110-9. http://doi.org/10.1097/QAI.0000000000000748.
Vinikoor, Michael J.; Zürcher, Samuel; Musukuma, Kalo; Kachuwaire, Obert; Rauch, Andri et al. (2015). Hepatitis B viral load in dried blood spots: A validation study in Zambia. Journal of Clinical Virology : The Official Publication of the Pan American Society for Clinical Virology, 72, S. 20–24. http://doi.org/10.1016/j.jcv.2015.08.019.
Davies, Mary-Ann; Ford, Nathan; Rabie, Helena; Fatti, Geoffrey; Stinson, Kathryn et al. (2015). Reducing CD4 Monitoring in Children on Antiretroviral Therapy With Virologic Suppression. The Pediatric Infectious Disease Journal, 34 (12), S. 1361–1364. http://doi.org/10.1097/INF.0000000000000912.
Johnson, Leigh F.; Dorrington, Rob E.; Laubscher, Ria; Hoffmann, Christopher J.; Wood, Robin et al. (2015). A comparison of death recording by health centres and civil registration in South Africans receiving antiretroviral treatment. Journal of the International AIDS Society, 18 (1). http://doi.org/10.7448/IAS.18.1.20628.
White, Richard G.; Hakim, Avi J.; Salganik, Matthew J.; Spiller, Michael W.; Johnston, Lisa G. et al. (2015). Strengthening the Reporting of Observational Studies in Epidemiology for respondent-driven sampling studies: “STROBE-RDS” statement. Journal of Clinical Epidemiology, 68 (12), S. 1463–1471. http://doi.org/10.1016/j.jclinepi.2015.04.002.
2014
IeDEA and ART Cohort Collaborations, Matthias; Avila, Dorita; Althoff, Keri N.; Mugglin, Catrina; Wools-Kaloustian, Kara et al. (2014). Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries. Journal of Acquired Immune Deficiency Syndromes (1999), 65 (1), S. e8-16. http://doi.org/10.1097/QAI.0b013e3182a39979.
Schomaker, M.; Gsponer, T.; Estill, J.; Fox, M. & Boulle, A. (2014). Non-ignorable loss to follow-up: correcting mortality estimates based on additional outcome ascertainment. Statistics in Medicine, 33 (1), S. 129–142. http://doi.org/10.1002/sim.5912.
Rohner, Eliane; Wyss, Natascha; Trelle, Sven; Mbulaiteye, Sam M.; Egger, Matthias et al. (2014). HHV-8 seroprevalence: a global view. Systematic Reviews, 3 (1), S. 11–11. http://doi.org/10.1186/2046-4053-3-11.
Tenthani, Lyson; Haas, Andreas D.; Tweya, Hannock; Jahn, Andreas; van Oosterhout, Joep J. et al. (2014). Retention in care under universal antiretroviral therapy for HIV-infected pregnant and breastfeeding women (‘Option B+’) in Malawi. AIDS (London, England), 28 (4), S. 589–598. http://doi.org/10.1097/QAD.0000000000000143.
Blaser, Nello; Wettstein, Celina; Estill, Janne; Vizcaya, Luisa Salazar; Wandeler, Gilles et al. (2014). Impact of viral load and the duration of primary infection on HIV transmission: systematic review and meta-analysis. AIDS (London, England), 28 (7), S. 1021–1029. http://doi.org/10.1097/QAD.0000000000000135.
Estill, Janne; Tweya, Hannock; Egger, Matthias; Wandeler, Gilles; Feldacker, Caryl et al. (2014). Tracing of patients lost to follow-up and HIV transmission: mathematical modeling study based on 2 large ART programs in Malawi. Journal of Acquired Immune Deficiency Syndromes (1999), 65 (5), S. e179-86. http://doi.org/10.1097/QAI.0000000000000075.
Davies, Mary-Ann & Kalk, Emma (2014). Provider-initiated HIV testing and counselling for children. PLoS Medicine, 11 (5), S. e1001650–e1001650. http://doi.org/10.1371/journal.pmed.1001650.
Mulenga, Lloyd; Musonda, Patrick; Mwango, Albert; Vinikoor, Michael J.; Davies, Mary-Ann et al. (2014). Effect of baseline renal function on tenofovir-containing antiretroviral therapy outcomes in Zambia. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 58 (10), S. 1473–1480. http://doi.org/10.1093/cid/ciu117.
Richardson, Eugene T.; Morrow, Carl D.; Kalil, Darryl B.; Ginsberg, Samuel; Bekker, Linda-Gail et al. (2014). Shared air: a renewed focus on ventilation for the prevention of tuberculosis transmission. PloS One, 9 (5), S. e96334–e96334. http://doi.org/10.1371/journal.pone.0096334.
Davies, Mary-Ann; May, Margaret; Bolton-Moore, Carolyn; Chimbetete, Cleophas; Eley, Brian et al. (2014). Prognosis of children with HIV-1 infection starting antiretroviral therapy in Southern Africa: a collaborative analysis of treatment programs. The Pediatric Infectious Disease Journal, 33 (6), S. 608–616. http://doi.org/10.1097/INF.0000000000000214.
Petersen, Maya; Schwab, Joshua; Gruber, Susan; Blaser, Nello; Schomaker, Michael et al. (2014). Targeted Maximum Likelihood Estimation for Dynamic and Static Longitudinal Marginal Structural Working Models. Journal of Causal Inference, 2 (2), S. 147–185. http://doi.org/10.1515/jci-2013-0007.
Technau, Karl-Günter; Schomaker, Michael; Kuhn, Louise; Moultrie, Harry; Coovadia, Ashraf et al. (2014). Virologic response in children treated with abacavir-compared with stavudine-based antiretroviral treatment: a South African multi-cohort analysis. The Pediatric Infectious Disease Journal, 33 (6), S. 617–622. http://doi.org/10.1097/INF.0000000000000222.
Andrews, Jason R.; Morrow, Carl; Walensky, Rochelle P. & Wood, Robin (2014). Integrating social contact and environmental data in evaluating tuberculosis transmission in a South African township. The Journal of Infectious Diseases, 210 (4), S. 597–603. http://doi.org/10.1093/infdis/jiu138.
Boulle, Andrew; Schomaker, Michael; May, Margaret T.; Hogg, Robert S.; Shepherd, Bryan E. et al. (2014). Mortality in patients with HIV-1 infection starting antiretroviral therapy in South Africa, Europe, or North America: a collaborative analysis of prospective studies. PLoS Medicine, 11 (9), S. e1001718–e1001718. http://doi.org/10.1371/journal.pmed.1001718.
Mbeye, Nyanyiwe M.; ter Kuile, Feiko O.; Davies, Mary-Ann; Phiri, Kamija S.; Egger, Matthias et al. (2014). Cotrimoxazole prophylactic treatment prevents malaria in children in sub-Saharan Africa: systematic review and meta-analysis. Tropical Medicine & International Health : TM & IH, 19 (9), S. 1057–1067. http://doi.org/10.1111/tmi.12352.
Petersen, Maya; Yiannoutsos, Constantin T.; Justice, Amy & Egger, Matthias (2014). Observational research on NCDs in HIV-positive populations: conceptual and methodological considerations. Journal of Acquired Immune Deficiency Syndromes (1999), 67 Suppl 1, S. S8-16. http://doi.org/10.1097/QAI.0000000000000253.
Cornell, Morna; Lessells, Richard; Fox, Matthew P.; Garone, Daniela B.; Giddy, Janet et al. (2014). Mortality among adults transferred and lost to follow-up from antiretroviral therapy programmes in South Africa: a multicenter cohort study. Journal of Acquired Immune Deficiency Syndromes (1999), 67 (2), S. e67-75. http://doi.org/10.1097/QAI.0000000000000269.
Salazar-Vizcaya, Luisa; Keiser, Olivia; Karl Technau; Davies, Mary-Ann; Haas, Andreas D. et al. (2014). Viral load versus CD4+ monitoring and 5-year outcomes of antiretroviral therapy in HIV-positive children in Southern Africa: a cohort-based modelling study. AIDS (London, England), 28 (16), S. 2451–2460. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/25392857
Ballif, M.; Nhandu, V.; Wood, R.; Dusingize, J. C.; Carter, E. J. et al. (2014). Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries. The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 18 (11), S. 1327–36. http://doi.org/10.5588/ijtld.14.0106.
Petersen, Maya L. (2014). Commentary: Applying a causal road map in settings with time-dependent confounding. Epidemiology (Cambridge, Mass.), 25 (6), S. 898–901. http://doi.org/10.1097/EDE.0000000000000178.
Bohlius, Julia; Valeri, Fabio; Maskew, Mhairi; Prozesky, Hans; Garone, Daniela et al. (2014). Kaposi’s Sarcoma in HIV-infected patients in South Africa: Multicohort study in the antiretroviral therapy era. International Journal of Cancer, 135 (11), S. 2644–2652. http://doi.org/10.1002/ijc.28894.
Duda, Stephany N.; Farr, Amanda M.; Lindegren, Mary Lou; Blevins, Meridith; Wester, C. William et al. (2014). Characteristics and comprehensiveness of adult HIV care and treatment programmes in Asia-Pacific, sub-Saharan Africa and the Americas: results of a site assessment conducted by the International epidemiologic Databases to Evaluate AIDS (IeDEA) Collaborati. Journal of the International AIDS Society, 17 (1), S. 19045–19045. http://doi.org/10.7448/IAS.17.1.19045.
Johnson, Leigh F.; Estill, Janne; Keiser, Olivia; Cornell, Morna; Moolla, Haroon et al. (2014). Do increasing rates of loss to follow-up in antiretroviral treatment programs imply deteriorating patient retention? American Journal of Epidemiology, 180 (12), S. 1208–1212. http://doi.org/10.1093/aje/kwu295.
Rohner, Eliane; Valeri, Fabio; Maskew, Mhairi; Prozesky, Hans; Rabie, Helena et al. (2014). Incidence rate of Kaposi sarcoma in HIV-infected patients on antiretroviral therapy in Southern Africa: a prospective multicohort study. Journal of Acquired Immune Deficiency Syndromes (1999), 67 (5), S. 547–554. http://doi.org/10.1097/QAI.0000000000000360.
Wandeler, Gilles; Gerber, Florian; Rohr, Julia; Chi, Benjamin H.; Orrell, Catherine et al. (2014). Tenofovir or zidovudine in second-line antiretroviral therapy after stavudine failure in southern Africa. Antiviral Therapy, 19 (5), S. 521–525. http://doi.org/10.3851/IMP2710.
2013
Cornell, M. (2013). Gender inequality: Bad for men’s health. Southern African Journal of HIV Medicine, 14 (1), S. 12–14. http://doi.org/10.7196/SAJHIVMED.894.
Cornell, Morna & Myer, Landon (2013). Does the success of HIV treatment depend on gender? Future Microbiology, 8 (1), S. 9–11. http://doi.org/10.2217/fmb.12.128.
IeDEA Pediatric Working Group (2013). A survey of paediatric HIV programmatic and clinical management practices in Asia and sub-Saharan Africa–the International epidemiologic Databases to Evaluate AIDS (IeDEA). Journal of the International AIDS Society, 16, S. 17998–17998. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23336728
Estill, Janne; Egger, Matthias; Johnson, Leigh F.; Gsponer, Thomas; Wandeler, Gilles et al. (2013). Monitoring of antiretroviral therapy and mortality in HIV programmes in Malawi, South Africa and Zambia: mathematical modelling study. PloS One, 8 (2), S. e57611–e57611. http://doi.org/10.1371/journal.pone.0057611.
Fenner, Lukas; Reid, Stewart E.; Fox, Matthew P.; Garone, Daniela; Wellington, Maureen et al. (2013). Tuberculosis and the risk of opportunistic infections and cancers in HIV-infected patients starting ART in Southern Africa. Tropical Medicine & International Health : TM & IH, 18 (2), S. 194–198. http://doi.org/10.1111/tmi.12026.
Gupta, Ankur; Wood, Robin; Kaplan, Richard; Bekker, Linda-Gail & Lawn, Stephen D. (2013). Prevalent and incident tuberculosis are independent risk factors for mortality among patients accessing antiretroviral therapy in South Africa. PloS One, 8 (2), S. e55824–e55824. http://doi.org/10.1371/journal.pone.0055824.
Leroy, Valeriane; Malateste, Karen; Rabie, Helena; Lumbiganon, Pagakrong; Ayaya, Samuel et al. (2013). Outcomes of antiretroviral therapy in children in Asia and Africa: a comparative analysis of the IeDEA pediatric multiregional collaboration. Journal of Acquired Immune Deficiency Syndromes, 62 (2), S. 208–219. http://doi.org/10.1097/QAI.0b013e31827b70bf.
Luque-Fernandez, Miguel Angel; Van Cutsem, Gilles; Goemaere, Eric; Hilderbrand, Katherine; Schomaker, Michael et al. (2013). Effectiveness of patient adherence groups as a model of care for stable patients on antiretroviral therapy in Khayelitsha, Cape Town, South Africa. PloS One, 8 (2), S. e56088–e56088. http://doi.org/10.1371/journal.pone.0056088.
Mugglin, Catrina; Wandeler, Gilles; Estill, Janne; Egger, Matthias; Bender, Nicole et al. (2013). Retention in care of HIV-infected children from HIV test to start of antiretroviral therapy: systematic review. PloS One, 8 (2), S. e56446–e56446. http://doi.org/10.1371/journal.pone.0056446.
Tweya, Hannock; Feldacker, Caryl; Phiri, Sam; Ben-Smith, Anne; Fenner, Lukas et al. (2013). Comparison of treatment outcomes of new smear-positive pulmonary tuberculosis patients by HIV and antiretroviral status in a TB/HIV clinic, Malawi. PloS One, 8 (2), S. e56248–e56248. http://doi.org/10.1371/journal.pone.0056248.
Cornell, Morna & Myer, Landon (2013). Men and mortality: sex inequality in health outcomes. AIDS (London, England), 27 (5), S. 849–850. http://doi.org/10.1097/QAD.0b013e32835e399b.
Fenner, Lukas; Egger, Matthias; Bodmer, Thomas; Furrer, Hansjakob; Ballif, Marie et al. (2013). HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis. PLoS Genetics, 9 (3), S. e1003318–e1003318. http://doi.org/10.1371/journal.pgen.1003318.
Nglazi, Mweete D.; Kaplan, Richard; Orrell, Catherine; Myer, Landon; Wood, Robin et al. (2013). Increasing transfers-out from an antiretroviral treatment service in South Africa: patient characteristics and rates of virological non-suppression. PloS One, 8 (3), S. e57907–e57907. http://doi.org/10.1371/journal.pone.0057907.
Anglemyer, Andrew; Rutherford, George W.; Horvath, Tara; Baggaley, Rachel C.; Egger, Matthias et al. (2013). Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. The Cochrane Database of Systematic Reviews, (4), S. CD009153–CD009153. http://doi.org/10.1002/14651858.CD009153.pub3.
Johnson, Leigh F.; Mossong, Joel; Dorrington, Rob E.; Schomaker, Michael; Hoffmann, Christopher J. et al. (2013). Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies. PLoS Medicine, 10 (4), S. e1001418–e1001418. http://doi.org/10.1371/journal.pmed.1001418.
Hoffmann, Christopher J.; Schomaker, Michael; Fox, Matthew P.; Mutevedzi, Portia; Giddy, Janet et al. (2013). CD4 count slope and mortality in HIV-infected patients on antiretroviral therapy: multicohort analysis from South Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 63 (1), S. 34–41. http://doi.org/10.1097/QAI.0b013e318287c1fe.
Lawn, S. D.; Kerkhoff, A. D.; Vogt, M. & Wood, R. (2013). Diagnostic and prognostic value of serum C-reactive protein for screening for HIV-associated tuberculosis. The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 17 (5), S. 636–643. http://doi.org/10.5588/ijtld.12.0811.
Schomaker, Michael; Egger, Matthias; Maskew, Mhairi; Garone, Daniela; Prozesky, Hans et al. (2013). Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 63 (1), S. 142–145. http://doi.org/10.1097/QAI.0b013e318288b39d.
Stuck, Andreas E.; Tenthani, Lyson & Egger, Matthias (2013). Assessing population aging and disability in sub-Saharan Africa: lessons from Malawi? PLoS Medicine, 10 (5), S. e1001441–e1001441. http://doi.org/10.1371/journal.pmed.1001441.
Estill, Janne; Egger, Matthias; Blaser, Nello; Vizcaya, Luisa Salazar; Garone, Daniela et al. (2013). Cost-effectiveness of point-of-care viral load monitoring of antiretroviral therapy in resource-limited settings: mathematical modelling study. AIDS (London, England), 27 (9), S. 1483–1492. http://doi.org/10.1097/QAD.0b013e328360a4e5.
Maskew, Mhairi; Fox, Matthew P.; van Cutsem, Gilles; Chu, Kathryn; Macphail, Patrick et al. (2013). Treatment response and mortality among patients starting antiretroviral therapy with and without Kaposi sarcoma: a cohort study. PloS One, 8 (6), S. e64392–e64392. http://doi.org/10.1371/journal.pone.0064392.
Kerkhoff, Andrew D.; Wood, Robin; Lowe, David M.; Vogt, Monica & Lawn, Stephen D. (2013). Blood neutrophil counts in HIV-infected patients with pulmonary tuberculosis: association with sputum mycobacterial load. PloS One, 8 (7), S. e67956–e67956. http://doi.org/10.1371/journal.pone.0067956.
McIlleron, Helen M.; Schomaker, Michael; Ren, Yuan; Sinxadi, Phumla; Nuttall, James J. C. et al. (2013). Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype. AIDS (London, England), 27 (12), S. 1933–1940. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24180002
Cornell, Morna & Myer, Landon (2013). Moving beyond gender stereotypes. Lancet (London, England), 382 (9891), S. 506–506. http://doi.org/10.1016/S0140-6736(13)61713-4.
Gupta, R. K.; Lawn, S. D.; Bekker, L. G.; Caldwell, J.; Kaplan, R. et al. (2013). Impact of human immunodeficiency virus and CD4 count on tuberculosis diagnosis: analysis of city-wide data from Cape Town, South Africa. The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 17 (8), S. 1014–1022. http://doi.org/10.5588/ijtld.13.0032.
Kranzer, Katharina; Lawn, Stephen D.; Johnson, Leigh F.; Bekker, Linda-Gail & Wood, Robin (2013). Community viral load and CD4 count distribution among people living with HIV in a South African Township: implications for treatment as prevention. Journal of Acquired Immune Deficiency Syndromes (1999), 63 (4), S. 498–505. http://doi.org/10.1097/QAI.0b013e318293ae48.
Maskew, Mhairi; MacPhail, A. Patrick; Whitby, Denise; Egger, Matthias & Fox, Matthew P. (2013). Kaposi sarcoma-associated herpes virus and response to antiretroviral therapy: a prospective study of HIV-infected adults. Journal of Acquired Immune Deficiency Syndromes (1999), 63 (4), S. 442–448. http://doi.org/10.1097/QAI.0b013e3182969cc1.
Technau, Karl-Günter; Lazarus, Erica; Kuhn, Louise; Abrams, Elaine J.; Sorour, Gillian et al. (2013). Poor early virologic performance and durability of abacavir-based first-line regimens for HIV-infected children. The Pediatric Infectious Disease Journal, 32 (8), S. 851–855. http://doi.org/10.1097/INF.0b013e31828c3738.
Grimsrud, Anna Thora; Cornell, Morna; Egger, Matthias; Boulle, Andrew & Myer, Landon (2013). Impact of definitions of loss to follow-up (LTFU) in antiretroviral therapy program evaluation: variation in the definition can have an appreciable impact on estimated proportions of LTFU. Journal of Clinical Epidemiology, 66 (9), S. 1006–1013. http://doi.org/10.1016/j.jclinepi.2013.03.013.
Pathai, Sophia; Lawn, Stephen D.; Gilbert, Clare E.; McGuinness, Dagmara; McGlynn, Liane et al. (2013). Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study. AIDS (London, England), 27 (15), S. 2375–2384. http://doi.org/10.1097/QAD.0b013e328363bf7f.
Wandeler, Gilles; Gsponer, Thomas; Mulenga, Lloyd; Garone, Daniela; Wood, Robin et al. (2013). Zidovudine impairs immunological recovery on first-line antiretroviral therapy: collaborative analysis of cohort studies in southern Africa. AIDS (London, England), 27 (14), S. 2225–2232. http://doi.org/10.1097/QAD.0b013e328362d887.
Fenner, Lukas; Ballif, Marie; Graber, Claire; Nhandu, Venerandah; Dusingize, Jean Claude et al. (2013). Tuberculosis in antiretroviral treatment programs in lower income countries: availability and use of diagnostics and screening. PloS One, 8 (10), S. e77697–e77697. http://doi.org/10.1371/journal.pone.0077697.
Siegfried, Nandi; Davies, Mary-Ann; Penazzato, Martina; Muhe, Lulu M. & Egger, Matthias (2013). Optimal time for initiating antiretroviral therapy (ART) in HIV-infected, treatment-naive children aged 2 to 5 years old. The Cochrane Database of Systematic Reviews, (10), S. CD010309–CD010309. http://doi.org/10.1002/14651858.CD010309.pub2.
Gupta-Wright, Ankur; Wood, Robin; Bekker, Linda-Gail & Lawn, Stephen D. (2013). Temporal association between incident tuberculosis and poor virological outcomes in a South African antiretroviral treatment service. Journal of Acquired Immune Deficiency Syndromes (1999), 64 (3), S. 261–270. http://doi.org/10.1097/QAI.0b013e3182a23e9a.
Keiser, Olivia; Sello, Motlalepula; Ishmael Lejone, Thabo; Pfeiffer, Karolin; Davies, Mary-Ann et al. (2013). Outcomes of antiretroviral treatment programmes in rural Lesotho: health centres and hospitals compared. Journal of the International AIDS Society, 16 (1). http://doi.org/10.7448/IAS.16.1.18616.
Schomaker, Michael; Egger, Matthias; Ndirangu, James; Phiri, Sam; Moultrie, Harry et al. (2013). When to start antiretroviral therapy in children aged 2-5 years: a collaborative causal modelling analysis of cohort studies from southern Africa. PLoS Medicine, 10 (11), S. e1001555–e1001555. http://doi.org/10.1371/journal.pmed.1001555.
Davies, Mary-Ann; Phiri, Sam; Wood, Robin; Wellington, Maureen; Cox, Vivian et al. (2013). Temporal trends in the characteristics of children at antiretroviral therapy initiation in southern Africa: the IeDEA-SA Collaboration. PloS One, 8 (12), S. e81037–e81037. http://doi.org/10.1371/journal.pone.0081037.
2012
Gsponer, Thomas; Petersen, Maya; Egger, Matthias; Phiri, Sam; Maathuis, Marloes H. et al. (2012). The causal effect of switching to second-line ART in programmes without access to routine viral load monitoring. AIDS (London, England), 26 (1), S. 57–65. http://doi.org/10.1097/QAD.0b013e32834e1b5f.
Weigel, Ralf; Estill, Janne; Egger, Matthias; Harries, Anthony D.; Makombe, Simon et al. (2012). Mortality and loss to follow-up in the first year of ART: Malawi national ART programme. AIDS (London, England), 26 (3), S. 365–373. http://doi.org/10.1097/QAD.0b013e32834ed814.
Zhou, Jialun; Jaquet, Antoine; Bissagnene, Emmanuel; Musick, Beverly; Wools-Kaloustian, Kara et al. (2012). Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America. Journal of the International AIDS Society, 15 (1), S. 5. http://doi.org/10.1186/1758-2652-15-5.
Fenner, Lukas; Gagneux, Sebastien; Helbling, Peter; Battegay, Manuel; Rieder, Hans L. et al. (2012). Mycobacterium tuberculosis transmission in a country with low tuberculosis incidence: role of immigration and HIV infection. Journal of Clinical Microbiology, 50 (2), S. 388–395. http://doi.org/10.1128/JCM.05392-11.
Kranzer, K.; Govindasamy, D.; van Schaik, N.; Thebus, E.; Davies, N. et al. (2012). Incentivized recruitment of a population sample to a mobile HIV testing service increases the yield of newly diagnosed cases, including those in need of antiretroviral therapy. HIV Medicine, 13 (2), S. 132–137. http://doi.org/10.1111/j.1468-1293.2011.00947.x.
Wandeler, Gilles; Keiser, Olivia; Pfeiffer, Karolin; Pestilli, Sabrina; Fritz, Christiane et al. (2012). Outcomes of antiretroviral treatment programs in rural Southern Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 59 (2), S. e9-16. http://doi.org/10.1097/QAI.0b013e31823edb6a.
Fenner, Lukas; Gagneux, Sebastien; Janssens, Jean-Paul; Fehr, Jan; Cavassini, Matthias et al. (2012). Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes. PloS One, 7 (3), S. e34186–e34186. http://doi.org/10.1371/journal.pone.0034186.
Morrow, Carl; Munro, Alison; Wilke, Marisa; Stark, Ruth & Wood, Robin (2012). Remote sensing of HIV care programmes using centrally collected laboratory results: can we monitor ART programme effectiveness? South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 102 (6), S. 501–505. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22668950
Calmy, Alexandra; Balestre, Eric; Bonnet, Fabrice; Boulle, Andrew; Sprinz, Eduardo et al. (2012). Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings. BMC Infectious Diseases, 12 (1), S. 147–147. http://doi.org/10.1186/1471-2334-12-147.
Fenner, Lukas; Egger, Matthias; Bodmer, Thomas; Altpeter, Ekkehardt; Zwahlen, Marcel et al. (2012). Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 56 (6), S. 3047–3053. http://doi.org/10.1128/AAC.06460-11.
Wood, Robin; Racow, Kimberly; Bekker, Linda-Gail; Morrow, Carl; Middelkoop, Keren et al. (2012). Indoor social networks in a South African township: potential contribution of location to tuberculosis transmission. PloS One, 7 (6), S. e39246–e39246. http://doi.org/10.1371/journal.pone.0039246.
Estill, Janne; Aubrière, Cindy; Egger, Matthias; Johnson, Leigh; Wood, Robin et al. (2012). Viral load monitoring of antiretroviral therapy, cohort viral load and HIV transmission in Southern Africa: a mathematical modelling analysis. AIDS (London, England), 26 (11), S. 1403–1413. http://doi.org/10.1097/QAD.0b013e3283536988.
Wood, Robin & Lawn, Stephen D. (2012). Challenges facing lipoarabinomannan urine antigen tests for diagnosing HIV-associated tuberculosis. Expert Review of Molecular Diagnostics, 12 (6), S. 549–551. http://doi.org/10.1586/erm.12.52.
Fox, Matthew P.; Cutsem, Gilles Van; Giddy, Janet; Maskew, Mhairi; Keiser, Olivia et al. (2012). Rates and predictors of failure of first-line antiretroviral therapy and switch to second-line ART in South Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 60 (4), S. 428–437. http://doi.org/10.1097/QAI.0b013e3182557785.
Kranzer, Katharina; Lawn, Stephen D.; Meyer-Rath, Gesine; Vassall, Anna; Raditlhalo, Eudoxia et al. (2012). Feasibility, yield, and cost of active tuberculosis case finding linked to a mobile HIV service in Cape Town, South Africa: a cross-sectional study. PLoS Medicine, 9 (8), S. e1001281–e1001281. http://doi.org/10.1371/journal.pmed.1001281.
Lawn, Stephen D. & Wood, Robin (2012). Short-course untargeted isoniazid preventive therapy in South Africa: time to rethink policy? The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 16 (8), S. 995–996. http://doi.org/10.5588/ijtld.12.0364.
Lawn, Stephen D.; Gupta, Ankur & Wood, Robin (2012). Assessing the impact of prevalent tuberculosis on mortality among antiretroviral treatment initiators: accurate tuberculosis diagnosis is essential. AIDS (London, England), 26 (13), S. 1730–1731; author reply 1728-9. http://doi.org/10.1097/QAD.0b013e3283565ebe.
Feldacker, C.; Tweya, H.; Keiser, O.; Weigel, R.; Kalulu, M. et al. (2012). Characteristics of adults and children diagnosed with tuberculosis in Lilongwe, Malawi: findings from an integrated HIV/TB clinic. Tropical Medicine & International Health : TM & IH, 17 (9), S. 1108–1116. http://doi.org/10.1111/j.1365-3156.2012.03041.x.
Wandeler, Gilles; Keiser, Olivia; Mulenga, Lloyd; Hoffmann, Christopher J.; Wood, Robin et al. (2012). Tenofovir in second-line ART in Zambia and South Africa: collaborative analysis of cohort studies. Journal of Acquired Immune Deficiency Syndromes (1999), 61 (1), S. 41–48. http://doi.org/10.1097/QAI.0b013e3182632540.
Egger, Matthias; Ekouevi, Didier K.; Williams, Carolyn; Lyamuya, Rita Elias; Mukumbi, Henri et al. (2012). Cohort Profile: the international epidemiological databases to evaluate AIDS (IeDEA) in sub-Saharan Africa. International Journal of Epidemiology, 41 (5), S. 1256–1264. http://doi.org/10.1093/ije/dyr080.
Gsponer, Thomas; Weigel, Ralf; Davies, Mary-Ann; Bolton, Carolyn; Moultrie, Harry et al. (2012). Variability of growth in children starting antiretroviral treatment in southern Africa. Pediatrics, 130 (4), S. e966-77. http://doi.org/10.1542/peds.2011-3020.
Nglazi, Mweete Debra; Kaplan, Richard; Caldwell, Judy; Peton, Neshaan; Lawn, Stephen D. et al. (2012). Antiretroviral treatment uptake in patients with HIV-associated TB attending co-located TB and ART services. South African Medical Journal, 102 (12), S. 936–936. http://doi.org/10.7196/SAMJ.6024.
Davies, Mary-Ann; Boulle, Andrew; Technau, Karl; Eley, Brian; Moultrie, Harry et al. (2012). The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure. Tropical Medicine & International Health : TM & IH, 17 (11), S. 1386–1390. http://doi.org/10.1111/j.1365-3156.2012.03073.x.
Lawn, Stephen D.; Harries, Anthony D.; Meintjes, Graeme; Getahun, Haileyesus; Havlir, Diane V. et al. (2012). Reducing deaths from tuberculosis in antiretroviral treatment programmes in sub-Saharan Africa. AIDS (London, England), 26 (17), S. 2121–2133. http://doi.org/10.1097/QAD.0b013e3283565dd1.
Wettstein, Celina; Mugglin, Catrina; Egger, Matthias; Blaser, Nello; Vizcaya, Luisa S. et al. (2012). Missed opportunities to prevent mother-to-child-transmission: systematic review and meta-analysis. AIDS (London, England), 26 (18), S. 2361–73. http://doi.org/10.1097/QAD.0b013e328359ab0c.
Malla, Bijaya; Stucki, David; Borrell, Sonia; Feldmann, Julia; Maharjan, Bhagwan et al. (2012). First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Nepal. PloS One, 7 (12), S. e52297–e52297. http://doi.org/10.1371/journal.pone.0052297.
Mugglin, Catrina; Estill, Janne; Wandeler, Gilles; Bender, Nicole; Egger, Matthias et al. (2012). Loss to programme between HIV diagnosis and initiation of antiretroviral therapy in sub-Saharan Africa: systematic review and meta-analysis. Tropical Medicine & International Health : TM & IH, 17 (12), S. 1509–1520. http://doi.org/10.1111/j.1365-3156.2012.03089.x.
Yiannoutsos, Constantin Theodore; Johnson, Leigh Francis; Boulle, Andrew; Musick, Beverly Sue; Gsponer, Thomas et al. (2012). Estimated mortality of adult HIV-infected patients starting treatment with combination antiretroviral therapy. Sexually Transmitted Infections, 88 Suppl 2 (Suppl 2), S. i33-43. http://doi.org/10.1136/sextrans-2012-050658.
Cornell, Morna; Schomaker, Michael; Garone, Daniela Belen; Giddy, Janet; Hoffmann, Christopher J. et al. (2012). Gender differences in survival among adult patients starting antiretroviral therapy in South Africa: a multicentre cohort study. PLoS Medicine, 9 (9), S. e1001304–e1001304. http://doi.org/10.1371/journal.pmed.1001304.
2011
Egger, Matthias; Spycher, Ben D.; Sidle, John; Weigel, Ralf; Geng, Elvin H. et al. (2011). Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa. PLoS Medicine, 8 (1), S. e1000390–e1000390. http://doi.org/10.1371/journal.pmed.1000390.
Weigel, Ralf; Hochgesang, Mindy; Brinkhof, Martin Wg; Hosseinipour, Mina C.; Boxshall, Matt et al. (2011). Outcomes and associated risk factors of patients traced after being lost to follow-up from antiretroviral treatment in Lilongwe, Malawi. BMC Infectious Diseases, 11 (1), S. 31–31. http://doi.org/10.1186/1471-2334-11-31.
TREAT Asia Pediatric HIV Observational Database (TApHOD) & International Epidemiologic Databases to Evaluate AIDS (IeDEA) Southern Africa Paediatric Group (2011). A biregional survey and review of first-line treatment failure and second-line pediatric antiretroviral access and use in Asia and southern Africa. Journal of the International AIDS Society, 14 (1), S. 17–17. Retrieved from http://archive.biomedcentral.com/1758-2652/14/7
Cornell, Morna; Grimsrud, Anna; Boulle, Andrew & Myer, Landon (2011). Retention among adults initiating antiretroviral therapy in South Africa: 2002-2007. Journal of Acquired Immune Deficiency Syndromes (1999), 56 (3), S. e102; author reply e102-3. http://doi.org/10.1097/QAI.0b013e318202c40e.
Davies, Mary-Ann; Moultrie, Harry; Eley, Brian; Rabie, Helena; Van Cutsem, Gilles et al. (2011). Virologic failure and second-line antiretroviral therapy in children in South Africa–the IeDEA Southern Africa collaboration. Journal of Acquired Immune Deficiency Syndromes (1999), 56 (3), S. 270–278. http://doi.org/10.1097/QAI.0b013e3182060610.
Fenner, L.; Forster, M.; Boulle, A.; Phiri, S.; Braitstein, P. et al. (2011). Tuberculosis in HIV programmes in lower-income countries: practices and risk factors. The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 15 (5), S. 620–627. http://doi.org/10.5588/ijtld.10.0249.
Lawn, Stephen D.; Campbell, Lucy; Kaplan, Richard; Boulle, Andrew; Cornell, Morna et al. (2011). Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 57 (2), S. 136–140. http://doi.org/10.1097/QAI.0b013e3182199ee9.
Cornell, Morna; McIntyre, James & Myer, Landon (2011). Men and antiretroviral therapy in Africa: our blind spot. Tropical Medicine & International Health : TM & IH, 16 (7), S. 828–829. http://doi.org/10.1111/j.1365-3156.2011.02767.x.
Fenner, Lukas; Malla, Bijaya; Ninet, Béatrice; Dubuis, Olivier; Stucki, David et al. (2011). Pseudo-Beijing: evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis. PloS One, 6 (9), S. e24737–e24737. http://doi.org/10.1371/journal.pone.0024737.
Keiser, Olivia; Chi, Benjamin H.; Gsponer, Thomas; Boulle, Andrew; Orrell, Catherine et al. (2011). Outcomes of antiretroviral treatment in programmes with and without routine viral load monitoring in Southern Africa. AIDS (London, England), 25 (14), S. 1761–1769. http://doi.org/10.1097/QAD.0b013e328349822f.
Kranzer, Katharina; van Schaik, Nienke; Karmue, Unice; Middelkoop, Keren; Sebastian, Elaine et al. (2011). High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa. PloS One, 6 (9), S. e25244–e25244. http://doi.org/10.1371/journal.pone.0025244.
Lawn, Stephen D.; Campbell, Lucy; Kaplan, Richard; Little, Francesca; Morrow, Carl et al. (2011). Delays in starting antiretroviral therapy in patients with HIV-associated tuberculosis accessing non-integrated clinical services in a South African township. BMC Infectious Diseases, 11 (1), S. 258–258. http://doi.org/10.1186/1471-2334-11-258.
Chi, Benjamin H.; Yiannoutsos, Constantin T.; Westfall, Andrew O.; Newman, Jamie E.; Zhou, Jialun et al. (2011). Universal Definition of Loss to Follow-Up in HIV Treatment Programs: A Statistical Analysis of 111 Facilities in Africa, Asia, and Latin America. PLoS Medicine, 8 (10), S. e1001111. http://doi.org/10.1371/journal.pmed.1001111.
Wood, Robin; Lawn, Stephen D.; Caldwell, Judy; Kaplan, Richard; Middelkoop, Keren et al. (2011). Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status. PloS One, 6 (10), S. e25098–e25098. http://doi.org/10.1371/journal.pone.0025098.
Davies, Mary-Ann; Boulle, Andrew; Eley, Brian; Moultrie, Harry; Technau, Karl et al. (2011). Accuracy of immunological criteria for identifying virological failure in children on antiretroviral therapy – the IeDEA Southern Africa Collaboration. Tropical Medicine & International Health : TM & IH, 16 (11), S. 1367–1371. http://doi.org/10.1111/j.1365-3156.2011.02854.x.
Kranzer, Katharina; Lewis, James J.; White, Richard G.; Glynn, Judith R.; Lawn, Stephen D. et al. (2011). Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods. PloS One, 6 (11), S. e27763–e27763. http://doi.org/10.1371/journal.pone.0027763.
Maskew, Mhairi; Macphail, A. Patrick; Whitby, Denise; Egger, Matthias; Wallis, Carole L. et al. (2011). Prevalence and predictors of kaposi sarcoma herpes virus seropositivity: a cross-sectional analysis of HIV-infected adults initiating ART in Johannesburg, South Africa. Infectious Agents and Cancer, 6 (1), S. 22–22. http://doi.org/10.1186/1750-9378-6-22.
Schöni-Affolter, Franziska; Keiser, Olivia; Mwango, Albert; Stringer, Jeffrey; Ledergerber, Bruno et al. (2011). Estimating loss to follow-up in HIV-infected patients on antiretroviral therapy: the effect of the competing risk of death in Zambia and Switzerland. PloS One, 6 (12), S. e27919–e27919. http://doi.org/10.1371/journal.pone.0027919.
2010
Lawn, Stephen D.; Edwards, David J. & Wood, Robin (2010). Reducing the burden of tuberculosis presenting during the initial months of antiretroviral therapy in resource-limited settings. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 50 (1), S. 124–125; author reply 125. http://doi.org/10.1086/649007.
Tuboi, Suely Hiromi; Pacheco, Antonio Guilherme; Harrison, Lee H.; Stone, Roslyn A.; May, Margaret et al. (2010). Mortality Associated With Discordant Responses to Antiretroviral Therapy in Resource-Constrained Settings. JAIDS Journal of Acquired Immune Deficiency Syndromes, 53 (1), S. 70–77. http://doi.org/10.1097/QAI.0b013e3181c22d19.
Keiser, Olivia; Tweya, Hannock; Braitstein, Paula; Dabis, François; MacPhail, Patrick et al. (2010). Mortality after failure of antiretroviral therapy in sub-Saharan Africa. Tropical Medicine & International Health : TM & IH, 15 (2), S. 251–258. http://doi.org/10.1111/j.1365-3156.2009.02445.x.
Müller, Monika; Wandel, Simon; Colebunders, Robert; Attia, Suzanna; Furrer, Hansjakob et al. (2010). Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis. The Lancet. Infectious Diseases, 10 (4), S. 251–261. http://doi.org/10.1016/S1473-3099(10)70026-8.
Connell, Tom G.; Davies, Mary-Ann; Johannisen, Christine; Wood, Kathryn; Pienaar, Sandy et al. (2010). Reversion and conversion of Mycobacterium tuberculosis IFN-gamma ELISpot results during anti-tuberculous treatment in HIV-infected children. BMC Infectious Diseases, 10 (1), S. 138. http://doi.org/10.1186/1471-2334-10-138.
Spaar, A.; Graber, C.; Dabis, F.; Coutsoudis, A.; Bachmann, L. et al. (2010). Prioritising prevention strategies for patients in antiretroviral treatment programmes in resource-limited settings. AIDS Care, 22 (6), S. 775–783. http://doi.org/10.1080/09540120903349102.
Fenner, Lukas; Brinkhof, Martin W. G.; Keiser, Olivia; Weigel, Ralf; Cornell, Morna et al. (2010). Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 54 (5), S. 524–532. http://doi.org/10.1097/QAI.0b013e3181e0c4cf.
May, Margaret; Boulle, Andrew; Phiri, Sam; Messou, Eugene; Myer, Landon et al. (2010). Prognosis of patients with HIV-1 infection starting antiretroviral therapy in sub-Saharan Africa: a collaborative analysis of scale-up programmes. Lancet (London, England), 376 (9739), S. 449–457. http://doi.org/10.1016/S0140-6736(10)60666-6.
Weigel, Ralf; Phiri, Sam; Chiputula, Fred; Gumulira, Joe; Brinkhof, Martin et al. (2010). Growth response to antiretroviral treatment in HIV-infected children: a cohort study from Lilongwe, Malawi. Tropical Medicine & International Health : TM & IH, 15 (8), S. 934–944. http://doi.org/10.1111/j.1365-3156.2010.02561.x.
Cornell, Morna; Grimsrud, Anna; Fairall, Lara; Fox, Matthew P.; van Cutsem, Gilles et al. (2010). Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007. AIDS (London, England), 24 (14), S. 2263–2270. http://doi.org/10.1097/QAD.0b013e32833d45c5.
Ingle, Suzanne M.; May, Margaret; Uebel, Kerry; Timmerman, Venessa; Kotze, Eduan et al. (2010). Differences in access and patient outcomes across antiretroviral treatment clinics in the Free State province: a prospective cohort study. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 100 (10), S. 675–681. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21080999
Brinkhof, Martin W. G.; Spycher, Ben D.; Yiannoutsos, Constantin; Weigel, Ralf; Wood, Robin et al. (2010). Adjusting mortality for loss to follow-up: analysis of five ART programmes in sub-Saharan Africa. PloS One, 5 (11), S. e14149–e14149. http://doi.org/10.1371/journal.pone.0014149.
Ingle, Suzanne M.; May, Margaret; Uebel, Kerry; Timmerman, Venessa; Kotze, Eduan et al. (2010). Outcomes in patients waiting for antiretroviral treatment in the Free State Province, South Africa: prospective linkage study. AIDS (London, England), 24 (17), S. 2717–2725. http://doi.org/10.1097/QAD.0b013e32833fb71f.
Tassie, Jean-Michel; Malateste, Karen; Pujades-Rodríguez, Mar; Poulet, Elisabeth; Bennett, Diane et al. (2010). Evaluation of three sampling methods to monitor outcomes of antiretroviral treatment programmes in low- and middle-income countries. PloS One, 5 (11), S. e13899–e13899. http://doi.org/10.1371/journal.pone.0013899.
Lawn, Stephen D. & Wood, Robin (2010). Immune reconstitution inflammatory syndrome. The Lancet. Infectious Diseases, 10 (12), S. 833–834. http://doi.org/10.1016/S1473-3099(10)70280-2.
Mahy, Mary; Lewden, Charlotte; Brinkhof, Martin W. G.; Dabis, Francois; Tassie, Jean-Michel et al. (2010). Derivation of parameters used in Spectrum for eligibility for antiretroviral therapy and survival on antiretroviral therapy. Sexually Transmitted Infections, 86 Suppl 2 (Suppl 2), S. ii28-34. http://doi.org/10.1136/sti.2010.044255.
2009
Brinkhof, Martin W. G.; Boulle, Andrew; Weigel, Ralf; Messou, Eugène; Mathers, Colin et al. (2009). Mortality of HIV-infected patients starting antiretroviral therapy in sub-Saharan Africa: comparison with HIV-unrelated mortality. PLoS Medicine, 6 (4), S. e1000066–e1000066. http://doi.org/10.1371/journal.pmed.1000066.
Davies, Mary-Ann; Connell, Tom; Johannisen, Christine; Wood, Kathryn; Pienaar, Sandy et al. (2009). Detection of tuberculosis in HIV-infected children using an enzyme-linked immunospot assay. AIDS (London, England), 23 (8), S. 961–969. http://doi.org/10.1097/QAD.0b013e32832956ad.
Cornell, Morna; Myer, Landon; Kaplan, Richard; Bekker, Linda-Gail & Wood, Robin (2009). The impact of gender and income on survival and retention in a South African antiretroviral therapy programme. Tropical Medicine & International Health : TM & IH, 14 (7), S. 722–731. http://doi.org/10.1111/j.1365-3156.2009.02290.x.
ART-LINC of IeDEA Study Group; Keiser, Olivia; Tweya, Hannock; Boulle, Andrew; Braitstein, Paula et al. (2009). Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring. AIDS (London, England), 23 (14), S. 1867–1874. http://doi.org/10.1097/QAD.0b013e32832e05b2.
Cornell, Morna; Technau, Karl; Fairall, Lara; Wood, Robin; Moultrie, Harry et al. (2009). Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the IeDEA Southern Africa collaboration. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 99 (9), S. 653–660. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20073292
Davies, Mary-Ann & Meintjes, Graeme (2009). Assessing the contribution of the immune reconstitution inflammatory syndrome to mortality in developing country antiretroviral therapy programs. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 49 (6), S. 973–975. http://doi.org/10.1086/605501.
Davies, Mary-Ann; Egger, Matthias; Keiser, Olivia & Boulle, Andrew (2009). Paediatric antiretroviral treatment programmes in sub-Saharan Africa: a review of published clinical studies. African Journal of AIDS Research : AJAR, 8 (3), S. 329–338. http://doi.org/10.2989/AJAR.2009.8.3.9.930.
Davies, Mary-Ann; Keiser, Olivia; Technau, Karl; Eley, Brian; Rabie, Helena et al. (2009). Outcomes of the South African National Antiretroviral Treatment Programme for children: the IeDEA Southern Africa collaboration. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 99 (10), S. 730–737. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20128272
Keiser, Olivia; MacPhail, Patrick; Boulle, Andrew; Wood, Robin; Schechter, Mauro et al. (2009). Accuracy of WHO CD4 cell count criteria for virological failure of antiretroviral therapy. Tropical Medicine & International Health : TM & IH, 14 (10), S. 1220–1225. http://doi.org/10.1111/j.1365-3156.2009.02338.x.
Losina, Elena; Touré, Hapsatou; Uhler, Lauren M.; Anglaret, Xavier; Paltiel, A. David et al. (2009). Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: a Côte d’Ivoire appraisal. PLoS Medicine, 6 (10), S. e1000173–e1000173. http://doi.org/10.1371/journal.pmed.1000173.
May, Margaret; Wood, Robin; Myer, Landon; Taffé, Patrick; Rauch, Andri et al. (2009). CD4(+) T cell count decreases by ethnicity among untreated patients with HIV infection in South Africa and Switzerland. The Journal of Infectious Diseases, 200 (11), S. 1729–1735. http://doi.org/10.1086/648096.
2008
Egger, Matthias & Boulle, Andrew (2008). Population effect of scaling up ART in resource-poor settings. Lancet (London, England), 371 (9624), S. 1558–1559. http://doi.org/10.1016/S0140-6736(08)60669-8.
Arrivé, Elise; Kyabayinze, Daniel J.; Marquis, Benoit; Tumwesigye, Nathan; Kieffer, Mary-Pat et al. (2008). Cohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaboration. International Journal of Epidemiology, 37 (3), S. 474–480. http://doi.org/10.1093/ije/dym216.
ART-LINC Collaboration of International Databases to Evaluate AIDS (IeDEA); Keiser, Olivia; Anastos, Kathryn; Schechter, Mauro; Balestre, Eric et al. (2008). Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America. Tropical Medicine & International Health : TM & IH, 13 (7), S. 870–879. http://doi.org/10.1111/j.1365-3156.2008.02078.x.
Brinkhof, Martin W. G.; Dabis, François; Myer, Landon; Bangsberg, David R.; Boulle, Andrew et al. (2008). Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries. Bulletin of the World Health Organization, 86 (7), S. 559–567. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18670668
Keiser, Olivia; Orrell, Catherine; Egger, Matthias; Wood, Robin; Brinkhof, Martin W. G. et al. (2008). Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared. PLoS Medicine, 5 (7), S. e148–e148. http://doi.org/10.1371/journal.pmed.0050148.
Boulle, Andrew; Bock, Peter; Osler, Meg; Cohen, Karen; Channing, Liezl et al. (2008). Antiretroviral therapy and early mortality in South Africa. Bulletin of the World Health Organization, 86 (9), S. 678–687. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18797643
Davies, Mary-Ann; Boulle, Andrew; Fakir, Tanzeem; Nuttall, James & Eley, Brian (2008). Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study. BMC Pediatrics, 8 (1), S. 34–34. http://doi.org/10.1186/1471-2431-8-34.
Nash, Denis; Katyal, Monica; Brinkhof, Martin W. G.; Keiser, Olivia; May, Margaret et al. (2008). Long-term immunologic response to antiretroviral therapy in low-income countries: a collaborative analysis of prospective studies. AIDS (London, England), 22 (17), S. 2291–2302. http://doi.org/10.1097/QAD.0b013e3283121ca9.
Forster, Mathieu; Bailey, Christopher; Brinkhof, Martin W. G.; Graber, Claire; Boulle, Andrew et al. (2008). Electronic medical record systems, data quality and loss to follow-up: survey of antiretroviral therapy programmes in resource-limited settings. Bulletin of the World Health Organization, 86 (12), S. 939–947. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19142294
Wood, Robin (2008). Atazanavir: its role in HIV treatment. Expert Review of Anti-Infective Therapy, 6 (6), S. 785–796. http://doi.org/10.1586/14787210.6.6.785.
2007
Tuboi, Suely H.; Brinkhof, Martin W. G.; Egger, Matthias; Stone, Roslyn A.; Braitstein, Paula et al. (2007). Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaboration. Journal of Acquired Immune Deficiency Syndromes (1999), 45 (1), S. 52–59. http://doi.org/10.1097/QAI.0b013e318042e1c3.
Antiretroviral Therapy in Low-Income Countries Collaboration of the International epidemiological Databases to Evaluate AIDS (IeDEA); ART Cohort Collaboration; Brinkhof, Martin W. G.; Egger, Matthias; Boulle, Andrew et al. (2007). Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 45 (11), S. 1518–1521. http://doi.org/10.1086/522986.
Boulle, Andrew; Orrel, Catherine; Kaplan, Richard; Van Cutsem, Gilles; McNally, Matthew et al. (2007). Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohort. Antiviral Therapy, 12 (5), S. 753–760. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17713158